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The map label for this gene is lpxD1

Identifier: 37521580

GI number: 37521580

Start: 2160369

End: 2161490

Strand: Direct

Name: lpxD1

Synonym: glr2011

Alternate gene names: 37521580

Gene position: 2160369-2161490 (Clockwise)

Preceding gene: 37521579

Following gene: 37521583

Centisome position: 46.37

GC content: 61.76

Gene sequence:

>1122_bases
ATGAAATTATCGGATATTTCAGCGAAGCTCGGCTGTGCGCTTGAGGGGGATGGACAAGTCGACATCGTCGGTATAGCGGG
CATCGAAGAGGCAGAAGCGGGACATTTGACCTTTCTTTCCAACCCAAAATACAAAGCCAAGCTTCGCCACACCAAAGCGT
CGGCGGCGATCGTCCCGGCCGATTTTGAGGCTTCTGCGGCATGGCCCCTGCCTTTGCTGCGGCACGCCAATCCCTATCTC
ACCTTTGCCCACGCGATCGAATTATTTTATTCGCCCCCGCCGGCACCCCACGGTGTCCACCCCACGGCCGTCGTCGCCCC
CACGGCCGTCTGCGGCCACAACGTGCGCATCGGCGCTTCGAGCGTCATCGGCGAGGGCGTGGTTCTGGCGGACGGTGTCA
CCGTCTACCCCAACTGCACCATCTACCCGGGGGTGCGCATCGGCCGCAACAGCACCATCCATTCCAACTGTGTCGTGCGC
GAGCACGTCGTGATTGGTGAAGACTGCATCGTCCAAAATGGAGCTGTGATCGGTGCCGATGGATTCGGTTATGCCAAACA
AGCCGACGGCACCTGGTACAAAATTGTCCAGTCGGGGAGCGTCGTGCTCGAAAACCGCGTCGAGATCGGCGCCTGTACGA
CCGTCGACCGCGCCACCATCGGCGAGACGCGCATCAAATCCGGCAGCAAGCTCGACAACCTGGTGATGATCGGCCACGGC
TCCAGTGTCGGCGAAAATACGCTGCTTTGCGGCCAGGTGGGGCTCGCGGGCAGCAGCACGGTGGGCCGCAACGTCATGCT
GGCCGGTCAGGTGGGCGTGGCCGGACATCTGCACATCGGGGACAACGTGGTCGCCACGGTCAAATCCTGCATCTGGAAAT
CGGTGGAGGCGAACCAGGTGCTCTACGGCAACATCCCCGCCAGCGACAGTCACACCTGGCTTAAAGCTTCGGCCGTGTTT
CGCCAATTGCCGCACATGCAAAAGTCGGTCCAGCAGATGCAAAAGCGGATCGCCGTGCTCGAAGAACCCTTCAAGACCAA
CGGCAAATCCGGCCAGGCCGATGCGCCGCCGAAGGTCGCCCTCGAATGCCACGGGACGACCGGCGATGCCCCCCAGGGCT
GA

Upstream 100 bases:

>100_bases
GGACAGGTTCCGGGCCTTGCCGAACGATAGTCCTAGCGCAGCTGGTCTTCGCGAGCGCTCGAACGGCGCCTTTGTACTTA
AACAACAGATGGAAAGTGTT

Downstream 100 bases:

>100_bases
TCACTCGCTCATCCGTCGCTGGACAAAGTTGGTGTAGACGTCGCCGCGCAGGAACCAGGCGTTGTCGAGCACCCGCAGGT
GAAAGGGAATGGTGGTCGGT

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MKLSDISAKLGCALEGDGQVDIVGIAGIEEAEAGHLTFLSNPKYKAKLRHTKASAAIVPADFEASAAWPLPLLRHANPYL
TFAHAIELFYSPPPAPHGVHPTAVVAPTAVCGHNVRIGASSVIGEGVVLADGVTVYPNCTIYPGVRIGRNSTIHSNCVVR
EHVVIGEDCIVQNGAVIGADGFGYAKQADGTWYKIVQSGSVVLENRVEIGACTTVDRATIGETRIKSGSKLDNLVMIGHG
SSVGENTLLCGQVGLAGSSTVGRNVMLAGQVGVAGHLHIGDNVVATVKSCIWKSVEANQVLYGNIPASDSHTWLKASAVF
RQLPHMQKSVQQMQKRIAVLEEPFKTNGKSGQADAPPKVALECHGTTGDAPQG

Sequences:

>Translated_373_residues
MKLSDISAKLGCALEGDGQVDIVGIAGIEEAEAGHLTFLSNPKYKAKLRHTKASAAIVPADFEASAAWPLPLLRHANPYL
TFAHAIELFYSPPPAPHGVHPTAVVAPTAVCGHNVRIGASSVIGEGVVLADGVTVYPNCTIYPGVRIGRNSTIHSNCVVR
EHVVIGEDCIVQNGAVIGADGFGYAKQADGTWYKIVQSGSVVLENRVEIGACTTVDRATIGETRIKSGSKLDNLVMIGHG
SSVGENTLLCGQVGLAGSSTVGRNVMLAGQVGVAGHLHIGDNVVATVKSCIWKSVEANQVLYGNIPASDSHTWLKASAVF
RQLPHMQKSVQQMQKRIAVLEEPFKTNGKSGQADAPPKVALECHGTTGDAPQG
>Mature_373_residues
MKLSDISAKLGCALEGDGQVDIVGIAGIEEAEAGHLTFLSNPKYKAKLRHTKASAAIVPADFEASAAWPLPLLRHANPYL
TFAHAIELFYSPPPAPHGVHPTAVVAPTAVCGHNVRIGASSVIGEGVVLADGVTVYPNCTIYPGVRIGRNSTIHSNCVVR
EHVVIGEDCIVQNGAVIGADGFGYAKQADGTWYKIVQSGSVVLENRVEIGACTTVDRATIGETRIKSGSKLDNLVMIGHG
SSVGENTLLCGQVGLAGSSTVGRNVMLAGQVGVAGHLHIGDNVVATVKSCIWKSVEANQVLYGNIPASDSHTWLKASAVF
RQLPHMQKSVQQMQKRIAVLEEPFKTNGKSGQADAPPKVALECHGTTGDAPQG

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily

Homologues:

Organism=Escherichia coli, GI1786376, Length=340, Percent_Identity=36.4705882352941, Blast_Score=233, Evalue=2e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXD1_GLOVI (Q7NJ21)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_924957.1
- ProteinModelPortal:   Q7NJ21
- GeneID:   2600413
- GenomeReviews:   BA000045_GR
- KEGG:   gvi:glr2011
- NMPDR:   fig|251221.1.peg.2011
- HOGENOM:   HBG469615
- OMA:   WFREIIA
- BioCyc:   GVIO251221:GLR2011-MONOMER
- HAMAP:   MF_00523
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573
- TIGRFAMs:   TIGR01853

Pfam domain/function: PF04613 LpxD; SSF51161 Trimer_LpxA_like

EC number: 2.3.1.-

Molecular weight: Translated: 39027; Mature: 39027

Theoretical pI: Translated: 7.39; Mature: 7.39

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLSDISAKLGCALEGDGQVDIVGIAGIEEAEAGHLTFLSNPKYKAKLRHTKASAAIVPA
CCCCCCCHHCCEEECCCCCEEEEEECCCCCCCCCEEEEECCCCEEEEEEECCCCEEEEEC
DFEASAAWPLPLLRHANPYLTFAHAIELFYSPPPAPHGVHPTAVVAPTAVCGHNVRIGAS
CCCCCCCCCCHHHHCCCCCEEHEEEEHHEECCCCCCCCCCCCCEECCHHHCCCCEEECCH
SVIGEGVVLADGVTVYPNCTIYPGVRIGRNSTIHSNCVVREHVVIGEDCIVQNGAVIGAD
HHCCCCEEEECCEEECCCCEECCCEEECCCCCCCCCCEEEEEEEECCCEEEECCCEEECC
GFGYAKQADGTWYKIVQSGSVVLENRVEIGACTTVDRATIGETRIKSGSKLDNLVMIGHG
CCCCCCCCCCCEEEEEECCCEEEECCEEEEEECCCCCCCCCHHHCCCCCCCCCEEEEECC
SSVGENTLLCGQVGLAGSSTVGRNVMLAGQVGVAGHLHIGDNVVATVKSCIWKSVEANQV
CCCCCCEEEEECCCCCCCCCCCCEEEEEECCCCEEEEEECCHHHHHHHHHHHCCCCCCEE
LYGNIPASDSHTWLKASAVFRQLPHMQKSVQQMQKRIAVLEEPFKTNGKSGQADAPPKVA
EEECCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCCCCCEEE
LECHGTTGDAPQG
EEECCCCCCCCCC
>Mature Secondary Structure
MKLSDISAKLGCALEGDGQVDIVGIAGIEEAEAGHLTFLSNPKYKAKLRHTKASAAIVPA
CCCCCCCHHCCEEECCCCCEEEEEECCCCCCCCCEEEEECCCCEEEEEEECCCCEEEEEC
DFEASAAWPLPLLRHANPYLTFAHAIELFYSPPPAPHGVHPTAVVAPTAVCGHNVRIGAS
CCCCCCCCCCHHHHCCCCCEEHEEEEHHEECCCCCCCCCCCCCEECCHHHCCCCEEECCH
SVIGEGVVLADGVTVYPNCTIYPGVRIGRNSTIHSNCVVREHVVIGEDCIVQNGAVIGAD
HHCCCCEEEECCEEECCCCEECCCEEECCCCCCCCCCEEEEEEEECCCEEEECCCEEECC
GFGYAKQADGTWYKIVQSGSVVLENRVEIGACTTVDRATIGETRIKSGSKLDNLVMIGHG
CCCCCCCCCCCEEEEEECCCEEEECCEEEEEECCCCCCCCCHHHCCCCCCCCCEEEEECC
SSVGENTLLCGQVGLAGSSTVGRNVMLAGQVGVAGHLHIGDNVVATVKSCIWKSVEANQV
CCCCCCEEEEECCCCCCCCCCCCEEEEEECCCCEEEEEECCHHHHHHHHHHHCCCCCCEE
LYGNIPASDSHTWLKASAVFRQLPHMQKSVQQMQKRIAVLEEPFKTNGKSGQADAPPKVA
EEECCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCCCCCEEE
LECHGTTGDAPQG
EEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292