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The map label for this gene is ffh [H]

Identifier: 37522208

GI number: 37522208

Start: 2795034

End: 2796527

Strand: Reverse

Name: ffh [H]

Synonym: gvip369

Alternate gene names: 37522208

Gene position: 2796527-2795034 (Counterclockwise)

Preceding gene: 37522212

Following gene: 37522207

Centisome position: 60.02

GC content: 63.12

Gene sequence:

>1494_bases
ATGTTCGAATCGCTCAGTGAAAAGCTTGAAGGTGCCTGGCGGAAGCTGCGCGGCCAGGACCGCATCACCGAGGGCAATAT
CGACGAGGCGTTGCGCGAGGTGCGCCGCGCTTTGCTCGAAGCCGACGTCAATTTTCAGGTGGCCAAGGAGTTCGTCGCCG
ACGTGCGCGACGACGCGCTGGGCGCCGAGGTCGTCAGCGGCGTCACTCCCGACCAGCAGTTCATCAAGATAGTCCACGAC
CAACTCGTCGCCCTGATGGGCGAGCAGAACGTCCCCCTAGCCGAGCCGCGCGCCAAGGGTCGTCCGGCGGTGGTGCTGAT
GGCCGGTCTGCAGGGTACCGGCAAGACGACCGCCTCCGCCAAGCTCGCACTCTATCTGCAAAAGAACGGCCAGAAGCCGC
TGCTGGCTGCTGCCGACGTCTACCGTCCCGCCGCCATCGACCAGTTGCAGACGTTGGGCGGCCAAATTCAGGTACCGGTC
TTCACCCTGGGCAAAGAGGCCGATCCGGTCGATATCGCCCGCGCTTCCCTGGAGCGGGCCATCGCGGACCGCCACGACGT
GCTCATCGTCGATACGGCCGGGCGGTTGTCGATCGATGACGCGATGATGGCCGAACTGGAACGCATCAAGGCGGCCATCG
ACCCCGAAGAAATTTTGTTGGTCGTGGACGCGATGACCGGTCAGGAGGCGGCCAACCTCACCCGTGCCTTCCACGACCGG
CTGGGGATTACCGGGGCCATCCTCACCAAGCTGGACGGCGATACCCGCGGCGGGGCCGCCCTCTCGGTGCGCAAAATCTC
CGGTCAGCCCATCAAGTTCGTGGGCGTGGGCGAAAAAGTCGAAGCGCTGCAGCCTTTCTATCCCGAGCGGATGGCCTCGC
GCATTTTGGGAATGGGCGATGTGCTCACCCTGGTTGAAAAAGCCCAGGAAGAAATCGATTTTGCCGACGCGGCCAAGATG
GAGCAGCAGCTGCTCACCGGGCAGTTCGACTTCGAAAGTTTCATCAAGCAGATGCGGATGATCAAGAACATGGGGCCTCT
GGGCGGTGTTCTGAAGATGATCCCCGGCATGAACAAGATCAGCGACGACCAGATTCGCCAGGGCGAAGTGCAGCTCAAAA
AAGCCGAGGCGATGATCGGTTCGATGACCACCCAGGAGCGGCGCAACCCGGATCTGATCAATCTCTCGCGCAAGCGCCGC
ATCTCCAAAGGTTCCGGTGTCTCCCTCGAAGATGTGGGCAAGTTGCTCAACGACTTTGGCAAGATGCGCCAGATGATGAA
GATGATGGGCGGCGGCGGTCCTTTCGGGGGCGGCATGCCCGGGGGGGGCCTGGGCGGCATGTTCGGCGGCGGCGGCCGAC
AGGCCCAAAGCGCCGGTCCCAACCCGGCTTTTGGCCCCGGCTGGCGCGGACAGTCCGCTTCCGGATCTCGAAGACCCAAC
CCGCCCAAGCCGCCCAAAGGCAAAGGCAAGAAAAAGCGCAAGGGTTTTGGGTGA

Upstream 100 bases:

>100_bases
TTGGCGTCGGCTTATCGGGCCGCCGGGGGGTGAAGGGGAGCACGGGACTTGCTGAGCGGTTTTTTCCCGTGCGATACTGG
CAGTCCGTGCTGCAAAGATC

Downstream 100 bases:

>100_bases
TAATTGAGTTTTTTGTAACCTACCAAGGAGGTGAACAGCAATCGCTGTTGCAATTCGCTTGAAGCGCATTGGCGCCAAGA
AAAAGCCGGTCTACCGCATC

Product: signal recognition particle protein SRP54

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 497; Mature: 497

Protein sequence:

>497_residues
MFESLSEKLEGAWRKLRGQDRITEGNIDEALREVRRALLEADVNFQVAKEFVADVRDDALGAEVVSGVTPDQQFIKIVHD
QLVALMGEQNVPLAEPRAKGRPAVVLMAGLQGTGKTTASAKLALYLQKNGQKPLLAAADVYRPAAIDQLQTLGGQIQVPV
FTLGKEADPVDIARASLERAIADRHDVLIVDTAGRLSIDDAMMAELERIKAAIDPEEILLVVDAMTGQEAANLTRAFHDR
LGITGAILTKLDGDTRGGAALSVRKISGQPIKFVGVGEKVEALQPFYPERMASRILGMGDVLTLVEKAQEEIDFADAAKM
EQQLLTGQFDFESFIKQMRMIKNMGPLGGVLKMIPGMNKISDDQIRQGEVQLKKAEAMIGSMTTQERRNPDLINLSRKRR
ISKGSGVSLEDVGKLLNDFGKMRQMMKMMGGGGPFGGGMPGGGLGGMFGGGGRQAQSAGPNPAFGPGWRGQSASGSRRPN
PPKPPKGKGKKKRKGFG

Sequences:

>Translated_497_residues
MFESLSEKLEGAWRKLRGQDRITEGNIDEALREVRRALLEADVNFQVAKEFVADVRDDALGAEVVSGVTPDQQFIKIVHD
QLVALMGEQNVPLAEPRAKGRPAVVLMAGLQGTGKTTASAKLALYLQKNGQKPLLAAADVYRPAAIDQLQTLGGQIQVPV
FTLGKEADPVDIARASLERAIADRHDVLIVDTAGRLSIDDAMMAELERIKAAIDPEEILLVVDAMTGQEAANLTRAFHDR
LGITGAILTKLDGDTRGGAALSVRKISGQPIKFVGVGEKVEALQPFYPERMASRILGMGDVLTLVEKAQEEIDFADAAKM
EQQLLTGQFDFESFIKQMRMIKNMGPLGGVLKMIPGMNKISDDQIRQGEVQLKKAEAMIGSMTTQERRNPDLINLSRKRR
ISKGSGVSLEDVGKLLNDFGKMRQMMKMMGGGGPFGGGMPGGGLGGMFGGGGRQAQSAGPNPAFGPGWRGQSASGSRRPN
PPKPPKGKGKKKRKGFG
>Mature_497_residues
MFESLSEKLEGAWRKLRGQDRITEGNIDEALREVRRALLEADVNFQVAKEFVADVRDDALGAEVVSGVTPDQQFIKIVHD
QLVALMGEQNVPLAEPRAKGRPAVVLMAGLQGTGKTTASAKLALYLQKNGQKPLLAAADVYRPAAIDQLQTLGGQIQVPV
FTLGKEADPVDIARASLERAIADRHDVLIVDTAGRLSIDDAMMAELERIKAAIDPEEILLVVDAMTGQEAANLTRAFHDR
LGITGAILTKLDGDTRGGAALSVRKISGQPIKFVGVGEKVEALQPFYPERMASRILGMGDVLTLVEKAQEEIDFADAAKM
EQQLLTGQFDFESFIKQMRMIKNMGPLGGVLKMIPGMNKISDDQIRQGEVQLKKAEAMIGSMTTQERRNPDLINLSRKRR
ISKGSGVSLEDVGKLLNDFGKMRQMMKMMGGGGPFGGGMPGGGLGGMFGGGGRQAQSAGPNPAFGPGWRGQSASGSRRPN
PPKPPKGKGKKKRKGFG

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=442, Percent_Identity=35.5203619909502, Blast_Score=256, Evalue=4e-68,
Organism=Homo sapiens, GI226371618, Length=384, Percent_Identity=35.6770833333333, Blast_Score=229, Evalue=6e-60,
Organism=Homo sapiens, GI89061728, Length=145, Percent_Identity=37.9310344827586, Blast_Score=113, Evalue=5e-25,
Organism=Homo sapiens, GI295424842, Length=298, Percent_Identity=28.8590604026846, Blast_Score=109, Evalue=7e-24,
Organism=Homo sapiens, GI23308697, Length=298, Percent_Identity=28.8590604026846, Blast_Score=109, Evalue=8e-24,
Organism=Escherichia coli, GI1788963, Length=430, Percent_Identity=50.6976744186047, Blast_Score=412, Evalue=1e-116,
Organism=Escherichia coli, GI1789874, Length=209, Percent_Identity=41.1483253588517, Blast_Score=149, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17539958, Length=466, Percent_Identity=30.2575107296137, Blast_Score=227, Evalue=9e-60,
Organism=Caenorhabditis elegans, GI193206261, Length=305, Percent_Identity=29.5081967213115, Blast_Score=116, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6325345, Length=413, Percent_Identity=32.4455205811138, Blast_Score=216, Evalue=6e-57,
Organism=Saccharomyces cerevisiae, GI6320498, Length=315, Percent_Identity=24.4444444444444, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI17647949, Length=437, Percent_Identity=32.7231121281465, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24641198, Length=251, Percent_Identity=31.0756972111554, Blast_Score=111, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 53448; Mature: 53448

Theoretical pI: Translated: 10.07; Mature: 10.07

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFESLSEKLEGAWRKLRGQDRITEGNIDEALREVRRALLEADVNFQVAKEFVADVRDDAL
CCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
GAEVVSGVTPDQQFIKIVHDQLVALMGEQNVPLAEPRAKGRPAVVLMAGLQGTGKTTASA
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCC
KLALYLQKNGQKPLLAAADVYRPAAIDQLQTLGGQIQVPVFTLGKEADPVDIARASLERA
EEEEEEECCCCCCEEEHHHHHCHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHH
IADRHDVLIVDTAGRLSIDDAMMAELERIKAAIDPEEILLVVDAMTGQEAANLTRAFHDR
HHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHH
LGITGAILTKLDGDTRGGAALSVRKISGQPIKFVGVGEKVEALQPFYPERMASRILGMGD
HCCCHHHHHHCCCCCCCCCEEEEEECCCCCEEEEECCCHHHHHCCCCHHHHHHHHHCCHH
VLTLVEKAQEEIDFADAAKMEQQLLTGQFDFESFIKQMRMIKNMGPLGGVLKMIPGMNKI
HHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCC
SDDQIRQGEVQLKKAEAMIGSMTTQERRNPDLINLSRKRRISKGSGVSLEDVGKLLNDFG
CHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHH
KMRQMMKMMGGGGPFGGGMPGGGLGGMFGGGGRQAQSAGPNPAFGPGWRGQSASGSRRPN
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PPKPPKGKGKKKRKGFG
CCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MFESLSEKLEGAWRKLRGQDRITEGNIDEALREVRRALLEADVNFQVAKEFVADVRDDAL
CCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
GAEVVSGVTPDQQFIKIVHDQLVALMGEQNVPLAEPRAKGRPAVVLMAGLQGTGKTTASA
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCC
KLALYLQKNGQKPLLAAADVYRPAAIDQLQTLGGQIQVPVFTLGKEADPVDIARASLERA
EEEEEEECCCCCCEEEHHHHHCHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHH
IADRHDVLIVDTAGRLSIDDAMMAELERIKAAIDPEEILLVVDAMTGQEAANLTRAFHDR
HHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHH
LGITGAILTKLDGDTRGGAALSVRKISGQPIKFVGVGEKVEALQPFYPERMASRILGMGD
HCCCHHHHHHCCCCCCCCCEEEEEECCCCCEEEEECCCHHHHHCCCCHHHHHHHHHCCHH
VLTLVEKAQEEIDFADAAKMEQQLLTGQFDFESFIKQMRMIKNMGPLGGVLKMIPGMNKI
HHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCC
SDDQIRQGEVQLKKAEAMIGSMTTQERRNPDLINLSRKRRISKGSGVSLEDVGKLLNDFG
CHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHH
KMRQMMKMMGGGGPFGGGMPGGGLGGMFGGGGRQAQSAGPNPAFGPGWRGQSASGSRRPN
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PPKPPKGKGKKKRKGFG
CCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]