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The map label for this gene is 37520468

Identifier: 37520468

GI number: 37520468

Start: 955562

End: 956467

Strand: Reverse

Name: 37520468

Synonym: gll0899

Alternate gene names: NA

Gene position: 956467-955562 (Counterclockwise)

Preceding gene: 37520469

Following gene: 37520466

Centisome position: 20.53

GC content: 58.39

Gene sequence:

>906_bases
ATGAAACGGACAATGGCATTGTTGTTTGCTGTGCTTGTTTGTGGCGCCGTGCCCTCTCAAGCAGCTGGAGAGCCAGGTTT
TGCGGTCGGCGGTTTTCTTTTTGAATCCAAAGAAGCGTTCATCGGCAGTGGTGCCCGTTGCGCCGCCGCTTCGCCGAACC
CGGCGGTGATTAAGGAAGTGCAGCAGAGAATCGACAAATGGCTCATCGAGCGGCGCAACAAGTCCAACATTGCTGCCCCC
CAGCGCGGTGCCAGCGTCCCGGTGGCTTTTCACGTCATCTCCAGCGGCTCCACAGGCAACCTTTCCGACACTGATGTCTA
CAATCAGATCGCCGTTTTGAACTCGGCCTACGGCGGTACCGGCTTTTCTTTTTATGTGCAGTCGATCGACCGCACCGACA
ATGCCACCTGGTTTGCAATGACGCCCGGTTCAAGCGCCGAGCGCGAAGCCAAATCGGCCCTTGCGGTCTCGCCCACCTCG
ACGCTCAATTTTTATACGGCCAATCCCAGCGGCGGTTTACTGGGCTGGGCGACTTTTCCCTGGTCGCTCTCGAGCGACCC
GACCAATGACGGTGTCGTGGTGTTGTACTCCTCTTTGCCCGGCGGCAGTGCCTTTCCATTTAACGAAGGCGACACGGGTA
CCCACGAAGTCGGGCATTGGCTGGGTCTCTATCACACCTTCCAGGGCGGCTGCTCTTACTACGGCGATTATGTCGGCGAC
ACTCCCAGCGAGAGTTCTCCCGCTTCCGGATGCCCCGTCGGTCGCGACACCTGCAGCGCATCCGGTCTCGATCCGATCGA
AAACTTTATGGATTACTCCGACGACGGTTGCATGTTTCAATTTACCGCCGGCCAGGTAAGCCGCATGCAGGCTGCCCGCG
ACATCTATCGACCCTTCCTGCCTTAG

Upstream 100 bases:

>100_bases
TTTATTTGCAATTTAAGTAATTGTTCGTATATATGCAAACCGTTTTGGGCTGTGGTGGATGCTACGGTAACCACCCGTAG
AGTTAAGTAGTGGTTACCCA

Downstream 100 bases:

>100_bases
CCTGGTGCGCATCGACGCTGCAGCCCCTTTTCTGACTCAGAAAAGGGGCTGCGGCACGGGCTCTGGGCAGTGGAAGGTCG
GCTCCGTCGCTAGGGGGCCT

Product: metalloprotease MEP1-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MKRTMALLFAVLVCGAVPSQAAGEPGFAVGGFLFESKEAFIGSGARCAAASPNPAVIKEVQQRIDKWLIERRNKSNIAAP
QRGASVPVAFHVISSGSTGNLSDTDVYNQIAVLNSAYGGTGFSFYVQSIDRTDNATWFAMTPGSSAEREAKSALAVSPTS
TLNFYTANPSGGLLGWATFPWSLSSDPTNDGVVVLYSSLPGGSAFPFNEGDTGTHEVGHWLGLYHTFQGGCSYYGDYVGD
TPSESSPASGCPVGRDTCSASGLDPIENFMDYSDDGCMFQFTAGQVSRMQAARDIYRPFLP

Sequences:

>Translated_301_residues
MKRTMALLFAVLVCGAVPSQAAGEPGFAVGGFLFESKEAFIGSGARCAAASPNPAVIKEVQQRIDKWLIERRNKSNIAAP
QRGASVPVAFHVISSGSTGNLSDTDVYNQIAVLNSAYGGTGFSFYVQSIDRTDNATWFAMTPGSSAEREAKSALAVSPTS
TLNFYTANPSGGLLGWATFPWSLSSDPTNDGVVVLYSSLPGGSAFPFNEGDTGTHEVGHWLGLYHTFQGGCSYYGDYVGD
TPSESSPASGCPVGRDTCSASGLDPIENFMDYSDDGCMFQFTAGQVSRMQAARDIYRPFLP
>Mature_301_residues
MKRTMALLFAVLVCGAVPSQAAGEPGFAVGGFLFESKEAFIGSGARCAAASPNPAVIKEVQQRIDKWLIERRNKSNIAAP
QRGASVPVAFHVISSGSTGNLSDTDVYNQIAVLNSAYGGTGFSFYVQSIDRTDNATWFAMTPGSSAEREAKSALAVSPTS
TLNFYTANPSGGLLGWATFPWSLSSDPTNDGVVVLYSSLPGGSAFPFNEGDTGTHEVGHWLGLYHTFQGGCSYYGDYVGD
TPSESSPASGCPVGRDTCSASGLDPIENFMDYSDDGCMFQFTAGQVSRMQAARDIYRPFLP

Specific function: Metalloprotease which in vitro specifically cleaves IGFBP-2 to -6, insulin, and extracellular matrix proteins but not IGFBP-1 or IGF-II. Shows a preference for substrates with an arginine in the P1' position, the first position downstream of the scissile

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M43B family [H]

Homologues:

Organism=Homo sapiens, GI116174738, Length=170, Percent_Identity=34.7058823529412, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI38045915, Length=169, Percent_Identity=33.1360946745562, Blast_Score=68, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008754 [H]

Pfam domain/function: PF05572 Peptidase_M43 [H]

EC number: NA

Molecular weight: Translated: 31838; Mature: 31838

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRTMALLFAVLVCGAVPSQAAGEPGFAVGGFLFESKEAFIGSGARCAAASPNPAVIKEV
CCHHHHHHHHHHHHCCCCCCCCCCCCCEECCEEECCCHHHHCCCCEEECCCCCHHHHHHH
QQRIDKWLIERRNKSNIAAPQRGASVPVAFHVISSGSTGNLSDTDVYNQIAVLNSAYGGT
HHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCC
GFSFYVQSIDRTDNATWFAMTPGSSAEREAKSALAVSPTSTLNFYTANPSGGLLGWATFP
CCEEHEEHHCCCCCCEEEEECCCCCHHHHHHHHEEECCCCCEEEEEECCCCCEEEEEECC
WSLSSDPTNDGVVVLYSSLPGGSAFPFNEGDTGTHEVGHWLGLYHTFQGGCSYYGDYVGD
CCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHCCCCCCC
TPSESSPASGCPVGRDTCSASGLDPIENFMDYSDDGCMFQFTAGQVSRMQAARDIYRPFL
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHCCC
P
C
>Mature Secondary Structure
MKRTMALLFAVLVCGAVPSQAAGEPGFAVGGFLFESKEAFIGSGARCAAASPNPAVIKEV
CCHHHHHHHHHHHHCCCCCCCCCCCCCEECCEEECCCHHHHCCCCEEECCCCCHHHHHHH
QQRIDKWLIERRNKSNIAAPQRGASVPVAFHVISSGSTGNLSDTDVYNQIAVLNSAYGGT
HHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCC
GFSFYVQSIDRTDNATWFAMTPGSSAEREAKSALAVSPTSTLNFYTANPSGGLLGWATFP
CCEEHEEHHCCCCCCEEEEECCCCCHHHHHHHHEEECCCCCEEEEEECCCCCEEEEEECC
WSLSSDPTNDGVVVLYSSLPGGSAFPFNEGDTGTHEVGHWLGLYHTFQGGCSYYGDYVGD
CCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHCCCCCCC
TPSESSPASGCPVGRDTCSASGLDPIENFMDYSDDGCMFQFTAGQVSRMQAARDIYRPFL
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHCCC
P
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]