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The map label for this gene is msrA2 [H]

Identifier: 37522085

GI number: 37522085

Start: 2675638

End: 2676303

Strand: Direct

Name: msrA2 [H]

Synonym: glr2516

Alternate gene names: 37522085

Gene position: 2675638-2676303 (Clockwise)

Preceding gene: 37522084

Following gene: 37522086

Centisome position: 57.43

GC content: 65.17

Gene sequence:

>666_bases
ATGGGGTTATTCAATAAACAAGTCCAGATGCCGACGACGGCGCAGGCTCTGCCCGGACGCGCGCAGAGGATGCCGGTGAG
CGTTCCTCACCACGTCAACGGCCGTCCCCTCCAGCCGCCCTTCCCCCAGGGAACAGAACAGGCCATGTTCGGCATGGGCT
GCTTCTGGGGAGCCGAACGCGTGTTCTGGCAAGCCGAAGGCGTCTACACGACGGCGGTCGGTTACGCCGCCGGGTTGACC
CCCAACCCGACCTATCGGGAAGTCTGCAGCGGCATGACCGGCCACAACGAAGTTGTCCTGGTCGTCTTCGATCCCAGGGT
GATTTCCTACGAGCGTCTGCTGCAAATCTTTTGGGAGAACCACGACCCGACCCAGGGCATGCGCCAGGGCAACGACGCGG
GTACCCAGTACCGCTCCGGAATCTACTGCTCTACCCCCGAGCAAAAGCAAATCGCCGAAGCGTCCCGCGCAGCCTATCAA
CAGCGCCTCACCGCCGCGGGCCTGGGCCGGATCACCACCGAGGTCCTCGACGCGCCGGAGTTCTATTACGCCGAGGATTA
CCACCAGCAATACCTCTCCAAGAACCCCGGCGGCTACTGCGGCCTGGGCGGCACCGGGGTCGCCTGCCCGGTGGGTGCGC
TCGAATCCCGGCCCACCGCCCCGTAG

Upstream 100 bases:

>100_bases
CCGCACCGCCTGGCCAAGGAGACACCCAGGCCAGGCGCTAAAATTGTAAAAGAACAGCAATAAACATTAGCCCACGACCG
GGCTGCGGAGAGTTTCCATC

Downstream 100 bases:

>100_bases
GCAAACGCTAAAGCTCCCAGTTAGACTGATGATCCCCATCCTGCCCGCGGGGTGGGGATTGCTTTTGGTTTTCGCTTGCG
TGCACCGGAGGTCGGCATGT

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 2; Peptide-methionine (S)-S-oxide reductase 2; Peptide Met(O) reductase 2 [H]

Number of amino acids: Translated: 221; Mature: 220

Protein sequence:

>221_residues
MGLFNKQVQMPTTAQALPGRAQRMPVSVPHHVNGRPLQPPFPQGTEQAMFGMGCFWGAERVFWQAEGVYTTAVGYAAGLT
PNPTYREVCSGMTGHNEVVLVVFDPRVISYERLLQIFWENHDPTQGMRQGNDAGTQYRSGIYCSTPEQKQIAEASRAAYQ
QRLTAAGLGRITTEVLDAPEFYYAEDYHQQYLSKNPGGYCGLGGTGVACPVGALESRPTAP

Sequences:

>Translated_221_residues
MGLFNKQVQMPTTAQALPGRAQRMPVSVPHHVNGRPLQPPFPQGTEQAMFGMGCFWGAERVFWQAEGVYTTAVGYAAGLT
PNPTYREVCSGMTGHNEVVLVVFDPRVISYERLLQIFWENHDPTQGMRQGNDAGTQYRSGIYCSTPEQKQIAEASRAAYQ
QRLTAAGLGRITTEVLDAPEFYYAEDYHQQYLSKNPGGYCGLGGTGVACPVGALESRPTAP
>Mature_220_residues
GLFNKQVQMPTTAQALPGRAQRMPVSVPHHVNGRPLQPPFPQGTEQAMFGMGCFWGAERVFWQAEGVYTTAVGYAAGLTP
NPTYREVCSGMTGHNEVVLVVFDPRVISYERLLQIFWENHDPTQGMRQGNDAGTQYRSGIYCSTPEQKQIAEASRAAYQQ
RLTAAGLGRITTEVLDAPEFYYAEDYHQQYLSKNPGGYCGLGGTGVACPVGALESRPTAP

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=208, Percent_Identity=61.0576923076923, Blast_Score=277, Evalue=4e-75,
Organism=Homo sapiens, GI208609995, Length=183, Percent_Identity=65.0273224043716, Blast_Score=260, Evalue=5e-70,
Organism=Homo sapiens, GI208609993, Length=208, Percent_Identity=47.1153846153846, Blast_Score=192, Evalue=2e-49,
Organism=Escherichia coli, GI1790665, Length=197, Percent_Identity=61.9289340101523, Blast_Score=242, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI17533973, Length=146, Percent_Identity=37.6712328767123, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6320881, Length=182, Percent_Identity=34.6153846153846, Blast_Score=100, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24664627, Length=146, Percent_Identity=43.8356164383562, Blast_Score=110, Evalue=8e-25,
Organism=Drosophila melanogaster, GI45553131, Length=142, Percent_Identity=42.9577464788732, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24664631, Length=146, Percent_Identity=41.7808219178082, Blast_Score=101, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 24211; Mature: 24079

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLFNKQVQMPTTAQALPGRAQRMPVSVPHHVNGRPLQPPFPQGTEQAMFGMGCFWGAER
CCCCCCCCCCCCHHHHCCCCHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHH
VFWQAEGVYTTAVGYAAGLTPNPTYREVCSGMTGHNEVVLVVFDPRVISYERLLQIFWEN
EEEECCCEEEEHHHHHCCCCCCCCHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHCC
HDPTQGMRQGNDAGTQYRSGIYCSTPEQKQIAEASRAAYQQRLTAAGLGRITTEVLDAPE
CCCHHHHHCCCCCCHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
FYYAEDYHQQYLSKNPGGYCGLGGTGVACPVGALESRPTAP
HHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GLFNKQVQMPTTAQALPGRAQRMPVSVPHHVNGRPLQPPFPQGTEQAMFGMGCFWGAER
CCCCCCCCCCCHHHHCCCCHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHH
VFWQAEGVYTTAVGYAAGLTPNPTYREVCSGMTGHNEVVLVVFDPRVISYERLLQIFWEN
EEEECCCEEEEHHHHHCCCCCCCCHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHCC
HDPTQGMRQGNDAGTQYRSGIYCSTPEQKQIAEASRAAYQQRLTAAGLGRITTEVLDAPE
CCCHHHHHCCCCCCHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
FYYAEDYHQQYLSKNPGGYCGLGGTGVACPVGALESRPTAP
HHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]