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The map label for this gene is tuaD [H]

Identifier: 37521749

GI number: 37521749

Start: 2330227

End: 2331615

Strand: Reverse

Name: tuaD [H]

Synonym: gll2180

Alternate gene names: 37521749

Gene position: 2331615-2330227 (Counterclockwise)

Preceding gene: 37521750

Following gene: 37521748

Centisome position: 50.05

GC content: 66.09

Gene sequence:

>1389_bases
ATGAAAGTAGGGGTTATCGGCACCGGTTACGTCGGCCTGGTCACGGGCGCCTGCCTGTCTACCATCGGCCACACCGTCGT
CTGCATGGACAACAACACCGCCAAAGTCGAAGGCTTGCGCCAGGGCGTCATGCCGATTTACGAACCCGGACTCGACGAGT
TGGTCGCTGCGGCCGTCGCCGCCGGGCGGCTGCAGTTCACCACCGGCATGGCCGAGACCGTTCAAGACAGTGACGTCGTC
TTCATCACCGTGGGCACCCCCTCCCGGGCGGACGGCTCGCCGGACCTCTCTGCCGTGCGCGCCGTGGCCCGCTCCATCGG
CTCCCACCTGGACGGCCGCTTCCGGGTGATTGTGAACAAATCGACCGTGCCGGTCGGTTCGGGCAACTGGGTGCGCATGC
TGGTCGAAGACGGGGCGAACCTCGTTGCCGCCACCGCCAGAAGCGGCCAGCACGCGGGCAACGGTCTGGCGGTGCTCGCC
CCCGCCGCCCCGCCGAACTTCAGTGTGGCGAGCAACCCGGAATTTTTGCGCGAAGGCAGCGCGGTCTGGGACACCTTCAA
TCCTGATCGCATCGTCATCGGGGCGGAGGACGCCCGCGCCGTCGAAGTGATGCGCCGACTGTACGCCCACTGGGTGAGTC
CCGCCGACACCGATACCCAGGCGGTGCCGATGGTGGTGACGGACTTGGCCTCCGCCGAGATGATCAAGTACGCCGCCAAC
GCCTTTCTGGCCACCAAAATCAGCTTCATCAACGAAATCGCCAACATCTGCGAGCGGGTGGGGGCGGATGTCACCCGCAT
CGCCGAGGCGATCGGACTCGACAAGCGCATCGGCCGCTCGTTTCTGAACGCCGGGGCGGGCTGGGGCGGTTCGTGCTTTC
CAAAAGACGTCTCGGCCTTGGTCTCGACGGCGGCTGAGTATGGCTACAACTGCGAGTTGCTGAAGGCGACCTTGTCGGTC
AACGAGCACCAGCGCCAACTGGTGATCGAGAAATTGCAGCGGGAGCTGCGCATTCTCAAGGGTCGGACGGTGGCGCTGTG
GGGATTGGCCTTCAAACCGCACACCGACGACATCCGTTGCGCGCCGGCGTTGGCGGTGGCGGAGCATCTGCTCAATCTCG
GTTGCCGGGTGGTGGCCCACGACCCGGTGGTGACGGCGGCCCAGGTGCAAGGTCAACTGCCGGACTTGCAAGTGGCGGGT
AGTGCTCTGGAGGCTGTCCAGGGGGCCGATGCGCTGTTGGTGATGACCGAGTGGCCCGAGTACGGTGGGATCGACCCGCA
GACGGTGGCGGCGGTACTGCGCCAACCGATTGTCATCGACGCGCGCAACTGCCTGGACACCCAGGCGGTGCAGGGTGCCG
GGCTGCGCTACGTCGGTGTCGGCCGCTAA

Upstream 100 bases:

>100_bases
CGACCTGCACAGCGGCGGATTTTCCAACAACTGACGCCCCGTTTGTCAGGCGATCGGTTTGTATAGCTTTTTTGACTACT
CAACCCAGCAAGGAGCATCC

Downstream 100 bases:

>100_bases
CAACTGAGGAGAACAACCCATGCGCATACTGGTTACCGGCGGAGCGGGCTTCATCGGCTCGCACCTGTGTGAACGACTGG
TTGGCGAAGGACACGAAGTC

Product: UDP-glucose dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH; Teichuronic acid biosynthesis protein tuaD [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MKVGVIGTGYVGLVTGACLSTIGHTVVCMDNNTAKVEGLRQGVMPIYEPGLDELVAAAVAAGRLQFTTGMAETVQDSDVV
FITVGTPSRADGSPDLSAVRAVARSIGSHLDGRFRVIVNKSTVPVGSGNWVRMLVEDGANLVAATARSGQHAGNGLAVLA
PAAPPNFSVASNPEFLREGSAVWDTFNPDRIVIGAEDARAVEVMRRLYAHWVSPADTDTQAVPMVVTDLASAEMIKYAAN
AFLATKISFINEIANICERVGADVTRIAEAIGLDKRIGRSFLNAGAGWGGSCFPKDVSALVSTAAEYGYNCELLKATLSV
NEHQRQLVIEKLQRELRILKGRTVALWGLAFKPHTDDIRCAPALAVAEHLLNLGCRVVAHDPVVTAAQVQGQLPDLQVAG
SALEAVQGADALLVMTEWPEYGGIDPQTVAAVLRQPIVIDARNCLDTQAVQGAGLRYVGVGR

Sequences:

>Translated_462_residues
MKVGVIGTGYVGLVTGACLSTIGHTVVCMDNNTAKVEGLRQGVMPIYEPGLDELVAAAVAAGRLQFTTGMAETVQDSDVV
FITVGTPSRADGSPDLSAVRAVARSIGSHLDGRFRVIVNKSTVPVGSGNWVRMLVEDGANLVAATARSGQHAGNGLAVLA
PAAPPNFSVASNPEFLREGSAVWDTFNPDRIVIGAEDARAVEVMRRLYAHWVSPADTDTQAVPMVVTDLASAEMIKYAAN
AFLATKISFINEIANICERVGADVTRIAEAIGLDKRIGRSFLNAGAGWGGSCFPKDVSALVSTAAEYGYNCELLKATLSV
NEHQRQLVIEKLQRELRILKGRTVALWGLAFKPHTDDIRCAPALAVAEHLLNLGCRVVAHDPVVTAAQVQGQLPDLQVAG
SALEAVQGADALLVMTEWPEYGGIDPQTVAAVLRQPIVIDARNCLDTQAVQGAGLRYVGVGR
>Mature_462_residues
MKVGVIGTGYVGLVTGACLSTIGHTVVCMDNNTAKVEGLRQGVMPIYEPGLDELVAAAVAAGRLQFTTGMAETVQDSDVV
FITVGTPSRADGSPDLSAVRAVARSIGSHLDGRFRVIVNKSTVPVGSGNWVRMLVEDGANLVAATARSGQHAGNGLAVLA
PAAPPNFSVASNPEFLREGSAVWDTFNPDRIVIGAEDARAVEVMRRLYAHWVSPADTDTQAVPMVVTDLASAEMIKYAAN
AFLATKISFINEIANICERVGADVTRIAEAIGLDKRIGRSFLNAGAGWGGSCFPKDVSALVSTAAEYGYNCELLKATLSV
NEHQRQLVIEKLQRELRILKGRTVALWGLAFKPHTDDIRCAPALAVAEHLLNLGCRVVAHDPVVTAAQVQGQLPDLQVAG
SALEAVQGADALLVMTEWPEYGGIDPQTVAAVLRQPIVIDARNCLDTQAVQGAGLRYVGVGR

Specific function: Catalyzes the conversion of UDP-glucose into UDP- glucuronate, one of the precursors of teichuronic acid [H]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=501, Percent_Identity=32.5349301397206, Blast_Score=238, Evalue=7e-63,
Organism=Homo sapiens, GI296040438, Length=398, Percent_Identity=32.4120603015075, Blast_Score=188, Evalue=9e-48,
Organism=Homo sapiens, GI296040443, Length=324, Percent_Identity=34.8765432098765, Blast_Score=176, Evalue=3e-44,
Organism=Escherichia coli, GI1788340, Length=385, Percent_Identity=26.4935064935065, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI48994968, Length=457, Percent_Identity=28.2275711159737, Blast_Score=127, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17560350, Length=496, Percent_Identity=34.6774193548387, Blast_Score=258, Evalue=3e-69,
Organism=Drosophila melanogaster, GI17136908, Length=497, Percent_Identity=31.9919517102616, Blast_Score=241, Evalue=1e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 48739; Mature: 48739

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVGVIGTGYVGLVTGACLSTIGHTVVCMDNNTAKVEGLRQGVMPIYEPGLDELVAAAVA
CEEEEEECCHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHCCCCCCCCCHHHHHHHHHH
AGRLQFTTGMAETVQDSDVVFITVGTPSRADGSPDLSAVRAVARSIGSHLDGRFRVIVNK
HCCEEEECCHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEC
STVPVGSGNWVRMLVEDGANLVAATARSGQHAGNGLAVLAPAAPPNFSVASNPEFLREGS
CCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHCCC
AVWDTFNPDRIVIGAEDARAVEVMRRLYAHWVSPADTDTQAVPMVVTDLASAEMIKYAAN
CEECCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
AFLATKISFINEIANICERVGADVTRIAEAIGLDKRIGRSFLNAGAGWGGSCFPKDVSAL
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHH
VSTAAEYGYNCELLKATLSVNEHQRQLVIEKLQRELRILKGRTVALWGLAFKPHTDDIRC
HHHHHHHCCCCEEEHEECCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCH
APALAVAEHLLNLGCRVVAHDPVVTAAQVQGQLPDLQVAGSALEAVQGADALLVMTEWPE
HHHHHHHHHHHHCCCEEEECCCCEEHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEEECCC
YGGIDPQTVAAVLRQPIVIDARNCLDTQAVQGAGLRYVGVGR
CCCCCHHHHHHHHHCCEEEECHHHHHHHHHCCCCEEEEECCC
>Mature Secondary Structure
MKVGVIGTGYVGLVTGACLSTIGHTVVCMDNNTAKVEGLRQGVMPIYEPGLDELVAAAVA
CEEEEEECCHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHCCCCCCCCCHHHHHHHHHH
AGRLQFTTGMAETVQDSDVVFITVGTPSRADGSPDLSAVRAVARSIGSHLDGRFRVIVNK
HCCEEEECCHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEC
STVPVGSGNWVRMLVEDGANLVAATARSGQHAGNGLAVLAPAAPPNFSVASNPEFLREGS
CCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHCCC
AVWDTFNPDRIVIGAEDARAVEVMRRLYAHWVSPADTDTQAVPMVVTDLASAEMIKYAAN
CEECCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
AFLATKISFINEIANICERVGADVTRIAEAIGLDKRIGRSFLNAGAGWGGSCFPKDVSAL
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHH
VSTAAEYGYNCELLKATLSVNEHQRQLVIEKLQRELRILKGRTVALWGLAFKPHTDDIRC
HHHHHHHCCCCEEEHEECCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCH
APALAVAEHLLNLGCRVVAHDPVVTAAQVQGQLPDLQVAGSALEAVQGADALLVMTEWPE
HHHHHHHHHHHHCCCEEEECCCCEEHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEEECCC
YGGIDPQTVAAVLRQPIVIDARNCLDTQAVQGAGLRYVGVGR
CCCCCHHHHHHHHHCCEEEECHHHHHHHHHCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10048024; 9384377; 10376820 [H]