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The map label for this gene is pcm [H]

Identifier: 37521268

GI number: 37521268

Start: 1808024

End: 1808728

Strand: Direct

Name: pcm [H]

Synonym: glr1699

Alternate gene names: 37521268

Gene position: 1808024-1808728 (Clockwise)

Preceding gene: 37521267

Following gene: 37521270

Centisome position: 38.81

GC content: 66.1

Gene sequence:

>705_bases
GTGTTCGCTCCCCCCTTCGGACCGCTTGAGCCCCCAGTGGGTCATCTGGCCCAACAAGCCGACCACCGCCAGTTCCAGAG
ACAACGGATGGTCGACGAACAGTTGCGGCCCCGCGGCGTCGAGGCGCAGGCGGTGCTCGCGGCGATGGCGAAGGTGCCGC
GCCACCGCTTTGTCCCGCCGCCCTATACCCGGCTTGCCTACGAGGACCGGCCGCTGCCCATCGGGCATAGCCAGACGATT
TCCCAGCCGTTTATTGTCGCCTACATGAGCGAGGCCGCCCGCATCACACCGGGTGCGAAGGTGCTCGAAATCGGCACAGG
CTCCGGTTACCAGGCTGCCGTGCTGGCCGAAATGGGGGCAGAGGTTTACACCGTCGAGATTGTACCGGAACTGGCCAAGC
GGGCGGAGCGCACCCTGGAGGAACTGGGCTACCGCAGTGTGCGCGTGAGGAGCGGGGACGGTTATCAAGGCTGGCCGCAG
CACGCCCCGTTCGATGCGATCGTGGTCACCGCCGCCCCGGAGCGCATCCCGCAGCCGCTCATCGATCAGCTCGCGGTGAA
CGGCCGGCTGATCGTTCCGGTGGGCACCCAGACGGAAGACCAGCGGATGACGGTACTGACCAGAACGCCCGGCGGCATCG
TCGAGCAAAAAACATTTCCGGTGCGCTTTGTGCCCCTGACCCGGGAGAAGCCTCAGGAACATTGA

Upstream 100 bases:

>100_bases
TCGACGACGCCCGGGCTCGATCCCTCCACAAAAGGTAGATGCGCAGTCACGTTTTCGCGCGCTTGATCGAAGCAGTACAA
GACATATTTTTGGAGGTTGG

Downstream 100 bases:

>100_bases
CCCCACCGATGAGCCGTCAGCGGGGAAGCCCGTGTTCGTCGCAGCCCGGAATTTGCTCGGGGGGGCAGGAGTCTAAAACC
GGCAGGGCGGCGGTTTGTCA

Product: protein-L-isoaspartate O-methyltransferase

Products: NA

Alternate protein names: L-isoaspartyl protein carboxyl methyltransferase; Protein L-isoaspartyl methyltransferase; Protein-beta-aspartate methyltransferase; PIMT [H]

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MFAPPFGPLEPPVGHLAQQADHRQFQRQRMVDEQLRPRGVEAQAVLAAMAKVPRHRFVPPPYTRLAYEDRPLPIGHSQTI
SQPFIVAYMSEAARITPGAKVLEIGTGSGYQAAVLAEMGAEVYTVEIVPELAKRAERTLEELGYRSVRVRSGDGYQGWPQ
HAPFDAIVVTAAPERIPQPLIDQLAVNGRLIVPVGTQTEDQRMTVLTRTPGGIVEQKTFPVRFVPLTREKPQEH

Sequences:

>Translated_234_residues
MFAPPFGPLEPPVGHLAQQADHRQFQRQRMVDEQLRPRGVEAQAVLAAMAKVPRHRFVPPPYTRLAYEDRPLPIGHSQTI
SQPFIVAYMSEAARITPGAKVLEIGTGSGYQAAVLAEMGAEVYTVEIVPELAKRAERTLEELGYRSVRVRSGDGYQGWPQ
HAPFDAIVVTAAPERIPQPLIDQLAVNGRLIVPVGTQTEDQRMTVLTRTPGGIVEQKTFPVRFVPLTREKPQEH
>Mature_234_residues
MFAPPFGPLEPPVGHLAQQADHRQFQRQRMVDEQLRPRGVEAQAVLAAMAKVPRHRFVPPPYTRLAYEDRPLPIGHSQTI
SQPFIVAYMSEAARITPGAKVLEIGTGSGYQAAVLAEMGAEVYTVEIVPELAKRAERTLEELGYRSVRVRSGDGYQGWPQ
HAPFDAIVVTAAPERIPQPLIDQLAVNGRLIVPVGTQTEDQRMTVLTRTPGGIVEQKTFPVRFVPLTREKPQEH

Specific function: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins [H]

COG id: COG2518

COG function: function code O; Protein-L-isoaspartate carboxylmethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI226530908, Length=212, Percent_Identity=32.5471698113208, Blast_Score=90, Evalue=2e-18,
Organism=Escherichia coli, GI1789100, Length=196, Percent_Identity=46.4285714285714, Blast_Score=172, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI71983477, Length=215, Percent_Identity=33.0232558139535, Blast_Score=104, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI193207222, Length=211, Percent_Identity=32.2274881516588, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17981723, Length=211, Percent_Identity=36.4928909952607, Blast_Score=104, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000682 [H]

Pfam domain/function: PF01135 PCMT [H]

EC number: =2.1.1.77 [H]

Molecular weight: Translated: 25982; Mature: 25982

Theoretical pI: Translated: 8.82; Mature: 8.82

Prosite motif: PS01279 PCMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFAPPFGPLEPPVGHLAQQADHRQFQRQRMVDEQLRPRGVEAQAVLAAMAKVPRHRFVPP
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCC
PYTRLAYEDRPLPIGHSQTISQPFIVAYMSEAARITPGAKVLEIGTGSGYQAAVLAEMGA
CHHHHCCCCCCCCCCCCCCCCCCHHEEEHHHHHHCCCCCEEEEECCCCCCHHHHHHHCCC
EVYTVEIVPELAKRAERTLEELGYRSVRVRSGDGYQGWPQHAPFDAIVVTAAPERIPQPL
EEEEEEEHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCEEEEEECHHHCCHHH
IDQLAVNGRLIVPVGTQTEDQRMTVLTRTPGGIVEQKTFPVRFVPLTREKPQEH
HHHHHCCCEEEEEECCCCCCCEEEEEEECCCCCCCCCCCCEEEEECCCCCCCCC
>Mature Secondary Structure
MFAPPFGPLEPPVGHLAQQADHRQFQRQRMVDEQLRPRGVEAQAVLAAMAKVPRHRFVPP
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCC
PYTRLAYEDRPLPIGHSQTISQPFIVAYMSEAARITPGAKVLEIGTGSGYQAAVLAEMGA
CHHHHCCCCCCCCCCCCCCCCCCHHEEEHHHHHHCCCCCEEEEECCCCCCHHHHHHHCCC
EVYTVEIVPELAKRAERTLEELGYRSVRVRSGDGYQGWPQHAPFDAIVVTAAPERIPQPL
EEEEEEEHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCEEEEEECHHHCCHHH
IDQLAVNGRLIVPVGTQTEDQRMTVLTRTPGGIVEQKTFPVRFVPLTREKPQEH
HHHHHCCCEEEEEECCCCCCCEEEEEEECCCCCCCCCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292 [H]