Click here to switch to the map view.

The map label for this gene is napA [H]

Identifier: 37521957

GI number: 37521957

Start: 2546119

End: 2548368

Strand: Direct

Name: napA [H]

Synonym: glr2388

Alternate gene names: 37521957

Gene position: 2546119-2548368 (Clockwise)

Preceding gene: 37521956

Following gene: 37521958

Centisome position: 54.65

GC content: 62.89

Gene sequence:

>2250_bases
GTGGAAGCCGCATTGCATTCATTTTTATATTTTGCTGCTGCGACCGCCCAGAGCGGGCCGATCAAACCCCTGGGCCACCA
CGAAGTGCTGCTGCTGCTGTTGCAACTGTCCTTGCTGCTGTTTGCGGCCCGGGGTCTCGGTGAACTGATGCGCCGCATCG
ATTTGCCGCCGGTGGTGGGCGAATTGCTCGCGGGGGTGGTGCTCGGACCGTCGGTCTTTGGGTTCCTGCTGCCGGCGCTC
CAGTCGGAAATCTTTCCCAAAAGTCAGATCCAGTCGGATCTGATCTCGGTGGTCTCCTGGCTGGGGGTGCTGTTTTTGTT
GATTGCCACGGGGCTTGAGACCGATCTCAACTTGATTGTCAGCAAAGGCAAGACGGCGCTACTCATCTCACTGGGGGGAA
TCGTTGTCCCTTTTGCCACCGGCTTCGGCCTCGGCATGCTGCTGCCTGACAATTTTCTGGCGGAGCCCTCCGAGCGGTTC
GTCTTCAGCCTGTTTATCGCCACGGCGATGAGCATCTCGGCCATTCCGGTGATCGCCAAGGTGCTGATGGATCTCAAGCT
CATCCGCCGCGACATCGGCCAGGTGACCCTCGCAGCGGGCATGACCGACGATACGATCGGCTGGATTTTGCTCTCCGTGG
TGGCGGGTCTGGCCAGCAGCGGCAAGCTCGACCTCACCGCCGCCTTGAGTTCGATCGGGGGGGCGGTGATCTTCCTGGGC
GTCGCCTTTACGATCGGCCGTACCCTGGTGGCCCAGCTGTTGCGGCTGGTGGACGACTGGATTGGCGGAGTACCTGCTCA
GCTCACGATCGTGCTGGTCGTTGCCCTAGCGGCGGCGGCCCTCACCCACCAGCTGGGCATCGAAGCGGCCCTCGGCGCCT
TTGTCACCGGCATCCTGGTGGGTCAGGCGCCGCGTTTCAGCCGTGAGGCCGGACACACCCTCGAAGTGTTCACCGCCGCT
TTTCTCGCACCCATCTTCTTCGCGGTCGCTGGTTTGAAAGTAAACCTGCTTCAGCTTCTCGAACCACAGACGTTGCTGAT
TGGGGCGCTGGTGCTGTTTATTGCCTGCTTCGGCAAGTTCGTGGGCGTCTACATTGGCGCGCGTGTGGGCGGGCTCGGTC
ACTGGGAGGGGCTGGCCCTCGGTTCCGGCATGAATGCCCGGGGGGCAATGGAGATCATCGTCGCCACCATCGGTCTGTCG
CTGGGTGTTCTCAACCAGCAGATGTATTCGATCATCGTCATGGTCGCCATCGTCACCTCGCTGATGGCACCGCCCCTGCT
GCGTTGGACGCTCTCGAAGGTCAAGATTGGCGACGAGGAAGCCCGCCGTCTGCAAATGGAAGACATGGCGAGCCGCAGTT
TCGTCAAAAGCATCCGTCGGGTGCTCCTACCCACCCGCGGCGGTGCCAATGTGCAGCTTGCGGCCCAACTGGTCAGCCAC
ATGGCCCAGCAGAATGAGCTCGAAGTGACCGCCCTTTTTGCCGAGTGCGGGGATCGGCCCGGGGGGGGCAAAAGCCGCGC
CGCCGTCGCCGCCCTGGAATCGAGTGCCGAGACCGCCTTTGCTGCGGTGGCCGACGAGATGAGCCTGCCCAAGGCGCTAC
AGACGCGGGTCGAATCGGGCCGCGACCCGGCCGAGGTGATCCTGCGCGAGGCGGCTAAAGGCTACAACCTGCTGGTGATG
GGGGCCACCGAGCAACGCTTCGCCGACGGCACGCTCTTCAATTCGATCGTGGACCGGGTGGTGCAGGAAGCCCCCTGCGC
GACGATGGTGGTCAAATCCCACCTGCCGCGGCCGGAAGGGGAGCACTGCACCATTGCCCTGCAGGAGATCCGCCACATCC
TGGTGCCCACGATCGGCACCGAGTACAGCAAACACGCGGTCGAGGTGGCAAGCACCATCGCCGCCCAGACCCAAGCGCTC
GTCACACTAGTACACGTGGTCAACCTGCCGCAGTTCGACGATTTTTATGTCGATCAGGACAACATGAGCATCGCCCTCGA
CATCGCCCAGCAAATCGTCGATCAGCAGGCCGACATCGGCCGCGGCCTCGGTGCCCAGGTGAATACAGCGGTGCTCACCG
GCAATAGCCCCGAAAAAGAGATCCTGAACTTTGCCCGCGACGAAGGGGTGGATCTGATCATCCTGGGCAGCAACATCCGG
CCGATCTCGGGGCGGGTCTTCTTCGGCCACCGCGTCGATACCCTCTTGCGCCAGGCCAGTTGCCCGGTGGCGGTGGTCAG
TTCCAGCTGA

Upstream 100 bases:

>100_bases
CGCGAAGCGGAAAGCCACTGTTAATATGTGCGAGAATCCCTACCCCCGGCCTTGCTGGGATCGCGGGGATCACCGTTTGC
GACACCGGGAGGCCGATACC

Downstream 100 bases:

>100_bases
ACTTTTGCATTCTTGCGCAATCCCCTAAGCTTGGGGCAGCGCAAGCAAAGGTTGCACCGGTTTGATGGCGAGAATACCGA
CACTGTTCAGAGCGTCCGCG

Product: Na/H antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 749; Mature: 749

Protein sequence:

>749_residues
MEAALHSFLYFAAATAQSGPIKPLGHHEVLLLLLQLSLLLFAARGLGELMRRIDLPPVVGELLAGVVLGPSVFGFLLPAL
QSEIFPKSQIQSDLISVVSWLGVLFLLIATGLETDLNLIVSKGKTALLISLGGIVVPFATGFGLGMLLPDNFLAEPSERF
VFSLFIATAMSISAIPVIAKVLMDLKLIRRDIGQVTLAAGMTDDTIGWILLSVVAGLASSGKLDLTAALSSIGGAVIFLG
VAFTIGRTLVAQLLRLVDDWIGGVPAQLTIVLVVALAAAALTHQLGIEAALGAFVTGILVGQAPRFSREAGHTLEVFTAA
FLAPIFFAVAGLKVNLLQLLEPQTLLIGALVLFIACFGKFVGVYIGARVGGLGHWEGLALGSGMNARGAMEIIVATIGLS
LGVLNQQMYSIIVMVAIVTSLMAPPLLRWTLSKVKIGDEEARRLQMEDMASRSFVKSIRRVLLPTRGGANVQLAAQLVSH
MAQQNELEVTALFAECGDRPGGGKSRAAVAALESSAETAFAAVADEMSLPKALQTRVESGRDPAEVILREAAKGYNLLVM
GATEQRFADGTLFNSIVDRVVQEAPCATMVVKSHLPRPEGEHCTIALQEIRHILVPTIGTEYSKHAVEVASTIAAQTQAL
VTLVHVVNLPQFDDFYVDQDNMSIALDIAQQIVDQQADIGRGLGAQVNTAVLTGNSPEKEILNFARDEGVDLIILGSNIR
PISGRVFFGHRVDTLLRQASCPVAVVSSS

Sequences:

>Translated_749_residues
MEAALHSFLYFAAATAQSGPIKPLGHHEVLLLLLQLSLLLFAARGLGELMRRIDLPPVVGELLAGVVLGPSVFGFLLPAL
QSEIFPKSQIQSDLISVVSWLGVLFLLIATGLETDLNLIVSKGKTALLISLGGIVVPFATGFGLGMLLPDNFLAEPSERF
VFSLFIATAMSISAIPVIAKVLMDLKLIRRDIGQVTLAAGMTDDTIGWILLSVVAGLASSGKLDLTAALSSIGGAVIFLG
VAFTIGRTLVAQLLRLVDDWIGGVPAQLTIVLVVALAAAALTHQLGIEAALGAFVTGILVGQAPRFSREAGHTLEVFTAA
FLAPIFFAVAGLKVNLLQLLEPQTLLIGALVLFIACFGKFVGVYIGARVGGLGHWEGLALGSGMNARGAMEIIVATIGLS
LGVLNQQMYSIIVMVAIVTSLMAPPLLRWTLSKVKIGDEEARRLQMEDMASRSFVKSIRRVLLPTRGGANVQLAAQLVSH
MAQQNELEVTALFAECGDRPGGGKSRAAVAALESSAETAFAAVADEMSLPKALQTRVESGRDPAEVILREAAKGYNLLVM
GATEQRFADGTLFNSIVDRVVQEAPCATMVVKSHLPRPEGEHCTIALQEIRHILVPTIGTEYSKHAVEVASTIAAQTQAL
VTLVHVVNLPQFDDFYVDQDNMSIALDIAQQIVDQQADIGRGLGAQVNTAVLTGNSPEKEILNFARDEGVDLIILGSNIR
PISGRVFFGHRVDTLLRQASCPVAVVSSS
>Mature_749_residues
MEAALHSFLYFAAATAQSGPIKPLGHHEVLLLLLQLSLLLFAARGLGELMRRIDLPPVVGELLAGVVLGPSVFGFLLPAL
QSEIFPKSQIQSDLISVVSWLGVLFLLIATGLETDLNLIVSKGKTALLISLGGIVVPFATGFGLGMLLPDNFLAEPSERF
VFSLFIATAMSISAIPVIAKVLMDLKLIRRDIGQVTLAAGMTDDTIGWILLSVVAGLASSGKLDLTAALSSIGGAVIFLG
VAFTIGRTLVAQLLRLVDDWIGGVPAQLTIVLVVALAAAALTHQLGIEAALGAFVTGILVGQAPRFSREAGHTLEVFTAA
FLAPIFFAVAGLKVNLLQLLEPQTLLIGALVLFIACFGKFVGVYIGARVGGLGHWEGLALGSGMNARGAMEIIVATIGLS
LGVLNQQMYSIIVMVAIVTSLMAPPLLRWTLSKVKIGDEEARRLQMEDMASRSFVKSIRRVLLPTRGGANVQLAAQLVSH
MAQQNELEVTALFAECGDRPGGGKSRAAVAALESSAETAFAAVADEMSLPKALQTRVESGRDPAEVILREAAKGYNLLVM
GATEQRFADGTLFNSIVDRVVQEAPCATMVVKSHLPRPEGEHCTIALQEIRHILVPTIGTEYSKHAVEVASTIAAQTQAL
VTLVHVVNLPQFDDFYVDQDNMSIALDIAQQIVDQQADIGRGLGAQVNTAVLTGNSPEKEILNFARDEGVDLIILGSNIR
PISGRVFFGHRVDTLLRQASCPVAVVSSS

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Escherichia coli, GI1786685, Length=413, Percent_Identity=25.90799031477, Blast_Score=66, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6322367, Length=404, Percent_Identity=30.4455445544554, Blast_Score=170, Evalue=8e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 79304; Mature: 79304

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAALHSFLYFAAATAQSGPIKPLGHHEVLLLLLQLSLLLFAARGLGELMRRIDLPPVVG
CCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
ELLAGVVLGPSVFGFLLPALQSEIFPKSQIQSDLISVVSWLGVLFLLIATGLETDLNLIV
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHE
SKGKTALLISLGGIVVPFATGFGLGMLLPDNFLAEPSERFVFSLFIATAMSISAIPVIAK
ECCCEEEEEEECCHHHHHHHCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VLMDLKLIRRDIGQVTLAAGMTDDTIGWILLSVVAGLASSGKLDLTAALSSIGGAVIFLG
HHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCHHHHHHH
VAFTIGRTLVAQLLRLVDDWIGGVPAQLTIVLVVALAAAALTHQLGIEAALGAFVTGILV
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GQAPRFSREAGHTLEVFTAAFLAPIFFAVAGLKVNLLQLLEPQTLLIGALVLFIACFGKF
CCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
VGVYIGARVGGLGHWEGLALGSGMNARGAMEIIVATIGLSLGVLNQQMYSIIVMVAIVTS
HHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMAPPLLRWTLSKVKIGDEEARRLQMEDMASRSFVKSIRRVLLPTRGGANVQLAAQLVSH
HHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
MAQQNELEVTALFAECGDRPGGGKSRAAVAALESSAETAFAAVADEMSLPKALQTRVESG
HHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
RDPAEVILREAAKGYNLLVMGATEQRFADGTLFNSIVDRVVQEAPCATMVVKSHLPRPEG
CCHHHHHHHHHCCCCEEEEECCCHHHHHCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCC
EHCTIALQEIRHILVPTIGTEYSKHAVEVASTIAAQTQALVTLVHVVNLPQFDDFYVDQD
CHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCC
NMSIALDIAQQIVDQQADIGRGLGAQVNTAVLTGNSPEKEILNFARDEGVDLIILGSNIR
CCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCEEEEECCCCC
PISGRVFFGHRVDTLLRQASCPVAVVSSS
CCCCEEEECHHHHHHHHHCCCCEEEEECC
>Mature Secondary Structure
MEAALHSFLYFAAATAQSGPIKPLGHHEVLLLLLQLSLLLFAARGLGELMRRIDLPPVVG
CCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
ELLAGVVLGPSVFGFLLPALQSEIFPKSQIQSDLISVVSWLGVLFLLIATGLETDLNLIV
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHE
SKGKTALLISLGGIVVPFATGFGLGMLLPDNFLAEPSERFVFSLFIATAMSISAIPVIAK
ECCCEEEEEEECCHHHHHHHCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VLMDLKLIRRDIGQVTLAAGMTDDTIGWILLSVVAGLASSGKLDLTAALSSIGGAVIFLG
HHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCHHHHHHH
VAFTIGRTLVAQLLRLVDDWIGGVPAQLTIVLVVALAAAALTHQLGIEAALGAFVTGILV
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GQAPRFSREAGHTLEVFTAAFLAPIFFAVAGLKVNLLQLLEPQTLLIGALVLFIACFGKF
CCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
VGVYIGARVGGLGHWEGLALGSGMNARGAMEIIVATIGLSLGVLNQQMYSIIVMVAIVTS
HHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMAPPLLRWTLSKVKIGDEEARRLQMEDMASRSFVKSIRRVLLPTRGGANVQLAAQLVSH
HHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
MAQQNELEVTALFAECGDRPGGGKSRAAVAALESSAETAFAAVADEMSLPKALQTRVESG
HHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
RDPAEVILREAAKGYNLLVMGATEQRFADGTLFNSIVDRVVQEAPCATMVVKSHLPRPEG
CCHHHHHHHHHCCCCEEEEECCCHHHHHCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCC
EHCTIALQEIRHILVPTIGTEYSKHAVEVASTIAAQTQALVTLVHVVNLPQFDDFYVDQD
CHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCC
NMSIALDIAQQIVDQQADIGRGLGAQVNTAVLTGNSPEKEILNFARDEGVDLIILGSNIR
CCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCEEEEECCCCC
PISGRVFFGHRVDTLLRQASCPVAVVSSS
CCCCEEEECHHHHHHHHHCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]