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The map label for this gene is macA [H]

Identifier: 37520374

GI number: 37520374

Start: 856360

End: 857640

Strand: Direct

Name: macA [H]

Synonym: glr0805

Alternate gene names: 37520374

Gene position: 856360-857640 (Clockwise)

Preceding gene: 37520372

Following gene: 37520375

Centisome position: 18.38

GC content: 70.73

Gene sequence:

>1281_bases
ATGGGAGGAGCAATCATGCGTCCATCTCTCGAAGGCATCGAGAACCCGCCCCCAACCGCGCACGGTGGAGCGATCGCCTC
CCCGGCGAAGCGCTCGGGATTGGCAGTCCGCCTGCTGGTGTTGGCCGGGATTGGGCTTGCCGGGGTGCTCGTCTTTGTCC
TCACCCGGCCGGCGCCCGAAGCGAGTGAGGCGGCCCGGCCGCCCGCGGCTTTGAGCGTTACCGTCGAGCCTGTCCAGAAA
CGCCTATTAGCCAGGACGCTCATGGTCACCGGTTCGATCGCCGCCTGGGACGAGTTGCCCATCGGGGCCGAGCTGACCGG
ACTGCGCATCGAGGGTGTCTACGTCGAAGAAGGCGAGCGGGTGCAGCGCGGTCAGTTGCTCGCCCGCCTTAACGACCGGC
CCCTGCGCGCCCAGATCCGGCAGGTCGAGGCGGAGATTGCCCGCGGCCGGGCGCTGATTGCCCAGAGCCGCGCGAACTTT
GCGGAGGCGAGGGCGCTGCGCGGCGAGGCGGAGGCCAACCGGCACCGCTTCGACGACCTGCAGCGCCAGGGGGCGATTAG
CGAAGTGGAGGCGACCGCGCGGCGCACCAGCGCCGACACGTATGGGGCGCGCTTGGGAGGCGCTTCGCAGGCGATTGCCG
TGGCCGAGAGCGATCTGGCCCGCGCCGAGGCGCGGCGCGAAGAGTTGCTCGCCATGCTCGCCCAGACGCGGATCACCGCT
CCTGCGGAGGGACTGATCAGCAAACGCCAGGCAAAACTCGGCAGTGTGGTCAGTCCCCTGAGCGCCCAGGCGCTCTTCAC
CCTCGTGCGCGACCGGCGCCTGGAGTTGCAGGCGGAGGTGAGCGAAGTGCGCCTGGGGGCGATTGCCCCGGGGCAGGCGG
TCGCTGTGCAGACCGATGCGCTCCCGGAACGCCGCTTCGCAGGGCGCGTGCGCGAAATTGCCCCGGCCGTGGACGCGGGC
AGCCGCAACGCCCTGGTGAAAATCGATCTCCCGCTCGATCCGGCTTTGCGGCCGGGCATGTTCGCCCGCGGCGAGTTGCG
CTTCGGTGCCGGCCCGGCGCTCGCGGTCCCCGAGGGAGCCCTGATCTTCGACAACGGCCGCGCCCACCTCTTTGTCGTCC
AGGGTGAGAAGGCCGTGCGCCGCGCAGTCGAGACCGGGGCGCGCTCCGGCGGACAGGTGGAGATCACCGGCGGGCTTGCA
GCCGGGGAGCAAATCGTGCTCGCCGGGGCGGGATATCTCAAAGACGGCGCGCGCGTGCGCACAGCGGGAGGCGCGTCATG
A

Upstream 100 bases:

>100_bases
ATTCTGTTCCGGTTGCGGCACTCCTGCCCCTGGTGGGGGCGGCTTGCACGTAGAGAATGAGTAGCCATCCGCAGGCCCTG
GGCTTGGCGGCCACTTTCCC

Downstream 100 bases:

>100_bases
ACAACCTCTCGGCCTGGTCGATTCGCCATCCGATCGTGATTGCGGTGCTGTTTATCGCCCTGGTGATTGCAGGAGTGGTG
GGCTTTGTGCAACTGCCCAT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MGGAIMRPSLEGIENPPPTAHGGAIASPAKRSGLAVRLLVLAGIGLAGVLVFVLTRPAPEASEAARPPAALSVTVEPVQK
RLLARTLMVTGSIAAWDELPIGAELTGLRIEGVYVEEGERVQRGQLLARLNDRPLRAQIRQVEAEIARGRALIAQSRANF
AEARALRGEAEANRHRFDDLQRQGAISEVEATARRTSADTYGARLGGASQAIAVAESDLARAEARREELLAMLAQTRITA
PAEGLISKRQAKLGSVVSPLSAQALFTLVRDRRLELQAEVSEVRLGAIAPGQAVAVQTDALPERRFAGRVREIAPAVDAG
SRNALVKIDLPLDPALRPGMFARGELRFGAGPALAVPEGALIFDNGRAHLFVVQGEKAVRRAVETGARSGGQVEITGGLA
AGEQIVLAGAGYLKDGARVRTAGGAS

Sequences:

>Translated_426_residues
MGGAIMRPSLEGIENPPPTAHGGAIASPAKRSGLAVRLLVLAGIGLAGVLVFVLTRPAPEASEAARPPAALSVTVEPVQK
RLLARTLMVTGSIAAWDELPIGAELTGLRIEGVYVEEGERVQRGQLLARLNDRPLRAQIRQVEAEIARGRALIAQSRANF
AEARALRGEAEANRHRFDDLQRQGAISEVEATARRTSADTYGARLGGASQAIAVAESDLARAEARREELLAMLAQTRITA
PAEGLISKRQAKLGSVVSPLSAQALFTLVRDRRLELQAEVSEVRLGAIAPGQAVAVQTDALPERRFAGRVREIAPAVDAG
SRNALVKIDLPLDPALRPGMFARGELRFGAGPALAVPEGALIFDNGRAHLFVVQGEKAVRRAVETGARSGGQVEITGGLA
AGEQIVLAGAGYLKDGARVRTAGGAS
>Mature_425_residues
GGAIMRPSLEGIENPPPTAHGGAIASPAKRSGLAVRLLVLAGIGLAGVLVFVLTRPAPEASEAARPPAALSVTVEPVQKR
LLARTLMVTGSIAAWDELPIGAELTGLRIEGVYVEEGERVQRGQLLARLNDRPLRAQIRQVEAEIARGRALIAQSRANFA
EARALRGEAEANRHRFDDLQRQGAISEVEATARRTSADTYGARLGGASQAIAVAESDLARAEARREELLAMLAQTRITAP
AEGLISKRQAKLGSVVSPLSAQALFTLVRDRRLELQAEVSEVRLGAIAPGQAVAVQTDALPERRFAGRVREIAPAVDAGS
RNALVKIDLPLDPALRPGMFARGELRFGAGPALAVPEGALIFDNGRAHLFVVQGEKAVRRAVETGARSGGQVEITGGLAA
GEQIVLAGAGYLKDGARVRTAGGAS

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=392, Percent_Identity=23.9795918367347, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87082036, Length=344, Percent_Identity=22.3837209302326, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1790012, Length=249, Percent_Identity=23.2931726907631, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 44660; Mature: 44529

Theoretical pI: Translated: 10.81; Mature: 10.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGAIMRPSLEGIENPPPTAHGGAIASPAKRSGLAVRLLVLAGIGLAGVLVFVLTRPAPE
CCCCCCCCCHHCCCCCCCCCCCCCCCCCHHHCCHHEEHHHHHCCCHHHHHHHHHCCCCCC
ASEAARPPAALSVTVEPVQKRLLARTLMVTGSIAAWDELPIGAELTGLRIEGVYVEEGER
HHHHCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECEEEEEEEECCCCH
VQRGQLLARLNDRPLRAQIRQVEAEIARGRALIAQSRANFAEARALRGEAEANRHRFDDL
HHHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
QRQGAISEVEATARRTSADTYGARLGGASQAIAVAESDLARAEARREELLAMLAQTRITA
HHCCCHHHHHHHHHHCCCCHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCC
PAEGLISKRQAKLGSVVSPLSAQALFTLVRDRRLELQAEVSEVRLGAIAPGQAVAVQTDA
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEECCC
LPERRFAGRVREIAPAVDAGSRNALVKIDLPLDPALRPGMFARGELRFGAGPALAVPEGA
CCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEECCCCCEECCCCE
LIFDNGRAHLFVVQGEKAVRRAVETGARSGGQVEITGGLAAGEQIVLAGAGYLKDGARVR
EEEECCCEEEEEEECHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEECCCCCCCCCEEE
TAGGAS
CCCCCC
>Mature Secondary Structure 
GGAIMRPSLEGIENPPPTAHGGAIASPAKRSGLAVRLLVLAGIGLAGVLVFVLTRPAPE
CCCCCCCCHHCCCCCCCCCCCCCCCCCHHHCCHHEEHHHHHCCCHHHHHHHHHCCCCCC
ASEAARPPAALSVTVEPVQKRLLARTLMVTGSIAAWDELPIGAELTGLRIEGVYVEEGER
HHHHCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECEEEEEEEECCCCH
VQRGQLLARLNDRPLRAQIRQVEAEIARGRALIAQSRANFAEARALRGEAEANRHRFDDL
HHHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
QRQGAISEVEATARRTSADTYGARLGGASQAIAVAESDLARAEARREELLAMLAQTRITA
HHCCCHHHHHHHHHHCCCCHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCC
PAEGLISKRQAKLGSVVSPLSAQALFTLVRDRRLELQAEVSEVRLGAIAPGQAVAVQTDA
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEECCC
LPERRFAGRVREIAPAVDAGSRNALVKIDLPLDPALRPGMFARGELRFGAGPALAVPEGA
CCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEECCCCCEECCCCE
LIFDNGRAHLFVVQGEKAVRRAVETGARSGGQVEITGGLAAGEQIVLAGAGYLKDGARVR
EEEECCCEEEEEEECHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEECCCCCCCCCEEE
TAGGAS
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]