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The map label for this gene is ipdC [H]

Identifier: 37521626

GI number: 37521626

Start: 2207671

End: 2209323

Strand: Reverse

Name: ipdC [H]

Synonym: gll2057

Alternate gene names: 37521626

Gene position: 2209323-2207671 (Counterclockwise)

Preceding gene: 37521630

Following gene: 37521625

Centisome position: 47.42

GC content: 64.19

Gene sequence:

>1653_bases
ATGGCTTCTTCTGTATTGACCGTGGGCGAGTACTTGATCGAACGGTTGTACTCCCACGGCGTGCACCATATCTTCGGCGT
GCCCGGCGATTACGTCCTCGGTTTTTTCAAGCAACTGTGCGACAGCCCCATAAAAGTGATCAATACGTGTGACGAACAGG
GGGCCGGGTTCGCCGCCGACGCCTACGCCCGCGTACGCGGACTCGGGGCCGTCTGCGTCACCTACTGCGTGGGCGGCCTC
AAAGTTGCCAATACTACTGCCCAGGCCTACGCCGAAAAATCGCCGGTCGTGGTGATTAGCGGCGCGCCGGGCACCAACGA
GCGCCACAAAAATCCGCTGTTGCACCACAAAGTGCGCGAGTTCGACACCCAACTCAAAGTGTTCGAGCAACTGACAGTCG
CCGCGACGGTACTGGACGACCCGCAGACGGCCTTCTGTGAAATCGACCGGGTGTTCGAGGCGGCTTTGCGCTACCGCCGG
CCGGTCTACATCGAATTGCCGCGCAACGTCGCCCGCGCCACCGGTTCCGCCTGTCACCTGCGCGAGTTGCCCCAGGAGAC
CAGCGACCCGGCCACGCTGGGCGAAGCCGTCAAAGAAGCCGTAGCCCGCATCAACGCGAGCCGCCAGCCGGTGATTCTGG
CTGGAGAAGAACTGCACCGCTTCGCGTTGCAGCCCTTGCTCGCGCAGCTCATCGAGAAGACCAACATTCCGGTGGCTTCG
ACCATCCTGGGCAAATCGGTCTTCCCTGAGTCCCATCCGCGCTACCTGGGCGTCTACGAGGGAGCGATGGGCCGCGAGGA
CGTGCGCGACTACGTCGAAGCGAGCGACTGCCTGGTGTTGCTCGGAGCGCTGATGACCGATATGAACCTGGGCATCTACA
CCGCCAATCTCGACCCGCGCCGGTCCATTTACTGCGCCACCGAGAAGCTCACTATCGGCTACCACTCCTACGAGGACGTG
CGGTTGCAGGACTTCGCAGCCGGTCTACTGGCAGGCGAGATCGAGCGGCGGGTGGACGGACCGACTCCCCATCCCCTGCC
CCTCGCCCAGTTCCAGCCGGTCCAGGATAGACCGATGACCGTGCTGCGCCTTTTCCAGCAGCTCAACGCCTTTTTGGACG
ACGAAACGATCGTGGTGGCCGACCCCGGCGACGCCCTTTTTGCCGGGGCGGATCTGTTTATCCCGGGCAAGACGCGGTTT
CTGGCTCCTGCCTACTACGCCTCCCTCGGCTTTGCCGTCCCCGCCGCCCTCGGCGCCCAGATGGCCGACGCGCGCCTCAG
GCCCCTGGTGCTGGTGGGCGACGGCGCCTTTCAGATGAGCGGCCTGGAACTCTCGACCATTGCCCGCTTCGGCCTCGACC
CGATTGTCGTGTTGCTCAACAACCGGGGCTACGGCACCGAGCGGCCGATGCAGGACGGTTCTTTCAACGACGTGCTCAAC
TGGAACTACAGCCGTCTGCCGGAGTTGCTGGGCACGGGCCGGGGCTTCGAAGTTTCGACAGAGGACCAACTTGCCGCCGC
CCTGCACGAAGCGCGCCGCCACCGGGGCAGTTTCTCCTTGATCGATGTGCACCTCGAACCGGGAGATCTCTCGCCCGCCC
TCCGGCGCATGACCGATTCGATGGGCCAGCGGGTGCGTCCGGCCGCCGTTTGA

Upstream 100 bases:

>100_bases
GCCGGTGCCGTCAAGGCGGGCATTTTGCGATTTGTGTGGGTCAAAAGCCGCCCCTTCCCCCATTGGGCATCATGGAAATC
GATGGGTCAGGGTTTGCACG

Downstream 100 bases:

>100_bases
TGGGGTTCCCCTCCAGCGATAGAGCATTTTGGCTGTACACGCCTCCTGGGTACCTCGCAAGACCGAGGAACAATTGTCCC
TTGTGGCAGGTGGAGTCGGA

Product: indole-3-pyruvate decarboxylase

Products: NA

Alternate protein names: Indolepyruvate decarboxylase [H]

Number of amino acids: Translated: 550; Mature: 549

Protein sequence:

>550_residues
MASSVLTVGEYLIERLYSHGVHHIFGVPGDYVLGFFKQLCDSPIKVINTCDEQGAGFAADAYARVRGLGAVCVTYCVGGL
KVANTTAQAYAEKSPVVVISGAPGTNERHKNPLLHHKVREFDTQLKVFEQLTVAATVLDDPQTAFCEIDRVFEAALRYRR
PVYIELPRNVARATGSACHLRELPQETSDPATLGEAVKEAVARINASRQPVILAGEELHRFALQPLLAQLIEKTNIPVAS
TILGKSVFPESHPRYLGVYEGAMGREDVRDYVEASDCLVLLGALMTDMNLGIYTANLDPRRSIYCATEKLTIGYHSYEDV
RLQDFAAGLLAGEIERRVDGPTPHPLPLAQFQPVQDRPMTVLRLFQQLNAFLDDETIVVADPGDALFAGADLFIPGKTRF
LAPAYYASLGFAVPAALGAQMADARLRPLVLVGDGAFQMSGLELSTIARFGLDPIVVLLNNRGYGTERPMQDGSFNDVLN
WNYSRLPELLGTGRGFEVSTEDQLAAALHEARRHRGSFSLIDVHLEPGDLSPALRRMTDSMGQRVRPAAV

Sequences:

>Translated_550_residues
MASSVLTVGEYLIERLYSHGVHHIFGVPGDYVLGFFKQLCDSPIKVINTCDEQGAGFAADAYARVRGLGAVCVTYCVGGL
KVANTTAQAYAEKSPVVVISGAPGTNERHKNPLLHHKVREFDTQLKVFEQLTVAATVLDDPQTAFCEIDRVFEAALRYRR
PVYIELPRNVARATGSACHLRELPQETSDPATLGEAVKEAVARINASRQPVILAGEELHRFALQPLLAQLIEKTNIPVAS
TILGKSVFPESHPRYLGVYEGAMGREDVRDYVEASDCLVLLGALMTDMNLGIYTANLDPRRSIYCATEKLTIGYHSYEDV
RLQDFAAGLLAGEIERRVDGPTPHPLPLAQFQPVQDRPMTVLRLFQQLNAFLDDETIVVADPGDALFAGADLFIPGKTRF
LAPAYYASLGFAVPAALGAQMADARLRPLVLVGDGAFQMSGLELSTIARFGLDPIVVLLNNRGYGTERPMQDGSFNDVLN
WNYSRLPELLGTGRGFEVSTEDQLAAALHEARRHRGSFSLIDVHLEPGDLSPALRRMTDSMGQRVRPAAV
>Mature_549_residues
ASSVLTVGEYLIERLYSHGVHHIFGVPGDYVLGFFKQLCDSPIKVINTCDEQGAGFAADAYARVRGLGAVCVTYCVGGLK
VANTTAQAYAEKSPVVVISGAPGTNERHKNPLLHHKVREFDTQLKVFEQLTVAATVLDDPQTAFCEIDRVFEAALRYRRP
VYIELPRNVARATGSACHLRELPQETSDPATLGEAVKEAVARINASRQPVILAGEELHRFALQPLLAQLIEKTNIPVAST
ILGKSVFPESHPRYLGVYEGAMGREDVRDYVEASDCLVLLGALMTDMNLGIYTANLDPRRSIYCATEKLTIGYHSYEDVR
LQDFAAGLLAGEIERRVDGPTPHPLPLAQFQPVQDRPMTVLRLFQQLNAFLDDETIVVADPGDALFAGADLFIPGKTRFL
APAYYASLGFAVPAALGAQMADARLRPLVLVGDGAFQMSGLELSTIARFGLDPIVVLLNNRGYGTERPMQDGSFNDVLNW
NYSRLPELLGTGRGFEVSTEDQLAAALHEARRHRGSFSLIDVHLEPGDLSPALRRMTDSMGQRVRPAAV

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG3961

COG function: function code GHR; Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Escherichia coli, GI1790104, Length=482, Percent_Identity=24.4813278008299, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI87081685, Length=564, Percent_Identity=24.290780141844, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1786717, Length=489, Percent_Identity=24.1308793456033, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1788716, Length=558, Percent_Identity=23.1182795698925, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323163, Length=512, Percent_Identity=30.078125, Blast_Score=232, Evalue=1e-61,
Organism=Saccharomyces cerevisiae, GI6321524, Length=546, Percent_Identity=29.1208791208791, Blast_Score=230, Evalue=4e-61,
Organism=Saccharomyces cerevisiae, GI6323073, Length=502, Percent_Identity=29.2828685258964, Blast_Score=226, Evalue=6e-60,
Organism=Saccharomyces cerevisiae, GI6320588, Length=616, Percent_Identity=27.9220779220779, Blast_Score=211, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6320123, Length=518, Percent_Identity=26.2548262548263, Blast_Score=205, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6323755, Length=581, Percent_Identity=23.407917383821, Blast_Score=108, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017765
- InterPro:   IPR012110
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =4.1.1.74 [H]

Molecular weight: Translated: 60116; Mature: 59985

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASSVLTVGEYLIERLYSHGVHHIFGVPGDYVLGFFKQLCDSPIKVINTCDEQGAGFAAD
CCCCHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHCCHHHHHHCCCCCCCCCHHH
AYARVRGLGAVCVTYCVGGLKVANTTAQAYAEKSPVVVISGAPGTNERHKNPLLHHKVRE
HHHHHHHHHHHHHHHHHCCEEEECHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHH
FDTQLKVFEQLTVAATVLDDPQTAFCEIDRVFEAALRYRRPVYIELPRNVARATGSACHL
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHCCCHHHH
RELPQETSDPATLGEAVKEAVARINASRQPVILAGEELHRFALQPLLAQLIEKTNIPVAS
HHCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCCHHH
TILGKSVFPESHPRYLGVYEGAMGREDVRDYVEASDCLVLLGALMTDMNLGIYTANLDPR
HHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCC
RSIYCATEKLTIGYHSYEDVRLQDFAAGLLAGEIERRVDGPTPHPLPLAQFQPVQDRPMT
CCEEEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHH
VLRLFQQLNAFLDDETIVVADPGDALFAGADLFIPGKTRFLAPAYYASLGFAVPAALGAQ
HHHHHHHHHHHCCCCEEEEECCCCCEEECCEEEECCCCCEECHHHHHHHHHHHHHHHHHH
MADARLRPLVLVGDGAFQMSGLELSTIARFGLDPIVVLLNNRGYGTERPMQDGSFNDVLN
HHHCCCCEEEEECCCCEEECCCHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCC
WNYSRLPELLGTGRGFEVSTEDQLAAALHEARRHRGSFSLIDVHLEPGDLSPALRRMTDS
CCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHH
MGQRVRPAAV
HCCCCCCCCC
>Mature Secondary Structure 
ASSVLTVGEYLIERLYSHGVHHIFGVPGDYVLGFFKQLCDSPIKVINTCDEQGAGFAAD
CCCHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHCCHHHHHHCCCCCCCCCHHH
AYARVRGLGAVCVTYCVGGLKVANTTAQAYAEKSPVVVISGAPGTNERHKNPLLHHKVRE
HHHHHHHHHHHHHHHHHCCEEEECHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHH
FDTQLKVFEQLTVAATVLDDPQTAFCEIDRVFEAALRYRRPVYIELPRNVARATGSACHL
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHCCCHHHH
RELPQETSDPATLGEAVKEAVARINASRQPVILAGEELHRFALQPLLAQLIEKTNIPVAS
HHCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCCHHH
TILGKSVFPESHPRYLGVYEGAMGREDVRDYVEASDCLVLLGALMTDMNLGIYTANLDPR
HHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCC
RSIYCATEKLTIGYHSYEDVRLQDFAAGLLAGEIERRVDGPTPHPLPLAQFQPVQDRPMT
CCEEEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHH
VLRLFQQLNAFLDDETIVVADPGDALFAGADLFIPGKTRFLAPAYYASLGFAVPAALGAQ
HHHHHHHHHHHCCCCEEEEECCCCCEEECCEEEECCCCCEECHHHHHHHHHHHHHHHHHH
MADARLRPLVLVGDGAFQMSGLELSTIARFGLDPIVVLLNNRGYGTERPMQDGSFNDVLN
HHHCCCCEEEEECCCCEEECCCHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCC
WNYSRLPELLGTGRGFEVSTEDQLAAALHEARRHRGSFSLIDVHLEPGDLSPALRRMTDS
CCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHH
MGQRVRPAAV
HCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8202090 [H]