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The map label for this gene is barA [H]

Identifier: 37522196

GI number: 37522196

Start: 2783410

End: 2785284

Strand: Reverse

Name: barA [H]

Synonym: gll2627

Alternate gene names: 37522196

Gene position: 2785284-2783410 (Counterclockwise)

Preceding gene: 37522197

Following gene: 37522191

Centisome position: 59.78

GC content: 64.8

Gene sequence:

>1875_bases
GTGAAAACACCCGAAAACGAAAACGTTTCCAAAGCAGAGTTGACGGCGCAGCTTGTCCAGCTGCGGCAAGAGGTTGAAGC
GTTGCGCTTCAGCGCCCAATCGCACCGCGAGGCAGTCGAAGAGTGCGACCGGCTCAAAGCTCAGCAAAAAATCGCCGCCG
AGCGTGCTCATTTTTTGGCCAATGCCGTGGCCATCCTCACCTCTTCCCTCGACTACGCCACCACGCTGGCCACGGTCGCC
CAGCTCGTGGTGGCACGGTTGGCCGACATCTGCATCATCGATTTGCTCGGAGACGATCTGACCATCCGGCGGCTGATTAC
CGCCAACGCCGCACTGCGGCGCACAGGACTCGCCTGGGAAGTCGAGCGGCGCTATCCGTTTATTTCCGGCGCTCTGTACG
GCCCGGCCCGGGTGGTAAGCACCGGCCTACCGGAGATCGTACCGGTGGTCGAAGACCGGTTTGCCGCCGCCCACGGTATC
GGCTGCGAGCACCCGGAGCTGCTCCGGTGTCTTGAATTGGGTTCCTGCATGTGCGTACCCCTGGTGACAGGGGAGCGAAT
CCTGGGAGCGCTCACTTTTGTCAGCGGCAGCACTTCGCGGCCCTACGGCGGTGACGATCTGGCGTTGGCGCAGGAACTGG
CCAATCGCGCCGCCCAGGCGATCGAAAATGCCCGGTTGCACCAGGCCGAGAGCCACGCACGCGCCGAAGCCGAGGCGGCC
AACCGCGCCAAGGACGAGTTTCTGGCCACCCTCAGTCACGAACTGCGCACTCCCCTCAACTCGATCATCGGCTTCAGCCA
GTTGCTGCGGCGCGGCCGGATGAACCCCGCCGCCATCGAGCAGGCCGCCGAGGCGATCGAGCGCAACGGCCGCCTGCAGG
CCCAACTGGTGGACGACCTGCTCGATGCGTCCTACATGCTGCGCGGCCAGTTGCAGTTGCACTGCTGCCGCGTCGATCTG
CGGGCGGTGGTCGAAAACGTGCTCACTTCCATGCGGGCGCTAATCCGCGAGAAGGGCCTGGTCCTCAGAACCCGCGTCGC
CCAGAACCTCGAACCGTTCTGGGGAGATCCGCGCCGCCTCAAGCAAATTGTCGCCAACCTGGTTGCCAACGCCATCAAAT
TCACGCCCCCCGGGGGAATGATAAGCGTACAGCTGGAGGCGACGGCAGGTCAGCTGCAGCTGACGGTGCGGGACACGGGC
GTGGGAATCGACGCCGAATTTCTGCCGCACGTTTTTGAAGTGTTTCGTCAAGCCGACGGCACCTCCACCCGTCGCCACGG
CGGCTTGGGGTTGGGGTTGAGTTTGGTGCAGCATCTGGTGCACCTGCACAGCGGCACGATCGAAGTGCAAAGCGACGGCA
AAAACTGGGGCAGCAGCTTTACGCTCCGCCTTCCCCTTGACGCCAGGCGCAGCGCCGAGGCGGAAGCCGCCGAGGATGGG
GCAGCTGCTGCAACCCTGAGGGGTTTGCGTCTGCTGTTGCTGGTGGAGGATGCCGAACTGCGCCGCACACTCCACGCCGC
GCTTGCCGCTCAAGGAGCGCGGGTGCTGACTGTCGATCGCGTCGAAGCGGCCCTGGAGCAGTTCGAGGGTTACCGCCCGG
ATGTGCTCATCACTGCCGCTCCCACCTACAACCGCGAGGGGCTCTGCTGCTCTCTGGTGCGCAAGCTCGGCGAGCAGGAG
GAGCCTTACCCCGCGGCGGAAATCGAAGCACAGGAGCGCCGGATGATGCTTGCAAGCTTCGCTATCCAACCTCCCCGGCC
CGTCGAGCCGGAGGACCTCGCCTCGGAGGTGGCGCGGTTGGTCGGCAGGCAGGTGATCACCCGCATGCCGGGCGAATCGA
GCACGGCCCCGAGTTGCCTATTGCGGGGAGATTAG

Upstream 100 bases:

>100_bases
GAATGGACTTGGGAAACATCCAACAAATCGGCGATTTGCGGTGTGTTGTCCCACATAAAACAATGCATCTTTCCATGGTG
CCTATCCGTGGAGCGCTTCT

Downstream 100 bases:

>100_bases
CCGGCGTTCGCGGTCGGAAGGCGGTTCGACATTGAGCGCTCCCAGTTCGATGAGCCCCGAGGCCCAGGCCGGATCGAGTT
CGCGGCATTCGTAAAAATCG

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 624; Mature: 624

Protein sequence:

>624_residues
MKTPENENVSKAELTAQLVQLRQEVEALRFSAQSHREAVEECDRLKAQQKIAAERAHFLANAVAILTSSLDYATTLATVA
QLVVARLADICIIDLLGDDLTIRRLITANAALRRTGLAWEVERRYPFISGALYGPARVVSTGLPEIVPVVEDRFAAAHGI
GCEHPELLRCLELGSCMCVPLVTGERILGALTFVSGSTSRPYGGDDLALAQELANRAAQAIENARLHQAESHARAEAEAA
NRAKDEFLATLSHELRTPLNSIIGFSQLLRRGRMNPAAIEQAAEAIERNGRLQAQLVDDLLDASYMLRGQLQLHCCRVDL
RAVVENVLTSMRALIREKGLVLRTRVAQNLEPFWGDPRRLKQIVANLVANAIKFTPPGGMISVQLEATAGQLQLTVRDTG
VGIDAEFLPHVFEVFRQADGTSTRRHGGLGLGLSLVQHLVHLHSGTIEVQSDGKNWGSSFTLRLPLDARRSAEAEAAEDG
AAAATLRGLRLLLLVEDAELRRTLHAALAAQGARVLTVDRVEAALEQFEGYRPDVLITAAPTYNREGLCCSLVRKLGEQE
EPYPAAEIEAQERRMMLASFAIQPPRPVEPEDLASEVARLVGRQVITRMPGESSTAPSCLLRGD

Sequences:

>Translated_624_residues
MKTPENENVSKAELTAQLVQLRQEVEALRFSAQSHREAVEECDRLKAQQKIAAERAHFLANAVAILTSSLDYATTLATVA
QLVVARLADICIIDLLGDDLTIRRLITANAALRRTGLAWEVERRYPFISGALYGPARVVSTGLPEIVPVVEDRFAAAHGI
GCEHPELLRCLELGSCMCVPLVTGERILGALTFVSGSTSRPYGGDDLALAQELANRAAQAIENARLHQAESHARAEAEAA
NRAKDEFLATLSHELRTPLNSIIGFSQLLRRGRMNPAAIEQAAEAIERNGRLQAQLVDDLLDASYMLRGQLQLHCCRVDL
RAVVENVLTSMRALIREKGLVLRTRVAQNLEPFWGDPRRLKQIVANLVANAIKFTPPGGMISVQLEATAGQLQLTVRDTG
VGIDAEFLPHVFEVFRQADGTSTRRHGGLGLGLSLVQHLVHLHSGTIEVQSDGKNWGSSFTLRLPLDARRSAEAEAAEDG
AAAATLRGLRLLLLVEDAELRRTLHAALAAQGARVLTVDRVEAALEQFEGYRPDVLITAAPTYNREGLCCSLVRKLGEQE
EPYPAAEIEAQERRMMLASFAIQPPRPVEPEDLASEVARLVGRQVITRMPGESSTAPSCLLRGD
>Mature_624_residues
MKTPENENVSKAELTAQLVQLRQEVEALRFSAQSHREAVEECDRLKAQQKIAAERAHFLANAVAILTSSLDYATTLATVA
QLVVARLADICIIDLLGDDLTIRRLITANAALRRTGLAWEVERRYPFISGALYGPARVVSTGLPEIVPVVEDRFAAAHGI
GCEHPELLRCLELGSCMCVPLVTGERILGALTFVSGSTSRPYGGDDLALAQELANRAAQAIENARLHQAESHARAEAEAA
NRAKDEFLATLSHELRTPLNSIIGFSQLLRRGRMNPAAIEQAAEAIERNGRLQAQLVDDLLDASYMLRGQLQLHCCRVDL
RAVVENVLTSMRALIREKGLVLRTRVAQNLEPFWGDPRRLKQIVANLVANAIKFTPPGGMISVQLEATAGQLQLTVRDTG
VGIDAEFLPHVFEVFRQADGTSTRRHGGLGLGLSLVQHLVHLHSGTIEVQSDGKNWGSSFTLRLPLDARRSAEAEAAEDG
AAAATLRGLRLLLLVEDAELRRTLHAALAAQGARVLTVDRVEAALEQFEGYRPDVLITAAPTYNREGLCCSLVRKLGEQE
EPYPAAEIEAQERRMMLASFAIQPPRPVEPEDLASEVARLVGRQVITRMPGESSTAPSCLLRGD

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=297, Percent_Identity=37.037037037037, Blast_Score=160, Evalue=3e-40,
Organism=Escherichia coli, GI145693157, Length=306, Percent_Identity=33.9869281045752, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI87081816, Length=388, Percent_Identity=32.2164948453608, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1788713, Length=362, Percent_Identity=28.7292817679558, Blast_Score=112, Evalue=8e-26,
Organism=Escherichia coli, GI48994928, Length=329, Percent_Identity=31.9148936170213, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1786783, Length=246, Percent_Identity=29.2682926829268, Blast_Score=95, Evalue=2e-20,
Organism=Escherichia coli, GI1788393, Length=252, Percent_Identity=30.952380952381, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786600, Length=224, Percent_Identity=29.9107142857143, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1790436, Length=223, Percent_Identity=30.9417040358744, Blast_Score=89, Evalue=9e-19,
Organism=Escherichia coli, GI1788549, Length=227, Percent_Identity=29.5154185022026, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1790861, Length=231, Percent_Identity=29.8701298701299, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1786912, Length=293, Percent_Identity=27.3037542662116, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1787894, Length=288, Percent_Identity=26.0416666666667, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI1790346, Length=229, Percent_Identity=27.0742358078603, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1790300, Length=237, Percent_Identity=31.2236286919831, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1788279, Length=222, Percent_Identity=26.5765765765766, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1789808, Length=226, Percent_Identity=28.3185840707965, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790551, Length=113, Percent_Identity=33.6283185840708, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR019247
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF09984 DUF2222; PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; PF01627 Hpt; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 68049; Mature: 68049

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTPENENVSKAELTAQLVQLRQEVEALRFSAQSHREAVEECDRLKAQQKIAAERAHFLA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NAVAILTSSLDYATTLATVAQLVVARLADICIIDLLGDDLTIRRLITANAALRRTGLAWE
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEE
VERRYPFISGALYGPARVVSTGLPEIVPVVEDRFAAAHGIGCEHPELLRCLELGSCMCVP
ECCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCEEEEE
LVTGERILGALTFVSGSTSRPYGGDDLALAQELANRAAQAIENARLHQAESHARAEAEAA
ECCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NRAKDEFLATLSHELRTPLNSIIGFSQLLRRGRMNPAAIEQAAEAIERNGRLQAQLVDDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHH
LDASYMLRGQLQLHCCRVDLRAVVENVLTSMRALIREKGLVLRTRVAQNLEPFWGDPRRL
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHH
KQIVANLVANAIKFTPPGGMISVQLEATAGQLQLTVRDTGVGIDAEFLPHVFEVFRQADG
HHHHHHHHHHHHEECCCCCEEEEEEEECCCEEEEEEEECCCCCCHHHHHHHHHHHHHCCC
TSTRRHGGLGLGLSLVQHLVHLHSGTIEVQSDGKNWGSSFTLRLPLDARRSAEAEAAEDG
CCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCEEEEEECCCCCCCCCCHHHCCC
AAAATLRGLRLLLLVEDAELRRTLHAALAAQGARVLTVDRVEAALEQFEGYRPDVLITAA
HHHHHHHHCEEEEEECCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHCCCCCCEEEEEC
PTYNREGLCCSLVRKLGEQEEPYPAAEIEAQERRMMLASFAIQPPRPVEPEDLASEVARL
CCCCCCCHHHHHHHHHCCCCCCCCCHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
VGRQVITRMPGESSTAPSCLLRGD
HHHHHHHHCCCCCCCCCCEEECCC
>Mature Secondary Structure
MKTPENENVSKAELTAQLVQLRQEVEALRFSAQSHREAVEECDRLKAQQKIAAERAHFLA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NAVAILTSSLDYATTLATVAQLVVARLADICIIDLLGDDLTIRRLITANAALRRTGLAWE
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEE
VERRYPFISGALYGPARVVSTGLPEIVPVVEDRFAAAHGIGCEHPELLRCLELGSCMCVP
ECCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCEEEEE
LVTGERILGALTFVSGSTSRPYGGDDLALAQELANRAAQAIENARLHQAESHARAEAEAA
ECCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NRAKDEFLATLSHELRTPLNSIIGFSQLLRRGRMNPAAIEQAAEAIERNGRLQAQLVDDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHH
LDASYMLRGQLQLHCCRVDLRAVVENVLTSMRALIREKGLVLRTRVAQNLEPFWGDPRRL
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHH
KQIVANLVANAIKFTPPGGMISVQLEATAGQLQLTVRDTGVGIDAEFLPHVFEVFRQADG
HHHHHHHHHHHHEECCCCCEEEEEEEECCCEEEEEEEECCCCCCHHHHHHHHHHHHHCCC
TSTRRHGGLGLGLSLVQHLVHLHSGTIEVQSDGKNWGSSFTLRLPLDARRSAEAEAAEDG
CCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCEEEEEECCCCCCCCCCHHHCCC
AAAATLRGLRLLLLVEDAELRRTLHAALAAQGARVLTVDRVEAALEQFEGYRPDVLITAA
HHHHHHHHCEEEEEECCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHCCCCCCEEEEEC
PTYNREGLCCSLVRKLGEQEEPYPAAEIEAQERRMMLASFAIQPPRPVEPEDLASEVARL
CCCCCCCHHHHHHHHHCCCCCCCCCHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
VGRQVITRMPGESSTAPSCLLRGD
HHHHHHHHCCCCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]