Click here to switch to the map view.

The map label for this gene is thyX [H]

Identifier: 37521890

GI number: 37521890

Start: 2485617

End: 2486390

Strand: Direct

Name: thyX [H]

Synonym: glr2321

Alternate gene names: 37521890

Gene position: 2485617-2486390 (Clockwise)

Preceding gene: 37521887

Following gene: 37521891

Centisome position: 53.35

GC content: 58.27

Gene sequence:

>774_bases
ATGACCAACGCCCACACGCTCAAGCTCAAAGACATCGCCGGCAAAGATCCGGGCGTCATCCGCGTCCTCGACCAGGGCTT
TATCCAGCTGGTGGATTACATGCCCTCCGACTACCCCTTCGGCCAGGTCGTCGAAGGCGCCACTGCCGGGGACATCGCCA
TCGTGGCCGCCGCCCGGGTCTCCTACGGTACGGTTACCAAGGGAACCGATGCCGACCGCAAGCTTATCGAGTTTCTCCTG
CGCCACGGCCATACCAGTCCGCTGGAGATGGTCGAATTCAAATTCATCGTCAAAGCACCGGTGGTGATGTGGTGGCAGCA
CGTCCGACATCGCATCCAAGAAATGAATTTTCAGTCGGGACGGTATACCCCTTACCCTGAGAACGAGTTCTATCTGCCCG
AGAAACTGCGCGCCCAGGACAAGGTCAACAAGCAAGGCTCGGTGCTGGTGGACTTTTTGAGCAGTGACGAAGAGCGGGCA
TTGCTCGAAGAATTGAGAGCGCACTACGAGGCAGGCTTTTCCTTATATAAGAAGATGCTTGCCAAAGGAGTGGCCAAAGA
AATGGCGCGTCTCGCCCTGCCGGGTTGGGCACTCTACCACACCGCCTACGTCAAGATGAACGCCCATGCGCTGATGCACT
ACCTGGCCAAGCGCACCGAACCCGATGCCCAGTACGAAATCCGGGTTTACGCCCAGGCCATGGAGCGTATATTCGCCGAA
AAGCTTCCCTGGGTGCATGACACCTGGCGCAATAGCCGGGGTGCGGCGATGTGA

Upstream 100 bases:

>100_bases
TTTTAGCAACTGTCCCGTAGCCAGGAATACATTCTTATCACACCCGGCTTGGTGGCAAGCGGAGGAGGTAGACTATCCAG
GATGTAGAGATCCGGCCGCC

Downstream 100 bases:

>100_bases
GGGCAAAAGGCTGAGAGTTGCTTAAAATTCTGCAACAATTCTCCCGAAGCCGCTTTCCCGGGCTGGAGGAGGCTTTTAGG
GTTTCAAGAACCCATTGGAT

Product: FAD-dependent thymidylate synthase

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 257; Mature: 256

Protein sequence:

>257_residues
MTNAHTLKLKDIAGKDPGVIRVLDQGFIQLVDYMPSDYPFGQVVEGATAGDIAIVAAARVSYGTVTKGTDADRKLIEFLL
RHGHTSPLEMVEFKFIVKAPVVMWWQHVRHRIQEMNFQSGRYTPYPENEFYLPEKLRAQDKVNKQGSVLVDFLSSDEERA
LLEELRAHYEAGFSLYKKMLAKGVAKEMARLALPGWALYHTAYVKMNAHALMHYLAKRTEPDAQYEIRVYAQAMERIFAE
KLPWVHDTWRNSRGAAM

Sequences:

>Translated_257_residues
MTNAHTLKLKDIAGKDPGVIRVLDQGFIQLVDYMPSDYPFGQVVEGATAGDIAIVAAARVSYGTVTKGTDADRKLIEFLL
RHGHTSPLEMVEFKFIVKAPVVMWWQHVRHRIQEMNFQSGRYTPYPENEFYLPEKLRAQDKVNKQGSVLVDFLSSDEERA
LLEELRAHYEAGFSLYKKMLAKGVAKEMARLALPGWALYHTAYVKMNAHALMHYLAKRTEPDAQYEIRVYAQAMERIFAE
KLPWVHDTWRNSRGAAM
>Mature_256_residues
TNAHTLKLKDIAGKDPGVIRVLDQGFIQLVDYMPSDYPFGQVVEGATAGDIAIVAAARVSYGTVTKGTDADRKLIEFLLR
HGHTSPLEMVEFKFIVKAPVVMWWQHVRHRIQEMNFQSGRYTPYPENEFYLPEKLRAQDKVNKQGSVLVDFLSSDEERAL
LEELRAHYEAGFSLYKKMLAKGVAKEMARLALPGWALYHTAYVKMNAHALMHYLAKRTEPDAQYEIRVYAQAMERIFAEK
LPWVHDTWRNSRGAAM

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate [H]

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003669 [H]

Pfam domain/function: PF02511 Thy1 [H]

EC number: =2.1.1.148 [H]

Molecular weight: Translated: 29419; Mature: 29288

Theoretical pI: Translated: 9.03; Mature: 9.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNAHTLKLKDIAGKDPGVIRVLDQGFIQLVDYMPSDYPFGQVVEGATAGDIAIVAAARV
CCCCEEEEECCCCCCCCCEEEHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCHHHHHHHHH
SYGTVTKGTDADRKLIEFLLRHGHTSPLEMVEFKFIVKAPVVMWWQHVRHRIQEMNFQSG
CCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
RYTPYPENEFYLPEKLRAQDKVNKQGSVLVDFLSSDEERALLEELRAHYEAGFSLYKKML
CCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
AKGVAKEMARLALPGWALYHTAYVKMNAHALMHYLAKRTEPDAQYEIRVYAQAMERIFAE
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
KLPWVHDTWRNSRGAAM
HCCCHHHHHCCCCCCCC
>Mature Secondary Structure 
TNAHTLKLKDIAGKDPGVIRVLDQGFIQLVDYMPSDYPFGQVVEGATAGDIAIVAAARV
CCCEEEEECCCCCCCCCEEEHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCHHHHHHHHH
SYGTVTKGTDADRKLIEFLLRHGHTSPLEMVEFKFIVKAPVVMWWQHVRHRIQEMNFQSG
CCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
RYTPYPENEFYLPEKLRAQDKVNKQGSVLVDFLSSDEERALLEELRAHYEAGFSLYKKML
CCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
AKGVAKEMARLALPGWALYHTAYVKMNAHALMHYLAKRTEPDAQYEIRVYAQAMERIFAE
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
KLPWVHDTWRNSRGAAM
HCCCHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA