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The map label for this gene is nrdR

Identifier: 37519712

GI number: 37519712

Start: 135699

End: 136217

Strand: Reverse

Name: nrdR

Synonym: gll0143

Alternate gene names: 37519712

Gene position: 136217-135699 (Counterclockwise)

Preceding gene: 37519713

Following gene: 37519711

Centisome position: 2.92

GC content: 62.24

Gene sequence:

>519_bases
ATGCTTTGCCCATTCTGCTCGTACTCTGACAACCGTGTCCTCGAGTCCCGTCTGGCCGAGGAGGGGGAGAGCGTGCGCCG
CCGCCGCGAGTGCAAACAATGCCGACGGCGCTTCACGACCTACGAGCGCATCGAATTTGTCCCAACAGTCGTGATCAAGC
GCAATGGGCGGCGCGAAGCGTTCGATCGCTCGAAGGTGTTGCGTGGGGTGATGATCGCCTGCGAGAAGACCGACGTGCCG
GCGGAGCTCATTGAGCAACTCGTCGACGATCTGCAGGCCGAGTTGCAGCAGCGCTCCAGCCGCGAGGTAACCAGTGCCGA
GATTGGCGAGATGGTCCTCGCTCTACTCAAGCCCCTCAACGAGGTGGCCTACGTGCGCTTCGCCTCGGTTTACCGCAAGT
TCAAGGGTGTCGCCGACTTTGTGAGCGAACTGCAAACCTTCGAAGCGAACGCTGAGCTCGATTCGCTCAAAGCCCGCCTG
GAGCGGCTTGCCGCAGCGCACGACCAGTCCGCCGACTGA

Upstream 100 bases:

>100_bases
TACCGAGACGGGGCTGGCCGCCCGCTGGTGTAAACTTCTGCAACAATATGTCTCGGGTGGACCGGATTGCCCCAAGGAAC
TGATTCAATAGTCGGTAATT

Downstream 100 bases:

>100_bases
CGCGGGCCGATGGACGAGTGCGAGGCGGTACTGGGTGCGAACGCGGCGTTTTATCGGGCGTTTGAGAAGCGCGACATAGA
GGCGATGGCTGCCGTCTGGT

Product: transcriptional regulator NrdR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 172; Mature: 172

Protein sequence:

>172_residues
MLCPFCSYSDNRVLESRLAEEGESVRRRRECKQCRRRFTTYERIEFVPTVVIKRNGRREAFDRSKVLRGVMIACEKTDVP
AELIEQLVDDLQAELQQRSSREVTSAEIGEMVLALLKPLNEVAYVRFASVYRKFKGVADFVSELQTFEANAELDSLKARL
ERLAAAHDQSAD

Sequences:

>Translated_172_residues
MLCPFCSYSDNRVLESRLAEEGESVRRRRECKQCRRRFTTYERIEFVPTVVIKRNGRREAFDRSKVLRGVMIACEKTDVP
AELIEQLVDDLQAELQQRSSREVTSAEIGEMVLALLKPLNEVAYVRFASVYRKFKGVADFVSELQTFEANAELDSLKARL
ERLAAAHDQSAD
>Mature_172_residues
MLCPFCSYSDNRVLESRLAEEGESVRRRRECKQCRRRFTTYERIEFVPTVVIKRNGRREAFDRSKVLRGVMIACEKTDVP
AELIEQLVDDLQAELQQRSSREVTSAEIGEMVLALLKPLNEVAYVRFASVYRKFKGVADFVSELQTFEANAELDSLKARL
ERLAAAHDQSAD

Specific function: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes

COG id: COG1327

COG function: function code K; Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain

Homologues:

Organism=Escherichia coli, GI1786615, Length=148, Percent_Identity=43.9189189189189, Blast_Score=127, Evalue=6e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NRDR_GLOVI (Q7NPB2)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_923089.1
- GeneID:   2600022
- GenomeReviews:   BA000045_GR
- KEGG:   gvi:gll0143
- NMPDR:   fig|251221.1.peg.143
- HOGENOM:   HBG351755
- OMA:   RRRRECK
- ProtClustDB:   PRK00464
- BioCyc:   GVIO251221:GLL0143-MONOMER
- GO:   GO:0006350
- HAMAP:   MF_00440
- InterPro:   IPR005144
- InterPro:   IPR003796
- TIGRFAMs:   TIGR00244

Pfam domain/function: PF03477 ATP-cone

EC number: NA

Molecular weight: Translated: 19781; Mature: 19781

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS51161 ATP_CONE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLCPFCSYSDNRVLESRLAEEGESVRRRRECKQCRRRFTTYERIEFVPTVVIKRNGRREA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
FDRSKVLRGVMIACEKTDVPAELIEQLVDDLQAELQQRSSREVTSAEIGEMVLALLKPLN
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
EVAYVRFASVYRKFKGVADFVSELQTFEANAELDSLKARLERLAAAHDQSAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLCPFCSYSDNRVLESRLAEEGESVRRRRECKQCRRRFTTYERIEFVPTVVIKRNGRREA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
FDRSKVLRGVMIACEKTDVPAELIEQLVDDLQAELQQRSSREVTSAEIGEMVLALLKPLN
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
EVAYVRFASVYRKFKGVADFVSELQTFEANAELDSLKARLERLAAAHDQSAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292