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The map label for this gene is aroB

Identifier: 37522082

GI number: 37522082

Start: 2672546

End: 2673631

Strand: Direct

Name: aroB

Synonym: gvip345

Alternate gene names: 37522082

Gene position: 2672546-2673631 (Clockwise)

Preceding gene: 37522079

Following gene: 37522083

Centisome position: 57.36

GC content: 67.5

Gene sequence:

>1086_bases
ATGATCCGCATCCCTGTTGCCCTGCCCATGGACAGTTACGACATCTGCATCGACGAGGGCGGTCTTGAGCGCCTCGGCGA
GTACCTGGCCGAACTGGGCAAAGTGAACCGGGCGCTGGTGGTGAGCAATCCCGTGGTTTTGCGCCATTACGGCGCCCGGG
TGGTACGCTCCTTGAACGCCGCTGGCTTCGAGACGGCAAGCGTCACCGTCCCGGCAGGCGAGCGCCACAAGCACCTGCGC
TCGGTGGAGCGCATTTATCAAGCAGCCCTCGAACACCGCCTGGAGCGCTCGTCGCTCATCGTCGCTTTGGGCGGCGGGGT
GGTGGGCGACATGGCGGGCTTCGCGGCCAGCACCTGGCTGCGGGGCATCCGGGTGGCCCAGGTGCCGACGACGTTGCTGG
CGATGGTGGACGCTGCCATCGGCGGCAAGACGGGGGTGAACCACCCCCTGGGCAAGAACTTGATCGGCACCTTCCACCAG
CCCTGCCTGGTGCTCATCGACCCGCAGGTGCTGGGGACACTGCCGCCGCGCGAGACGCGCGCCGCCATGGCCGAGGTGAT
CAAATACGGGGTGATCTGGGACGGGGACTTATTTAAGCGGCTGGAGCAATTGCCCAGCCTGCAACGCCCGGACGCGCGCA
CCCTCACCACGCTGCTGGTGCGCTCCTGCCAGGCCAAAGCCGAGGTGGTCGTGCGCGACGAGCGCGAAGGCGGTCTGCGC
GCCATCCTCAACTACGGCCACACCGTCGGCCACGCCCTCGAAAGTGCCACCGGTTACCGCCGCTATCTGCACGGCGAAGG
GGTCGCCCTCGGTATGGCGGCGGCGGGCCGGGTGGCAGTGGCGCTCGATCTCTGGAGCCCCGAGGAGCTTCGCCGCCAGG
AGGCGTTGATTATCAAAGCCCGCCTGCCGGTGCGCTGGAAGAGCGACATCGCCAGCGAGGCGCTGCTGTTGCGCATGCAA
TCGGACAAAAAAGTCGAGGCGGGCAAGGTGCGCTTCGTGTTGCCGGAAGCGATCGGTCGCGTCCACACCGGGGTCGAGGT
GCCCACAGAGGTGCTGCGCAGGGTGCTCGACACCCTGCGCGGTTGA

Upstream 100 bases:

>100_bases
CGGTACCTAGCGCAACTAGGCTGGAACATTGACGGAACCCCGCCCGGCGCTACACTCGAGTGGCTCCCGATTCGCCCGCG
CCGCTGAACAGGCCGCCCGT

Downstream 100 bases:

>100_bases
GGGTGCAGCGGCACCCCTACCGGCCCAAAATGCATTGGCCCGGACAATGGCATTGGCCGGGCCACGGCTCAATATGGCCG
ACACCAGGGCGCCTGCGGCG

Product: 3-dehydroquinate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MIRIPVALPMDSYDICIDEGGLERLGEYLAELGKVNRALVVSNPVVLRHYGARVVRSLNAAGFETASVTVPAGERHKHLR
SVERIYQAALEHRLERSSLIVALGGGVVGDMAGFAASTWLRGIRVAQVPTTLLAMVDAAIGGKTGVNHPLGKNLIGTFHQ
PCLVLIDPQVLGTLPPRETRAAMAEVIKYGVIWDGDLFKRLEQLPSLQRPDARTLTTLLVRSCQAKAEVVVRDEREGGLR
AILNYGHTVGHALESATGYRRYLHGEGVALGMAAAGRVAVALDLWSPEELRRQEALIIKARLPVRWKSDIASEALLLRMQ
SDKKVEAGKVRFVLPEAIGRVHTGVEVPTEVLRRVLDTLRG

Sequences:

>Translated_361_residues
MIRIPVALPMDSYDICIDEGGLERLGEYLAELGKVNRALVVSNPVVLRHYGARVVRSLNAAGFETASVTVPAGERHKHLR
SVERIYQAALEHRLERSSLIVALGGGVVGDMAGFAASTWLRGIRVAQVPTTLLAMVDAAIGGKTGVNHPLGKNLIGTFHQ
PCLVLIDPQVLGTLPPRETRAAMAEVIKYGVIWDGDLFKRLEQLPSLQRPDARTLTTLLVRSCQAKAEVVVRDEREGGLR
AILNYGHTVGHALESATGYRRYLHGEGVALGMAAAGRVAVALDLWSPEELRRQEALIIKARLPVRWKSDIASEALLLRMQ
SDKKVEAGKVRFVLPEAIGRVHTGVEVPTEVLRRVLDTLRG
>Mature_361_residues
MIRIPVALPMDSYDICIDEGGLERLGEYLAELGKVNRALVVSNPVVLRHYGARVVRSLNAAGFETASVTVPAGERHKHLR
SVERIYQAALEHRLERSSLIVALGGGVVGDMAGFAASTWLRGIRVAQVPTTLLAMVDAAIGGKTGVNHPLGKNLIGTFHQ
PCLVLIDPQVLGTLPPRETRAAMAEVIKYGVIWDGDLFKRLEQLPSLQRPDARTLTTLLVRSCQAKAEVVVRDEREGGLR
AILNYGHTVGHALESATGYRRYLHGEGVALGMAAAGRVAVALDLWSPEELRRQEALIIKARLPVRWKSDIASEALLLRMQ
SDKKVEAGKVRFVLPEAIGRVHTGVEVPTEVLRRVLDTLRG

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; second step. [C]

COG id: COG0337

COG function: function code E; 3-dehydroquinate synthetase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dehydroquinate synthase family

Homologues:

Organism=Escherichia coli, GI1789791, Length=348, Percent_Identity=46.264367816092, Blast_Score=273, Evalue=1e-74,
Organism=Saccharomyces cerevisiae, GI6320332, Length=335, Percent_Identity=37.910447761194, Blast_Score=201, Evalue=1e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROB_GLOVI (Q7NHM2)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_925459.1
- ProteinModelPortal:   Q7NHM2
- SMR:   Q7NHM2
- GeneID:   2600914
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.2513
- HOGENOM:   HBG632303
- OMA:   CEIKAEV
- ProtClustDB:   PRK00002
- BioCyc:   GVIO251221:GLR2513-MONOMER
- BRENDA:   4.2.3.4
- GO:   GO:0005737
- HAMAP:   MF_00110
- InterPro:   IPR016303
- InterPro:   IPR002658
- InterPro:   IPR016037
- PANTHER:   PTHR21090:SF1
- PIRSF:   PIRSF001455
- TIGRFAMs:   TIGR01357

Pfam domain/function: PF01761 DHQ_synthase

EC number: =4.2.3.4

Molecular weight: Translated: 39371; Mature: 39371

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRIPVALPMDSYDICIDEGGLERLGEYLAELGKVNRALVVSNPVVLRHYGARVVRSLNA
CEEECEECCCCCCCEEECCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCC
AGFETASVTVPAGERHKHLRSVERIYQAALEHRLERSSLIVALGGGVVGDMAGFAASTWL
CCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHH
RGIRVAQVPTTLLAMVDAAIGGKTGVNHPLGKNLIGTFHQPCLVLIDPQVLGTLPPRETR
HCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCEEEEECHHHHCCCCCHHHH
AAMAEVIKYGVIWDGDLFKRLEQLPSLQRPDARTLTTLLVRSCQAKAEVVVRDEREGGLR
HHHHHHHHHCCEECCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCHH
AILNYGHTVGHALESATGYRRYLHGEGVALGMAAAGRVAVALDLWSPEELRRQEALIIKA
HHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEECCCHHHHHHHHEEEEEE
RLPVRWKSDIASEALLLRMQSDKKVEAGKVRFVLPEAIGRVHTGVEVPTEVLRRVLDTLR
CCCCCHHHHHHHHHHHEEECCCCCCCCCCEEEECHHHHHHHHCCCCCHHHHHHHHHHHHC
G
C
>Mature Secondary Structure
MIRIPVALPMDSYDICIDEGGLERLGEYLAELGKVNRALVVSNPVVLRHYGARVVRSLNA
CEEECEECCCCCCCEEECCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCC
AGFETASVTVPAGERHKHLRSVERIYQAALEHRLERSSLIVALGGGVVGDMAGFAASTWL
CCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHH
RGIRVAQVPTTLLAMVDAAIGGKTGVNHPLGKNLIGTFHQPCLVLIDPQVLGTLPPRETR
HCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCEEEEECHHHHCCCCCHHHH
AAMAEVIKYGVIWDGDLFKRLEQLPSLQRPDARTLTTLLVRSCQAKAEVVVRDEREGGLR
HHHHHHHHHCCEECCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCHH
AILNYGHTVGHALESATGYRRYLHGEGVALGMAAAGRVAVALDLWSPEELRRQEALIIKA
HHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEECCCHHHHHHHHEEEEEE
RLPVRWKSDIASEALLLRMQSDKKVEAGKVRFVLPEAIGRVHTGVEVPTEVLRRVLDTLR
CCCCCHHHHHHHHHHHEEECCCCCCCCCCEEEECHHHHHHHHCCCCCHHHHHHHHHHHHC
G
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292