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The map label for this gene is 37520663

Identifier: 37520663

GI number: 37520663

Start: 1172555

End: 1174000

Strand: Reverse

Name: 37520663

Synonym: gll1094

Alternate gene names: NA

Gene position: 1174000-1172555 (Counterclockwise)

Preceding gene: 37520664

Following gene: 37520662

Centisome position: 25.2

GC content: 46.75

Gene sequence:

>1446_bases
ATGAGGATCTCAGATCAATCTCTCACAATTCCTTTGAAAGAATTACTGAATTTGATGTTGATTGTACGTGAAGGTGATTT
GCGTGAAGGGAATCTGATGCGCCAGGGAAAAGGCTGGATTCATATCCCAGGGATGGGGCATGAATCCTTGATTGCCATCA
CCCACCATTTGCATCGTGAAGATTATCTTTTCACGTACTATCGAGATCGCGCATTGATGCTGGGAAAAGGTTTCACAGCT
CAGCAGTTAGCCTGGGACTATTTTGCCTGCGCCAAGTCTTCGACCGGTGGGCGAGGCATGCCTGTTCACTGTTCAGCTAA
ACATCTGAATATTTTCCCACCTGCTACACCGACCGCAAGTCAATGCTTACCTGCTGTCGGCGCTGCATGGGGGATCAAAC
ATTCTGAAAAAACCGATGTGGTGATCTGTACTATTGGGGATGCCTCCGTTAGACAAGGTGAATTTTATGAGGCAGTTTGT
ATGGCGGTTCAAGAAAGGCTGCCCGTGATATTCGTAGTTGAAGATAATGCCTATGGAATTAGCACATCTACCAAACATCA
ACTTCCATTCCGGTTAGGCATATTCAATGAAGAGATTTTCGTTCGAGTCGATGGACGACATCCTGCGGAAATTTTCAATC
ACAGCGGACAAGCCATTACCAAGGCAAGACAGGGAAATGGGCCTACAATTCTTTGGGTTGAATTGGATCGGTTGGTTTCC
CATACCAATTCTGATGATCATCGCATCTACCGTCCGAAAGAAGAGATCGATGCGATGCTGCAACGGGATCCACTTTCTGT
ACTGGCCAGACATCTAATCAACGCTGGAGAGCTAACAGCAACTGAATGGCAGGCTTTGCAGTTTAAAACTGCAATGACGA
TCGACGAGATTTATCAGCAAGCCGAACGGGAAAACTCCCCAAACCCTGATCAGATTTTGGTTCATCTATATGGCTCAAAA
GTTGATCATCAATGTGTTCCTTTCCAACCCGTTGAACGAACCACAACGATGGTTGCGGCCATAAACCAGACTCTGCGAGA
AGCATTGCAACTTTACCCTCAAATGATCATGTTTGGTCAAGATATTGAGGATCCTAAAGGGGGAGTCTTTGGCTTTACCA
AAGGGTTGAGTAGTCAGTTCTCACAGAGAGTTACTAACTCGCCTTTGGCAGAAGCAACCATTGTGGGCGTTGCAGCAGGG
TTGGCTGCAACGGGTTACAAACCTGTATTTGAGTTACAGTTTATAGACTTCATTACTCCCGCTTTTAACCAATTGGTGCA
ACAAATTGCCACGCTGCGCTGGCGATCACAGGGCGACTGGAGTTGCCCAATGGTACTCTATGCGCCCTACGGAGCCTATC
TACCAGGTGGAAGCACTTGGCACAGCCAGAGTAATGAGGGGTGGTGGACACATATTCCAGCAGAAGTGTTGAATGTCAGG
AATTGA

Upstream 100 bases:

>100_bases
CAAGCCAGAAATAGGCATTGGGTGTTTCAACACCGCCTATCAAATCAGGTGAGGAATAGAGGATAAAAACATGACGCAGA
ATCCACTGTGCGACAGAGTG

Downstream 100 bases:

>100_bases
TCCTACAAAAACAGCTCGAAGTCGTGTAAACTTCGAGCTGTGTTCAATTTCATTATGTTGAGACAATGCTACTCGATTTT
CCGCAACTTGTCAAAACCGC

Product: 2-oxoisovalerate dehydrogenase E1 component subunits alpha and beta

Products: NA

Alternate protein names: Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDH E1-alpha [H]

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MRISDQSLTIPLKELLNLMLIVREGDLREGNLMRQGKGWIHIPGMGHESLIAITHHLHREDYLFTYYRDRALMLGKGFTA
QQLAWDYFACAKSSTGGRGMPVHCSAKHLNIFPPATPTASQCLPAVGAAWGIKHSEKTDVVICTIGDASVRQGEFYEAVC
MAVQERLPVIFVVEDNAYGISTSTKHQLPFRLGIFNEEIFVRVDGRHPAEIFNHSGQAITKARQGNGPTILWVELDRLVS
HTNSDDHRIYRPKEEIDAMLQRDPLSVLARHLINAGELTATEWQALQFKTAMTIDEIYQQAERENSPNPDQILVHLYGSK
VDHQCVPFQPVERTTTMVAAINQTLREALQLYPQMIMFGQDIEDPKGGVFGFTKGLSSQFSQRVTNSPLAEATIVGVAAG
LAATGYKPVFELQFIDFITPAFNQLVQQIATLRWRSQGDWSCPMVLYAPYGAYLPGGSTWHSQSNEGWWTHIPAEVLNVR
N

Sequences:

>Translated_481_residues
MRISDQSLTIPLKELLNLMLIVREGDLREGNLMRQGKGWIHIPGMGHESLIAITHHLHREDYLFTYYRDRALMLGKGFTA
QQLAWDYFACAKSSTGGRGMPVHCSAKHLNIFPPATPTASQCLPAVGAAWGIKHSEKTDVVICTIGDASVRQGEFYEAVC
MAVQERLPVIFVVEDNAYGISTSTKHQLPFRLGIFNEEIFVRVDGRHPAEIFNHSGQAITKARQGNGPTILWVELDRLVS
HTNSDDHRIYRPKEEIDAMLQRDPLSVLARHLINAGELTATEWQALQFKTAMTIDEIYQQAERENSPNPDQILVHLYGSK
VDHQCVPFQPVERTTTMVAAINQTLREALQLYPQMIMFGQDIEDPKGGVFGFTKGLSSQFSQRVTNSPLAEATIVGVAAG
LAATGYKPVFELQFIDFITPAFNQLVQQIATLRWRSQGDWSCPMVLYAPYGAYLPGGSTWHSQSNEGWWTHIPAEVLNVR
N
>Mature_481_residues
MRISDQSLTIPLKELLNLMLIVREGDLREGNLMRQGKGWIHIPGMGHESLIAITHHLHREDYLFTYYRDRALMLGKGFTA
QQLAWDYFACAKSSTGGRGMPVHCSAKHLNIFPPATPTASQCLPAVGAAWGIKHSEKTDVVICTIGDASVRQGEFYEAVC
MAVQERLPVIFVVEDNAYGISTSTKHQLPFRLGIFNEEIFVRVDGRHPAEIFNHSGQAITKARQGNGPTILWVELDRLVS
HTNSDDHRIYRPKEEIDAMLQRDPLSVLARHLINAGELTATEWQALQFKTAMTIDEIYQQAERENSPNPDQILVHLYGSK
VDHQCVPFQPVERTTTMVAAINQTLREALQLYPQMIMFGQDIEDPKGGVFGFTKGLSSQFSQRVTNSPLAEATIVGVAAG
LAATGYKPVFELQFIDFITPAFNQLVQQIATLRWRSQGDWSCPMVLYAPYGAYLPGGSTWHSQSNEGWWTHIPAEVLNVR
N

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltran

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BCKDHA family [H]

Homologues:

Organism=Homo sapiens, GI258645172, Length=295, Percent_Identity=26.7796610169492, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI11386135, Length=296, Percent_Identity=26.6891891891892, Blast_Score=109, Evalue=7e-24,
Organism=Homo sapiens, GI4885543, Length=309, Percent_Identity=24.2718446601942, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI4505685, Length=309, Percent_Identity=24.5954692556634, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI291084742, Length=309, Percent_Identity=24.5954692556634, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI291084744, Length=316, Percent_Identity=24.3670886075949, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI4557353, Length=140, Percent_Identity=36.4285714285714, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI34101272, Length=140, Percent_Identity=36.4285714285714, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI291084757, Length=310, Percent_Identity=22.5806451612903, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI156564403, Length=145, Percent_Identity=27.5862068965517, Blast_Score=71, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI86563355, Length=271, Percent_Identity=25.830258302583, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI86563357, Length=271, Percent_Identity=25.830258302583, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17536047, Length=362, Percent_Identity=22.3756906077348, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI32564172, Length=345, Percent_Identity=22.6086956521739, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17506935, Length=152, Percent_Identity=35.5263157894737, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17538422, Length=141, Percent_Identity=28.3687943262411, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6321026, Length=323, Percent_Identity=23.8390092879257, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319698, Length=142, Percent_Identity=30.2816901408451, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21355903, Length=303, Percent_Identity=26.0726072607261, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI160714828, Length=144, Percent_Identity=38.1944444444444, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI160714832, Length=144, Percent_Identity=38.1944444444444, Blast_Score=95, Evalue=9e-20,
Organism=Drosophila melanogaster, GI24639748, Length=317, Percent_Identity=25.5520504731861, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24639746, Length=315, Percent_Identity=22.5396825396825, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24639744, Length=289, Percent_Identity=23.8754325259516, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28571106, Length=289, Percent_Identity=23.8754325259516, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24639740, Length=315, Percent_Identity=22.5396825396825, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.4 [H]

Molecular weight: Translated: 53871; Mature: 53871

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRISDQSLTIPLKELLNLMLIVREGDLREGNLMRQGKGWIHIPGMGHESLIAITHHLHRE
CCCCCCCCEECHHHHHHHEEEEECCCCCCCCEEECCCCEEEECCCCCCHHHHHHHHHCCC
DYLFTYYRDRALMLGKGFTAQQLAWDYFACAKSSTGGRGMPVHCSAKHLNIFPPATPTAS
CEEEEEEECCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCEEEECCCCCCCHH
QCLPAVGAAWGIKHSEKTDVVICTIGDASVRQGEFYEAVCMAVQERLPVIFVVEDNAYGI
HHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCC
STSTKHQLPFRLGIFNEEIFVRVDGRHPAEIFNHSGQAITKARQGNGPTILWVELDRLVS
CCCCCCCCCEEEEEECCEEEEEECCCCHHHHHCCCCHHHHHHHCCCCCEEEEEEHHHHHH
HTNSDDHRIYRPKEEIDAMLQRDPLSVLARHLINAGELTATEWQALQFKTAMTIDEIYQQ
CCCCCCCEEECCHHHHHHHHCCCHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHHH
AERENSPNPDQILVHLYGSKVDHQCVPFQPVERTTTMVAAINQTLREALQLYPQMIMFGQ
HHHCCCCCHHHEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DIEDPKGGVFGFTKGLSSQFSQRVTNSPLAEATIVGVAAGLAATGYKPVFELQFIDFITP
CCCCCCCCEEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHH
AFNQLVQQIATLRWRSQGDWSCPMVLYAPYGAYLPGGSTWHSQSNEGWWTHIPAEVLNVR
HHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEECCHHHHCCC
N
C
>Mature Secondary Structure
MRISDQSLTIPLKELLNLMLIVREGDLREGNLMRQGKGWIHIPGMGHESLIAITHHLHRE
CCCCCCCCEECHHHHHHHEEEEECCCCCCCCEEECCCCEEEECCCCCCHHHHHHHHHCCC
DYLFTYYRDRALMLGKGFTAQQLAWDYFACAKSSTGGRGMPVHCSAKHLNIFPPATPTAS
CEEEEEEECCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCEEEECCCCCCCHH
QCLPAVGAAWGIKHSEKTDVVICTIGDASVRQGEFYEAVCMAVQERLPVIFVVEDNAYGI
HHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCC
STSTKHQLPFRLGIFNEEIFVRVDGRHPAEIFNHSGQAITKARQGNGPTILWVELDRLVS
CCCCCCCCCEEEEEECCEEEEEECCCCHHHHHCCCCHHHHHHHCCCCCEEEEEEHHHHHH
HTNSDDHRIYRPKEEIDAMLQRDPLSVLARHLINAGELTATEWQALQFKTAMTIDEIYQQ
CCCCCCCEEECCHHHHHHHHCCCHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHHH
AERENSPNPDQILVHLYGSKVDHQCVPFQPVERTTTMVAAINQTLREALQLYPQMIMFGQ
HHHCCCCCHHHEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DIEDPKGGVFGFTKGLSSQFSQRVTNSPLAEATIVGVAAGLAATGYKPVFELQFIDFITP
CCCCCCCCEEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHH
AFNQLVQQIATLRWRSQGDWSCPMVLYAPYGAYLPGGSTWHSQSNEGWWTHIPAEVLNVR
HHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEECCHHHHCCC
N
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA