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The map label for this gene is pepA

Identifier: 37522180

GI number: 37522180

Start: 2765111

End: 2766625

Strand: Direct

Name: pepA

Synonym: glr2611

Alternate gene names: 37522180

Gene position: 2765111-2766625 (Clockwise)

Preceding gene: 37522178

Following gene: 37522182

Centisome position: 59.35

GC content: 65.02

Gene sequence:

>1515_bases
ATGGAATTTGAAGCGGTCCGGATCTCTCCGGGGAAATATCGGGGGGACGCCCTGCTGGTGGGCCTGTTCCAGGACGGGCC
GGAACCGGCCCTGGCCCTGGCCGCCCTCGATGCGGCGGTGGCGGCGGTGGTGCTCGAAGTCATTTCCGAAGAAGAATTTA
AACCGAAAAGCCGCCAGAAGCTCACGGTGCGCGTGGGCGGCGATACCGGCCTGCGCAAGGTGGTGCTGGTGGGTCTGGGC
GAGCAGGCCAAGTACAAACCCGAGTCGCTGCGCCAGTGCATCGGCGAGGGTGCCCGCACCCTCAAGGCGATCAAGGCGAC
CACCGCCGGGGTGTGGGTACCGCCCCTGGGCGAGGGCGGCGAAGAGGCGACCGTCGAAGCGCTCGTCGAGGCGATCCGCT
TGGCCCTGCACGAGGACAGGCGCTTTCGCTCCAAAAAATCGGACAGCGAAGAAAACGGCAACAGCAACAACGGCGGCGAG
AACAAATTGACCAAAGTGAGCCTGGTGGTGGCGGGCGAAGGCGACTACGCCGCGGCCGTCCGCCGGGGCAATATCCTGGC
CGAAGGGACGATCTTTGCGCGCGAACTGGTCTCCGCCCCCGCCAACTACGTCACCTCCGTCACCCTGGCTGAGCAGGCGA
CAGCGATCGCCGAGGCGAACGGCCTGGAGTGCGAGATTCTCGAAAAAGAAGATTGCGAACGGCTGGGCATGGGTGCGTAC
CTGGGAGTGGCCCAGGGCACCGATTTGCCGCCCAAATTCATCCACCTCACCTACAAACCCGCCCACAGCGCCCCGCGCAA
GCGCATCGCCATCATCGGCAAGGGCATCACCTTCGACTCGGGTGGACTGTCCATCAAACCCGCCAAGGGCATGGAATTGA
TGAAAGTCGACATGGGCGGGGCCGCCGCCGCCCTGGGAGCCGCCAAGGTCCTGGGGCAGCTCAAACCCGACATCGAAGTG
CACTTTATCGTGGCGGCCACCGAGAACATGGTCTCGGGCCACGCCATCCACCCCGGCGACATCCTCACCGCCTCCAACGG
CAAGACCATCGAAGTCGACAACACCGACGCCGAGGGACGGCTCACCCTGGCGGACGCACTGGTCTTCTCCGAGAAACTGG
GCGTCGATGCGATTGTCGATCTGGCCACCCTTACCGGCGCCTGCGTCGTCGCCCTGGGTAACGACATCGCGGGGCTGCTC
ACCGAAAACGAAGAACTGGCCCGGCAGATCCGCGCGGCGGGTGAGGCGAGCGGCGAGAAGTTCTGGCAACTCCCCATGGA
AGAGAGCTACTTCGAAGGGATGAAGTCGGTGGTGGCCGACATGCGCAACACCGGCTCGCGCGAAGGCGGCACGATCACCG
CGGCGCTCTTTCTCAAGCAGTTCGTCGAGAAGACCCCCTGGGTGCACCTCGACATCGCCGGTCCGGTGTGGACCGAAAAG
CAGAAAGGCTACACCAACCGGGGCGGTACCGGCTTCGGCGTGCGCACGCTGGTACGCTTCGTGCTGGCGCAGTAG

Upstream 100 bases:

>100_bases
AAACCACCGCAACGATGGTAAAGCAATGCCCCGCCCGCCGCCACGGCGATCCCCTGGCGAAGCTAACTTAGAGAAATCAG
CAAAGCAACGGAGTCAAGGC

Downstream 100 bases:

>100_bases
CGGCGGACGGTCTATTGGGCTGGGTGGATTAAGAAGAGAGCCCAGAAATTCCCCCCTGGACAATCGGACATATCCCGACT
GAGCTCTGTCGTGTTTCCCT

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MEFEAVRISPGKYRGDALLVGLFQDGPEPALALAALDAAVAAVVLEVISEEEFKPKSRQKLTVRVGGDTGLRKVVLVGLG
EQAKYKPESLRQCIGEGARTLKAIKATTAGVWVPPLGEGGEEATVEALVEAIRLALHEDRRFRSKKSDSEENGNSNNGGE
NKLTKVSLVVAGEGDYAAAVRRGNILAEGTIFARELVSAPANYVTSVTLAEQATAIAEANGLECEILEKEDCERLGMGAY
LGVAQGTDLPPKFIHLTYKPAHSAPRKRIAIIGKGITFDSGGLSIKPAKGMELMKVDMGGAAAALGAAKVLGQLKPDIEV
HFIVAATENMVSGHAIHPGDILTASNGKTIEVDNTDAEGRLTLADALVFSEKLGVDAIVDLATLTGACVVALGNDIAGLL
TENEELARQIRAAGEASGEKFWQLPMEESYFEGMKSVVADMRNTGSREGGTITAALFLKQFVEKTPWVHLDIAGPVWTEK
QKGYTNRGGTGFGVRTLVRFVLAQ

Sequences:

>Translated_504_residues
MEFEAVRISPGKYRGDALLVGLFQDGPEPALALAALDAAVAAVVLEVISEEEFKPKSRQKLTVRVGGDTGLRKVVLVGLG
EQAKYKPESLRQCIGEGARTLKAIKATTAGVWVPPLGEGGEEATVEALVEAIRLALHEDRRFRSKKSDSEENGNSNNGGE
NKLTKVSLVVAGEGDYAAAVRRGNILAEGTIFARELVSAPANYVTSVTLAEQATAIAEANGLECEILEKEDCERLGMGAY
LGVAQGTDLPPKFIHLTYKPAHSAPRKRIAIIGKGITFDSGGLSIKPAKGMELMKVDMGGAAAALGAAKVLGQLKPDIEV
HFIVAATENMVSGHAIHPGDILTASNGKTIEVDNTDAEGRLTLADALVFSEKLGVDAIVDLATLTGACVVALGNDIAGLL
TENEELARQIRAAGEASGEKFWQLPMEESYFEGMKSVVADMRNTGSREGGTITAALFLKQFVEKTPWVHLDIAGPVWTEK
QKGYTNRGGTGFGVRTLVRFVLAQ
>Mature_504_residues
MEFEAVRISPGKYRGDALLVGLFQDGPEPALALAALDAAVAAVVLEVISEEEFKPKSRQKLTVRVGGDTGLRKVVLVGLG
EQAKYKPESLRQCIGEGARTLKAIKATTAGVWVPPLGEGGEEATVEALVEAIRLALHEDRRFRSKKSDSEENGNSNNGGE
NKLTKVSLVVAGEGDYAAAVRRGNILAEGTIFARELVSAPANYVTSVTLAEQATAIAEANGLECEILEKEDCERLGMGAY
LGVAQGTDLPPKFIHLTYKPAHSAPRKRIAIIGKGITFDSGGLSIKPAKGMELMKVDMGGAAAALGAAKVLGQLKPDIEV
HFIVAATENMVSGHAIHPGDILTASNGKTIEVDNTDAEGRLTLADALVFSEKLGVDAIVDLATLTGACVVALGNDIAGLL
TENEELARQIRAAGEASGEKFWQLPMEESYFEGMKSVVADMRNTGSREGGTITAALFLKQFVEKTPWVHLDIAGPVWTEK
QKGYTNRGGTGFGVRTLVRFVLAQ

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=442, Percent_Identity=37.10407239819, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI47155554, Length=349, Percent_Identity=35.243553008596, Blast_Score=163, Evalue=3e-40,
Organism=Escherichia coli, GI1790710, Length=509, Percent_Identity=34.1846758349705, Blast_Score=268, Evalue=8e-73,
Organism=Escherichia coli, GI87082123, Length=321, Percent_Identity=36.7601246105919, Blast_Score=181, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17556903, Length=316, Percent_Identity=36.0759493670886, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17565172, Length=206, Percent_Identity=30.0970873786408, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI21355725, Length=313, Percent_Identity=31.3099041533546, Blast_Score=171, Evalue=8e-43,
Organism=Drosophila melanogaster, GI24661038, Length=313, Percent_Identity=30.3514376996805, Blast_Score=169, Evalue=6e-42,
Organism=Drosophila melanogaster, GI20129969, Length=326, Percent_Identity=32.5153374233129, Blast_Score=166, Evalue=5e-41,
Organism=Drosophila melanogaster, GI161077148, Length=509, Percent_Identity=27.1119842829077, Blast_Score=159, Evalue=5e-39,
Organism=Drosophila melanogaster, GI20130057, Length=509, Percent_Identity=27.1119842829077, Blast_Score=159, Evalue=5e-39,
Organism=Drosophila melanogaster, GI21355645, Length=507, Percent_Identity=26.0355029585799, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24662223, Length=507, Percent_Identity=26.0355029585799, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI21357381, Length=325, Percent_Identity=33.2307692307692, Blast_Score=152, Evalue=7e-37,
Organism=Drosophila melanogaster, GI24662227, Length=326, Percent_Identity=30.3680981595092, Blast_Score=151, Evalue=8e-37,
Organism=Drosophila melanogaster, GI221379063, Length=325, Percent_Identity=33.2307692307692, Blast_Score=151, Evalue=9e-37,
Organism=Drosophila melanogaster, GI221379062, Length=325, Percent_Identity=33.2307692307692, Blast_Score=151, Evalue=9e-37,
Organism=Drosophila melanogaster, GI20129963, Length=357, Percent_Identity=29.9719887955182, Blast_Score=148, Evalue=7e-36,
Organism=Drosophila melanogaster, GI19922386, Length=391, Percent_Identity=29.4117647058824, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24646701, Length=182, Percent_Identity=35.7142857142857, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24646703, Length=182, Percent_Identity=35.7142857142857, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21358201, Length=182, Percent_Identity=35.7142857142857, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_GLOVI (Q7NHC6)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_925557.1
- ProteinModelPortal:   Q7NHC6
- SMR:   Q7NHC6
- MEROPS:   M17.002
- GeneID:   2601012
- GenomeReviews:   BA000045_GR
- KEGG:   gvi:glr2611
- NMPDR:   fig|251221.1.peg.2611
- HOGENOM:   HBG742580
- OMA:   ELHKPCE
- ProtClustDB:   PRK00913
- BioCyc:   GVIO251221:GLR2611-MONOMER
- BRENDA:   3.4.11.1
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 53389; Mature: 53389

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 286-286 ACT_SITE 360-360

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFEAVRISPGKYRGDALLVGLFQDGPEPALALAALDAAVAAVVLEVISEEEFKPKSRQK
CCCEEEEECCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCE
LTVRVGGDTGLRKVVLVGLGEQAKYKPESLRQCIGEGARTLKAIKATTAGVWVPPLGEGG
EEEEECCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCC
EEATVEALVEAIRLALHEDRRFRSKKSDSEENGNSNNGGENKLTKVSLVVAGEGDYAAAV
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCHHHHH
RRGNILAEGTIFARELVSAPANYVTSVTLAEQATAIAEANGLECEILEKEDCERLGMGAY
HCCCEEECCHHHHHHHHHCCHHHHEEEHHHHHHHHHHHCCCCEEEEECHHHHHHHCCCCE
LGVAQGTDLPPKFIHLTYKPAHSAPRKRIAIIGKGITFDSGGLSIKPAKGMELMKVDMGG
EEECCCCCCCCCEEEEEECCCCCCCCCEEEEEECCEEECCCCEEECCCCCCEEEEEECCC
AAAALGAAKVLGQLKPDIEVHFIVAATENMVSGHAIHPGDILTASNGKTIEVDNTDAEGR
HHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCEEECCCCCEEEECCCCCCCE
LTLADALVFSEKLGVDAIVDLATLTGACVVALGNDIAGLLTENEELARQIRAAGEASGEK
EEHHHHHHHHHHCCHHHHHHHHHHHCEEEEEECCCHHEEECCCHHHHHHHHHHCCCCCCC
FWQLPMEESYFEGMKSVVADMRNTGSREGGTITAALFLKQFVEKTPWVHLDIAGPVWTEK
EEECCCHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHCCEEEEEECCCCCCCC
QKGYTNRGGTGFGVRTLVRFVLAQ
CCCCCCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MEFEAVRISPGKYRGDALLVGLFQDGPEPALALAALDAAVAAVVLEVISEEEFKPKSRQK
CCCEEEEECCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCE
LTVRVGGDTGLRKVVLVGLGEQAKYKPESLRQCIGEGARTLKAIKATTAGVWVPPLGEGG
EEEEECCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCC
EEATVEALVEAIRLALHEDRRFRSKKSDSEENGNSNNGGENKLTKVSLVVAGEGDYAAAV
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCHHHHH
RRGNILAEGTIFARELVSAPANYVTSVTLAEQATAIAEANGLECEILEKEDCERLGMGAY
HCCCEEECCHHHHHHHHHCCHHHHEEEHHHHHHHHHHHCCCCEEEEECHHHHHHHCCCCE
LGVAQGTDLPPKFIHLTYKPAHSAPRKRIAIIGKGITFDSGGLSIKPAKGMELMKVDMGG
EEECCCCCCCCCEEEEEECCCCCCCCCEEEEEECCEEECCCCEEECCCCCCEEEEEECCC
AAAALGAAKVLGQLKPDIEVHFIVAATENMVSGHAIHPGDILTASNGKTIEVDNTDAEGR
HHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCEEECCCCCEEEECCCCCCCE
LTLADALVFSEKLGVDAIVDLATLTGACVVALGNDIAGLLTENEELARQIRAAGEASGEK
EEHHHHHHHHHHCCHHHHHHHHHHHCEEEEEECCCHHEEECCCHHHHHHHHHHCCCCCCC
FWQLPMEESYFEGMKSVVADMRNTGSREGGTITAALFLKQFVEKTPWVHLDIAGPVWTEK
EEECCCHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHCCEEEEEECCCCCCCC
QKGYTNRGGTGFGVRTLVRFVLAQ
CCCCCCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292