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The map label for this gene is hemG [H]

Identifier: 37520512

GI number: 37520512

Start: 999853

End: 1001253

Strand: Direct

Name: hemG [H]

Synonym: gvip126

Alternate gene names: 37520512

Gene position: 999853-1001253 (Clockwise)

Preceding gene: 37520511

Following gene: 37520513

Centisome position: 21.46

GC content: 66.67

Gene sequence:

>1401_bases
ATGAACACGGCCGAGGAATTGCTGGATGTACTGGTGGTGGGCGCTGGCCTGAGCGGGCTGGCGCTCGCCTGGAAACTCAA
GCGGGCCGGCTGCACGTTCTTGGTCTGTCAGGCGGGCGAGCGGGTGGGCGGAGCGATCACCACCGCGATCGCCGACGGTT
TTGTATGCGAGGGGGGTCCGAACAGTTTTCAAGAATCCCCACCCCTCATCGAGCTGTTGACCCAGTTGCAACTCGAAGAT
CAAATCGTCACCGCCGATCCGCGCCTGGCGCGCTTTGTTTGGTGGGAGAACCGCCTGCGCTCGGTGCCGCTCACCCCGGC
GCAGCTGGTGCGCTCCGACTTACTCAGTTGGTCCGGTAAAGCCCGGCTGCTGTGGGAGTTGTTCGTCCCGGCCCTAGGCG
AGCCCCGCGAGGAGACGGTGGCCGAATTTGTCCTGCGCCGCTTCGGCGAAGAAGTCCTCTCGCGGCTGGTCGATCCGCTG
GTTTCGGGGATGTGCGCGGGCGATGTCGGCCAGTTGAGCATCGAAGCCACCTTCGAGCGGCTGGTCGATCTGGAGCGCCG
CCACGGCGGGGTGCTGCGGGGTTTGTGGCGGACTGCCCGCACCCGCCCACCCTTCAAGCGCCTCTGCACGTTGCGCGGCG
GCCTGGAGCAGTTGCCCCAGGCACTCGCCCAGCGCCTGCAGCCGCAAATCCTGCTTTCCCACCGCCTCGAGGCGCTTGAA
CACCTGGCCGGGGATCGCTGGCGGGCGGTGGTGGCCGGTCCGCAGGGCGAGCCGGTGGCAATTGCGGCGCGCACGGTGAT
TCTGTCGGGTTCCGCCCACGCCATGGCTTCGGTCTTGCGTCCCCTGGACGCCGGTCTCGGACGCGCCCTTGAAAGCATTT
ACTACCCACCGGTCGTGAGCATCAGTCTCGCCTACTCCAAAAGCCAGGTGCCCAACGCGCCGGAGGGCTTCGGGCATTTG
ATTCCCCGCAACCAGACCCTGCGCAGTCTCGGGGTGATCTGGAACAGCAGCCTCTTTCCCCATACCGCCCCACCCAACTG
GCGGCTCTATACCTGTTTTGTGGGCGGCACCACCGATCCGGCCACCCCCAACCTCAGCGACACCGAACTGGCCAGCCTCG
CCCACCGCGAACTGCAGACGGTCCTCGGTTTCCAGGCGGGCTATCAACTGCTGCGCGTGACGCGCTGGCCCCAGGCCATC
CCCCAGTACGCCCTCGGCCATCCCAGCAAGCAGGAGCGGGTCGAACGGGCGCTGTTGGGACTGCCGGGGTTGTTCCTGGT
CGGCAATTACTTCGGCGGCATCTCCCTGGGAGATTGCGTGCGCCATTCCGGTGCGGTCGCCTCCCGCGTACTGCAGTTTT
TAACCACGGTGGCCAGCAACGGCAGCCTGCGCCCGGCCTGA

Upstream 100 bases:

>100_bases
TCGGCAATGTTTCGTCGCGGAACATTGCCCGCGGCAGCGCACGGGGAGATCCCGGGGAAGGGCGGTCGTGTCATAGTTGG
CAAAGAGACTGATTCGGGCA

Downstream 100 bases:

>100_bases
GCCCGGATAGACTGAATAGATGAAGCAATATTGCGAAGTCGGGCCGCTGGCGGACTGGTGGCCTGGGGAGCGCGCCGAAG
CGATCGCCCTGGGTGCCCTG

Product: protoporphyrinogen oxidase

Products: NA

Alternate protein names: PPO [H]

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MNTAEELLDVLVVGAGLSGLALAWKLKRAGCTFLVCQAGERVGGAITTAIADGFVCEGGPNSFQESPPLIELLTQLQLED
QIVTADPRLARFVWWENRLRSVPLTPAQLVRSDLLSWSGKARLLWELFVPALGEPREETVAEFVLRRFGEEVLSRLVDPL
VSGMCAGDVGQLSIEATFERLVDLERRHGGVLRGLWRTARTRPPFKRLCTLRGGLEQLPQALAQRLQPQILLSHRLEALE
HLAGDRWRAVVAGPQGEPVAIAARTVILSGSAHAMASVLRPLDAGLGRALESIYYPPVVSISLAYSKSQVPNAPEGFGHL
IPRNQTLRSLGVIWNSSLFPHTAPPNWRLYTCFVGGTTDPATPNLSDTELASLAHRELQTVLGFQAGYQLLRVTRWPQAI
PQYALGHPSKQERVERALLGLPGLFLVGNYFGGISLGDCVRHSGAVASRVLQFLTTVASNGSLRPA

Sequences:

>Translated_466_residues
MNTAEELLDVLVVGAGLSGLALAWKLKRAGCTFLVCQAGERVGGAITTAIADGFVCEGGPNSFQESPPLIELLTQLQLED
QIVTADPRLARFVWWENRLRSVPLTPAQLVRSDLLSWSGKARLLWELFVPALGEPREETVAEFVLRRFGEEVLSRLVDPL
VSGMCAGDVGQLSIEATFERLVDLERRHGGVLRGLWRTARTRPPFKRLCTLRGGLEQLPQALAQRLQPQILLSHRLEALE
HLAGDRWRAVVAGPQGEPVAIAARTVILSGSAHAMASVLRPLDAGLGRALESIYYPPVVSISLAYSKSQVPNAPEGFGHL
IPRNQTLRSLGVIWNSSLFPHTAPPNWRLYTCFVGGTTDPATPNLSDTELASLAHRELQTVLGFQAGYQLLRVTRWPQAI
PQYALGHPSKQERVERALLGLPGLFLVGNYFGGISLGDCVRHSGAVASRVLQFLTTVASNGSLRPA
>Mature_466_residues
MNTAEELLDVLVVGAGLSGLALAWKLKRAGCTFLVCQAGERVGGAITTAIADGFVCEGGPNSFQESPPLIELLTQLQLED
QIVTADPRLARFVWWENRLRSVPLTPAQLVRSDLLSWSGKARLLWELFVPALGEPREETVAEFVLRRFGEEVLSRLVDPL
VSGMCAGDVGQLSIEATFERLVDLERRHGGVLRGLWRTARTRPPFKRLCTLRGGLEQLPQALAQRLQPQILLSHRLEALE
HLAGDRWRAVVAGPQGEPVAIAARTVILSGSAHAMASVLRPLDAGLGRALESIYYPPVVSISLAYSKSQVPNAPEGFGHL
IPRNQTLRSLGVIWNSSLFPHTAPPNWRLYTCFVGGTTDPATPNLSDTELASLAHRELQTVLGFQAGYQLLRVTRWPQAI
PQYALGHPSKQERVERALLGLPGLFLVGNYFGGISLGDCVRHSGAVASRVLQFLTTVASNGSLRPA

Specific function: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. May have an essential extracellular function during development, possibly as a pheromone [H]

COG id: COG1232

COG function: function code H; Protoporphyrinogen oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protoporphyrinogen oxidase family [H]

Homologues:

Organism=Homo sapiens, GI170650615, Length=481, Percent_Identity=31.6008316008316, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI4506001, Length=481, Percent_Identity=31.6008316008316, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24649745, Length=473, Percent_Identity=23.4672304439746, Blast_Score=99, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002937
- InterPro:   IPR016040
- InterPro:   IPR004572 [H]

Pfam domain/function: PF01593 Amino_oxidase [H]

EC number: =1.3.3.4 [H]

Molecular weight: Translated: 50718; Mature: 50718

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTAEELLDVLVVGAGLSGLALAWKLKRAGCTFLVCQAGERVGGAITTAIADGFVCEGGP
CCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEECCCCHHCHHHHHHHHCCCEECCCC
NSFQESPPLIELLTQLQLEDQIVTADPRLARFVWWENRLRSVPLTPAQLVRSDLLSWSGK
CCCCCCCCHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCC
ARLLWELFVPALGEPREETVAEFVLRRFGEEVLSRLVDPLVSGMCAGDVGQLSIEATFER
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
LVDLERRHGGVLRGLWRTARTRPPFKRLCTLRGGLEQLPQALAQRLQPQILLSHRLEALE
HHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHH
HLAGDRWRAVVAGPQGEPVAIAARTVILSGSAHAMASVLRPLDAGLGRALESIYYPPVVS
HHCCCCEEEEEECCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
ISLAYSKSQVPNAPEGFGHLIPRNQTLRSLGVIWNSSLFPHTAPPNWRLYTCFVGGTTDP
EEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCC
ATPNLSDTELASLAHRELQTVLGFQAGYQLLRVTRWPQAIPQYALGHPSKQERVERALLG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCHHHHHHHHHHC
LPGLFLVGNYFGGISLGDCVRHSGAVASRVLQFLTTVASNGSLRPA
CCHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MNTAEELLDVLVVGAGLSGLALAWKLKRAGCTFLVCQAGERVGGAITTAIADGFVCEGGP
CCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEECCCCHHCHHHHHHHHCCCEECCCC
NSFQESPPLIELLTQLQLEDQIVTADPRLARFVWWENRLRSVPLTPAQLVRSDLLSWSGK
CCCCCCCCHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCC
ARLLWELFVPALGEPREETVAEFVLRRFGEEVLSRLVDPLVSGMCAGDVGQLSIEATFER
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
LVDLERRHGGVLRGLWRTARTRPPFKRLCTLRGGLEQLPQALAQRLQPQILLSHRLEALE
HHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHH
HLAGDRWRAVVAGPQGEPVAIAARTVILSGSAHAMASVLRPLDAGLGRALESIYYPPVVS
HHCCCCEEEEEECCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
ISLAYSKSQVPNAPEGFGHLIPRNQTLRSLGVIWNSSLFPHTAPPNWRLYTCFVGGTTDP
EEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCC
ATPNLSDTELASLAHRELQTVLGFQAGYQLLRVTRWPQAIPQYALGHPSKQERVERALLG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCHHHHHHHHHHC
LPGLFLVGNYFGGISLGDCVRHSGAVASRVLQFLTTVASNGSLRPA
CCHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1372277; 8621504 [H]