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The map label for this gene is coaE

Identifier: 37521703

GI number: 37521703

Start: 2285824

End: 2286441

Strand: Direct

Name: coaE

Synonym: glr2134

Alternate gene names: 37521703

Gene position: 2285824-2286441 (Clockwise)

Preceding gene: 37521700

Following gene: 37521705

Centisome position: 49.06

GC content: 66.34

Gene sequence:

>618_bases
ATGGCAGGGCGGGCGCAGGGGGCGCGCTGGATGGCAAGACGGGTAATCGGCCTGACAGGCGGGATCGCAACGGGCAAGAG
CACAGTGGGCCGCCTGCTCGCCGGGTGGGGCATCCCGGTCATCGACGCCGACCTTCTGGCGCGCGAAGCGGTTGCACCCG
GCAGCGCCGCCCTGGCCGAGATCGTTCAGCATTACGGTAGTACGATGCTCACCAACGCCGGAGCGCTCGACCGCTCAGCC
CTGGCGCGCATCATTTTCTCCGACCCGCAGGAGCGCCGCTGGGTGGAAAGCCGCATCCATCCGTCCGTGCGCGCGGCCAT
GCAGGCGGCCGTCGAACGCGAGCCCGGGACCATCTGCTTGATGATCCCGCTGCTGTTCGAAGCGGGCATGACCGACCTGG
TAACCGAAATCTGGGTGGTGAGCTGCAAGCCTGAGCGGCAACACGCGCGGCTAAAGGAGCGCGACGGGCTCGATGACCAG
GCGATTGCGGCGCGCATCGCAAGCCAGTGGCCGCTTACCGAAAAAGTGCGGCATGCCGACGTCGTACTCGACAACGACGG
CGACTTTGCCCACCTGAAAATTCAGGTGGAGCGCGCCCTCGATCAAGCTTCGATCTGA

Upstream 100 bases:

>100_bases
AAAAGCGCCCCGGCGCACAGTCCGCCGATGCCGCTGCCGATAACAATCGCGTCGAACATGCCTCAATCATCGCAGCAGCA
GACGCTTCGAGGCTGCCACA

Downstream 100 bases:

>100_bases
ACGGCCGCAGCCTGCCAGCGCCGAAAATCACTTTCGAGGGACCTGCTGAGCCGGTCGCGCAAGATCCACAGGAAACTTTC
GAGGATCGTGCGCGCTGCCC

Product: dephospho-CoA kinase

Products: NA

Alternate protein names: Dephosphocoenzyme A kinase

Number of amino acids: Translated: 205; Mature: 204

Protein sequence:

>205_residues
MAGRAQGARWMARRVIGLTGGIATGKSTVGRLLAGWGIPVIDADLLAREAVAPGSAALAEIVQHYGSTMLTNAGALDRSA
LARIIFSDPQERRWVESRIHPSVRAAMQAAVEREPGTICLMIPLLFEAGMTDLVTEIWVVSCKPERQHARLKERDGLDDQ
AIAARIASQWPLTEKVRHADVVLDNDGDFAHLKIQVERALDQASI

Sequences:

>Translated_205_residues
MAGRAQGARWMARRVIGLTGGIATGKSTVGRLLAGWGIPVIDADLLAREAVAPGSAALAEIVQHYGSTMLTNAGALDRSA
LARIIFSDPQERRWVESRIHPSVRAAMQAAVEREPGTICLMIPLLFEAGMTDLVTEIWVVSCKPERQHARLKERDGLDDQ
AIAARIASQWPLTEKVRHADVVLDNDGDFAHLKIQVERALDQASI
>Mature_204_residues
AGRAQGARWMARRVIGLTGGIATGKSTVGRLLAGWGIPVIDADLLAREAVAPGSAALAEIVQHYGSTMLTNAGALDRSAL
ARIIFSDPQERRWVESRIHPSVRAAMQAAVEREPGTICLMIPLLFEAGMTDLVTEIWVVSCKPERQHARLKERDGLDDQA
IAARIASQWPLTEKVRHADVVLDNDGDFAHLKIQVERALDQASI

Specific function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A

COG id: COG0237

COG function: function code H; Dephospho-CoA kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain

Homologues:

Organism=Homo sapiens, GI191252797, Length=187, Percent_Identity=38.5026737967914, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI191252795, Length=187, Percent_Identity=38.5026737967914, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI110227607, Length=189, Percent_Identity=31.2169312169312, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI110227605, Length=189, Percent_Identity=31.2169312169312, Blast_Score=84, Evalue=7e-17,
Organism=Homo sapiens, GI110227603, Length=189, Percent_Identity=31.2169312169312, Blast_Score=84, Evalue=7e-17,
Organism=Homo sapiens, GI110227601, Length=189, Percent_Identity=31.2169312169312, Blast_Score=84, Evalue=7e-17,
Organism=Homo sapiens, GI205277394, Length=189, Percent_Identity=31.2169312169312, Blast_Score=84, Evalue=8e-17,
Organism=Escherichia coli, GI1786292, Length=176, Percent_Identity=36.3636363636364, Blast_Score=118, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17554944, Length=194, Percent_Identity=34.5360824742268, Blast_Score=120, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI25143409, Length=201, Percent_Identity=28.8557213930348, Blast_Score=70, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6320402, Length=197, Percent_Identity=32.48730964467, Blast_Score=103, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24644728, Length=178, Percent_Identity=35.9550561797753, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24658602, Length=191, Percent_Identity=32.4607329842932, Blast_Score=103, Evalue=8e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAE_GLOVI (Q7NIP9)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_925080.1
- ProteinModelPortal:   Q7NIP9
- SMR:   Q7NIP9
- GeneID:   2600535
- GenomeReviews:   BA000045_GR
- KEGG:   gvi:glr2134
- NMPDR:   fig|251221.1.peg.2134
- HOGENOM:   HBG650290
- OMA:   IIAREVV
- ProtClustDB:   PRK14730
- BioCyc:   GVIO251221:GLR2134-MONOMER
- BRENDA:   2.7.1.24
- GO:   GO:0005737
- HAMAP:   MF_00376
- InterPro:   IPR001977
- TIGRFAMs:   TIGR00152

Pfam domain/function: PF01121 CoaE

EC number: =2.7.1.24

Molecular weight: Translated: 22277; Mature: 22146

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS51219 DPCK; PS01294 COAE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGRAQGARWMARRVIGLTGGIATGKSTVGRLLAGWGIPVIDADLLAREAVAPGSAALAE
CCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHH
IVQHYGSTMLTNAGALDRSALARIIFSDPQERRWVESRIHPSVRAAMQAAVEREPGTICL
HHHHHCCHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEE
MIPLLFEAGMTDLVTEIWVVSCKPERQHARLKERDGLDDQAIAARIASQWPLTEKVRHAD
HHHHHHHCCHHHHHHHHHHEECCCHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHC
VVLDNDGDFAHLKIQVERALDQASI
EEEECCCCEEEEEEEHHHHHHHCCC
>Mature Secondary Structure 
AGRAQGARWMARRVIGLTGGIATGKSTVGRLLAGWGIPVIDADLLAREAVAPGSAALAE
CCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHH
IVQHYGSTMLTNAGALDRSALARIIFSDPQERRWVESRIHPSVRAAMQAAVEREPGTICL
HHHHHCCHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEE
MIPLLFEAGMTDLVTEIWVVSCKPERQHARLKERDGLDDQAIAARIASQWPLTEKVRHAD
HHHHHHHCCHHHHHHHHHHEECCCHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHC
VVLDNDGDFAHLKIQVERALDQASI
EEEECCCCEEEEEEEHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292