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The map label for this gene is gcp

Identifier: 37520923

GI number: 37520923

Start: 1447768

End: 1448796

Strand: Reverse

Name: gcp

Synonym: gll1354

Alternate gene names: 37520923

Gene position: 1448796-1447768 (Counterclockwise)

Preceding gene: 37520924

Following gene: 37520922

Centisome position: 31.1

GC content: 67.35

Gene sequence:

>1029_bases
GTGACAACCATCTTTGCCATCGAGACCAGTTGTGACGAAAGCGCCGCCGCCATCGTGCGCGGTCGGACCGTCGTCGCGTC
GATCATCGCTTCGCAAATCGACGTGCACCGCCTGACCGGCGGTGTTGTGCCGGAGGTCGCCTCGCGCGAGCACCTGCAGG
CGTTGGGCGGGGTGATCGCGGCGTGTTTTGCCGAGGGCGGCCTGGGGTGGGCCGACATCGACGCTGTCGCCTTTACCTGT
GCTCCCGGCCTGGTCGGCTCGTTGCTGATGGGATCGATGGCAGCCAAGACCCTGGCTCTCGTTCACGCCAGGCCGCTGGT
CGGCATCCACCACCTCGAAGGTCACATCTACTCGGCTTTTTTGAGCGACCCGGCCCTGGAGCCGCCCTTTTTGTGTCTGC
TCGTCTCGGGGGGACACACCAGCTTGGTGGCTGTCGAGGATCATGGCCGCTACCGCATCCTGGGGCGCACCCGCGACGAC
GCCGTGGGCGAAGCCTACGACAAGGTGGCGCGGGTACTGGGACTTGGTTACCCGGGCGGTCCTGCGATCGACAAATTGGC
GCAGCGGGGAGACCCGCGCGCCTTTGCGCTGCCGGGGGGGCGGGTCGAATCGCCCTTCGACACCAGCTTCAGCGGCCTGA
AGACCGCCGTGCTGCGCCTGGCCGAAAAACACCGGCTCCAGCGTCTGCCCATCGACCGGGCGGATCTGGCCGCGAGCTTC
CAGCGCACCGTGGTAGAGACCCTGGCCGAGCGGGTGGAGTTGGCCCTGGCCCACACCGGCTATGACACGGTGGTGGTGGC
GGGGGGCGTCTCCGCCAACCGCGGCTTGCGCGAACGCCTCGGGCAAGCCGGACCCTACCGGGCCGTTTTCCCGCCGATGC
ACTTTTGTACCGACAACGCGGCGATGATCGCCTGCGCCGGGGTGGCCCGCTTCGAGAGGGGGTTCCGTTCATCTCTCGAT
CTGCCGGTGCAATCGCGCTTGTCGCTCGAAGCGTGTGACAGCCTTTACCAGTGCCTGCCGGTCCCTTGA

Upstream 100 bases:

>100_bases
TCAATGTCGAAGCCCAGCACCGCGATTGCTTGGATTACGATCGAGCGAGGGGACACCTTGACTATCAAACCCGGATGCTG
CGCGCCCTCGAATCGCTGCT

Downstream 100 bases:

>100_bases
GCGCTGGTCACAATGTGGGACAATTGAGCCTACGGATACGACCCCTGGAGTGGACGGGTGTTCGCACTGGCAGAAATACT
GGACAAACCCTGGGCGCGGG

Product: putative DNA-binding/iron metalloprotein/AP endonuclease

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MTTIFAIETSCDESAAAIVRGRTVVASIIASQIDVHRLTGGVVPEVASREHLQALGGVIAACFAEGGLGWADIDAVAFTC
APGLVGSLLMGSMAAKTLALVHARPLVGIHHLEGHIYSAFLSDPALEPPFLCLLVSGGHTSLVAVEDHGRYRILGRTRDD
AVGEAYDKVARVLGLGYPGGPAIDKLAQRGDPRAFALPGGRVESPFDTSFSGLKTAVLRLAEKHRLQRLPIDRADLAASF
QRTVVETLAERVELALAHTGYDTVVVAGGVSANRGLRERLGQAGPYRAVFPPMHFCTDNAAMIACAGVARFERGFRSSLD
LPVQSRLSLEACDSLYQCLPVP

Sequences:

>Translated_342_residues
MTTIFAIETSCDESAAAIVRGRTVVASIIASQIDVHRLTGGVVPEVASREHLQALGGVIAACFAEGGLGWADIDAVAFTC
APGLVGSLLMGSMAAKTLALVHARPLVGIHHLEGHIYSAFLSDPALEPPFLCLLVSGGHTSLVAVEDHGRYRILGRTRDD
AVGEAYDKVARVLGLGYPGGPAIDKLAQRGDPRAFALPGGRVESPFDTSFSGLKTAVLRLAEKHRLQRLPIDRADLAASF
QRTVVETLAERVELALAHTGYDTVVVAGGVSANRGLRERLGQAGPYRAVFPPMHFCTDNAAMIACAGVARFERGFRSSLD
LPVQSRLSLEACDSLYQCLPVP
>Mature_341_residues
TTIFAIETSCDESAAAIVRGRTVVASIIASQIDVHRLTGGVVPEVASREHLQALGGVIAACFAEGGLGWADIDAVAFTCA
PGLVGSLLMGSMAAKTLALVHARPLVGIHHLEGHIYSAFLSDPALEPPFLCLLVSGGHTSLVAVEDHGRYRILGRTRDDA
VGEAYDKVARVLGLGYPGGPAIDKLAQRGDPRAFALPGGRVESPFDTSFSGLKTAVLRLAEKHRLQRLPIDRADLAASFQ
RTVVETLAERVELALAHTGYDTVVVAGGVSANRGLRERLGQAGPYRAVFPPMHFCTDNAAMIACAGVARFERGFRSSLDL
PVQSRLSLEACDSLYQCLPVP

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI116812636, Length=338, Percent_Identity=33.4319526627219, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI8923380, Length=324, Percent_Identity=33.641975308642, Blast_Score=139, Evalue=3e-33,
Organism=Escherichia coli, GI1789445, Length=331, Percent_Identity=43.8066465256798, Blast_Score=255, Evalue=3e-69,
Organism=Caenorhabditis elegans, GI17557464, Length=347, Percent_Identity=32.5648414985591, Blast_Score=147, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI71995670, Length=329, Percent_Identity=31.306990881459, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6320099, Length=350, Percent_Identity=29.7142857142857, Blast_Score=120, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6322891, Length=302, Percent_Identity=31.7880794701987, Blast_Score=116, Evalue=6e-27,
Organism=Drosophila melanogaster, GI20129063, Length=342, Percent_Identity=33.9181286549708, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI21357207, Length=331, Percent_Identity=32.9305135951662, Blast_Score=148, Evalue=6e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_GLOVI (Q7NKX2)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_924300.1
- ProteinModelPortal:   Q7NKX2
- SMR:   Q7NKX2
- MEROPS:   M22.001
- GeneID:   2598816
- GenomeReviews:   BA000045_GR
- KEGG:   gvi:gll1354
- NMPDR:   fig|251221.1.peg.1354
- HOGENOM:   HBG304663
- OMA:   PAVGVHH
- ProtClustDB:   PRK09604
- BioCyc:   GVIO251221:GLL1354-MONOMER
- BRENDA:   3.4.24.57
- GO:   GO:0006508
- HAMAP:   MF_01445
- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03723
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 36173; Mature: 36042

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTIFAIETSCDESAAAIVRGRTVVASIIASQIDVHRLTGGVVPEVASREHLQALGGVIA
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
ACFAEGGLGWADIDAVAFTCAPGLVGSLLMGSMAAKTLALVHARPLVGIHHLEGHIYSAF
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LSDPALEPPFLCLLVSGGHTSLVAVEDHGRYRILGRTRDDAVGEAYDKVARVLGLGYPGG
HCCCCCCCCEEEEEEECCCEEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCC
PAIDKLAQRGDPRAFALPGGRVESPFDTSFSGLKTAVLRLAEKHRLQRLPIDRADLAASF
HHHHHHHHCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
QRTVVETLAERVELALAHTGYDTVVVAGGVSANRGLRERLGQAGPYRAVFPPMHFCTDNA
HHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHCCCCCCCCCCCCHHHHCCCC
AMIACAGVARFERGFRSSLDLPVQSRLSLEACDSLYQCLPVP
HHHHHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
TTIFAIETSCDESAAAIVRGRTVVASIIASQIDVHRLTGGVVPEVASREHLQALGGVIA
CEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
ACFAEGGLGWADIDAVAFTCAPGLVGSLLMGSMAAKTLALVHARPLVGIHHLEGHIYSAF
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LSDPALEPPFLCLLVSGGHTSLVAVEDHGRYRILGRTRDDAVGEAYDKVARVLGLGYPGG
HCCCCCCCCEEEEEEECCCEEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCC
PAIDKLAQRGDPRAFALPGGRVESPFDTSFSGLKTAVLRLAEKHRLQRLPIDRADLAASF
HHHHHHHHCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
QRTVVETLAERVELALAHTGYDTVVVAGGVSANRGLRERLGQAGPYRAVFPPMHFCTDNA
HHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHCCCCCCCCCCCCHHHHCCCC
AMIACAGVARFERGFRSSLDLPVQSRLSLEACDSLYQCLPVP
HHHHHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292