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The map label for this gene is tmk

Identifier: 37520247

GI number: 37520247

Start: 723697

End: 724335

Strand: Direct

Name: tmk

Synonym: glr0678

Alternate gene names: 37520247

Gene position: 723697-724335 (Clockwise)

Preceding gene: 37520245

Following gene: 37520248

Centisome position: 15.53

GC content: 64.16

Gene sequence:

>639_bases
ATGTTCATCACCTTTGAAGGCGGCGAAGGCTGCGGCAAGACCACGCAACTTACTCTTTTAGGCGACTGGCTCGAAAAGCG
GTGCCACCGGGTCGTGCGCACCCGCGAACCCGGCGGCACCGCCCTGGGCCGCTCGCTGCGCGGTCTGCTCCTCGATGCCC
GGAGCGAAATCACCCCCACCGCCGAGTTGCTTCTGTACGCGACCGATCGGGCCGAGCACCTGGCGCGGGTCGTCCGCCCC
GCCCTTGCCTCGGGTGCGGCAGTGCTGTGCGACCGCTTCTCTGATTCGACAGTGGCTTACCAGGGCTATGGCCGTGGTCT
GGATCTGGGGCTCATCGAGCGACTCAACGCCATCGCCACCGGTGGGCTCCTCCCAGATCTGACTTTCTGGCTGAAACTCG
ATCCGCAGGCTGGACTGGTGCGGCGCCTCGCAAGCAACGGCAACACCCCCGATCGCATCGAAGCGGAAACGCTCGCCTTC
CACCAGCGGGTGCACATGGGCTTCGCGGCCCTGGCAAATCGTTATCCGGGCCGCATCCGGCCCGTCGACGCCGGTCTGAG
CGTCGAGGCGACCGCCGAACAGATCCGCTCTGCCGTAGATGTATTCTTGAATGAGAATCAATCTAAACTAGAGAAGTAG

Upstream 100 bases:

>100_bases
CCTCCTGATCGCATGATCTTGGCGCGAGACTCATTAATTAGCATCGCTCGGCCATTTCGCTTCCGCTTTGCGATTAAAAT
ACACAATCAACGCTCGGCCC

Downstream 100 bases:

>100_bases
CCGAATTCGGCGGGAGAGTGTACTGATGGTCAAAGTTGTCGGTCTATGCGGAAGTTTGCGCCCGGGCTCCCATGCCGAAA
AAGCGCTGCTGCTGGCTCTG

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MFITFEGGEGCGKTTQLTLLGDWLEKRCHRVVRTREPGGTALGRSLRGLLLDARSEITPTAELLLYATDRAEHLARVVRP
ALASGAAVLCDRFSDSTVAYQGYGRGLDLGLIERLNAIATGGLLPDLTFWLKLDPQAGLVRRLASNGNTPDRIEAETLAF
HQRVHMGFAALANRYPGRIRPVDAGLSVEATAEQIRSAVDVFLNENQSKLEK

Sequences:

>Translated_212_residues
MFITFEGGEGCGKTTQLTLLGDWLEKRCHRVVRTREPGGTALGRSLRGLLLDARSEITPTAELLLYATDRAEHLARVVRP
ALASGAAVLCDRFSDSTVAYQGYGRGLDLGLIERLNAIATGGLLPDLTFWLKLDPQAGLVRRLASNGNTPDRIEAETLAF
HQRVHMGFAALANRYPGRIRPVDAGLSVEATAEQIRSAVDVFLNENQSKLEK
>Mature_212_residues
MFITFEGGEGCGKTTQLTLLGDWLEKRCHRVVRTREPGGTALGRSLRGLLLDARSEITPTAELLLYATDRAEHLARVVRP
ALASGAAVLCDRFSDSTVAYQGYGRGLDLGLIERLNAIATGGLLPDLTFWLKLDPQAGLVRRLASNGNTPDRIEAETLAF
HQRVHMGFAALANRYPGRIRPVDAGLSVEATAEQIRSAVDVFLNENQSKLEK

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=209, Percent_Identity=39.2344497607655, Blast_Score=123, Evalue=8e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_GLOVI (Q7NMT7)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_923624.1
- ProteinModelPortal:   Q7NMT7
- SMR:   Q7NMT7
- GeneID:   2599503
- GenomeReviews:   BA000045_GR
- KEGG:   gvi:glr0678
- NMPDR:   fig|251221.1.peg.678
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- BioCyc:   GVIO251221:GLR0678-MONOMER
- BRENDA:   2.7.4.9
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 23113; Mature: 23113

Theoretical pI: Translated: 8.08; Mature: 8.08

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFITFEGGEGCGKTTQLTLLGDWLEKRCHRVVRTREPGGTALGRSLRGLLLDARSEITPT
CEEEEECCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCH
AELLLYATDRAEHLARVVRPALASGAAVLCDRFSDSTVAYQGYGRGLDLGLIERLNAIAT
HHEEEEECCHHHHHHHHHHHHHHCCHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHC
GGLLPDLTFWLKLDPQAGLVRRLASNGNTPDRIEAETLAFHQRVHMGFAALANRYPGRIR
CCCCCCEEEEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
PVDAGLSVEATAEQIRSAVDVFLNENQSKLEK
EECCCCCCHHHHHHHHHHHHHHHCCCHHHHCC
>Mature Secondary Structure
MFITFEGGEGCGKTTQLTLLGDWLEKRCHRVVRTREPGGTALGRSLRGLLLDARSEITPT
CEEEEECCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCH
AELLLYATDRAEHLARVVRPALASGAAVLCDRFSDSTVAYQGYGRGLDLGLIERLNAIAT
HHEEEEECCHHHHHHHHHHHHHHCCHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHC
GGLLPDLTFWLKLDPQAGLVRRLASNGNTPDRIEAETLAFHQRVHMGFAALANRYPGRIR
CCCCCCEEEEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
PVDAGLSVEATAEQIRSAVDVFLNENQSKLEK
EECCCCCCHHHHHHHHHHHHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292