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The map label for this gene is purN [H]

Identifier: 37520970

GI number: 37520970

Start: 1501893

End: 1502486

Strand: Direct

Name: purN [H]

Synonym: gvip199

Alternate gene names: 37520970

Gene position: 1501893-1502486 (Clockwise)

Preceding gene: 37520969

Following gene: 37520984

Centisome position: 32.24

GC content: 64.31

Gene sequence:

>594_bases
GTGCTCGCCGATGCGGCGCGCTCGGGCCGGTTGCCAGTCGAAATCGCCGTACTCGTCTACAACAACCCCGGCGCCTACGT
CGCCGATCGCGCCCGCGCCGCGGGCATCGCGGCAGTCCTACTCGACCACCGCAAATTCGTCAGCCGCGAAGTACTCGATG
AGGAGATTGTCGCCACCCTCGAAGCCCACGGCGTCGAACTGGTGGTGATGGCCGGTTGGATGCGCAAGGTGACGGAGGTG
CTGATCGGCCGCTTTGCAGATCGCATCCTCAACATCCATCCGAGTTTGCTGCCTGCCTTTCGGGGCGCCAAAGCGATCGA
GCAGGCCCTCGACTACGGCGTCAAAGTGGCGGGTTGCACAGTCCATATCGTGCGCCTCGAAGTCGACGCCGGTCCGATTA
TCCTGCAGGCGGCGGAGGCGGTGCGCGAGGACGACACCCCCGAAACCCTGGCTGTGCGCATCCACGCCCACGAATACCGG
ATCCTTCCCGAGGCGGTACGGCTTTTTGCCGAGGGCCGGGTGCGCGTCGAGGGCAACCGCGCCCGTATTGTTATCGATGA
AGTCGAACCGACCGGTTTTGAAGAGCAACTCTAG

Upstream 100 bases:

>100_bases
AGCGCCGCAAGCGCGAGGAACGGGCCGTTTCCCAGCCTGGTTGAGGCGAGGGTTGCTGCGCGTCGGCATTCTGGCCTCCG
GTAGCGGCACCAACTTTCAG

Downstream 100 bases:

>100_bases
CGAAGGGCGAAAGAGATGTACGCCATTAAATCTAATTGAATAGTCAGGCCGGCAAAAGGCGTTATCTCTGACCTGTCAGA
CGGCAGTAATTCAGTTAGTA

Product: phosphoribosylglycinamide formyltransferase

Products: NA

Alternate protein names: 5'-phosphoribosylglycinamide transformylase; GAR transformylase; GART [H]

Number of amino acids: Translated: 197; Mature: 197

Protein sequence:

>197_residues
MLADAARSGRLPVEIAVLVYNNPGAYVADRARAAGIAAVLLDHRKFVSREVLDEEIVATLEAHGVELVVMAGWMRKVTEV
LIGRFADRILNIHPSLLPAFRGAKAIEQALDYGVKVAGCTVHIVRLEVDAGPIILQAAEAVREDDTPETLAVRIHAHEYR
ILPEAVRLFAEGRVRVEGNRARIVIDEVEPTGFEEQL

Sequences:

>Translated_197_residues
MLADAARSGRLPVEIAVLVYNNPGAYVADRARAAGIAAVLLDHRKFVSREVLDEEIVATLEAHGVELVVMAGWMRKVTEV
LIGRFADRILNIHPSLLPAFRGAKAIEQALDYGVKVAGCTVHIVRLEVDAGPIILQAAEAVREDDTPETLAVRIHAHEYR
ILPEAVRLFAEGRVRVEGNRARIVIDEVEPTGFEEQL
>Mature_197_residues
MLADAARSGRLPVEIAVLVYNNPGAYVADRARAAGIAAVLLDHRKFVSREVLDEEIVATLEAHGVELVVMAGWMRKVTEV
LIGRFADRILNIHPSLLPAFRGAKAIEQALDYGVKVAGCTVHIVRLEVDAGPIILQAAEAVREDDTPETLAVRIHAHEYR
ILPEAVRLFAEGRVRVEGNRARIVIDEVEPTGFEEQL

Specific function: De novo purine biosynthesis; third step. [C]

COG id: COG0299

COG function: function code F; Folate-dependent phosphoribosylglycinamide formyltransferase PurN

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GART family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=178, Percent_Identity=39.3258426966292, Blast_Score=133, Evalue=1e-31,
Organism=Homo sapiens, GI209869995, Length=178, Percent_Identity=39.3258426966292, Blast_Score=133, Evalue=1e-31,
Organism=Homo sapiens, GI209869993, Length=178, Percent_Identity=39.3258426966292, Blast_Score=133, Evalue=1e-31,
Organism=Escherichia coli, GI1788846, Length=190, Percent_Identity=34.7368421052632, Blast_Score=127, Evalue=4e-31,
Organism=Escherichia coli, GI1787483, Length=183, Percent_Identity=34.4262295081967, Blast_Score=87, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17567511, Length=153, Percent_Identity=39.2156862745098, Blast_Score=113, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24582400, Length=159, Percent_Identity=38.9937106918239, Blast_Score=122, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002376
- InterPro:   IPR001555
- InterPro:   IPR004607 [H]

Pfam domain/function: PF00551 Formyl_trans_N [H]

EC number: =2.1.2.2 [H]

Molecular weight: Translated: 21627; Mature: 21627

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLADAARSGRLPVEIAVLVYNNPGAYVADRARAAGIAAVLLDHRKFVSREVLDEEIVATL
CCCCCCCCCCCCEEEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAHGVELVVMAGWMRKVTEVLIGRFADRILNIHPSLLPAFRGAKAIEQALDYGVKVAGCT
HHCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHCCEEEECEE
VHIVRLEVDAGPIILQAAEAVREDDTPETLAVRIHAHEYRILPEAVRLFAEGRVRVEGNR
EEEEEEEECCCCCEEHHHHHHCCCCCCCEEEEEEEHHHEEHHHHHHHHHHCCEEEEECCE
ARIVIDEVEPTGFEEQL
EEEEEECCCCCCCCCCC
>Mature Secondary Structure
MLADAARSGRLPVEIAVLVYNNPGAYVADRARAAGIAAVLLDHRKFVSREVLDEEIVATL
CCCCCCCCCCCCEEEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAHGVELVVMAGWMRKVTEVLIGRFADRILNIHPSLLPAFRGAKAIEQALDYGVKVAGCT
HHCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHCCEEEECEE
VHIVRLEVDAGPIILQAAEAVREDDTPETLAVRIHAHEYRILPEAVRLFAEGRVRVEGNR
EEEEEEEECCCCCEEHHHHHHCCCCCCCEEEEEEEHHHEEHHHHHHHHHHCCEEEEECCE
ARIVIDEVEPTGFEEQL
EEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]