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The map label for this gene is mtnP [H]

Identifier: 37521993

GI number: 37521993

Start: 2582082

End: 2582981

Strand: Reverse

Name: mtnP [H]

Synonym: gll2424

Alternate gene names: 37521993

Gene position: 2582981-2582082 (Counterclockwise)

Preceding gene: 37521995

Following gene: 37521992

Centisome position: 55.44

GC content: 64.44

Gene sequence:

>900_bases
ATGAGCTATCCCCAGGCCCGCATCGGGGTGATCGGCGGCAGCGGTCTCTACCAGATGGCCGACCTTGCCGACACCGTCGA
AGTGCAGTTCAACACCCCCTTTGGTCCACCCTCCGACGCCCTGGTCATCGGCACCCTCGCAGGCGAACGCGTCGCCTTTC
TGCCCCGCCACGGCCGCGGCCACCGGCTTTTGCCGGCCGAGTTGCCCTTTCAGGCGAACATCTACGCGATGAAGATGCTG
GGGGTGGAATATCTCCTCTCCGCCTCAGCGGTAGGTTCGCTGCGCGAGGAGTACCGGCCGCGCGACATCGTCTTTCCGGA
TCAGTTTTTTGACCGCACCAAGGACCGGCCCTCGACTTTTTTTGGTGGCGGCCTGGTGGCCCACATCGGCTTCGACCAGC
CCATCTGCACGGAACTTGCCCACCTGGCGGCCGAGGCGGCGCGCGGCGTCGAGTTGATTGGCGAGACGCGCATCCACACC
GGCGGCACCTACGTGTGCATGGAAGGACCGGCCTTCTCGACTTTGGCTGAATCGCGGCTCTACCGCAGCTGGGGCATGGA
CATCATCGGCATGACTAATCTGCAAGAGGCGAAACTCGCCCGCGAAGCGGAAATTTGCTACGCGACGATGGCGCTGGTCA
CCGACTACGACTGCTGGCACCCCGACCACGGCGCGGTGACGGTGGAGCTGATTATCGACAACCTCCACAAGAACGCCGAG
AATGCCCAGCGCATCGTGCGCGCTGTGGTGGAACGCCTGCACGCAGCAGCTCCGCCCTGCGCCAGCCACTCCGCCCTCAA
GTACGCCCTGCTCACCCAACCCGAGGACGTACCGCAAGCCACCAAGCAAAAGCTGGCTGCGATCCTGGCCAAATACCCCG
CCTACCGGCCCGAGGTTTAG

Upstream 100 bases:

>100_bases
AGCCTGCTTCCAGGCAAGCCCCTGCCCGCTTGCCCAGAATTGGATGCACTGCGCAAGAACCGAGACCGGTAGACTAAGAG
CGCAGTGCATCCGCCACACC

Downstream 100 bases:

>100_bases
GAGCGAACCATGCCGCTGCACCCGCGGCTGTCGCTGCCTTTGTTCTGCCACGCAGCGGTTAACCGTTGAACACAGTTGCC
GATAATTTATTTACATTTAT

Product: 5'-methylthioadenosine phosphorylase

Products: NA

Alternate protein names: 5'-methylthioadenosine phosphorylase; MTA phosphorylase [H]

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MSYPQARIGVIGGSGLYQMADLADTVEVQFNTPFGPPSDALVIGTLAGERVAFLPRHGRGHRLLPAELPFQANIYAMKML
GVEYLLSASAVGSLREEYRPRDIVFPDQFFDRTKDRPSTFFGGGLVAHIGFDQPICTELAHLAAEAARGVELIGETRIHT
GGTYVCMEGPAFSTLAESRLYRSWGMDIIGMTNLQEAKLAREAEICYATMALVTDYDCWHPDHGAVTVELIIDNLHKNAE
NAQRIVRAVVERLHAAAPPCASHSALKYALLTQPEDVPQATKQKLAAILAKYPAYRPEV

Sequences:

>Translated_299_residues
MSYPQARIGVIGGSGLYQMADLADTVEVQFNTPFGPPSDALVIGTLAGERVAFLPRHGRGHRLLPAELPFQANIYAMKML
GVEYLLSASAVGSLREEYRPRDIVFPDQFFDRTKDRPSTFFGGGLVAHIGFDQPICTELAHLAAEAARGVELIGETRIHT
GGTYVCMEGPAFSTLAESRLYRSWGMDIIGMTNLQEAKLAREAEICYATMALVTDYDCWHPDHGAVTVELIIDNLHKNAE
NAQRIVRAVVERLHAAAPPCASHSALKYALLTQPEDVPQATKQKLAAILAKYPAYRPEV
>Mature_298_residues
SYPQARIGVIGGSGLYQMADLADTVEVQFNTPFGPPSDALVIGTLAGERVAFLPRHGRGHRLLPAELPFQANIYAMKMLG
VEYLLSASAVGSLREEYRPRDIVFPDQFFDRTKDRPSTFFGGGLVAHIGFDQPICTELAHLAAEAARGVELIGETRIHTG
GTYVCMEGPAFSTLAESRLYRSWGMDIIGMTNLQEAKLAREAEICYATMALVTDYDCWHPDHGAVTVELIIDNLHKNAEN
AQRIVRAVVERLHAAAPPCASHSALKYALLTQPEDVPQATKQKLAAILAKYPAYRPEV

Specific function: Catalyzes the formation of methylthio-D-ribose 1- phosphate (MTR-1-P) from methylthioadenosine (MTA) [H]

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=252, Percent_Identity=41.6666666666667, Blast_Score=216, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI71980569, Length=252, Percent_Identity=41.6666666666667, Blast_Score=185, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6323045, Length=303, Percent_Identity=36.6336633663366, Blast_Score=184, Evalue=1e-47,
Organism=Drosophila melanogaster, GI20130079, Length=253, Percent_Identity=36.3636363636364, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI221459247, Length=256, Percent_Identity=33.984375, Blast_Score=165, Evalue=4e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: =2.4.2.28 [H]

Molecular weight: Translated: 32753; Mature: 32622

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS01240 PNP_MTAP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYPQARIGVIGGSGLYQMADLADTVEVQFNTPFGPPSDALVIGTLAGERVAFLPRHGRG
CCCCCCEEEEECCCCHHHHHHCCCEEEEEEECCCCCCCCCEEEEECCCCEEEEECCCCCC
HRLLPAELPFQANIYAMKMLGVEYLLSASAVGSLREEYRPRDIVFPDQFFDRTKDRPSTF
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCEE
FGGGLVAHIGFDQPICTELAHLAAEAARGVELIGETRIHTGGTYVCMEGPAFSTLAESRL
ECCCEEEEECCCCHHHHHHHHHHHHHHCCHHHHCCCEEECCCEEEEECCCCHHHHHHHHH
YRSWGMDIIGMTNLQEAKLAREAEICYATMALVTDYDCWHPDHGAVTVELIIDNLHKNAE
HHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEHHHHCCHH
NAQRIVRAVVERLHAAAPPCASHSALKYALLTQPEDVPQATKQKLAAILAKYPAYRPEV
HHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SYPQARIGVIGGSGLYQMADLADTVEVQFNTPFGPPSDALVIGTLAGERVAFLPRHGRG
CCCCCEEEEECCCCHHHHHHCCCEEEEEEECCCCCCCCCEEEEECCCCEEEEECCCCCC
HRLLPAELPFQANIYAMKMLGVEYLLSASAVGSLREEYRPRDIVFPDQFFDRTKDRPSTF
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCEE
FGGGLVAHIGFDQPICTELAHLAAEAARGVELIGETRIHTGGTYVCMEGPAFSTLAESRL
ECCCEEEEECCCCHHHHHHHHHHHHHHCCHHHHCCCEEECCCEEEEECCCCHHHHHHHHH
YRSWGMDIIGMTNLQEAKLAREAEICYATMALVTDYDCWHPDHGAVTVELIIDNLHKNAE
HHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEHHHHCCHH
NAQRIVRAVVERLHAAAPPCASHSALKYALLTQPEDVPQATKQKLAAILAKYPAYRPEV
HHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA