Click here to switch to the map view.

The map label for this gene is lktA [H]

Identifier: 37522042

GI number: 37522042

Start: 2630919

End: 2631608

Strand: Reverse

Name: lktA [H]

Synonym: gll2473

Alternate gene names: 37522042

Gene position: 2631608-2630919 (Counterclockwise)

Preceding gene: 37522043

Following gene: 37522037

Centisome position: 56.48

GC content: 61.59

Gene sequence:

>690_bases
ATGGTGACCCGCGAACGCGATCCGAAAACTGGCAAGGTGACCTTCAAAGGGACGCCGGGCAACGACAATATCCGGGTGAG
CAACCGGCGCAACACTGCCGGTGAAGTGGACGGCCTTCTGGTGATCGTGCTCGATGCCCACGGCAAAGAGTGCGAGCGCT
TCTCTTTGGACCGCGAAGAATTCAAAGACGGCCTGTGCATCCGCGGTGGAGCGGGCGACGACATTATTCAGGTGGACGAA
GATGTCGAATTCGACCTCGAACTGTACGGCGAGGAGGGCAATGACCTGATTATCGGCGGCGCGGGCAACGACCTCATCGA
TGGCGGCCCCGGCAACGACCGGCTGTACGGCGGCGAAGGCAACGACACCATCCACGGCGGCGATGGGGATGATTTGATTG
ACGGCGGCCCCGGTGACGATAAACTTTACGGCGGCGCGGGCAACGACAAAATCCTGGGCGGCCCCGGCAACGATTTGTTG
GATGGCGGTCCCGGCGACGACTGTTTGGTGGGTGGCCCGGGCGACGATATTTTGATTGGCGGGGAAGACAACGACCGGCT
ATTTGGCGGCGAAGGCATGGACCAGCTTATCGGTGGTACGGGCAAAGACATCGTCCATGCCGATCTGAGCGACCTGCCCG
TGCAGCGCGGCAACGACGAACAGGACACGGTGCACATCGATCGCGGCTGA

Upstream 100 bases:

>100_bases
CCGGCTCACCGCGCCGGAGAATTTGCCGAAGTAGTCTGCAACGCTTGCCCTGGGTGGGTGTCTTCTTATACTGAGAGCGA
CTTGCAGCAGGAGCAGGGCA

Downstream 100 bases:

>100_bases
ATGGTGCAGCGCACGCTGCGCTGAAATATTTTTTCGGAGGTACTTCGGGCAACAAGTAATCATTCGCACCGAATTTGAGA
ACAACCGCTAGGCAGAATCA

Product: hypothetical protein

Products: NA

Alternate protein names: Lkt [H]

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MVTRERDPKTGKVTFKGTPGNDNIRVSNRRNTAGEVDGLLVIVLDAHGKECERFSLDREEFKDGLCIRGGAGDDIIQVDE
DVEFDLELYGEEGNDLIIGGAGNDLIDGGPGNDRLYGGEGNDTIHGGDGDDLIDGGPGDDKLYGGAGNDKILGGPGNDLL
DGGPGDDCLVGGPGDDILIGGEDNDRLFGGEGMDQLIGGTGKDIVHADLSDLPVQRGNDEQDTVHIDRG

Sequences:

>Translated_229_residues
MVTRERDPKTGKVTFKGTPGNDNIRVSNRRNTAGEVDGLLVIVLDAHGKECERFSLDREEFKDGLCIRGGAGDDIIQVDE
DVEFDLELYGEEGNDLIIGGAGNDLIDGGPGNDRLYGGEGNDTIHGGDGDDLIDGGPGDDKLYGGAGNDKILGGPGNDLL
DGGPGDDCLVGGPGDDILIGGEDNDRLFGGEGMDQLIGGTGKDIVHADLSDLPVQRGNDEQDTVHIDRG
>Mature_229_residues
MVTRERDPKTGKVTFKGTPGNDNIRVSNRRNTAGEVDGLLVIVLDAHGKECERFSLDREEFKDGLCIRGGAGDDIIQVDE
DVEFDLELYGEEGNDLIIGGAGNDLIDGGPGNDRLYGGEGNDTIHGGDGDDLIDGGPGDDKLYGGAGNDKILGGPGNDLL
DGGPGDDCLVGGPGDDILIGGEDNDRLFGGEGMDQLIGGTGKDIVHADLSDLPVQRGNDEQDTVHIDRG

Specific function: One of the virulence factors of A.actinomycetemcomitans might be a cytotoxin, possibly the membrane-bound hemolysin [H]

COG id: COG2931

COG function: function code Q; RTX toxins and related Ca2+-binding proteins

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein. Secreted (By similarity) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 7 hemolysin-type calcium-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018511
- InterPro:   IPR001343
- InterPro:   IPR018504
- InterPro:   IPR003995
- InterPro:   IPR011049 [H]

Pfam domain/function: PF00353 HemolysinCabind; PF02382 RTX [H]

EC number: NA

Molecular weight: Translated: 23901; Mature: 23901

Theoretical pI: Translated: 3.88; Mature: 3.88

Prosite motif: PS00330 HEMOLYSIN_CALCIUM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTRERDPKTGKVTFKGTPGNDNIRVSNRRNTAGEVDGLLVIVLDAHGKECERFSLDREE
CCCCCCCCCCCEEEEEECCCCCCEEEECCCCCCCCCCCEEEEEECCCCCCCHHHCCCHHH
FKDGLCIRGGAGDDIIQVDEDVEFDLELYGEEGNDLIIGGAGNDLIDGGPGNDRLYGGEG
HHCCEEEECCCCCCEEEECCCCEEEEEEECCCCCEEEEECCCCCCCCCCCCCCEEECCCC
NDTIHGGDGDDLIDGGPGDDKLYGGAGNDKILGGPGNDLLDGGPGDDCLVGGPGDDILIG
CCEEECCCCCCCCCCCCCCCCEECCCCCCCEECCCCCCCCCCCCCCCEEEECCCCEEEEC
GEDNDRLFGGEGMDQLIGGTGKDIVHADLSDLPVQRGNDEQDTVHIDRG
CCCCCEEECCCCHHHHHCCCCCCEEECCHHHCCCCCCCCCCCEEEEECC
>Mature Secondary Structure
MVTRERDPKTGKVTFKGTPGNDNIRVSNRRNTAGEVDGLLVIVLDAHGKECERFSLDREE
CCCCCCCCCCCEEEEEECCCCCCEEEECCCCCCCCCCCEEEEEECCCCCCCHHHCCCHHH
FKDGLCIRGGAGDDIIQVDEDVEFDLELYGEEGNDLIIGGAGNDLIDGGPGNDRLYGGEG
HHCCEEEECCCCCCEEEECCCCEEEEEEECCCCCEEEEECCCCCCCCCCCCCCEEECCCC
NDTIHGGDGDDLIDGGPGDDKLYGGAGNDKILGGPGNDLLDGGPGDDCLVGGPGDDILIG
CCEEECCCCCCCCCCCCCCCCEECCCCCCCEECCCCCCCCCCCCCCCEEEECCCCEEEEC
GEDNDRLFGGEGMDQLIGGTGKDIVHADLSDLPVQRGNDEQDTVHIDRG
CCCCCEEECCCCHHHHHCCCCCCEEECCHHHCCCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2670940 [H]