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The map label for this gene is thrB

Identifier: 37520696

GI number: 37520696

Start: 1207911

End: 1208810

Strand: Reverse

Name: thrB

Synonym: gvip149

Alternate gene names: 37520696

Gene position: 1208810-1207911 (Counterclockwise)

Preceding gene: 37520697

Following gene: 37520695

Centisome position: 25.95

GC content: 67.89

Gene sequence:

>900_bases
GTGTGCGTGCGGGTGCCGGCCACCTCCGCCAACCTTGGGCCGGGCTTCGACTGCCTGGGGGTGGCCCTAGATCTGGCCAA
CGAATTTGAATTTTGCGAAGCTGATCGCTTTAGGTGCGTCGTCCACAGCACCGTCTCGCCCGAAGACGCCCGGCAGGTGG
CCACCGACGAGCGCAACCTTGCCTGGCGGGCATTTACCCATCTGTTCGAGCACCTGGGCAAAACCCCGCCCACGGTGGCG
CTCACCGTGATGATGCACGTACCTCTCGGGCGCGGTCTCGGCAGCTCGGCCACGGCGATCGTGGGCGGCATCGCCGCCGC
CAACCGCTGGCTGGGTTCGCCCCTTTCCACCCCCGAATGGCTGCTGCTGGCGAGCCGCCTGGAAGGGCATCCCGACAACG
TCGTACCCGCCGCTTTGGGTGGCTGTCAGTTGTCAATTTTGGGCGAAACGCTGCTCACCTGCGCCCTCGATTGGCACCCG
CAGATCGCCCTGGTGCTCGCGGTGCCGGATTTTGCCCTGGCCACCAGCAAAGCCCGCGCCGCCCTACCCAAAACCGTTCC
CCACACCGACGCCGTCTTCAACGCCGTCCACCTGGCTCTGCTGGTGCGCGCCCTAGCCACGGGCGACGCCCGTTGGCTTG
CCGAAGCGCTTCAAGACCGGCTGCACCAGCCCTACCGCACCGGGCTGATTCCCGGCTGGCAGGACGTGCGCGCCGCCGCT
CTGGAAGCGGGCGCCTGGGGCGTGGTCATCAGCGGGGCCGGACCCAGCGTTCTTGCTCTCACCCATCTCGATTGCGCTGA
GGCCGTCCGGCAGGCCATGGCCTCTACGTGGCCAAACGCCTGCCTCTACTGCCCCGGGCTGGACCCGAACGGCTGTCGGG
TCGAAGTCGAAGCAGGCTGA

Upstream 100 bases:

>100_bases
GAACCGCCGCCTGCCGGTCACGGTGCAGGCGGGCAAACCCGCCCGGGTCGGCTACAACACCAACACGGCGCTTGAGAAGG
CGGGCGGCTAATTGAAGCGC

Downstream 100 bases:

>100_bases
GCTGCCAGTTATGATCGGTCCAACCGACGAGCGTGCGAAAAGGCACCCGTGCGATGCAGACACCGACTTTTGTGCAGGAT
GCCTGGATGCGGGCCAGTTG

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MCVRVPATSANLGPGFDCLGVALDLANEFEFCEADRFRCVVHSTVSPEDARQVATDERNLAWRAFTHLFEHLGKTPPTVA
LTVMMHVPLGRGLGSSATAIVGGIAAANRWLGSPLSTPEWLLLASRLEGHPDNVVPAALGGCQLSILGETLLTCALDWHP
QIALVLAVPDFALATSKARAALPKTVPHTDAVFNAVHLALLVRALATGDARWLAEALQDRLHQPYRTGLIPGWQDVRAAA
LEAGAWGVVISGAGPSVLALTHLDCAEAVRQAMASTWPNACLYCPGLDPNGCRVEVEAG

Sequences:

>Translated_299_residues
MCVRVPATSANLGPGFDCLGVALDLANEFEFCEADRFRCVVHSTVSPEDARQVATDERNLAWRAFTHLFEHLGKTPPTVA
LTVMMHVPLGRGLGSSATAIVGGIAAANRWLGSPLSTPEWLLLASRLEGHPDNVVPAALGGCQLSILGETLLTCALDWHP
QIALVLAVPDFALATSKARAALPKTVPHTDAVFNAVHLALLVRALATGDARWLAEALQDRLHQPYRTGLIPGWQDVRAAA
LEAGAWGVVISGAGPSVLALTHLDCAEAVRQAMASTWPNACLYCPGLDPNGCRVEVEAG
>Mature_299_residues
MCVRVPATSANLGPGFDCLGVALDLANEFEFCEADRFRCVVHSTVSPEDARQVATDERNLAWRAFTHLFEHLGKTPPTVA
LTVMMHVPLGRGLGSSATAIVGGIAAANRWLGSPLSTPEWLLLASRLEGHPDNVVPAALGGCQLSILGETLLTCALDWHP
QIALVLAVPDFALATSKARAALPKTVPHTDAVFNAVHLALLVRALATGDARWLAEALQDRLHQPYRTGLIPGWQDVRAAA
LEAGAWGVVISGAGPSVLALTHLDCAEAVRQAMASTWPNACLYCPGLDPNGCRVEVEAG

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily

Homologues:

Organism=Escherichia coli, GI1786184, Length=278, Percent_Identity=32.7338129496403, Blast_Score=132, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6321814, Length=335, Percent_Identity=31.044776119403, Blast_Score=134, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KHSE_GLOVI (Q7NLJ6)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_924073.1
- ProteinModelPortal:   Q7NLJ6
- GeneID:   2598994
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.1127
- HOGENOM:   HBG646290
- OMA:   FDCLGAA
- ProtClustDB:   PRK01212
- BioCyc:   GVIO251221:GLL1127-MONOMER
- BRENDA:   2.7.1.39
- GO:   GO:0005737
- HAMAP:   MF_00384
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PIRSF:   PIRSF000676
- PRINTS:   PR00958
- TIGRFAMs:   TIGR00191

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.39

Molecular weight: Translated: 31595; Mature: 31595

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCVRVPATSANLGPGFDCLGVALDLANEFEFCEADRFRCVVHSTVSPEDARQVATDERNL
CEEECCCCCCCCCCCHHHHHHHHHHHCCCCHHCCCCEEEEEECCCCHHHHHHHHCCCCCH
AWRAFTHLFEHLGKTPPTVALTVMMHVPLGRGLGSSATAIVGGIAAANRWLGSPLSTPEW
HHHHHHHHHHHHCCCCCHHEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHH
LLLASRLEGHPDNVVPAALGGCQLSILGETLLTCALDWHPQIALVLAVPDFALATSKARA
HHHHHHHCCCCCCCCHHHHCCCEEEHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHH
ALPKTVPHTDAVFNAVHLALLVRALATGDARWLAEALQDRLHQPYRTGLIPGWQDVRAAA
HCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHH
LEAGAWGVVISGAGPSVLALTHLDCAEAVRQAMASTWPNACLYCPGLDPNGCRVEVEAG
HCCCCCEEEEECCCCCEEEEEHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCEEEEECC
>Mature Secondary Structure
MCVRVPATSANLGPGFDCLGVALDLANEFEFCEADRFRCVVHSTVSPEDARQVATDERNL
CEEECCCCCCCCCCCHHHHHHHHHHHCCCCHHCCCCEEEEEECCCCHHHHHHHHCCCCCH
AWRAFTHLFEHLGKTPPTVALTVMMHVPLGRGLGSSATAIVGGIAAANRWLGSPLSTPEW
HHHHHHHHHHHHCCCCCHHEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHH
LLLASRLEGHPDNVVPAALGGCQLSILGETLLTCALDWHPQIALVLAVPDFALATSKARA
HHHHHHHCCCCCCCCHHHHCCCEEEHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHH
ALPKTVPHTDAVFNAVHLALLVRALATGDARWLAEALQDRLHQPYRTGLIPGWQDVRAAA
HCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHH
LEAGAWGVVISGAGPSVLALTHLDCAEAVRQAMASTWPNACLYCPGLDPNGCRVEVEAG
HCCCCCEEEEECCCCCEEEEEHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292