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The map label for this gene is gnd [H]

Identifier: 37520686

GI number: 37520686

Start: 1195311

End: 1196762

Strand: Reverse

Name: gnd [H]

Synonym: gll1117

Alternate gene names: 37520686

Gene position: 1196762-1195311 (Counterclockwise)

Preceding gene: 37520688

Following gene: 37520683

Centisome position: 25.69

GC content: 61.78

Gene sequence:

>1452_bases
ATGGAAACATCGGCTCTGCAATCCGGCGCGCAGGCGACCCACGAAAAACCCAGCATTGGGCTGATCGGGCTTGCGGTGAT
GGGCGAGAATCTGGCGCTCAACATTGCCAACCACGGTTTTCCAATCTCGGTCTACAACCGCACCGCCGCTAAAACCCAAG
AACTGGCCGAAGGCCGCGCCCGGGGCAAGGCGCTCTACCCGACTTTCACCATGGAAGAATTCGTCGCCTCCATGGAGCGC
CCCCGCAAAATCATCATCCTGGTCAAGGCCGGCGCTCCGGTCGATGCGGTGATCGACCAGCTCAAGCCGCTGCTCGAAAA
AGACGACGTGATCATCGACGGCGGCAACTCGCTGTTTACCGATACCGAGAAGCGCTCCGGCGAGATCGAAGCGCTCGGAT
TGCGCTTCGTGGGCATGGGGGTCTCGGGCGGCGAAGAGGGTGCCCTCAAGGGTCCCAGCCTGATGCCCGGCGGACCGAAG
ACCGCCTACGACGATCTGGCCCCGATTCTCACCCAGATTGCCGCCCAGGTCGACGACGGCCCCTGCGTCACCTATATCGG
CCCGCGCGGCGCCGGCCACTACGTGAAGATGGTCCACAACGGCATCGAGTACGGCGACATGCAACTCATCGCCGAAGCCT
ACGACCTGCTGCGCCAGACCCTGGGTCTGGGGGCCGCCGAACTGCACGACATCTTTGCCGAGTGGAACGCAGGGGAACTC
AAGTCGTTTTTGATCGAGATCACCGCCGACATTTTTACCAAGATCGACCCCGAGACCGGCAAGCCGCTGGTGGACTTGAT
CCTCGACAAAGCGGGCCAAAAAGGCACCGGCAAGTGGACCAGCCAGAACGCCTACGATCTGGGTATTCCGATTCCGACCA
TCAACGCCGCAGTCGAATCGCGCATCCTCTCGGCCTACAAAAGCGAACGGGTGGCCGCTTCCAAAATCCTGAGCGGTCCG
GAGCGGCCTCCGTTTACGGGCGAGAAGAAACAATTTATCGATGCGGTGCGCGACGCGCTCTACTGCGCCAAGATCTGCTC
CTACGCCCAGGGGATGGCCCTGCTCAAAGCCGCTTCCCACGAGTACGACTACCACCTCAACCTTTCTGAACTGGCGCGCA
TCTGGAAGGGCGGCTGCATCATCCGGGCCATCTTCCTGGATAAGATCAAAAACGCTTTCCTGCGCGACCCGGCCCTCACC
AACTTGCTCATCGACAGCGAATTCAGCGGCGATATTCAGGCGCGCCAGGCCAACTGGCGCTACGCGGTACAGACGGCCGC
CCAACTGGGCATCCCAGCCTACGCCACGGGTGCGTCCCTTGCCTACTACGACGCCTACCGCACAGCCCAACTGCCCCTCA
ACCTCACCCAGGCCCAGCGCGACTACTTCGGCGCCCACACCTACGAGCGCATCGACAAAGAAGGAGTCTTCCACACCGAG
TGGTTCAGCTGA

Upstream 100 bases:

>100_bases
GCACACCCCGTCCACCGGCAAATACTAAACAAATCGTGAGAGACCGGCGGCAGGCTCTATCCGCTGCCTAGACTGGGACT
GAACAAAGGAAGCGATTTCT

Downstream 100 bases:

>100_bases
GTGAGTCAGGAGCTGTTTTTGCGAGGGTGCCTACTTGACTGCATTCAGAACTTGTCCCGCCGTTAGCACAACAGCAATGC
CCATCTCCGCAAGTTTTGGC

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
METSALQSGAQATHEKPSIGLIGLAVMGENLALNIANHGFPISVYNRTAAKTQELAEGRARGKALYPTFTMEEFVASMER
PRKIIILVKAGAPVDAVIDQLKPLLEKDDVIIDGGNSLFTDTEKRSGEIEALGLRFVGMGVSGGEEGALKGPSLMPGGPK
TAYDDLAPILTQIAAQVDDGPCVTYIGPRGAGHYVKMVHNGIEYGDMQLIAEAYDLLRQTLGLGAAELHDIFAEWNAGEL
KSFLIEITADIFTKIDPETGKPLVDLILDKAGQKGTGKWTSQNAYDLGIPIPTINAAVESRILSAYKSERVAASKILSGP
ERPPFTGEKKQFIDAVRDALYCAKICSYAQGMALLKAASHEYDYHLNLSELARIWKGGCIIRAIFLDKIKNAFLRDPALT
NLLIDSEFSGDIQARQANWRYAVQTAAQLGIPAYATGASLAYYDAYRTAQLPLNLTQAQRDYFGAHTYERIDKEGVFHTE
WFS

Sequences:

>Translated_483_residues
METSALQSGAQATHEKPSIGLIGLAVMGENLALNIANHGFPISVYNRTAAKTQELAEGRARGKALYPTFTMEEFVASMER
PRKIIILVKAGAPVDAVIDQLKPLLEKDDVIIDGGNSLFTDTEKRSGEIEALGLRFVGMGVSGGEEGALKGPSLMPGGPK
TAYDDLAPILTQIAAQVDDGPCVTYIGPRGAGHYVKMVHNGIEYGDMQLIAEAYDLLRQTLGLGAAELHDIFAEWNAGEL
KSFLIEITADIFTKIDPETGKPLVDLILDKAGQKGTGKWTSQNAYDLGIPIPTINAAVESRILSAYKSERVAASKILSGP
ERPPFTGEKKQFIDAVRDALYCAKICSYAQGMALLKAASHEYDYHLNLSELARIWKGGCIIRAIFLDKIKNAFLRDPALT
NLLIDSEFSGDIQARQANWRYAVQTAAQLGIPAYATGASLAYYDAYRTAQLPLNLTQAQRDYFGAHTYERIDKEGVFHTE
WFS
>Mature_483_residues
METSALQSGAQATHEKPSIGLIGLAVMGENLALNIANHGFPISVYNRTAAKTQELAEGRARGKALYPTFTMEEFVASMER
PRKIIILVKAGAPVDAVIDQLKPLLEKDDVIIDGGNSLFTDTEKRSGEIEALGLRFVGMGVSGGEEGALKGPSLMPGGPK
TAYDDLAPILTQIAAQVDDGPCVTYIGPRGAGHYVKMVHNGIEYGDMQLIAEAYDLLRQTLGLGAAELHDIFAEWNAGEL
KSFLIEITADIFTKIDPETGKPLVDLILDKAGQKGTGKWTSQNAYDLGIPIPTINAAVESRILSAYKSERVAASKILSGP
ERPPFTGEKKQFIDAVRDALYCAKICSYAQGMALLKAASHEYDYHLNLSELARIWKGGCIIRAIFLDKIKNAFLRDPALT
NLLIDSEFSGDIQARQANWRYAVQTAAQLGIPAYATGASLAYYDAYRTAQLPLNLTQAQRDYFGAHTYERIDKEGVFHTE
WFS

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=468, Percent_Identity=51.4957264957265, Blast_Score=461, Evalue=1e-130,
Organism=Escherichia coli, GI1788341, Length=468, Percent_Identity=59.1880341880342, Blast_Score=548, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI17542558, Length=466, Percent_Identity=50, Blast_Score=465, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6321695, Length=452, Percent_Identity=51.5486725663717, Blast_Score=474, Evalue=1e-134,
Organism=Saccharomyces cerevisiae, GI6321977, Length=452, Percent_Identity=52.8761061946903, Blast_Score=473, Evalue=1e-134,
Organism=Drosophila melanogaster, GI24639279, Length=468, Percent_Identity=52.1367521367521, Blast_Score=455, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 52551; Mature: 52551

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METSALQSGAQATHEKPSIGLIGLAVMGENLALNIANHGFPISVYNRTAAKTQELAEGRA
CCCHHHHCCHHHCCCCCCCCEEEEEEECCCEEEEEECCCCEEEEECCHHHHHHHHHHHHH
RGKALYPTFTMEEFVASMERPRKIIILVKAGAPVDAVIDQLKPLLEKDDVIIDGGNSLFT
CCCEECCCCCHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCCEEC
DTEKRSGEIEALGLRFVGMGVSGGEEGALKGPSLMPGGPKTAYDDLAPILTQIAAQVDDG
CCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
PCVTYIGPRGAGHYVKMVHNGIEYGDMQLIAEAYDLLRQTLGLGAAELHDIFAEWNAGEL
CEEEEECCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHH
KSFLIEITADIFTKIDPETGKPLVDLILDKAGQKGTGKWTSQNAYDLGIPIPTINAAVES
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCEECCCCCCCHHHHHHH
RILSAYKSERVAASKILSGPERPPFTGEKKQFIDAVRDALYCAKICSYAQGMALLKAASH
HHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
EYDYHLNLSELARIWKGGCIIRAIFLDKIKNAFLRDPALTNLLIDSEFSGDIQARQANWR
CCEEEECHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHEEECCCCCCCEEECCCCCH
YAVQTAAQLGIPAYATGASLAYYDAYRTAQLPLNLTQAQRDYFGAHTYERIDKEGVFHTE
HHHHHHHHHCCCCEECCCCEEEHHHHHHEECCCCHHHHHHHHHCCHHHHHHCCCCCEECC
WFS
CCC
>Mature Secondary Structure
METSALQSGAQATHEKPSIGLIGLAVMGENLALNIANHGFPISVYNRTAAKTQELAEGRA
CCCHHHHCCHHHCCCCCCCCEEEEEEECCCEEEEEECCCCEEEEECCHHHHHHHHHHHHH
RGKALYPTFTMEEFVASMERPRKIIILVKAGAPVDAVIDQLKPLLEKDDVIIDGGNSLFT
CCCEECCCCCHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCCEEC
DTEKRSGEIEALGLRFVGMGVSGGEEGALKGPSLMPGGPKTAYDDLAPILTQIAAQVDDG
CCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
PCVTYIGPRGAGHYVKMVHNGIEYGDMQLIAEAYDLLRQTLGLGAAELHDIFAEWNAGEL
CEEEEECCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHH
KSFLIEITADIFTKIDPETGKPLVDLILDKAGQKGTGKWTSQNAYDLGIPIPTINAAVES
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCEECCCCCCCHHHHHHH
RILSAYKSERVAASKILSGPERPPFTGEKKQFIDAVRDALYCAKICSYAQGMALLKAASH
HHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
EYDYHLNLSELARIWKGGCIIRAIFLDKIKNAFLRDPALTNLLIDSEFSGDIQARQANWR
CCEEEECHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHEEECCCCCCCEEECCCCCH
YAVQTAAQLGIPAYATGASLAYYDAYRTAQLPLNLTQAQRDYFGAHTYERIDKEGVFHTE
HHHHHHHHHCCCCEECCCCEEEHHHHHHEECCCCHHHHHHHHHCCHHHHHHCCCCCEECC
WFS
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2113917 [H]