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The map label for this gene is liaR [H]

Identifier: 37521252

GI number: 37521252

Start: 1795322

End: 1795954

Strand: Reverse

Name: liaR [H]

Synonym: gll1683

Alternate gene names: 37521252

Gene position: 1795954-1795322 (Counterclockwise)

Preceding gene: 37521254

Following gene: 37521249

Centisome position: 38.55

GC content: 63.35

Gene sequence:

>633_bases
ATGCCTTCCGATGCGACCATTCGGATTTTGATCGCCGACGATCACCCCGTCGTTCGGCAGGGATTGGCCGCCATGATCGA
TCGCCAAGCGGCCATGCGCGTCGTCGCCGAAGCGGCCGACGGCCGCGAAGCGGTGACGCGCTACCGGGAGCACCTGCCCG
ATGTGGCCCTGATGGATTTGCGGATGCCCGCCATGGACGGCGTCGAAGCGATTGTCGCTATCCGCTCCGAATTTCCCGAC
TCGCGGATTATCGTGCTCACCACCTACGACACCGATGAGGATATCTATCGGGGGCTGCGGGCCGGGGCGATGGCCTTTTT
GCTCAAAGAAGCGCCCACCGAAGAGTTGGTCGAGGCGATCCGGGCTGTGCACGCGGGCCACAAGCGCATTCCCCAACAGG
TGGCCGCCAAACTGGCCAACCGCCTGAGCAATCCCGAACTGACCGCCCGCGAGCTCGAAGTGTTGCACCTGGTGGTCAAA
GGCCAGACCAACAAAGAGATTGCCGCCAGTCTGTTTATCGGCGAGGGCACCGTGCGCGCCCACATGAACAACATCCTCGC
CAAAATGGGCGCCCACGACCGCACCCAGGCAGCCACCCTCGCCATTCGTCGCGGGCTGGTTCGACTCGAATAA

Upstream 100 bases:

>100_bases
AAGCCTCAGATGGCCGTGGAAAAGCCGCCACTGGGCCGCGGAGCATCGCACGGTGTACGATTGTCGCAATGAGTGTGCTG
ACCGGCGGGAGGTCAACCCG

Downstream 100 bases:

>100_bases
ATCGGCAGTTCGCCGATAAAAATCTCTGGGCATTTATTCCATAGTAATTCACAAAAATAAATGGCGGCTCCTATATGAAG
ACAGCCGCCAGCATTGAAAA

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 210; Mature: 209

Protein sequence:

>210_residues
MPSDATIRILIADDHPVVRQGLAAMIDRQAAMRVVAEAADGREAVTRYREHLPDVALMDLRMPAMDGVEAIVAIRSEFPD
SRIIVLTTYDTDEDIYRGLRAGAMAFLLKEAPTEELVEAIRAVHAGHKRIPQQVAAKLANRLSNPELTARELEVLHLVVK
GQTNKEIAASLFIGEGTVRAHMNNILAKMGAHDRTQAATLAIRRGLVRLE

Sequences:

>Translated_210_residues
MPSDATIRILIADDHPVVRQGLAAMIDRQAAMRVVAEAADGREAVTRYREHLPDVALMDLRMPAMDGVEAIVAIRSEFPD
SRIIVLTTYDTDEDIYRGLRAGAMAFLLKEAPTEELVEAIRAVHAGHKRIPQQVAAKLANRLSNPELTARELEVLHLVVK
GQTNKEIAASLFIGEGTVRAHMNNILAKMGAHDRTQAATLAIRRGLVRLE
>Mature_209_residues
PSDATIRILIADDHPVVRQGLAAMIDRQAAMRVVAEAADGREAVTRYREHLPDVALMDLRMPAMDGVEAIVAIRSEFPDS
RIIVLTTYDTDEDIYRGLRAGAMAFLLKEAPTEELVEAIRAVHAGHKRIPQQVAAKLANRLSNPELTARELEVLHLVVKG
QTNKEIAASLFIGEGTVRAHMNNILAKMGAHDRTQAATLAIRRGLVRLE

Specific function: Member of the two-component regulatory system liaS/liaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=211, Percent_Identity=36.4928909952607, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1788222, Length=212, Percent_Identity=33.4905660377358, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1790102, Length=193, Percent_Identity=32.6424870466321, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1786747, Length=192, Percent_Identity=26.5625, Blast_Score=94, Evalue=8e-21,
Organism=Escherichia coli, GI1787473, Length=199, Percent_Identity=34.6733668341709, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1788712, Length=202, Percent_Identity=23.2673267326733, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1788546, Length=195, Percent_Identity=27.6923076923077, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1788550, Length=109, Percent_Identity=36.697247706422, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23097; Mature: 22966

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSDATIRILIADDHPVVRQGLAAMIDRQAAMRVVAEAADGREAVTRYREHLPDVALMDL
CCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEHHC
RMPAMDGVEAIVAIRSEFPDSRIIVLTTYDTDEDIYRGLRAGAMAFLLKEAPTEELVEAI
CCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHH
RAVHAGHKRIPQQVAAKLANRLSNPELTARELEVLHLVVKGQTNKEIAASLFIGEGTVRA
HHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHEECCCHHHH
HMNNILAKMGAHDRTQAATLAIRRGLVRLE
HHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PSDATIRILIADDHPVVRQGLAAMIDRQAAMRVVAEAADGREAVTRYREHLPDVALMDL
CCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEHHC
RMPAMDGVEAIVAIRSEFPDSRIIVLTTYDTDEDIYRGLRAGAMAFLLKEAPTEELVEAI
CCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHH
RAVHAGHKRIPQQVAAKLANRLSNPELTARELEVLHLVVKGQTNKEIAASLFIGEGTVRA
HHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHEECCCHHHH
HMNNILAKMGAHDRTQAATLAIRRGLVRLE
HHHHHHHHHCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]