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The map label for this gene is uppS

Identifier: 37519677

GI number: 37519677

Start: 105491

End: 106240

Strand: Reverse

Name: uppS

Synonym: gll0108

Alternate gene names: 37519677

Gene position: 106240-105491 (Counterclockwise)

Preceding gene: 37519678

Following gene: 37519675

Centisome position: 2.28

GC content: 61.07

Gene sequence:

>750_bases
ATGACCACCCCGCATACGCTCCTGCGCAGCCTGCCCTCCGATCTTGATCCCAATCGCCTGCCGCGCCATGTCGCCGCCAT
CATGGACGGCAACGGCCGCTGGGCGTCAAAGCGCAACCTTCCCCGAGTGATGGGCCATCAGGCTGGGGTGAGTGCCCTCA
AAGAGCTGTTGCGCTGTTGCAAAGACTGGGGCATCGGTGCTCTCACGGTCTATGCCTTCTCGACGGAGAACTGGAAGCGG
CCGCAATACGAGGTCGAATTTTTGATGGCCCTTTTTGAGAAAGTGCTCAACCACGAGCTTTCGGAGATGGTGGATGAGGG
GGTGCGCATTCGCTTCGTCGGGGCACTCGCCCATCTGCCCGGAGCTCTGCAGAGTGCCATCGAGGGAGCGATGGCGGCCA
CAGAGGCGAACACGGCGGTCGAGTTCACCGTCGCCACCAACTACGGTGGCCGGCAAGAGATCGTCAATGCCTGCCGCGAA
CTGGCCGAGCAGGTACGGTCAGGCCGTCTCCTGCCCGAGCAGATCGACGAGAAGCTTTTTGCCCAGCACCTCTACACCCG
CGAGCTTAGCGATCCCGACTTACTGATCCGCACCAGCGGCGAGCAGCGCCTGAGCAACTATTTGCTCTGGCAGATGGCCT
ATACCGAAATTTATGTAGCCGACGTGTTATGGCCCGACTTTGACCGAGCGGCCTTCCACGCTGCGCTGCAATCCTACCAA
GGTCGCCAGCGTCGCTTTGGTAAGGTGTGA

Upstream 100 bases:

>100_bases
GACCAGCCTCCCTCGGTGTTTACCATTCCGGCGCTGAGCGACTGGACGCGCAAGCTCTTCCCCGCCTCCTCCAGCCAATC
GGGCAACAGCGACTAAATCG

Downstream 100 bases:

>100_bases
GATCTCCCCCGGCCCCCCCTTGGGAAGGGGGGGCCGGGGGGGTCAAATCCTTGCCTTGACCGTGAAGGCGTAGGTCTCCC
CAGTCTCCAGTCGAAAATCA

Product: undecaprenyl pyrophosphate synthetase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MTTPHTLLRSLPSDLDPNRLPRHVAAIMDGNGRWASKRNLPRVMGHQAGVSALKELLRCCKDWGIGALTVYAFSTENWKR
PQYEVEFLMALFEKVLNHELSEMVDEGVRIRFVGALAHLPGALQSAIEGAMAATEANTAVEFTVATNYGGRQEIVNACRE
LAEQVRSGRLLPEQIDEKLFAQHLYTRELSDPDLLIRTSGEQRLSNYLLWQMAYTEIYVADVLWPDFDRAAFHAALQSYQ
GRQRRFGKV

Sequences:

>Translated_249_residues
MTTPHTLLRSLPSDLDPNRLPRHVAAIMDGNGRWASKRNLPRVMGHQAGVSALKELLRCCKDWGIGALTVYAFSTENWKR
PQYEVEFLMALFEKVLNHELSEMVDEGVRIRFVGALAHLPGALQSAIEGAMAATEANTAVEFTVATNYGGRQEIVNACRE
LAEQVRSGRLLPEQIDEKLFAQHLYTRELSDPDLLIRTSGEQRLSNYLLWQMAYTEIYVADVLWPDFDRAAFHAALQSYQ
GRQRRFGKV
>Mature_248_residues
TTPHTLLRSLPSDLDPNRLPRHVAAIMDGNGRWASKRNLPRVMGHQAGVSALKELLRCCKDWGIGALTVYAFSTENWKRP
QYEVEFLMALFEKVLNHELSEMVDEGVRIRFVGALAHLPGALQSAIEGAMAATEANTAVEFTVATNYGGRQEIVNACREL
AEQVRSGRLLPEQIDEKLFAQHLYTRELSDPDLLIRTSGEQRLSNYLLWQMAYTEIYVADVLWPDFDRAAFHAALQSYQG
RQRRFGKV

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580738, Length=225, Percent_Identity=42.2222222222222, Blast_Score=162, Evalue=2e-40,
Organism=Homo sapiens, GI45580742, Length=225, Percent_Identity=42.2222222222222, Blast_Score=162, Evalue=3e-40,
Organism=Escherichia coli, GI1786371, Length=231, Percent_Identity=48.0519480519481, Blast_Score=230, Evalue=6e-62,
Organism=Caenorhabditis elegans, GI71993029, Length=228, Percent_Identity=38.5964912280702, Blast_Score=146, Evalue=8e-36,
Organism=Saccharomyces cerevisiae, GI6319474, Length=215, Percent_Identity=39.0697674418605, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6323748, Length=240, Percent_Identity=32.5, Blast_Score=116, Evalue=3e-27,
Organism=Drosophila melanogaster, GI18857969, Length=225, Percent_Identity=39.1111111111111, Blast_Score=160, Evalue=9e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS_GLOVI (Q7NPE7)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_923054.1
- ProteinModelPortal:   Q7NPE7
- SMR:   Q7NPE7
- GeneID:   2600085
- GenomeReviews:   BA000045_GR
- KEGG:   gvi:gll0108
- NMPDR:   fig|251221.1.peg.108
- HOGENOM:   HBG627837
- OMA:   RVRWAGR
- BioCyc:   GVIO251221:GLL0108-MONOMER
- BRENDA:   2.5.1.31
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 28176; Mature: 28044

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 29-29

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPHTLLRSLPSDLDPNRLPRHVAAIMDGNGRWASKRNLPRVMGHQAGVSALKELLRCC
CCCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
KDWGIGALTVYAFSTENWKRPQYEVEFLMALFEKVLNHELSEMVDEGVRIRFVGALAHLP
HHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHCC
GALQSAIEGAMAATEANTAVEFTVATNYGGRQEIVNACRELAEQVRSGRLLPEQIDEKLF
HHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
AQHLYTRELSDPDLLIRTSGEQRLSNYLLWQMAYTEIYVADVLWPDFDRAAFHAALQSYQ
HHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
GRQRRFGKV
HHHHHCCCC
>Mature Secondary Structure 
TTPHTLLRSLPSDLDPNRLPRHVAAIMDGNGRWASKRNLPRVMGHQAGVSALKELLRCC
CCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
KDWGIGALTVYAFSTENWKRPQYEVEFLMALFEKVLNHELSEMVDEGVRIRFVGALAHLP
HHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHCC
GALQSAIEGAMAATEANTAVEFTVATNYGGRQEIVNACRELAEQVRSGRLLPEQIDEKLF
HHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
AQHLYTRELSDPDLLIRTSGEQRLSNYLLWQMAYTEIYVADVLWPDFDRAAFHAALQSYQ
HHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
GRQRRFGKV
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292