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The map label for this gene is groEL

Identifier: 37520596

GI number: 37520596

Start: 1102925

End: 1104553

Strand: Reverse

Name: groEL

Synonym: gvip138

Alternate gene names: 37520596

Gene position: 1104553-1102925 (Counterclockwise)

Preceding gene: 37520597

Following gene: 37520595

Centisome position: 23.71

GC content: 62.98

Gene sequence:

>1629_bases
ATGGCAAAGCAAGTCGTATTCGATGAGACCGCCCGCCGCGCCCTCGAGCGCGGCATCGACGCCCTCGCCAACGCGGTGCG
CGTCACCCTCGGCCCCAAGGGCCGCAACGTCGTACTTGAGAAAAAGTTCGGCGCGCCCCAGATCATCAACGACGGTGTGA
CGATCGCCAAAGAAATCGAGCTTGAAAATAAGCTCGAAAATACCGGCGCCCAACTGATCAAAGAAGTCGCCTCTAAGACC
AACGATGTGGCGGGCGACGGCACCACCACCGCCTGCGTGCTGGCCCAGTCGCTGGTCAAAGAGGGTCTCAAAAACGTCGC
CGCCGGTTCCAACCCGATGAACCTCAAGCGCGGCATGGAGAAGACCGTCCGCCACCTGGTGGCTGAACTGGAGAAAGTCG
CCAAGCCGGTCGAAGGCTCCCAGGCGATCGCCCAGGTCGCGGCCGTCTCCGCCGGCAACGACGATGAAATCGGCGAGATG
ATCGCCCGCGCCATGGAGACCGTCGGCAAAGAAGGCGTGATCACCGTCGAAGAATCGAAGTCCCTGACCACCGAACTGGA
GGTGACCGAGGGCATGCAGTTCGACCGCGGCTACGTCTCGCCCTACCTGGTTACCGACCAGGAGCGCATGGAAGCGGTCT
TCGACGAGCCCTTCTTGCTGATTACCGACAAAAAGATCTCGATCATCACCGACCTGGTGCCGATTCTTGAAAAAGTCGCC
CGCGCCGGCCGACCGCTGGTAATCATCGCCGAGGACATCGAAAAAGAAGCCCTCGCCACCCTCGTAGTCAACAAGCTGCG
CGGCGTCCTCAACGTGGCTGCCGTCAAGGCCCCCGGCTTCGGCGACCGGCGCAAGGCGATGCTGCAAGATATTGCGGTGC
TCACCGACGGCGAAGTGATCTCCGAAGACACCGGCATCAAGCTCGAGAACGTCACCACCGACCAGCTCGGCAAGGCCCGA
AAAATGACGATCACCAAGGACAACACCACGATCGTGGCCGAGGGCAACGAAGCCGCCGTCAAGGCCCGCTGCGCTCAGAT
CAAGCAGCAGATCGAAGAGACCGACTCCGAGTACGACCGCGAGAAGCTCCAGGAGCGCCTTGCCAAGCTCTCGGGCGGTG
TGGCGGTGATCAAAGTCGGTGCGGCGACCGAGACCGAACTCAAAGACCGCAAGCTGCGCATCGAGGATGCCGTCAACGCC
ACCAAGGCGGCCATCGCCGAGGGGATCGTCCCGGGCGGCGGTACGGCGCTGTTGCACCTGGCGGCCGGTATGGGCGGGTT
CATCGACAGCCTGAGCGGCGAAGAGAAAATCGGGGCGCGCATCATCCAGAAGGCCCTCGAAGGTCCCCTGCGCCAGATCG
CCGAGAACGCCGGCCTCGAAGGCTCGGTGATCGCCGAGAAGGTGCGCAACTTGGAGTTCAACTTCGGCTTCAACGCGATG
ACCAACGAGTATGAGGACCTGGTCGCCGCCGGGATCATCGACCCGGTGAAGGTGACCCGCTCGGCACTGCAGAATGCCGC
CTCGATTGCCGCGATGGTGCTCACCACCGAGTGCATCGTGGTCGACAAGCCCGAGGATGATAAGACCCCGGCCGGTGCCG
GCGGTGGCGGCATGCCCGACTTCGACTGA

Upstream 100 bases:

>100_bases
TATTCCGGCACCGACCTGAAACTTGGCGACGCCGAGTACATGCTGGTGGCCGAAAAAGACATTCTGGCAATCGTGGCTTA
ATCGGGGAGAGAACACAATC

Downstream 100 bases:

>100_bases
TCTGCGTCAGCTTTCAGGTATCAGTAAGGGCACCCCGATGCCTGAAACCCGACAGTTCAGAATCCCCGGCCGATCGGCCG
GGGATTTTTTGTAGGACCGC

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 1; Protein Cpn60 1

Number of amino acids: Translated: 542; Mature: 541

Protein sequence:

>542_residues
MAKQVVFDETARRALERGIDALANAVRVTLGPKGRNVVLEKKFGAPQIINDGVTIAKEIELENKLENTGAQLIKEVASKT
NDVAGDGTTTACVLAQSLVKEGLKNVAAGSNPMNLKRGMEKTVRHLVAELEKVAKPVEGSQAIAQVAAVSAGNDDEIGEM
IARAMETVGKEGVITVEESKSLTTELEVTEGMQFDRGYVSPYLVTDQERMEAVFDEPFLLITDKKISIITDLVPILEKVA
RAGRPLVIIAEDIEKEALATLVVNKLRGVLNVAAVKAPGFGDRRKAMLQDIAVLTDGEVISEDTGIKLENVTTDQLGKAR
KMTITKDNTTIVAEGNEAAVKARCAQIKQQIEETDSEYDREKLQERLAKLSGGVAVIKVGAATETELKDRKLRIEDAVNA
TKAAIAEGIVPGGGTALLHLAAGMGGFIDSLSGEEKIGARIIQKALEGPLRQIAENAGLEGSVIAEKVRNLEFNFGFNAM
TNEYEDLVAAGIIDPVKVTRSALQNAASIAAMVLTTECIVVDKPEDDKTPAGAGGGGMPDFD

Sequences:

>Translated_542_residues
MAKQVVFDETARRALERGIDALANAVRVTLGPKGRNVVLEKKFGAPQIINDGVTIAKEIELENKLENTGAQLIKEVASKT
NDVAGDGTTTACVLAQSLVKEGLKNVAAGSNPMNLKRGMEKTVRHLVAELEKVAKPVEGSQAIAQVAAVSAGNDDEIGEM
IARAMETVGKEGVITVEESKSLTTELEVTEGMQFDRGYVSPYLVTDQERMEAVFDEPFLLITDKKISIITDLVPILEKVA
RAGRPLVIIAEDIEKEALATLVVNKLRGVLNVAAVKAPGFGDRRKAMLQDIAVLTDGEVISEDTGIKLENVTTDQLGKAR
KMTITKDNTTIVAEGNEAAVKARCAQIKQQIEETDSEYDREKLQERLAKLSGGVAVIKVGAATETELKDRKLRIEDAVNA
TKAAIAEGIVPGGGTALLHLAAGMGGFIDSLSGEEKIGARIIQKALEGPLRQIAENAGLEGSVIAEKVRNLEFNFGFNAM
TNEYEDLVAAGIIDPVKVTRSALQNAASIAAMVLTTECIVVDKPEDDKTPAGAGGGGMPDFD
>Mature_541_residues
AKQVVFDETARRALERGIDALANAVRVTLGPKGRNVVLEKKFGAPQIINDGVTIAKEIELENKLENTGAQLIKEVASKTN
DVAGDGTTTACVLAQSLVKEGLKNVAAGSNPMNLKRGMEKTVRHLVAELEKVAKPVEGSQAIAQVAAVSAGNDDEIGEMI
ARAMETVGKEGVITVEESKSLTTELEVTEGMQFDRGYVSPYLVTDQERMEAVFDEPFLLITDKKISIITDLVPILEKVAR
AGRPLVIIAEDIEKEALATLVVNKLRGVLNVAAVKAPGFGDRRKAMLQDIAVLTDGEVISEDTGIKLENVTTDQLGKARK
MTITKDNTTIVAEGNEAAVKARCAQIKQQIEETDSEYDREKLQERLAKLSGGVAVIKVGAATETELKDRKLRIEDAVNAT
KAAIAEGIVPGGGTALLHLAAGMGGFIDSLSGEEKIGARIIQKALEGPLRQIAENAGLEGSVIAEKVRNLEFNFGFNAMT
NEYEDLVAAGIIDPVKVTRSALQNAASIAAMVLTTECIVVDKPEDDKTPAGAGGGGMPDFD

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=536, Percent_Identity=47.3880597014925, Blast_Score=479, Evalue=1e-135,
Organism=Homo sapiens, GI31542947, Length=536, Percent_Identity=47.3880597014925, Blast_Score=479, Evalue=1e-135,
Organism=Homo sapiens, GI38455427, Length=536, Percent_Identity=22.3880597014925, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI24307939, Length=537, Percent_Identity=20.4841713221602, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1790586, Length=530, Percent_Identity=58.4905660377358, Blast_Score=614, Evalue=1e-177,
Organism=Caenorhabditis elegans, GI17555558, Length=530, Percent_Identity=45.6603773584906, Blast_Score=475, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI193210679, Length=211, Percent_Identity=43.1279620853081, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI25144674, Length=543, Percent_Identity=21.5469613259669, Blast_Score=72, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=50.3802281368821, Blast_Score=499, Evalue=1e-142,
Organism=Saccharomyces cerevisiae, GI6322524, Length=537, Percent_Identity=21.2290502793296, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24641193, Length=529, Percent_Identity=47.069943289225, Blast_Score=492, Evalue=1e-139,
Organism=Drosophila melanogaster, GI24641191, Length=529, Percent_Identity=47.069943289225, Blast_Score=492, Evalue=1e-139,
Organism=Drosophila melanogaster, GI45550936, Length=528, Percent_Identity=43.75, Blast_Score=454, Evalue=1e-128,
Organism=Drosophila melanogaster, GI45550132, Length=528, Percent_Identity=43.75, Blast_Score=454, Evalue=1e-128,
Organism=Drosophila melanogaster, GI45550935, Length=528, Percent_Identity=43.75, Blast_Score=454, Evalue=1e-128,
Organism=Drosophila melanogaster, GI17864606, Length=546, Percent_Identity=40.8424908424908, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24584129, Length=533, Percent_Identity=33.7711069418386, Blast_Score=296, Evalue=2e-80,
Organism=Drosophila melanogaster, GI19921262, Length=533, Percent_Identity=33.7711069418386, Blast_Score=296, Evalue=2e-80,
Organism=Drosophila melanogaster, GI17647245, Length=537, Percent_Identity=21.9739292364991, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24652903, Length=537, Percent_Identity=21.9739292364991, Blast_Score=73, Evalue=5e-13,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH601_GLOVI (Q7MBC7)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_923973.1
- ProteinModelPortal:   Q7MBC7
- SMR:   Q7MBC7
- GeneID:   2599145
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.1027
- HOGENOM:   HBG625289
- OMA:   GINIVVR
- BioCyc:   GVIO251221:GLL1027-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 57678; Mature: 57547

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKQVVFDETARRALERGIDALANAVRVTLGPKGRNVVLEKKFGAPQIINDGVTIAKEIE
CCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEEEECCCCCCEECCCCHHHHHHH
LENKLENTGAQLIKEVASKTNDVAGDGTTTACVLAQSLVKEGLKNVAAGSNPMNLKRGME
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
KTVRHLVAELEKVAKPVEGSQAIAQVAAVSAGNDDEIGEMIARAMETVGKEGVITVEESK
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEECCC
SLTTELEVTEGMQFDRGYVSPYLVTDQERMEAVFDEPFLLITDKKISIITDLVPILEKVA
CCEEEEEHHCCCCCCCCCCCCEEECCHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHH
RAGRPLVIIAEDIEKEALATLVVNKLRGVLNVAAVKAPGFGDRRKAMLQDIAVLTDGEVI
HCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEE
SEDTGIKLENVTTDQLGKARKMTITKDNTTIVAEGNEAAVKARCAQIKQQIEETDSEYDR
CCCCCEEEECCCHHHHCCCEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
EKLQERLAKLSGGVAVIKVGAATETELKDRKLRIEDAVNATKAAIAEGIVPGGGTALLHL
HHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
AAGMGGFIDSLSGEEKIGARIIQKALEGPLRQIAENAGLEGSVIAEKVRNLEFNFGFNAM
HHCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCEEECCCCHH
TNEYEDLVAAGIIDPVKVTRSALQNAASIAAMVLTTECIVVDKPEDDKTPAGAGGGGMPD
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCCCCCCC
FD
CC
>Mature Secondary Structure 
AKQVVFDETARRALERGIDALANAVRVTLGPKGRNVVLEKKFGAPQIINDGVTIAKEIE
CCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEEEECCCCCCEECCCCHHHHHHH
LENKLENTGAQLIKEVASKTNDVAGDGTTTACVLAQSLVKEGLKNVAAGSNPMNLKRGME
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
KTVRHLVAELEKVAKPVEGSQAIAQVAAVSAGNDDEIGEMIARAMETVGKEGVITVEESK
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEECCC
SLTTELEVTEGMQFDRGYVSPYLVTDQERMEAVFDEPFLLITDKKISIITDLVPILEKVA
CCEEEEEHHCCCCCCCCCCCCEEECCHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHH
RAGRPLVIIAEDIEKEALATLVVNKLRGVLNVAAVKAPGFGDRRKAMLQDIAVLTDGEVI
HCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEE
SEDTGIKLENVTTDQLGKARKMTITKDNTTIVAEGNEAAVKARCAQIKQQIEETDSEYDR
CCCCCEEEECCCHHHHCCCEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
EKLQERLAKLSGGVAVIKVGAATETELKDRKLRIEDAVNATKAAIAEGIVPGGGTALLHL
HHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
AAGMGGFIDSLSGEEKIGARIIQKALEGPLRQIAENAGLEGSVIAEKVRNLEFNFGFNAM
HHCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCEEECCCCHH
TNEYEDLVAAGIIDPVKVTRSALQNAASIAAMVLTTECIVVDKPEDDKTPAGAGGGGMPD
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCCCCCCC
FD
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292