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The map label for this gene is lysA [H]

Identifier: 37519679

GI number: 37519679

Start: 107123

End: 108457

Strand: Reverse

Name: lysA [H]

Synonym: gvip012

Alternate gene names: 37519679

Gene position: 108457-107123 (Counterclockwise)

Preceding gene: 37519683

Following gene: 37519678

Centisome position: 2.33

GC content: 62.02

Gene sequence:

>1335_bases
ATGCCCGCCGACATCCCTTCGCCGAACCAGATGATCGCACCGCTTGAGACCCGCACCGACGCTCGAGGGCACCTCATGAT
CGGCGGCTGCGATGTGGTCGATCTGGCGCAGCGCTTCGGCACACCCCTGTATATTCTCGACGAGGCGACACTGCGCGCTG
CCTGTACCCAGTACGTCGAAGCGTTCAAGCGCCACTACGCCGGGGATTTTCGGGTGCTCTACGCCTCGAAGGCCTGGAGC
AACCTGGCGATCTGCGCCATCGTCCATCGCTGCGGCTTAGGCATTGACGCGGTCTCGGCGGGCGAAGTCCACACGGCCTT
GCGGGCGGGGGTACCCGGCGAACTGGTGTACCTGCACGGCAACAACAAATCCGAAGCGGAGATTCTCCTCGCCGCAGAAG
TCGGTGCAACGGTGGTGGCCGACAACTGGCTCGATCTCGAGATTTTGAGTGCTATCTCTGCCGAGTGTCCGGTACGGGTG
ATGGTGCGCGTCGCCCCCGGCATCGACATCCACACCCACGAATACATCCGCACCGGCCACCTCGACAGCAAATTCGGCTT
CGATCCGTCCGAACTCGCCGCAGTACTCGCCTACCTGGCGCGCATTCCCAGCCTCAGAGCCGTCGGTCTGCACGCCCATA
TCGGCTCGCAAAGCTTCGAGCTTGCTCCCCACGGCGATGCCGCCCAACTGCTTTTGGAGTGGTACCCCAAGGCACTGGCC
CTTGGCCTGTCGGATTTCAATGAACTGAACGTGGGGGGCGGCCTGGGGATCCGCTACACCGACGACGACGACCCGCCCGC
CATCGACGAGTGGGTAGGCACGATCTGCCAGGCAGTGACGCGCACCTGCAATACCTACAATTTACCCCTGCCAAAATTGT
TGTGCGAACCGGGCCGCTCGCTGGTAGGCCCCGCCTGCGCCACGGCTTACACCGTCGGTTCCACCAAGACCATACCCAGC
ATACGTAAATATTTCTCCGTAGATGGCGGCATGTCTGACAATCCCCGGCCCATCACCTATAAAGCGCTCTACACGGCCGT
TGTCGCCAACAAGATGCACGATGGACGCCGTGAGAAGGTGACCGTGGCCGGCAAGCACTGCGAGTCTGGGGACGTGCTGC
TGCGCGATGTTGAGCTGCCTCCACTCGAGAGGGGAGATTGCCTGGTCGTCTTTAGCACCGGTGCGTACAATTGCAGTATG
GCTTCAAACTACAACCGTATCCCTCGTCCAGCGGCGGTGCTTGTCAGTGACGGCGAGGCGACCCTCATCGTCAAGCGTGA
GAGCCCGGACGACCTGTTGCGCTGCGACTGTCTACCGGAACGACTGCAGACATGA

Upstream 100 bases:

>100_bases
CCCCAACGCCTGCGCGATCTCCGTAGACTTTGGACGAAAGGCAGGCGCGGACGGACGAAGCTTACAGGTAAACTATTAGA
AACTATCGCCGCCGTCCTCC

Downstream 100 bases:

>100_bases
ACGGCCCCCTGGAACAACTGTCAGGCGAACTGGCTCTGCGACCGCTCATCATTTCGATTCTCGATTGGGCTGCGGTGGGC
CTGCTGCTCTACCTGGCCTT

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MPADIPSPNQMIAPLETRTDARGHLMIGGCDVVDLAQRFGTPLYILDEATLRAACTQYVEAFKRHYAGDFRVLYASKAWS
NLAICAIVHRCGLGIDAVSAGEVHTALRAGVPGELVYLHGNNKSEAEILLAAEVGATVVADNWLDLEILSAISAECPVRV
MVRVAPGIDIHTHEYIRTGHLDSKFGFDPSELAAVLAYLARIPSLRAVGLHAHIGSQSFELAPHGDAAQLLLEWYPKALA
LGLSDFNELNVGGGLGIRYTDDDDPPAIDEWVGTICQAVTRTCNTYNLPLPKLLCEPGRSLVGPACATAYTVGSTKTIPS
IRKYFSVDGGMSDNPRPITYKALYTAVVANKMHDGRREKVTVAGKHCESGDVLLRDVELPPLERGDCLVVFSTGAYNCSM
ASNYNRIPRPAAVLVSDGEATLIVKRESPDDLLRCDCLPERLQT

Sequences:

>Translated_444_residues
MPADIPSPNQMIAPLETRTDARGHLMIGGCDVVDLAQRFGTPLYILDEATLRAACTQYVEAFKRHYAGDFRVLYASKAWS
NLAICAIVHRCGLGIDAVSAGEVHTALRAGVPGELVYLHGNNKSEAEILLAAEVGATVVADNWLDLEILSAISAECPVRV
MVRVAPGIDIHTHEYIRTGHLDSKFGFDPSELAAVLAYLARIPSLRAVGLHAHIGSQSFELAPHGDAAQLLLEWYPKALA
LGLSDFNELNVGGGLGIRYTDDDDPPAIDEWVGTICQAVTRTCNTYNLPLPKLLCEPGRSLVGPACATAYTVGSTKTIPS
IRKYFSVDGGMSDNPRPITYKALYTAVVANKMHDGRREKVTVAGKHCESGDVLLRDVELPPLERGDCLVVFSTGAYNCSM
ASNYNRIPRPAAVLVSDGEATLIVKRESPDDLLRCDCLPERLQT
>Mature_443_residues
PADIPSPNQMIAPLETRTDARGHLMIGGCDVVDLAQRFGTPLYILDEATLRAACTQYVEAFKRHYAGDFRVLYASKAWSN
LAICAIVHRCGLGIDAVSAGEVHTALRAGVPGELVYLHGNNKSEAEILLAAEVGATVVADNWLDLEILSAISAECPVRVM
VRVAPGIDIHTHEYIRTGHLDSKFGFDPSELAAVLAYLARIPSLRAVGLHAHIGSQSFELAPHGDAAQLLLEWYPKALAL
GLSDFNELNVGGGLGIRYTDDDDPPAIDEWVGTICQAVTRTCNTYNLPLPKLLCEPGRSLVGPACATAYTVGSTKTIPSI
RKYFSVDGGMSDNPRPITYKALYTAVVANKMHDGRREKVTVAGKHCESGDVLLRDVELPPLERGDCLVVFSTGAYNCSMA
SNYNRIPRPAAVLVSDGEATLIVKRESPDDLLRCDCLPERLQT

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=419, Percent_Identity=30.7875894988067, Blast_Score=136, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 47964; Mature: 47833

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPADIPSPNQMIAPLETRTDARGHLMIGGCDVVDLAQRFGTPLYILDEATLRAACTQYVE
CCCCCCCCCCEECCCCCCCCCCCEEEECCCCHHHHHHHHCCCEEEECCHHHHHHHHHHHH
AFKRHYAGDFRVLYASKAWSNLAICAIVHRCGLGIDAVSAGEVHTALRAGVPGELVYLHG
HHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCEEEEEC
NNKSEAEILLAAEVGATVVADNWLDLEILSAISAECPVRVMVRVAPGIDIHTHEYIRTGH
CCCCCEEEEEEECCCCEEEECCCCCHHHHHHHCCCCCEEEEEEECCCCEEECHHHHEECC
LDSKFGFDPSELAAVLAYLARIPSLRAVGLHAHIGSQSFELAPHGDAAQLLLEWYPKALA
CCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEECCCCHHHHHHHHHHHHHHH
LGLSDFNELNVGGGLGIRYTDDDDPPAIDEWVGTICQAVTRTCNTYNLPLPKLLCEPGRS
HCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCC
LVGPACATAYTVGSTKTIPSIRKYFSVDGGMSDNPRPITYKALYTAVVANKMHDGRREKV
CCCCHHHHEEECCCCCCCHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHCCCCCCEE
TVAGKHCESGDVLLRDVELPPLERGDCLVVFSTGAYNCSMASNYNRIPRPAAVLVSDGEA
EEECCCCCCCCEEEEECCCCCCCCCCEEEEECCCCCEEEECCCCCCCCCCEEEEEECCCE
TLIVKRESPDDLLRCDCLPERLQT
EEEEEECCCCHHHHHCCCHHHHCC
>Mature Secondary Structure 
PADIPSPNQMIAPLETRTDARGHLMIGGCDVVDLAQRFGTPLYILDEATLRAACTQYVE
CCCCCCCCCEECCCCCCCCCCCEEEECCCCHHHHHHHHCCCEEEECCHHHHHHHHHHHH
AFKRHYAGDFRVLYASKAWSNLAICAIVHRCGLGIDAVSAGEVHTALRAGVPGELVYLHG
HHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCEEEEEC
NNKSEAEILLAAEVGATVVADNWLDLEILSAISAECPVRVMVRVAPGIDIHTHEYIRTGH
CCCCCEEEEEEECCCCEEEECCCCCHHHHHHHCCCCCEEEEEEECCCCEEECHHHHEECC
LDSKFGFDPSELAAVLAYLARIPSLRAVGLHAHIGSQSFELAPHGDAAQLLLEWYPKALA
CCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEECCCCHHHHHHHHHHHHHHH
LGLSDFNELNVGGGLGIRYTDDDDPPAIDEWVGTICQAVTRTCNTYNLPLPKLLCEPGRS
HCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCC
LVGPACATAYTVGSTKTIPSIRKYFSVDGGMSDNPRPITYKALYTAVVANKMHDGRREKV
CCCCHHHHEEECCCCCCCHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHCCCCCCEE
TVAGKHCESGDVLLRDVELPPLERGDCLVVFSTGAYNCSMASNYNRIPRPAAVLVSDGEA
EEECCCCCCCCEEEEECCCCCCCCCCEEEEECCCCCEEEECCCCCCCCCCEEEEEECCCE
TLIVKRESPDDLLRCDCLPERLQT
EEEEEECCCCHHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]