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The map label for this gene is adk

Identifier: 37520961

GI number: 37520961

Start: 1494864

End: 1495526

Strand: Reverse

Name: adk

Synonym: gll1392

Alternate gene names: 37520961

Gene position: 1495526-1494864 (Counterclockwise)

Preceding gene: 37520962

Following gene: 37520960

Centisome position: 32.1

GC content: 65.16

Gene sequence:

>663_bases
GTGGCCACTCGACGGCTGATGTTGCTCGGCGCTCCGGGAGCGGGCAAGGGTACCCAGGCCCAACTGCTCATGCAGGAGCT
GGGACTGCCACAGGTTTCAACGGGCGATATTCTGCGCGCTGCGGTCAAAGAAGGCACCCCCCTGGGACTCGAAGCCCAGA
GCTATATGAACCGCGGCGCGCTGGTGCCTGACGCGGTGGTCGTCGGCTTGATCGAAGACCGCCTGGCCCGGCCGGACGCC
GGCGGCGGCTGGATCCTCGACGGCTTTCCCCGCACCCCCGCCCAGGCGGAAGCGCTCGACGGACTGCTTGCCCACCTGGC
TCAGTCCCTGGAGGCGGTCGTGCTCATCGACGTACCCGAGGCGCAACTCATCGAGCGGCTCACCGGACGGCGCACTTGCC
CGCTGTGCAAGCGCATCTTTCACGTGCGCTTCAATCCGCCGCCCGCGGCGCCGCCTTTTTGTACCGACCATACCGACTGC
CCGAGCGAACTGGTGCAGCGCCCCGACGACACCCTTGAGGTGGTCAGCAAACGGCTGAACGTCTATCGCGAATCGACCGA
GCCGCTGATTCGGTACTACCAGGAGCAGCAGAAACTGACGAGTGTCGATGGGGATCGGTCGCCGGAAGTGGTATACAGCG
AACTGCGGGAATTATTGGGTTAA

Upstream 100 bases:

>100_bases
CCACCTCGCTGTTGATTCTGGTGGGCGTCGCCATCGACACCGTGCGCCAGATCCAGACCTACGTGATCTCCCAGCGCTAC
GAAGGCATGGTGAAACGCTA

Downstream 100 bases:

>100_bases
TCGCTGACGTACCCGCCCTTTCGGGGTCTATGCTAGTATCTACCCAGTACCGCGCGGACACGCGGAAACCAAAGTCTGGC
AACGATTAGAGCATGTTTTC

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 220; Mature: 219

Protein sequence:

>220_residues
MATRRLMLLGAPGAGKGTQAQLLMQELGLPQVSTGDILRAAVKEGTPLGLEAQSYMNRGALVPDAVVVGLIEDRLARPDA
GGGWILDGFPRTPAQAEALDGLLAHLAQSLEAVVLIDVPEAQLIERLTGRRTCPLCKRIFHVRFNPPPAAPPFCTDHTDC
PSELVQRPDDTLEVVSKRLNVYRESTEPLIRYYQEQQKLTSVDGDRSPEVVYSELRELLG

Sequences:

>Translated_220_residues
MATRRLMLLGAPGAGKGTQAQLLMQELGLPQVSTGDILRAAVKEGTPLGLEAQSYMNRGALVPDAVVVGLIEDRLARPDA
GGGWILDGFPRTPAQAEALDGLLAHLAQSLEAVVLIDVPEAQLIERLTGRRTCPLCKRIFHVRFNPPPAAPPFCTDHTDC
PSELVQRPDDTLEVVSKRLNVYRESTEPLIRYYQEQQKLTSVDGDRSPEVVYSELRELLG
>Mature_219_residues
ATRRLMLLGAPGAGKGTQAQLLMQELGLPQVSTGDILRAAVKEGTPLGLEAQSYMNRGALVPDAVVVGLIEDRLARPDAG
GGWILDGFPRTPAQAEALDGLLAHLAQSLEAVVLIDVPEAQLIERLTGRRTCPLCKRIFHVRFNPPPAAPPFCTDHTDCP
SELVQRPDDTLEVVSKRLNVYRESTEPLIRYYQEQQKLTSVDGDRSPEVVYSELRELLG

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=211, Percent_Identity=41.2322274881517, Blast_Score=160, Evalue=8e-40,
Organism=Homo sapiens, GI4502013, Length=211, Percent_Identity=41.2322274881517, Blast_Score=160, Evalue=8e-40,
Organism=Homo sapiens, GI19923437, Length=215, Percent_Identity=36.2790697674419, Blast_Score=133, Evalue=9e-32,
Organism=Homo sapiens, GI310110345, Length=212, Percent_Identity=35.8490566037736, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI53832003, Length=212, Percent_Identity=35.8490566037736, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI8051579, Length=212, Percent_Identity=35.8490566037736, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI53832001, Length=212, Percent_Identity=35.8490566037736, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI22749187, Length=211, Percent_Identity=30.8056872037915, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4502011, Length=214, Percent_Identity=28.5046728971963, Blast_Score=95, Evalue=6e-20,
Organism=Escherichia coli, GI1786680, Length=221, Percent_Identity=43.4389140271493, Blast_Score=176, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI17552384, Length=202, Percent_Identity=40.0990099009901, Blast_Score=144, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17537943, Length=212, Percent_Identity=33.9622641509434, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17567503, Length=210, Percent_Identity=28.5714285714286, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320432, Length=219, Percent_Identity=39.7260273972603, Blast_Score=158, Evalue=8e-40,
Organism=Saccharomyces cerevisiae, GI6321018, Length=204, Percent_Identity=42.6470588235294, Blast_Score=150, Evalue=2e-37,
Organism=Drosophila melanogaster, GI22026816, Length=213, Percent_Identity=39.4366197183099, Blast_Score=153, Evalue=8e-38,
Organism=Drosophila melanogaster, GI17737899, Length=208, Percent_Identity=37.9807692307692, Blast_Score=133, Evalue=8e-32,
Organism=Drosophila melanogaster, GI24645822, Length=208, Percent_Identity=37.9807692307692, Blast_Score=133, Evalue=8e-32,
Organism=Drosophila melanogaster, GI24663208, Length=211, Percent_Identity=22.7488151658768, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI17647141, Length=211, Percent_Identity=22.7488151658768, Blast_Score=77, Evalue=8e-15,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_GLOVI (Q7NKT5)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_924338.1
- ProteinModelPortal:   Q7NKT5
- SMR:   Q7NKT5
- GeneID:   2598760
- GenomeReviews:   BA000045_GR
- KEGG:   gvi:gll1392
- NMPDR:   fig|251221.1.peg.1392
- HOGENOM:   HBG630208
- OMA:   EINQPLE
- BioCyc:   GVIO251221:GLL1392-MONOMER
- BRENDA:   2.7.4.3
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 24031; Mature: 23900

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATRRLMLLGAPGAGKGTQAQLLMQELGLPQVSTGDILRAAVKEGTPLGLEAQSYMNRGA
CCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHCCC
LVPDAVVVGLIEDRLARPDAGGGWILDGFPRTPAQAEALDGLLAHLAQSLEAVVLIDVPE
CCHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHCCEEEEEECCH
AQLIERLTGRRTCPLCKRIFHVRFNPPPAAPPFCTDHTDCPSELVQRPDDTLEVVSKRLN
HHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHH
VYRESTEPLIRYYQEQQKLTSVDGDRSPEVVYSELRELLG
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
>Mature Secondary Structure 
ATRRLMLLGAPGAGKGTQAQLLMQELGLPQVSTGDILRAAVKEGTPLGLEAQSYMNRGA
CCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHCCC
LVPDAVVVGLIEDRLARPDAGGGWILDGFPRTPAQAEALDGLLAHLAQSLEAVVLIDVPE
CCHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHCCEEEEEECCH
AQLIERLTGRRTCPLCKRIFHVRFNPPPAAPPFCTDHTDCPSELVQRPDDTLEVVSKRLN
HHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHH
VYRESTEPLIRYYQEQQKLTSVDGDRSPEVVYSELRELLG
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292