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The map label for this gene is fdh [H]

Identifier: 37520304

GI number: 37520304

Start: 787028

End: 788200

Strand: Reverse

Name: fdh [H]

Synonym: gll0735

Alternate gene names: 37520304

Gene position: 788200-787028 (Counterclockwise)

Preceding gene: 37520305

Following gene: 37520300

Centisome position: 16.92

GC content: 61.21

Gene sequence:

>1173_bases
ATGAAAGCGGTTTGCTGGCACGGTGCGGGCGATGTGCGGGTTGAGACCGTCCCGGATCCGGCCATTCTTTATCCTCGCGA
CGCCATTATCAAAGTAACCTCCACGGCCATCTGCGGCTCGGATTTGCACCTCTATGACGGGGTGATCCCGACGATGCAAA
AAGGCGACATTCTTGGCCACGAATTCATGGGCGAAGTGGTCGAAGTCGGGGCGGCCGTCAAGAACCTGCGCAAGGGCGAT
CGCGTGGTGGTGCCCTTCACCATCGCCTGCGGCCACTGCCACTTCTGCGAGCGGACGCTGTGGTCGCTGTGCGACAACTC
CAACCCCAATGCCTGGATGGCCGAGAAAGTCTACGGATCTACCTCCGGTTCCGGGCTTTTTGGGTATTCGCACCTGTTCG
GAGGCTACGCGGGCGGACAGGCGGAGTACGTGCGGGTTCCCTTCGCGGATACCGGACCGATGAAGGTACCCGAAAGCCTG
ACGGACGAGCAAGTGTTGTTCTTGACCGACATCTTTCCGACCGGTTATATGGCGGCGGAGAACTGCAACATCCAGCCGGG
GGACACGGTGGCGGTCTGGGGTTGCGGGCCGGTTGGGCAGTTTGCGATTAAAAGTGCCTACATGCTCGGGGCGGACCGGG
TGATCGGTATCGACCGCCATCCCAAGCGCCTCAAAATGGCCAAGGAGCAGGGGGGTGCCGAGGTGCTCAACCTCGACGAG
GTAGAGGTGGGTGAGGCCCTTAAAGAAATGACCGGCGGTTGGGGGCCGAGCCACTGCATCGACGCGGTGGGTCTGGAAGC
CCACGGCAGCGGCATCGAAGGGATTTACGACAACGTCATGAACGCCTTGAAGCTGGAGACCGACAAGCCCGCCGCCCTGC
GCCAGGCAATCGTCGCCTGCCGCAAAGGCGGCACAGTCTCGATCCCCGGCGTCTACGGCGGCCTACTCGACAAGATGCCC
ATGGGGGCGGCGTTTGCCAAGGGGCTTACCTTCAAGATGGGCCAGACCCATGTCCACCGCTACTTGCAACCACTGTTGGA
ACGCATCGTGCAGGGCGAACTCGATCCGACTTTCGTGATCACCCACCGCCTCAAACTCGACGACGCACCGGAAGGCTACC
GGACCTTCCGCGATCAAAAAGACGACTGTATCAAGGTTGTGCTCAAGCCTTGA

Upstream 100 bases:

>100_bases
GACGATCTGCGCCGCTTCAAACAACTTATGGAAGCGGGCGAGCTTATTTCCACCGACGGCCAACCCACCGGTCAGCGCTA
ATCCACCCATAGGAGCGATT

Downstream 100 bases:

>100_bases
CTTGTGGCATCAAACCAGCAACTCGGCGCGGACGGCCGGCTTACACCGTCTAGCGCCGGCCGCCTCGTGTAGGCCGGTAA
GCAATTGCTCTGTCTGTTCC

Product: Zn-dependent alcohol dehydrogenase

Products: NA

Alternate protein names: Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MKAVCWHGAGDVRVETVPDPAILYPRDAIIKVTSTAICGSDLHLYDGVIPTMQKGDILGHEFMGEVVEVGAAVKNLRKGD
RVVVPFTIACGHCHFCERTLWSLCDNSNPNAWMAEKVYGSTSGSGLFGYSHLFGGYAGGQAEYVRVPFADTGPMKVPESL
TDEQVLFLTDIFPTGYMAAENCNIQPGDTVAVWGCGPVGQFAIKSAYMLGADRVIGIDRHPKRLKMAKEQGGAEVLNLDE
VEVGEALKEMTGGWGPSHCIDAVGLEAHGSGIEGIYDNVMNALKLETDKPAALRQAIVACRKGGTVSIPGVYGGLLDKMP
MGAAFAKGLTFKMGQTHVHRYLQPLLERIVQGELDPTFVITHRLKLDDAPEGYRTFRDQKDDCIKVVLKP

Sequences:

>Translated_390_residues
MKAVCWHGAGDVRVETVPDPAILYPRDAIIKVTSTAICGSDLHLYDGVIPTMQKGDILGHEFMGEVVEVGAAVKNLRKGD
RVVVPFTIACGHCHFCERTLWSLCDNSNPNAWMAEKVYGSTSGSGLFGYSHLFGGYAGGQAEYVRVPFADTGPMKVPESL
TDEQVLFLTDIFPTGYMAAENCNIQPGDTVAVWGCGPVGQFAIKSAYMLGADRVIGIDRHPKRLKMAKEQGGAEVLNLDE
VEVGEALKEMTGGWGPSHCIDAVGLEAHGSGIEGIYDNVMNALKLETDKPAALRQAIVACRKGGTVSIPGVYGGLLDKMP
MGAAFAKGLTFKMGQTHVHRYLQPLLERIVQGELDPTFVITHRLKLDDAPEGYRTFRDQKDDCIKVVLKP
>Mature_390_residues
MKAVCWHGAGDVRVETVPDPAILYPRDAIIKVTSTAICGSDLHLYDGVIPTMQKGDILGHEFMGEVVEVGAAVKNLRKGD
RVVVPFTIACGHCHFCERTLWSLCDNSNPNAWMAEKVYGSTSGSGLFGYSHLFGGYAGGQAEYVRVPFADTGPMKVPESL
TDEQVLFLTDIFPTGYMAAENCNIQPGDTVAVWGCGPVGQFAIKSAYMLGADRVIGIDRHPKRLKMAKEQGGAEVLNLDE
VEVGEALKEMTGGWGPSHCIDAVGLEAHGSGIEGIYDNVMNALKLETDKPAALRQAIVACRKGGTVSIPGVYGGLLDKMP
MGAAFAKGLTFKMGQTHVHRYLQPLLERIVQGELDPTFVITHRLKLDDAPEGYRTFRDQKDDCIKVVLKP

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI156523966, Length=396, Percent_Identity=25.2525252525253, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI4501939, Length=388, Percent_Identity=25, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI71565152, Length=270, Percent_Identity=29.6296296296296, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI4501929, Length=258, Percent_Identity=32.1705426356589, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI71565154, Length=275, Percent_Identity=31.2727272727273, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI34577061, Length=230, Percent_Identity=31.7391304347826, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI4501933, Length=258, Percent_Identity=31.0077519379845, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI71743840, Length=255, Percent_Identity=28.6274509803922, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI262073058, Length=255, Percent_Identity=28.6274509803922, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1786825, Length=392, Percent_Identity=50.2551020408163, Blast_Score=383, Evalue=1e-107,
Organism=Escherichia coli, GI1790045, Length=383, Percent_Identity=27.154046997389, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1787863, Length=362, Percent_Identity=25.414364640884, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI87082125, Length=229, Percent_Identity=31.8777292576419, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788073, Length=368, Percent_Identity=25, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1786552, Length=371, Percent_Identity=26.4150943396226, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI226510992, Length=364, Percent_Identity=25, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788075, Length=400, Percent_Identity=25.5, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI87081918, Length=228, Percent_Identity=33.3333333333333, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790718, Length=363, Percent_Identity=21.4876033057851, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788407, Length=259, Percent_Identity=25.8687258687259, Blast_Score=73, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI25146526, Length=395, Percent_Identity=28.6075949367089, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71997431, Length=396, Percent_Identity=28.2828282828283, Blast_Score=101, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17562876, Length=393, Percent_Identity=24.9363867684478, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17565904, Length=359, Percent_Identity=28.133704735376, Blast_Score=93, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6320033, Length=373, Percent_Identity=27.6139410187668, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6319257, Length=414, Percent_Identity=25.3623188405797, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6319258, Length=409, Percent_Identity=25.9168704156479, Blast_Score=83, Evalue=6e-17,
Organism=Drosophila melanogaster, GI17137530, Length=389, Percent_Identity=25.706940874036, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI17737895, Length=244, Percent_Identity=31.5573770491803, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17737897, Length=389, Percent_Identity=25.706940874036, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284 [H]

Molecular weight: Translated: 42184; Mature: 42184

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVCWHGAGDVRVETVPDPAILYPRDAIIKVTSTAICGSDLHLYDGVIPTMQKGDILGH
CCEEEECCCCCEEEEECCCCCEECCCCCEEEEEEHEECCCCCHHHCCCCCCCCCCCCCCH
EFMGEVVEVGAAVKNLRKGDRVVVPFTIACGHCHFCERTLWSLCDNSNPNAWMAEKVYGS
HHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHHHHHHHCCCCCCCEEEHHHCCC
TSGSGLFGYSHLFGGYAGGQAEYVRVPFADTGPMKVPESLTDEQVLFLTDIFPTGYMAAE
CCCCCCEEHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEEECCCCCCEEEC
NCNIQPGDTVAVWGCGPVGQFAIKSAYMLGADRVIGIDRHPKRLKMAKEQGGAEVLNLDE
CCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHCCCCEEEECCH
VEVGEALKEMTGGWGPSHCIDAVGLEAHGSGIEGIYDNVMNALKLETDKPAALRQAIVAC
HHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHH
RKGGTVSIPGVYGGLLDKMPMGAAFAKGLTFKMGQTHVHRYLQPLLERIVQGELDPTFVI
HCCCEEECCHHHHHHHHHCCCCHHHHCCCEEECCHHHHHHHHHHHHHHHHCCCCCCEEEE
THRLKLDDAPEGYRTFRDQKDDCIKVVLKP
EEEEECCCCCCHHHHHHCCCCCEEEEEECC
>Mature Secondary Structure
MKAVCWHGAGDVRVETVPDPAILYPRDAIIKVTSTAICGSDLHLYDGVIPTMQKGDILGH
CCEEEECCCCCEEEEECCCCCEECCCCCEEEEEEHEECCCCCHHHCCCCCCCCCCCCCCH
EFMGEVVEVGAAVKNLRKGDRVVVPFTIACGHCHFCERTLWSLCDNSNPNAWMAEKVYGS
HHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHHHHHHHCCCCCCCEEEHHHCCC
TSGSGLFGYSHLFGGYAGGQAEYVRVPFADTGPMKVPESLTDEQVLFLTDIFPTGYMAAE
CCCCCCEEHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEEECCCCCCEEEC
NCNIQPGDTVAVWGCGPVGQFAIKSAYMLGADRVIGIDRHPKRLKMAKEQGGAEVLNLDE
CCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHCCCCEEEECCH
VEVGEALKEMTGGWGPSHCIDAVGLEAHGSGIEGIYDNVMNALKLETDKPAALRQAIVAC
HHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHH
RKGGTVSIPGVYGGLLDKMPMGAAFAKGLTFKMGQTHVHRYLQPLLERIVQGELDPTFVI
HCCCEEECCHHHHHHHHHCCCCHHHHCCCEEECCHHHHHHHHHHHHHHHHCCCCCCEEEE
THRLKLDDAPEGYRTFRDQKDDCIKVVLKP
EEEEECCCCCCHHHHHHCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7926692 [H]