Click here to switch to the map view.

The map label for this gene is ppiA [C]

Identifier: 37522179

GI number: 37522179

Start: 2764314

End: 2765054

Strand: Reverse

Name: ppiA [C]

Synonym: gll2610

Alternate gene names: 37522179

Gene position: 2765054-2764314 (Counterclockwise)

Preceding gene: 37522181

Following gene: 37522175

Centisome position: 59.35

GC content: 63.43

Gene sequence:

>741_bases
GTGGCGGCGGGCGGGGCATTGCTTTACCATCGTTGCGGTGGTTTTGGACGTGTCTGCATGCTTCGACTGTGCGCTTCAGC
CCTCGCCTTACTTCTGGTGATTCCCGGTCTTGCTCTGGCGGCGGACCCGCCTTCCGGGCCGATCCCGGCCGCCGCTTCGC
CCGATCGGATCAAAACTCTGCCCCAGCTTACTTCCAAGGCCTACGTCAAGCTCGACACGACTAAAGGAGCGATTGTGCTC
GAACTGGACGGTCCGAACGCCCCGGTCTCCGCCGGTAATTTTTTGGATCTGGTGAAGCGCAAATTTTATGATGGCCTGGT
CTTCCACCGGGTGGTGCCCGATTTTGTCATCCAGGGCGGCGATCCCAAAGGCAACGGCACCGGCGGCTTTATCGACCCGG
CCACCGGCCGCGAGCGCACGATTCCGCTGGAAATCAAACCCACCGGTGCCAAGGAGCCCGTCTACGGCCGCATCGTCGAA
ACGACCACCCCGCCGGTGCTCACCCACAGCAAAGGTGCGCTTGCCTGGGCACGGGACAATAACCCCAATTCCGCCAGCTC
CCAGTTCTATATCGCCCTTTCCGACAACCCCTCGATCCGCGCCCTGGATGGCCGCTACGCGGTCTTCGGGCGGGTGGTGA
GCGGCATGGAGGTAGTGGCCGCTATCCGGGCGGGCGACAAGATTCTCAAGGCCGCAGAGACCTCCGCACCACCCGCCGGA
GCCGTCCCCAAGACTCCCTAG

Upstream 100 bases:

>100_bases
CCCCGATATTTCCCCGGAGAGATCCGGACCGCTTCAAATTCCATGCCTTGACTCCGTTGCTTTGCTGATTTCTCTAAGTT
AGCTTCGCCAGGGGATCGCC

Downstream 100 bases:

>100_bases
CCAGGCGAACCGCAGTGGCGCAGGAGGTAGGCTCCTAATTCACGAAACAGGGTTTTCGCCGAGAATTTCGAGAAACTGGA
CGGCACTGACTATCTTGATG

Product: peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase sll0227; Rotamase sll0227 [H]

Number of amino acids: Translated: 246; Mature: 245

Protein sequence:

>246_residues
MAAGGALLYHRCGGFGRVCMLRLCASALALLLVIPGLALAADPPSGPIPAAASPDRIKTLPQLTSKAYVKLDTTKGAIVL
ELDGPNAPVSAGNFLDLVKRKFYDGLVFHRVVPDFVIQGGDPKGNGTGGFIDPATGRERTIPLEIKPTGAKEPVYGRIVE
TTTPPVLTHSKGALAWARDNNPNSASSQFYIALSDNPSIRALDGRYAVFGRVVSGMEVVAAIRAGDKILKAAETSAPPAG
AVPKTP

Sequences:

>Translated_246_residues
MAAGGALLYHRCGGFGRVCMLRLCASALALLLVIPGLALAADPPSGPIPAAASPDRIKTLPQLTSKAYVKLDTTKGAIVL
ELDGPNAPVSAGNFLDLVKRKFYDGLVFHRVVPDFVIQGGDPKGNGTGGFIDPATGRERTIPLEIKPTGAKEPVYGRIVE
TTTPPVLTHSKGALAWARDNNPNSASSQFYIALSDNPSIRALDGRYAVFGRVVSGMEVVAAIRAGDKILKAAETSAPPAG
AVPKTP
>Mature_245_residues
AAGGALLYHRCGGFGRVCMLRLCASALALLLVIPGLALAADPPSGPIPAAASPDRIKTLPQLTSKAYVKLDTTKGAIVLE
LDGPNAPVSAGNFLDLVKRKFYDGLVFHRVVPDFVIQGGDPKGNGTGGFIDPATGRERTIPLEIKPTGAKEPVYGRIVET
TTPPVLTHSKGALAWARDNNPNSASSQFYIALSDNPSIRALDGRYAVFGRVVSGMEVVAAIRAGDKILKAAETSAPPAGA
VPKTP

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=154, Percent_Identity=33.1168831168831, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI22547212, Length=203, Percent_Identity=30.0492610837438, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI7657473, Length=203, Percent_Identity=30.0492610837438, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI22547215, Length=181, Percent_Identity=31.4917127071823, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI19557636, Length=155, Percent_Identity=29.6774193548387, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI20911035, Length=161, Percent_Identity=31.055900621118, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI24308049, Length=152, Percent_Identity=30.2631578947368, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI64276486, Length=145, Percent_Identity=30.3448275862069, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI42560244, Length=159, Percent_Identity=32.7044025157233, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1789763, Length=181, Percent_Identity=34.8066298342541, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1786736, Length=160, Percent_Identity=34.375, Blast_Score=81, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17539496, Length=155, Percent_Identity=37.4193548387097, Blast_Score=104, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI71980594, Length=157, Percent_Identity=32.484076433121, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI71980590, Length=157, Percent_Identity=32.484076433121, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17506311, Length=153, Percent_Identity=33.9869281045752, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17506307, Length=175, Percent_Identity=32, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI32563659, Length=161, Percent_Identity=29.1925465838509, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71997782, Length=149, Percent_Identity=31.5436241610738, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17551282, Length=121, Percent_Identity=37.1900826446281, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17551284, Length=121, Percent_Identity=37.1900826446281, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17532641, Length=163, Percent_Identity=26.9938650306748, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321848, Length=184, Percent_Identity=30.9782608695652, Blast_Score=69, Evalue=5e-13,
Organism=Drosophila melanogaster, GI19922376, Length=181, Percent_Identity=30.3867403314917, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17986117, Length=155, Percent_Identity=34.8387096774194, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21355677, Length=154, Percent_Identity=30.5194805194805, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 25592; Mature: 25461

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAGGALLYHRCGGFGRVCMLRLCASALALLLVIPGLALAADPPSGPIPAAASPDRIKTL
CCCCCEEHEECCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCHHHHHH
PQLTSKAYVKLDTTKGAIVLELDGPNAPVSAGNFLDLVKRKFYDGLVFHRVVPDFVIQGG
HHHCCCEEEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHEEECC
DPKGNGTGGFIDPATGRERTIPLEIKPTGAKEPVYGRIVETTTPPVLTHSKGALAWARDN
CCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEEECCCCCEEECCCCCEEEECCC
NPNSASSQFYIALSDNPSIRALDGRYAVFGRVVSGMEVVAAIRAGDKILKAAETSAPPAG
CCCCCCCEEEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCC
AVPKTP
CCCCCC
>Mature Secondary Structure 
AAGGALLYHRCGGFGRVCMLRLCASALALLLVIPGLALAADPPSGPIPAAASPDRIKTL
CCCCEEHEECCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCHHHHHH
PQLTSKAYVKLDTTKGAIVLELDGPNAPVSAGNFLDLVKRKFYDGLVFHRVVPDFVIQGG
HHHCCCEEEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHEEECC
DPKGNGTGGFIDPATGRERTIPLEIKPTGAKEPVYGRIVETTTPPVLTHSKGALAWARDN
CCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEEECCCCCEEECCCCCEEEECCC
NPNSASSQFYIALSDNPSIRALDGRYAVFGRVVSGMEVVAAIRAGDKILKAAETSAPPAG
CCCCCCCEEEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCC
AVPKTP
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]