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The map label for this gene is aroA

Identifier: 37520607

GI number: 37520607

Start: 1112732

End: 1114030

Strand: Reverse

Name: aroA

Synonym: gvip141

Alternate gene names: 37520607

Gene position: 1114030-1112732 (Counterclockwise)

Preceding gene: 37520609

Following gene: 37520606

Centisome position: 23.91

GC content: 68.98

Gene sequence:

>1299_bases
GTGGGACAAGCGTTTTCGATTACCCCGGCCCGGCGGCTGAGCGGGGAGATCGCCGTGGCGGGCGATAAGTCTATCTCCCA
TCGTGCCTTGATGCTCGCGGCCCTGGCCGAGGGTGAATCGGTGATCGAGGGACTGCTGCCGGGGGACGACCCGCGCAGTA
CTGCCGCGTGTTTGCGGGCTCTGGGCGCCGAGATTTCGGGGATCGACGGCCCGTCGGTGCGGGTGCGCGGCGTTGGCCTG
GGCCGGCTGCATGAACCTGCGGATGTGCTGGATATGGGCAATTCCGGTACGACGATGCGGCTGATGCTGGGGGTGCTTGC
CGGCCAGCCGGGGCTTTTTTGTACCCTCACGGGCGACCGATCGCTGCGCTCGCGGCCGATGCTCAGGGTGGTCTCACCGC
TTCGGCAGATGGGGGCGCGCATCTGGGGGCGCGAGGAGGGCGGCCGGGCGCCGCTCGCGGTTTGGGGAGAGCAGCTCAGG
GCGATCGACTTTGTTTCTCCTGTTGCCTCCGCCCAGGTCAAATCGGCCGTGCTGCTGGCCGGGTTGCTCGCCGAGGGGCT
GACCAGCGTCAGTGAACCGGTCCGCTCGCGCGATCACAGCGAACGAATGCTCAGAGCCTTCGGAGCCGAGGTCCTGGTAG
ACGGCACCACCGCCGCGGTGCGCGGGCCTGCCAGATTGCGCGCCCAAAGTTTGCGGGTGCCCGGGGACATCAGCTCGGCC
GCCTTCTGGCTGGTGGCAGGCTCGATTGTGCCCGATTCGCAGTTGCTCCTGAGCGGGGTCGGCGTCAACCCGACCCGCAC
GGGGGTACTCGACGCCCTCGCCGCCATGGGAGCGGATATCGCCGTGGAAAACCGGCGCGAAGTGTGCGGCGAGCCGGTGG
CCGACCTGCGGGTGCGCTCAGCCCCCCTCAAAGCCTGCACGATCGGGGGCGAGTGGATTCCCCGGCTGGTGGATGAGATA
CCGGTGCTGGCGGTGGCCGCCTGCTGTGCCGCGGGCAAAACCGTGATCCGCGACGCCGCCGAATTGCGCGTCAAAGAGAG
CGACCGGCTGGCCACGATGGCCCGCGAACTGGGCCGCCTTGGGGCGCACATCGAGGAGCGGCCGGACGGTCTGGTGATCG
AAGGCGGCCATCGCCTGGTGGGAGCCGGTGTCGAGAGCCATGACGATCACCGGGTGGCGATGAGCCTGGCGGTGGCCGGG
TTGGTGGCCACCGGCACCACCGAAATCGCCGACCCCGACTGTGCGACGGTCTCCTACCCGCAGTTCTACGAACACCTGGC
CCGGGTGCGGCAGCAATAA

Upstream 100 bases:

>100_bases
TAAAGCTTTTCTCTATCAGGCTATCCCAGAGATAGGCCCTTGGACAAGAACCCGGCCGTCTGGCGTACAATCGTCTGCGA
TTTGACAGCAAAGGTGCGCT

Downstream 100 bases:

>100_bases
CCTGGGCTCGCGACAATCTGGCTGCAGGAAGGATTCCTTCGCCAGGGCAACCTGTATCGTGGAAAAAATCCAATCGAAAT
CTTACTTATGCGGGCTACCG

Product: 3-phosphoshikimate 1-carboxyvinyltransferase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS

Number of amino acids: Translated: 432; Mature: 431

Protein sequence:

>432_residues
MGQAFSITPARRLSGEIAVAGDKSISHRALMLAALAEGESVIEGLLPGDDPRSTAACLRALGAEISGIDGPSVRVRGVGL
GRLHEPADVLDMGNSGTTMRLMLGVLAGQPGLFCTLTGDRSLRSRPMLRVVSPLRQMGARIWGREEGGRAPLAVWGEQLR
AIDFVSPVASAQVKSAVLLAGLLAEGLTSVSEPVRSRDHSERMLRAFGAEVLVDGTTAAVRGPARLRAQSLRVPGDISSA
AFWLVAGSIVPDSQLLLSGVGVNPTRTGVLDALAAMGADIAVENRREVCGEPVADLRVRSAPLKACTIGGEWIPRLVDEI
PVLAVAACCAAGKTVIRDAAELRVKESDRLATMARELGRLGAHIEERPDGLVIEGGHRLVGAGVESHDDHRVAMSLAVAG
LVATGTTEIADPDCATVSYPQFYEHLARVRQQ

Sequences:

>Translated_432_residues
MGQAFSITPARRLSGEIAVAGDKSISHRALMLAALAEGESVIEGLLPGDDPRSTAACLRALGAEISGIDGPSVRVRGVGL
GRLHEPADVLDMGNSGTTMRLMLGVLAGQPGLFCTLTGDRSLRSRPMLRVVSPLRQMGARIWGREEGGRAPLAVWGEQLR
AIDFVSPVASAQVKSAVLLAGLLAEGLTSVSEPVRSRDHSERMLRAFGAEVLVDGTTAAVRGPARLRAQSLRVPGDISSA
AFWLVAGSIVPDSQLLLSGVGVNPTRTGVLDALAAMGADIAVENRREVCGEPVADLRVRSAPLKACTIGGEWIPRLVDEI
PVLAVAACCAAGKTVIRDAAELRVKESDRLATMARELGRLGAHIEERPDGLVIEGGHRLVGAGVESHDDHRVAMSLAVAG
LVATGTTEIADPDCATVSYPQFYEHLARVRQQ
>Mature_431_residues
GQAFSITPARRLSGEIAVAGDKSISHRALMLAALAEGESVIEGLLPGDDPRSTAACLRALGAEISGIDGPSVRVRGVGLG
RLHEPADVLDMGNSGTTMRLMLGVLAGQPGLFCTLTGDRSLRSRPMLRVVSPLRQMGARIWGREEGGRAPLAVWGEQLRA
IDFVSPVASAQVKSAVLLAGLLAEGLTSVSEPVRSRDHSERMLRAFGAEVLVDGTTAAVRGPARLRAQSLRVPGDISSAA
FWLVAGSIVPDSQLLLSGVGVNPTRTGVLDALAAMGADIAVENRREVCGEPVADLRVRSAPLKACTIGGEWIPRLVDEIP
VLAVAACCAAGKTVIRDAAELRVKESDRLATMARELGRLGAHIEERPDGLVIEGGHRLVGAGVESHDDHRVAMSLAVAGL
VATGTTEIADPDCATVSYPQFYEHLARVRQQ

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; sixth step. [C]

COG id: COG0128

COG function: function code E; 5-enolpyruvylshikimate-3-phosphate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family

Homologues:

Organism=Escherichia coli, GI1787137, Length=443, Percent_Identity=32.5056433408578, Blast_Score=152, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6320332, Length=452, Percent_Identity=28.9823008849558, Blast_Score=124, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROA_GLOVI (Q7NLT3)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_923984.1
- HSSP:   Q9S400
- ProteinModelPortal:   Q7NLT3
- SMR:   Q7NLT3
- GeneID:   2599156
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.1038
- HOGENOM:   HBG646626
- OMA:   LSRNHTE
- ProtClustDB:   PRK02427
- BioCyc:   GVIO251221:GLL1038-MONOMER
- BRENDA:   2.5.1.19
- GO:   GO:0005737
- HAMAP:   MF_00210
- InterPro:   IPR001986
- InterPro:   IPR006264
- InterPro:   IPR023193
- InterPro:   IPR013792
- Gene3D:   G3DSA:3.65.10.10
- PIRSF:   PIRSF000505
- TIGRFAMs:   TIGR01356

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.19

Molecular weight: Translated: 45311; Mature: 45180

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00104 EPSP_SYNTHASE_1; PS00885 EPSP_SYNTHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGQAFSITPARRLSGEIAVAGDKSISHRALMLAALAEGESVIEGLLPGDDPRSTAACLRA
CCCCCCCCHHHHCCCCEEEECCCCHHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHH
LGAEISGIDGPSVRVRGVGLGRLHEPADVLDMGNSGTTMRLMLGVLAGQPGLFCTLTGDR
HCCCCCCCCCCCEEEEEECCCCCCCCHHHHHCCCCCCHHHHHHHHHCCCCCEEEEEECCC
SLRSRPMLRVVSPLRQMGARIWGREEGGRAPLAVWGEQLRAIDFVSPVASAQVKSAVLLA
CCHHCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLLAEGLTSVSEPVRSRDHSERMLRAFGAEVLVDGTTAAVRGPARLRAQSLRVPGDISSA
HHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEECCCHHHHCCHHHHHHHHCCCCCCCCHH
AFWLVAGSIVPDSQLLLSGVGVNPTRTGVLDALAAMGADIAVENRREVCGEPVADLRVRS
HHHHEECCCCCCHHHHHCCCCCCCCHHHHHHHHHHCCCCEEECCCHHHCCCCHHHHEECC
APLKACTIGGEWIPRLVDEIPVLAVAACCAAGKTVIRDAAELRVKESDRLATMARELGRL
CCCCEEECCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHH
GAHIEERPDGLVIEGGHRLVGAGVESHDDHRVAMSLAVAGLVATGTTEIADPDCATVSYP
CCCHHCCCCCEEEECCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCH
QFYEHLARVRQQ
HHHHHHHHHHCC
>Mature Secondary Structure 
GQAFSITPARRLSGEIAVAGDKSISHRALMLAALAEGESVIEGLLPGDDPRSTAACLRA
CCCCCCCHHHHCCCCEEEECCCCHHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHH
LGAEISGIDGPSVRVRGVGLGRLHEPADVLDMGNSGTTMRLMLGVLAGQPGLFCTLTGDR
HCCCCCCCCCCCEEEEEECCCCCCCCHHHHHCCCCCCHHHHHHHHHCCCCCEEEEEECCC
SLRSRPMLRVVSPLRQMGARIWGREEGGRAPLAVWGEQLRAIDFVSPVASAQVKSAVLLA
CCHHCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLLAEGLTSVSEPVRSRDHSERMLRAFGAEVLVDGTTAAVRGPARLRAQSLRVPGDISSA
HHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEECCCHHHHCCHHHHHHHHCCCCCCCCHH
AFWLVAGSIVPDSQLLLSGVGVNPTRTGVLDALAAMGADIAVENRREVCGEPVADLRVRS
HHHHEECCCCCCHHHHHCCCCCCCCHHHHHHHHHHCCCCEEECCCHHHCCCCHHHHEECC
APLKACTIGGEWIPRLVDEIPVLAVAACCAAGKTVIRDAAELRVKESDRLATMARELGRL
CCCCEEECCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHH
GAHIEERPDGLVIEGGHRLVGAGVESHDDHRVAMSLAVAGLVATGTTEIADPDCATVSYP
CCCHHCCCCCEEEECCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCH
QFYEHLARVRQQ
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292