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The map label for this gene is upp [H]

Identifier: 37519632

GI number: 37519632

Start: 65718

End: 66386

Strand: Reverse

Name: upp [H]

Synonym: gll0063

Alternate gene names: 37519632

Gene position: 66386-65718 (Counterclockwise)

Preceding gene: 37519633

Following gene: 37519631

Centisome position: 1.42

GC content: 68.46

Gene sequence:

>669_bases
ATGGCCCTCAAAATCCACGTTCCACCCCATCCGTTCGTGACCAATCTGCTGGCCGTCTGCCGCAGCGAGGCCACGCCCAC
CCCGGTCTTTCGCGCCGCAGTGGCCGATTTGGGCCGCTGGCTCACCTACGAATGCGTGCGCGACTGGCTGCCGGTGCTCG
AAGTCGGCGTGAAAACACCCCTCGACGTGATCACCGCCGCCCGCATCGTCGACAGCAGTGTACCGGTGGCGATCGTGCCG
GTGCTGCGCGCCGGGCTCGCGTTGCTCGACGGGGTGCTGCCGCTGTTGCCGGCCGCCTCGGTCTACCACCTGGGCTACGC
CCGCGACGAGCGCACCCTCGAAGCCGCCTGCTACCTCGATCGTTTGCCGCCCCGCTTCGCCCCCGAGACGCGGGTGCTGG
TACTCGAACCGATGCTTGCCACCGGCGGCACCGCCACTGCCGTCGTCGCCAAGCTCGTCGAGCGCGGCGCCGATCCGGCC
CTGGTGCGGATCATTTCGGTGATCTGTGCGCCCCCGGCGTTGCAGCGTTTGGGGCTAAGCTACCCGAGCCTCGCCATTTA
CACCGCCATGATCGACGAGCGGCTCGACGAGCGCGGATTTATCGTGCCGGGTCTCGGCGACGCTGGGGATAGGGCCTTCG
GTACCGGGCATCCCCCAGGCGTAGGATGA

Upstream 100 bases:

>100_bases
GTACGTCGAGGAAAACCATTTCACCTTTCCTTCGCTGGCGCTGTTGCGCGCTCAACTGAGCGGCGAAGCCCAGGGCGACT
CGGTCGCCTGAAGATCACCG

Downstream 100 bases:

>100_bases
CATGGTGCGCCTGCTAACATAGGCGCAAACAATTGCGTTCGGTGATACGATGTCCATCCGCGTTGTCGTTGTCGATGATC
ACCCGGATGTGCTGCTCGGT

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 222; Mature: 221

Protein sequence:

>222_residues
MALKIHVPPHPFVTNLLAVCRSEATPTPVFRAAVADLGRWLTYECVRDWLPVLEVGVKTPLDVITAARIVDSSVPVAIVP
VLRAGLALLDGVLPLLPAASVYHLGYARDERTLEAACYLDRLPPRFAPETRVLVLEPMLATGGTATAVVAKLVERGADPA
LVRIISVICAPPALQRLGLSYPSLAIYTAMIDERLDERGFIVPGLGDAGDRAFGTGHPPGVG

Sequences:

>Translated_222_residues
MALKIHVPPHPFVTNLLAVCRSEATPTPVFRAAVADLGRWLTYECVRDWLPVLEVGVKTPLDVITAARIVDSSVPVAIVP
VLRAGLALLDGVLPLLPAASVYHLGYARDERTLEAACYLDRLPPRFAPETRVLVLEPMLATGGTATAVVAKLVERGADPA
LVRIISVICAPPALQRLGLSYPSLAIYTAMIDERLDERGFIVPGLGDAGDRAFGTGHPPGVG
>Mature_221_residues
ALKIHVPPHPFVTNLLAVCRSEATPTPVFRAAVADLGRWLTYECVRDWLPVLEVGVKTPLDVITAARIVDSSVPVAIVPV
LRAGLALLDGVLPLLPAASVYHLGYARDERTLEAACYLDRLPPRFAPETRVLVLEPMLATGGTATAVVAKLVERGADPAL
VRIISVICAPPALQRLGLSYPSLAIYTAMIDERLDERGFIVPGLGDAGDRAFGTGHPPGVG

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Escherichia coli, GI87082118, Length=218, Percent_Identity=35.7798165137615, Blast_Score=135, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17539892, Length=206, Percent_Identity=21.3592233009709, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17539894, Length=206, Percent_Identity=21.3592233009709, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321920, Length=198, Percent_Identity=29.7979797979798, Blast_Score=92, Evalue=6e-20,
Organism=Drosophila melanogaster, GI45550449, Length=207, Percent_Identity=23.6714975845411, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI28573516, Length=207, Percent_Identity=23.6714975845411, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI28573514, Length=207, Percent_Identity=23.6714975845411, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI28573512, Length=207, Percent_Identity=23.6714975845411, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 23610; Mature: 23479

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALKIHVPPHPFVTNLLAVCRSEATPTPVFRAAVADLGRWLTYECVRDWLPVLEVGVKTP
CEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
LDVITAARIVDSSVPVAIVPVLRAGLALLDGVLPLLPAASVYHLGYARDERTLEAACYLD
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCHHHHHHHHHHH
RLPPRFAPETRVLVLEPMLATGGTATAVVAKLVERGADPALVRIISVICAPPALQRLGLS
HCCCCCCCCCEEEEECCHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHCCC
YPSLAIYTAMIDERLDERGFIVPGLGDAGDRAFGTGHPPGVG
CCHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ALKIHVPPHPFVTNLLAVCRSEATPTPVFRAAVADLGRWLTYECVRDWLPVLEVGVKTP
EEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
LDVITAARIVDSSVPVAIVPVLRAGLALLDGVLPLLPAASVYHLGYARDERTLEAACYLD
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCHHHHHHHHHHH
RLPPRFAPETRVLVLEPMLATGGTATAVVAKLVERGADPALVRIISVICAPPALQRLGLS
HCCCCCCCCCEEEEECCHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHCCC
YPSLAIYTAMIDERLDERGFIVPGLGDAGDRAFGTGHPPGVG
CCHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]