Click here to switch to the map view.

The map label for this gene is ribA [H]

Identifier: 37520557

GI number: 37520557

Start: 1053093

End: 1054811

Strand: Direct

Name: ribA [H]

Synonym: gvip130

Alternate gene names: 37520557

Gene position: 1053093-1054811 (Clockwise)

Preceding gene: 37520556

Following gene: 37520559

Centisome position: 22.6

GC content: 64.11

Gene sequence:

>1719_bases
GTGGCCACTGGTTTTCACTCCGTTCCCGAGATCCTGGACGAATTGCGCGCCGGCCGGGCGGTGGTGGTCGTCGACGACGA
GAACCGCGAGAACGAAGGCGATCTCATCTGTGCCGCCCAGTTCGCCTCCCCCGAAATGATCAACTTCATGGCCACCCACG
CCCGGGGCCTCATTTGCCTGGCGATGACCGCCGAGCGGCTCGACCAGTTGCAGTTGCCGCTGATGGTGAGCGAAAACACC
GACCGCAACCAGACGGCTTTTACCGTGAGCATCGACGCCGGCCCCCACCTGGGGGTGAGCACCGGCATCTCCGCCGCCGA
CCGGGCCAAGACCATCCAGGCGGCCATCGATTCGCGCACCCGTGCAGGCGACCTGACCCGCCCCGGCCACATCTTTCCGA
TCCGCGCCCGCGAGGGAGGCGTGCTGAAGCGCGCCGGTCACACCGAGGCGGCGGTCGATCTGGCGCGCATGGCGGGGCTG
TATCCGGCCGGGGTGATCTGCGAAATCCAGAACCCCGACGGTTCGATGTCGCGCCTGCCGGAACTGCTCCAGTACGCCCG
CACCTTCAACCTCAAGATTGTCACCATCGCCGAAATTATCGCCTACCGGCTGCAGAACGAACGCTTCATCAAGCGCGAGA
CGGTGGCGATGCTGCCTACCGCCTTCGGCAAATTCGAGATTTTTGCCTACCGCGACACCCTCGACGGCAAGGAACACGTC
GCCCTGGTGCGCCGTCCACCCGCGGGCTCGGGCCTTTTTGACGGGGCGCCGCCTTTTGCCGGCAGCGAGGAGCCGGTACT
GGTGCGCGTCCACTCCGAATGCCTGACCGGCGACACCTTCGGCTCGCTGCGCTGCGACTGCCGCCAGCAGTTGCAGGCTG
CCCTCAAGATGATCGACCACCACGGCCAGGGTGTGGTCGTCTATCTGCGCCAGGAGGGCCGCGGCATCGGGCTGATCAAC
AAGCTCAAAGCTTACGCCTTACAAGATATGGGCCTCGACACGGTCGAAGCGAACGAGCGGCTGGGGTTTGCCGCCGATCT
GCGCAGCTATGGCGTCGGCGCCCAGATCCTCAACGACCTGGGGGTGCACCGCATGAAATTGATCACCAACAATCCGCGCA
AGATCGCGGGCCTGAGCGGCTATAACCTCGAAGTGGTGGACCGCGTGCCCCTCATCATCGAAGAGACCGACTACAACTCC
ACCTACCTCAACACCAAAGCCCAGAAGCTCGGGCACCTGCTGCCGGGGGTGCGGCTTTTGACGCTGGGGGTGCTCTGGCG
TCGGGCGACTATGCAGCCCTACGACCCGGAGCGCTCCAATCAAGTCGAACTGCTGCGCGAACTGTTTGGTCAGCAGGATC
TGCTCATCCAGGAGGAGCGCCGCCCGGTGGCGAGCGCCGTCTTTGGGCCGGACGCCGTCGTGGTGCACATCGGGCTCCCT
TCTGCGGGCAACAAGAGCCCCAACGCTTGGTATACCGACCCGACGAGTGCTTGCCGCCGGGCGATCTTGGCCGCTTTGGA
GGAACTTGTGCAGAACAACCCACCGCAAGTGCTGCAATTTTTGGTCAGCTCCGGAGCTGATCCGCTCAATCACCTCAGCG
AACGCCTTCAGCATCGCGAAGAAGATCTAGCATCCCTGCCGGATGCCATCAAAGGACCGCTCTCCCCCGAGACTGTCTAC
ATCTTCAAAGCCGACGCCACCCAACCACCCACCTCCTGA

Upstream 100 bases:

>100_bases
GTGCGCTTCTGTCGGCCGGAACGCGCCATGTTCGTCCCAACGCTCCCGTTCGCGGGAGCGTTTTTGGTATCAATGAAGTG
ATCTACTAGGAGAGAAGAGC

Downstream 100 bases:

>100_bases
GCAGCCGGGCCATCTTCCTGAGATGCGCCGTAGGACACCGATGACGAATAGCTGAATCTCAGCCTCAATCACAAAAAATA
GCTACTATTCAAGCGAGACG

Product: bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 572; Mature: 571

Protein sequence:

>572_residues
MATGFHSVPEILDELRAGRAVVVVDDENRENEGDLICAAQFASPEMINFMATHARGLICLAMTAERLDQLQLPLMVSENT
DRNQTAFTVSIDAGPHLGVSTGISAADRAKTIQAAIDSRTRAGDLTRPGHIFPIRAREGGVLKRAGHTEAAVDLARMAGL
YPAGVICEIQNPDGSMSRLPELLQYARTFNLKIVTIAEIIAYRLQNERFIKRETVAMLPTAFGKFEIFAYRDTLDGKEHV
ALVRRPPAGSGLFDGAPPFAGSEEPVLVRVHSECLTGDTFGSLRCDCRQQLQAALKMIDHHGQGVVVYLRQEGRGIGLIN
KLKAYALQDMGLDTVEANERLGFAADLRSYGVGAQILNDLGVHRMKLITNNPRKIAGLSGYNLEVVDRVPLIIEETDYNS
TYLNTKAQKLGHLLPGVRLLTLGVLWRRATMQPYDPERSNQVELLRELFGQQDLLIQEERRPVASAVFGPDAVVVHIGLP
SAGNKSPNAWYTDPTSACRRAILAALEELVQNNPPQVLQFLVSSGADPLNHLSERLQHREEDLASLPDAIKGPLSPETVY
IFKADATQPPTS

Sequences:

>Translated_572_residues
MATGFHSVPEILDELRAGRAVVVVDDENRENEGDLICAAQFASPEMINFMATHARGLICLAMTAERLDQLQLPLMVSENT
DRNQTAFTVSIDAGPHLGVSTGISAADRAKTIQAAIDSRTRAGDLTRPGHIFPIRAREGGVLKRAGHTEAAVDLARMAGL
YPAGVICEIQNPDGSMSRLPELLQYARTFNLKIVTIAEIIAYRLQNERFIKRETVAMLPTAFGKFEIFAYRDTLDGKEHV
ALVRRPPAGSGLFDGAPPFAGSEEPVLVRVHSECLTGDTFGSLRCDCRQQLQAALKMIDHHGQGVVVYLRQEGRGIGLIN
KLKAYALQDMGLDTVEANERLGFAADLRSYGVGAQILNDLGVHRMKLITNNPRKIAGLSGYNLEVVDRVPLIIEETDYNS
TYLNTKAQKLGHLLPGVRLLTLGVLWRRATMQPYDPERSNQVELLRELFGQQDLLIQEERRPVASAVFGPDAVVVHIGLP
SAGNKSPNAWYTDPTSACRRAILAALEELVQNNPPQVLQFLVSSGADPLNHLSERLQHREEDLASLPDAIKGPLSPETVY
IFKADATQPPTS
>Mature_571_residues
ATGFHSVPEILDELRAGRAVVVVDDENRENEGDLICAAQFASPEMINFMATHARGLICLAMTAERLDQLQLPLMVSENTD
RNQTAFTVSIDAGPHLGVSTGISAADRAKTIQAAIDSRTRAGDLTRPGHIFPIRAREGGVLKRAGHTEAAVDLARMAGLY
PAGVICEIQNPDGSMSRLPELLQYARTFNLKIVTIAEIIAYRLQNERFIKRETVAMLPTAFGKFEIFAYRDTLDGKEHVA
LVRRPPAGSGLFDGAPPFAGSEEPVLVRVHSECLTGDTFGSLRCDCRQQLQAALKMIDHHGQGVVVYLRQEGRGIGLINK
LKAYALQDMGLDTVEANERLGFAADLRSYGVGAQILNDLGVHRMKLITNNPRKIAGLSGYNLEVVDRVPLIIEETDYNST
YLNTKAQKLGHLLPGVRLLTLGVLWRRATMQPYDPERSNQVELLRELFGQQDLLIQEERRPVASAVFGPDAVVVHIGLPS
AGNKSPNAWYTDPTSACRRAILAALEELVQNNPPQVLQFLVSSGADPLNHLSERLQHREEDLASLPDAIKGPLSPETVYI
FKADATQPPTS

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the central section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=206, Percent_Identity=49.5145631067961, Blast_Score=211, Evalue=1e-55,
Organism=Escherichia coli, GI1787533, Length=205, Percent_Identity=49.2682926829268, Blast_Score=195, Evalue=7e-51,
Organism=Saccharomyces cerevisiae, GI6320695, Length=206, Percent_Identity=40.2912621359223, Blast_Score=162, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6319438, Length=170, Percent_Identity=46.4705882352941, Blast_Score=135, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 62653; Mature: 62522

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATGFHSVPEILDELRAGRAVVVVDDENRENEGDLICAAQFASPEMINFMATHARGLICL
CCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHCCCEEEE
AMTAERLDQLQLPLMVSENTDRNQTAFTVSIDAGPHLGVSTGISAADRAKTIQAAIDSRT
EEHHHHHHHHCCCEEEECCCCCCCEEEEEEECCCCCCCHHCCCCHHHHHHHHHHHHHCCC
RAGDLTRPGHIFPIRAREGGVLKRAGHTEAAVDLARMAGLYPAGVICEIQNPDGSMSRLP
CCCCCCCCCCEEEEECCCCCCEECCCCHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHH
ELLQYARTFNLKIVTIAEIIAYRLQNERFIKRETVAMLPTAFGKFEIFAYRDTLDGKEHV
HHHHHHHHCCEEEEHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCE
ALVRRPPAGSGLFDGAPPFAGSEEPVLVRVHSECLTGDTFGSLRCDCRQQLQAALKMIDH
EEEECCCCCCCCCCCCCCCCCCCCCEEEEEECHHHCCCCCCCHHHHHHHHHHHHHHHHHC
HGQGVVVYLRQEGRGIGLINKLKAYALQDMGLDTVEANERLGFAADLRSYGVGAQILNDL
CCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHC
GVHRMKLITNNPRKIAGLSGYNLEVVDRVPLIIEETDYNSTYLNTKAQKLGHLLPGVRLL
CHHEEEEEECCCCEEECCCCCCEEEECCCCEEEEECCCCCEEECCHHHHHHHHCCCHHHH
TLGVLWRRATMQPYDPERSNQVELLRELFGQQDLLIQEERRPVASAVFGPDAVVVHIGLP
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCEEEEHHCCCHHHHHCCCCEEEEEEECC
SAGNKSPNAWYTDPTSACRRAILAALEELVQNNPPQVLQFLVSSGADPLNHLSERLQHRE
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHH
EDLASLPDAIKGPLSPETVYIFKADATQPPTS
HHHHHCCHHHCCCCCCCEEEEEECCCCCCCCC
>Mature Secondary Structure 
ATGFHSVPEILDELRAGRAVVVVDDENRENEGDLICAAQFASPEMINFMATHARGLICL
CCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHCCCEEEE
AMTAERLDQLQLPLMVSENTDRNQTAFTVSIDAGPHLGVSTGISAADRAKTIQAAIDSRT
EEHHHHHHHHCCCEEEECCCCCCCEEEEEEECCCCCCCHHCCCCHHHHHHHHHHHHHCCC
RAGDLTRPGHIFPIRAREGGVLKRAGHTEAAVDLARMAGLYPAGVICEIQNPDGSMSRLP
CCCCCCCCCCEEEEECCCCCCEECCCCHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHH
ELLQYARTFNLKIVTIAEIIAYRLQNERFIKRETVAMLPTAFGKFEIFAYRDTLDGKEHV
HHHHHHHHCCEEEEHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCE
ALVRRPPAGSGLFDGAPPFAGSEEPVLVRVHSECLTGDTFGSLRCDCRQQLQAALKMIDH
EEEECCCCCCCCCCCCCCCCCCCCCEEEEEECHHHCCCCCCCHHHHHHHHHHHHHHHHHC
HGQGVVVYLRQEGRGIGLINKLKAYALQDMGLDTVEANERLGFAADLRSYGVGAQILNDL
CCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHC
GVHRMKLITNNPRKIAGLSGYNLEVVDRVPLIIEETDYNSTYLNTKAQKLGHLLPGVRLL
CHHEEEEEECCCCEEECCCCCCEEEECCCCEEEEECCCCCEEECCHHHHHHHHCCCHHHH
TLGVLWRRATMQPYDPERSNQVELLRELFGQQDLLIQEERRPVASAVFGPDAVVVHIGLP
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCEEEEHHCCCHHHHHCCCCEEEEEEECC
SAGNKSPNAWYTDPTSACRRAILAALEELVQNNPPQVLQFLVSSGADPLNHLSERLQHRE
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHH
EDLASLPDAIKGPLSPETVYIFKADATQPPTS
HHHHHCCHHHCCCCCCCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]