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The map label for this gene is uvrC [H]

Identifier: 37521011

GI number: 37521011

Start: 1544264

End: 1545376

Strand: Reverse

Name: uvrC [H]

Synonym: gvip202

Alternate gene names: 37521011

Gene position: 1545376-1544264 (Counterclockwise)

Preceding gene: 37521012

Following gene: 37521009

Centisome position: 33.17

GC content: 65.86

Gene sequence:

>1113_bases
ATGCAACCGTGGTTTCGTGTTTCGCTCGACCGTCTGGAGGACTTGCCCGACGCGCCGGGGGTTTACCGGTTTGTCGACTG
CGACGGCCGTTTGCTCTATATCGGCAAGTCCGTGCACCTGCGCACGCGGGTGCGCTCCTACCTGCGCCGCGACGGCGGCC
ACTCCCGCCAGACCGAGCGGCTCAAGTTCGAGGCGCAGGCGGTGGAGGTGCTGTGCACCGGCTCGGAACTGGCCGCACTC
CTGCTGGAGGGCCGGCTGATCCGCGAGTATCTGCCGCCTTTTAACCAGGCCCAAAAGCGCTACCGCCAGTATCCGTTTTT
GCGTTTGTCGGTCCAGGAGGACTATCCGCGGCTGCATCTGACCCGGGTGCTTGCAGGCGACGGCGCCGAGTACTACGGCC
CCTACAGCCAGGCGCGCTTTGTGAGCTGGATGGCGGATTTGCTCTCGGCGAGCCTGGGTCTGCGCACCTGCCGCGACTTT
TCGGCCATCTATCACGGCTGTCTGCTCGACCAGCTCGGCAAATGCCTGGGACCGTGCCGCACCGGGGCGCTGGTAGCGCA
GTACCGCGAGCGCGTCGAGCGGCTGCGGGCGCTGTTGCGCGGCGAAGACACTGGCAGCGGGATTATCGTGGATTTCGAGC
GGCAGATGCTGAACGCCGCCCAGCGCGAGGATTTTGAGCAGGCGGCGCGCTGGCGGGATCGCCGGCAGGCGCTCGCAAAC
TTTGTGACCCACCAGGGCCACTTGCGCGAGCGGGTCAGCCTCGATGCGGTGGCGGTCTACCCGGGGGCGCCCCGCTCCCC
GACCAGCGTGCAGCTTTTTTGGATCCGCCAGGGCAAACTTACTTTGCAGCAGAGTTTCGCAGGCGATCTGCCGCAGGAGC
GGCTGCGCGCCGAACTGGCCCACACCCTTGCCGGCCACTACAGTGAAGGGTTGCCGCCAGCCCCGCTATTTGCCCTGCCC
CAACAGGATCTCGACGAAGTGCAGATGGTGAGCGGCTGGCTCTATCGTCACCGCACCGACGACACGCTTTTGTGGTTGGC
GGGAATCGAGCCCGAGCGGGCTGCGGAACTGCTGCTTACGTTGATCGACCAGGCACATCGACGGTCGTCGTAA

Upstream 100 bases:

>100_bases
TGGGCCTGATCTAAGCCAGGAAATCGGCCTTTTTGAGTGTTGCACGGGAGCCCGATTGGGGCTCCCGTGTTTTTTGGGCC
GCCTGTGCTACATCAAAAAC

Downstream 100 bases:

>100_bases
CCGCCGGGTCTGCCTGCAGCGAAGCAGGGGACCGCTCCGGCTCGTCGAGGCGGTACTGGTGCTGAGCCCAGACCACAGCA
CCGAGGTGGATGAGCGCGAT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MQPWFRVSLDRLEDLPDAPGVYRFVDCDGRLLYIGKSVHLRTRVRSYLRRDGGHSRQTERLKFEAQAVEVLCTGSELAAL
LLEGRLIREYLPPFNQAQKRYRQYPFLRLSVQEDYPRLHLTRVLAGDGAEYYGPYSQARFVSWMADLLSASLGLRTCRDF
SAIYHGCLLDQLGKCLGPCRTGALVAQYRERVERLRALLRGEDTGSGIIVDFERQMLNAAQREDFEQAARWRDRRQALAN
FVTHQGHLRERVSLDAVAVYPGAPRSPTSVQLFWIRQGKLTLQQSFAGDLPQERLRAELAHTLAGHYSEGLPPAPLFALP
QQDLDEVQMVSGWLYRHRTDDTLLWLAGIEPERAAELLLTLIDQAHRRSS

Sequences:

>Translated_370_residues
MQPWFRVSLDRLEDLPDAPGVYRFVDCDGRLLYIGKSVHLRTRVRSYLRRDGGHSRQTERLKFEAQAVEVLCTGSELAAL
LLEGRLIREYLPPFNQAQKRYRQYPFLRLSVQEDYPRLHLTRVLAGDGAEYYGPYSQARFVSWMADLLSASLGLRTCRDF
SAIYHGCLLDQLGKCLGPCRTGALVAQYRERVERLRALLRGEDTGSGIIVDFERQMLNAAQREDFEQAARWRDRRQALAN
FVTHQGHLRERVSLDAVAVYPGAPRSPTSVQLFWIRQGKLTLQQSFAGDLPQERLRAELAHTLAGHYSEGLPPAPLFALP
QQDLDEVQMVSGWLYRHRTDDTLLWLAGIEPERAAELLLTLIDQAHRRSS
>Mature_370_residues
MQPWFRVSLDRLEDLPDAPGVYRFVDCDGRLLYIGKSVHLRTRVRSYLRRDGGHSRQTERLKFEAQAVEVLCTGSELAAL
LLEGRLIREYLPPFNQAQKRYRQYPFLRLSVQEDYPRLHLTRVLAGDGAEYYGPYSQARFVSWMADLLSASLGLRTCRDF
SAIYHGCLLDQLGKCLGPCRTGALVAQYRERVERLRALLRGEDTGSGIIVDFERQMLNAAQREDFEQAARWRDRRQALAN
FVTHQGHLRERVSLDAVAVYPGAPRSPTSVQLFWIRQGKLTLQQSFAGDLPQERLRAELAHTLAGHYSEGLPPAPLFALP
QQDLDEVQMVSGWLYRHRTDDTLLWLAGIEPERAAELLLTLIDQAHRRSS

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=306, Percent_Identity=32.6797385620915, Blast_Score=144, Evalue=8e-36,
Organism=Escherichia coli, GI1788037, Length=197, Percent_Identity=32.994923857868, Blast_Score=75, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 42361; Mature: 42361

Theoretical pI: Translated: 8.55; Mature: 8.55

Prosite motif: PS50151 UVR ; PS50164 UVRC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPWFRVSLDRLEDLPDAPGVYRFVDCDGRLLYIGKSVHLRTRVRSYLRRDGGHSRQTER
CCCHHHHHHHHHHCCCCCCCCEEEEECCCEEEEEECCHHHHHHHHHHHHHCCCCCCHHHH
LKFEAQAVEVLCTGSELAALLLEGRLIREYLPPFNQAQKRYRQYPFLRLSVQEDYPRLHL
HHHHHHHHHHEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCEEEEEECCCCCHHHH
TRVLAGDGAEYYGPYSQARFVSWMADLLSASLGLRTCRDFSAIYHGCLLDQLGKCLGPCR
HHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
TGALVAQYRERVERLRALLRGEDTGSGIIVDFERQMLNAAQREDFEQAARWRDRRQALAN
HHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVTHQGHLRERVSLDAVAVYPGAPRSPTSVQLFWIRQGKLTLQQSFAGDLPQERLRAELA
HHHCCHHHHHHHCCCEEEECCCCCCCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHH
HTLAGHYSEGLPPAPLFALPQQDLDEVQMVSGWLYRHRTDDTLLWLAGIEPERAAELLLT
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHH
LIDQAHRRSS
HHHHHHHCCC
>Mature Secondary Structure
MQPWFRVSLDRLEDLPDAPGVYRFVDCDGRLLYIGKSVHLRTRVRSYLRRDGGHSRQTER
CCCHHHHHHHHHHCCCCCCCCEEEEECCCEEEEEECCHHHHHHHHHHHHHCCCCCCHHHH
LKFEAQAVEVLCTGSELAALLLEGRLIREYLPPFNQAQKRYRQYPFLRLSVQEDYPRLHL
HHHHHHHHHHEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCEEEEEECCCCCHHHH
TRVLAGDGAEYYGPYSQARFVSWMADLLSASLGLRTCRDFSAIYHGCLLDQLGKCLGPCR
HHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
TGALVAQYRERVERLRALLRGEDTGSGIIVDFERQMLNAAQREDFEQAARWRDRRQALAN
HHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVTHQGHLRERVSLDAVAVYPGAPRSPTSVQLFWIRQGKLTLQQSFAGDLPQERLRAELA
HHHCCHHHHHHHCCCEEEECCCCCCCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHH
HTLAGHYSEGLPPAPLFALPQQDLDEVQMVSGWLYRHRTDDTLLWLAGIEPERAAELLLT
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHH
LIDQAHRRSS
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA