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The map label for this gene is purQ

Identifier: 37520894

GI number: 37520894

Start: 1417629

End: 1418327

Strand: Direct

Name: purQ

Synonym: gvip195

Alternate gene names: 37520894

Gene position: 1417629-1418327 (Clockwise)

Preceding gene: 37520891

Following gene: 37520898

Centisome position: 30.43

GC content: 66.95

Gene sequence:

>699_bases
ATGAAATTCGCCGTCATCGTCTTTCCCGGTTCCAACTGCGACCGCGACGTGGTCACTGTCACCCGCGGCCTGCTGGACCA
GCCGACCCGCCTGGTCTGGCACACCGAGGACGACCTGGACGGCTGCGATGTGGCCGTGATCCCCGGCGGCTTCAGCTACG
GCGACTACCTGCGCTGCGGCGCCATCGCCCGCTTCTCGCCCGTCATGCAGGCTGTGCGCCGCCACGCCGAGCGCGGCGGT
CTGGTGATCGGCATCTGCAACGGTTTTCAGGTGCTCACCGAGGCGGGATTGCTTCCGGGTGCCCTGGTGCGCAACCGCGA
TCTGCAGTTCGTCTGCGATCGGGTGGCTCTCAAAGTCGAGCGCACCGATCTGCCATGGGTGCACTCCTACCGGCCGGGCG
AGGTGATTACCCTGCCCATCGCCCACGGCGAGGGCTGCTACTACGCCGAGGAAGCGACCCTGGCCGAGCTGGAAGAAAAC
CGCCAAGTCGTCTTTCGTTACTGCCGTCCGGATGGCACCATCGACGCCGTCGGCAACCCGAACGGTTCGCTCCACAACAT
CGCCGGCCTCTGCAACCGGCACGGCAACGTGCTGGGCATGATGCCCCACCCCGAGCGGGCGAGCGACCCGATCCTCGGGG
GCAGCGACGGGCGAAGGCTTTTCGAGAGCCTGGTGGCAAGCGCCCTGGCTGTCGTTTGA

Upstream 100 bases:

>100_bases
ATCATCAAGGCCAGATACCGGCAGGTCCCGGTTGCCGCGCCTGCTCCAGCCCTCGAGGGTCCGGATCTGGCACAATGGTC
GCGTAGCCCTGGGGCCTGCC

Downstream 100 bases:

>100_bases
GCGGTGCCAGGCGTCAGGGGCTTACTGACGCCTGATCTATGGCACCTGCACTTCGAGGGTTTCCCCTTCGGGAATCGCCG
CTTCAAAACGGCCGTCGCGG

Product: phosphoribosylformyl glycinamidine synthetase

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase I; FGAM synthase I

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MKFAVIVFPGSNCDRDVVTVTRGLLDQPTRLVWHTEDDLDGCDVAVIPGGFSYGDYLRCGAIARFSPVMQAVRRHAERGG
LVIGICNGFQVLTEAGLLPGALVRNRDLQFVCDRVALKVERTDLPWVHSYRPGEVITLPIAHGEGCYYAEEATLAELEEN
RQVVFRYCRPDGTIDAVGNPNGSLHNIAGLCNRHGNVLGMMPHPERASDPILGGSDGRRLFESLVASALAVV

Sequences:

>Translated_232_residues
MKFAVIVFPGSNCDRDVVTVTRGLLDQPTRLVWHTEDDLDGCDVAVIPGGFSYGDYLRCGAIARFSPVMQAVRRHAERGG
LVIGICNGFQVLTEAGLLPGALVRNRDLQFVCDRVALKVERTDLPWVHSYRPGEVITLPIAHGEGCYYAEEATLAELEEN
RQVVFRYCRPDGTIDAVGNPNGSLHNIAGLCNRHGNVLGMMPHPERASDPILGGSDGRRLFESLVASALAVV
>Mature_232_residues
MKFAVIVFPGSNCDRDVVTVTRGLLDQPTRLVWHTEDDLDGCDVAVIPGGFSYGDYLRCGAIARFSPVMQAVRRHAERGG
LVIGICNGFQVLTEAGLLPGALVRNRDLQFVCDRVALKVERTDLPWVHSYRPGEVITLPIAHGEGCYYAEEATLAELEEN
RQVVFRYCRPDGTIDAVGNPNGSLHNIAGLCNRHGNVLGMMPHPERASDPILGGSDGRRLFESLVASALAVV

Specific function: Unknown

COG id: COG0047

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Escherichia coli, GI48994899, Length=173, Percent_Identity=32.9479768786127, Blast_Score=64, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24582111, Length=192, Percent_Identity=31.7708333333333, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24582109, Length=192, Percent_Identity=31.7708333333333, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI17137292, Length=192, Percent_Identity=31.7708333333333, Blast_Score=77, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURQ_GLOVI (Q7NL01)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_924271.1
- ProteinModelPortal:   Q7NL01
- SMR:   Q7NL01
- GeneID:   2598787
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.1325
- HOGENOM:   HBG302712
- OMA:   FPGTNCD
- BioCyc:   GVIO251221:GLR1325-MONOMER
- BRENDA:   6.3.5.3
- GO:   GO:0005737
- HAMAP:   MF_00421
- InterPro:   IPR017926
- InterPro:   IPR011698
- InterPro:   IPR010075
- PIRSF:   PIRSF001586
- TIGRFAMs:   TIGR01737

Pfam domain/function: PF07685 GATase_3

EC number: =6.3.5.3

Molecular weight: Translated: 25255; Mature: 25255

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS51273 GATASE_TYPE_1

Important sites: ACT_SITE 86-86 ACT_SITE 203-203 ACT_SITE 205-205

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFAVIVFPGSNCDRDVVTVTRGLLDQPTRLVWHTEDDLDGCDVAVIPGGFSYGDYLRCG
CEEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEECCCCCCCCHHHHC
AIARFSPVMQAVRRHAERGGLVIGICNGFQVLTEAGLLPGALVRNRDLQFVCDRVALKVE
HHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHCCCCCCHHHCCCCHHHHHHHHHEEEE
RTDLPWVHSYRPGEVITLPIAHGEGCYYAEEATLAELEENRQVVFRYCRPDGTIDAVGNP
CCCCCEEECCCCCCEEEEEEECCCCCEEECCHHHHHHHCCCEEEEEEECCCCCEEECCCC
NGSLHNIAGLCNRHGNVLGMMPHPERASDPILGGSDGRRLFESLVASALAVV
CCCHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKFAVIVFPGSNCDRDVVTVTRGLLDQPTRLVWHTEDDLDGCDVAVIPGGFSYGDYLRCG
CEEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEECCCCCCCCHHHHC
AIARFSPVMQAVRRHAERGGLVIGICNGFQVLTEAGLLPGALVRNRDLQFVCDRVALKVE
HHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHCCCCCCHHHCCCCHHHHHHHHHEEEE
RTDLPWVHSYRPGEVITLPIAHGEGCYYAEEATLAELEENRQVVFRYCRPDGTIDAVGNP
CCCCCEEECCCCCCEEEEEEECCCCCEEECCHHHHHHHCCCEEEEEEECCCCCEEECCCC
NGSLHNIAGLCNRHGNVLGMMPHPERASDPILGGSDGRRLFESLVASALAVV
CCCHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292