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The map label for this gene is dspA [H]

Identifier: 37519624

GI number: 37519624

Start: 55984

End: 57918

Strand: Reverse

Name: dspA [H]

Synonym: gll0055

Alternate gene names: 37519624

Gene position: 57918-55984 (Counterclockwise)

Preceding gene: 37519630

Following gene: 37519623

Centisome position: 1.24

GC content: 61.4

Gene sequence:

>1935_bases
ATGGGGATATGGCAGAATGACGTCATTGCAGTGGACATCACAAACGCATCGGCCTTGAATTTTTCTAAGAATCTCCAGCG
CTGGTTCAGTGAATTCCGTATCCAGACCCGTCTGCTCGCGGCGGCGGCGCTGATTATTTCGCTGGTGCTGGCAAGCTTTA
CTTTCTGGGCGCTTAATTACATCCAGGAGGACGCCCGCCGCAGCGACCAGCGCTTTGGCGAAGCGGTGGGCAATTTGCTC
GCCGCCACCGCCGCCCCGCTCATCGCCCTCGATCAATACCCCCAACTGGGCGAATTTACCGAAGAATTCCTGGCCAGCAA
CGCCGACAACATCCTCTATGTCCTTTACGCCGATTCCAAAGGCGACATTCTCTACGGCAGTCCCTTCAATACCAACGACA
CCCGGGCCAACGCCCCCGTACCCGCCCTCATCCGCCACATCGAACTGCCGCCGGTGCTTCCGGCCAAGCGCCAGCACCGC
ACCCCCCGGGGTCTGGTGACCGATATTTTTGTGCCCATCGAGTACGGCGAGCGCCAACTGGGCGTCGTGCTGGTGGGCAT
CAACCCGGAGGCCAACCTGGTGAGCCGCTCCGACCTGACGCGCGATGTGACCGTCGCCGTGTTCGTCCTGGTCTGGATCA
TCGCCATTCTGGGTTCGGTCTTCAACGCGCTCACGATCACCCAGCCGCTCAAAGAGTTGGTGCAGGGGGTACAGCGCATC
GCCCAGGGCAACTTCAAGCAGCGGGTCACCCTGGCTTACCCGGGAGAAATCGGTGAACTGATCACCAGCTTCAACCTGAT
GGCCCAGCGCCTGCAAAGCTACGAAGAACAAAATATCGAAGAGATCACCGCCGAGAAGGCCAAGCTCGAAACGTTCATCG
CCACGATCGCCGACGGCGGCATCCTGCTCGATTCGTCGCTGCGCATCCTGCTGGTCAACCCGGCGATGCTGCGCATCTTT
GGGTGGGGATCCAGGGTGGTGGGCAAGAACATCCTGGATCTGTTGCCGGTGGGCATGCGCGCCGAGGTGGAGGAGCCCCT
CGACTCCGTCTCGCGCAACATCCTGGAGCAGGCCGAGTGCCGGGTCGTCCTGGACAAGCGCACGCTGCGGGTGCTCATCT
CGCCGGTGCTCGCCCCCCGGGGCGACAACCTGCTCAAGGGCGTGGTGCTCACGGTTCAGGATCTCTCCAAAGAAGCCGAA
CTCAACCAGGCCAAAAGCCAGTTCATCAGCAACGTCTCCCACGAGTTGCGCACGCCGCTTTCGAGCATCAAGTCCTACAT
CGAGACGGTGTACGAGTTTGGCGACAGCCTGGATGATTCGACCAAGAACGAATTTCTCAAAACCGCCAATCAGGAGACCG
ACCGGTTGACGCGCCTGGTCAACGACGTACTGGATCTTTCGCGCCTGGAATCGGGCCGCGAGTATCACTTTGAGCCGGTG
GACCTCGTCCAGCCCATCGAGCAGACCCTGCGTACCCACCGCCTCACCGCCCGCGACCGCGAGATTGAACTGGTGAGCGA
CATCGCCACCGACCTGCCGCTGGTCCTGGGCAATTACGACCTGCTGCAGCAGGTCTTCTCCAACCTGGTCGGAAACGCCC
TCAAATTTACCGAGCCGGGGGGGCGGGTCACCCTCTCGGCCCGCCGCACCGACGACCCGGCCAAAGTGCGCGTCGCCGTC
ACCGACACCGGCATCGGCATCTCCGAGGAGGACCAGCGCCGCATTTTCGAGCGCTTCTTTCGGGTCGAAAACCGGGTGCA
CACCCTGGAGGGCACGGGCCTGGGGCTTTCGATCGTCGACAATATCGTCAAGAAGCACAACGCCCAGGTCCACATCGAAA
GCGAAGTGGGCCAAGGTTCGACCTTCTGGTTCGACGTCGAAGCCTACATGGAAACCTGCGAGTGGCCCCGACGCGAGCAG
GAAGAAGTGATCTGA

Upstream 100 bases:

>100_bases
CAACAGCAGCAATCGACGCCGTACAATACTCATTGCGATTCCCTGTTCCCGCAAGAGAATAGCAGTATTGGCGCCCGTCC
GGCCAGGTGCGATCCGACCG

Downstream 100 bases:

>100_bases
GCACCTTTTGGCGAACGTCCCTTCCCTACTGAATCTATAAGCTTTGCAAAGGAGCGGGCAGGTAGGGGATGGCTTCCGAA
TCACTGCAGGGTTTTGCGAT

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 644; Mature: 643

Protein sequence:

>644_residues
MGIWQNDVIAVDITNASALNFSKNLQRWFSEFRIQTRLLAAAALIISLVLASFTFWALNYIQEDARRSDQRFGEAVGNLL
AATAAPLIALDQYPQLGEFTEEFLASNADNILYVLYADSKGDILYGSPFNTNDTRANAPVPALIRHIELPPVLPAKRQHR
TPRGLVTDIFVPIEYGERQLGVVLVGINPEANLVSRSDLTRDVTVAVFVLVWIIAILGSVFNALTITQPLKELVQGVQRI
AQGNFKQRVTLAYPGEIGELITSFNLMAQRLQSYEEQNIEEITAEKAKLETFIATIADGGILLDSSLRILLVNPAMLRIF
GWGSRVVGKNILDLLPVGMRAEVEEPLDSVSRNILEQAECRVVLDKRTLRVLISPVLAPRGDNLLKGVVLTVQDLSKEAE
LNQAKSQFISNVSHELRTPLSSIKSYIETVYEFGDSLDDSTKNEFLKTANQETDRLTRLVNDVLDLSRLESGREYHFEPV
DLVQPIEQTLRTHRLTARDREIELVSDIATDLPLVLGNYDLLQQVFSNLVGNALKFTEPGGRVTLSARRTDDPAKVRVAV
TDTGIGISEEDQRRIFERFFRVENRVHTLEGTGLGLSIVDNIVKKHNAQVHIESEVGQGSTFWFDVEAYMETCEWPRREQ
EEVI

Sequences:

>Translated_644_residues
MGIWQNDVIAVDITNASALNFSKNLQRWFSEFRIQTRLLAAAALIISLVLASFTFWALNYIQEDARRSDQRFGEAVGNLL
AATAAPLIALDQYPQLGEFTEEFLASNADNILYVLYADSKGDILYGSPFNTNDTRANAPVPALIRHIELPPVLPAKRQHR
TPRGLVTDIFVPIEYGERQLGVVLVGINPEANLVSRSDLTRDVTVAVFVLVWIIAILGSVFNALTITQPLKELVQGVQRI
AQGNFKQRVTLAYPGEIGELITSFNLMAQRLQSYEEQNIEEITAEKAKLETFIATIADGGILLDSSLRILLVNPAMLRIF
GWGSRVVGKNILDLLPVGMRAEVEEPLDSVSRNILEQAECRVVLDKRTLRVLISPVLAPRGDNLLKGVVLTVQDLSKEAE
LNQAKSQFISNVSHELRTPLSSIKSYIETVYEFGDSLDDSTKNEFLKTANQETDRLTRLVNDVLDLSRLESGREYHFEPV
DLVQPIEQTLRTHRLTARDREIELVSDIATDLPLVLGNYDLLQQVFSNLVGNALKFTEPGGRVTLSARRTDDPAKVRVAV
TDTGIGISEEDQRRIFERFFRVENRVHTLEGTGLGLSIVDNIVKKHNAQVHIESEVGQGSTFWFDVEAYMETCEWPRREQ
EEVI
>Mature_643_residues
GIWQNDVIAVDITNASALNFSKNLQRWFSEFRIQTRLLAAAALIISLVLASFTFWALNYIQEDARRSDQRFGEAVGNLLA
ATAAPLIALDQYPQLGEFTEEFLASNADNILYVLYADSKGDILYGSPFNTNDTRANAPVPALIRHIELPPVLPAKRQHRT
PRGLVTDIFVPIEYGERQLGVVLVGINPEANLVSRSDLTRDVTVAVFVLVWIIAILGSVFNALTITQPLKELVQGVQRIA
QGNFKQRVTLAYPGEIGELITSFNLMAQRLQSYEEQNIEEITAEKAKLETFIATIADGGILLDSSLRILLVNPAMLRIFG
WGSRVVGKNILDLLPVGMRAEVEEPLDSVSRNILEQAECRVVLDKRTLRVLISPVLAPRGDNLLKGVVLTVQDLSKEAEL
NQAKSQFISNVSHELRTPLSSIKSYIETVYEFGDSLDDSTKNEFLKTANQETDRLTRLVNDVLDLSRLESGREYHFEPVD
LVQPIEQTLRTHRLTARDREIELVSDIATDLPLVLGNYDLLQQVFSNLVGNALKFTEPGGRVTLSARRTDDPAKVRVAVT
DTGIGISEEDQRRIFERFFRVENRVHTLEGTGLGLSIVDNIVKKHNAQVHIESEVGQGSTFWFDVEAYMETCEWPRREQE
EVI

Specific function: Member Of The Two-Component Regulatory System Uvry/Bara Involved In The Regulation Of Carbon Metabolism Via The Csra/Csrb Regulatory System. Phosphorylates Uvry, Probably Via A Four-Step Phosphorelay. [C]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=242, Percent_Identity=35.1239669421488, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1786600, Length=241, Percent_Identity=33.6099585062241, Blast_Score=122, Evalue=6e-29,
Organism=Escherichia coli, GI145693157, Length=261, Percent_Identity=32.183908045977, Blast_Score=115, Evalue=8e-27,
Organism=Escherichia coli, GI1788713, Length=225, Percent_Identity=34.2222222222222, Blast_Score=115, Evalue=9e-27,
Organism=Escherichia coli, GI1788393, Length=237, Percent_Identity=32.0675105485232, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI1790436, Length=237, Percent_Identity=32.4894514767932, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI1788549, Length=385, Percent_Identity=24.1558441558442, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI87081816, Length=261, Percent_Identity=31.4176245210728, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI87082128, Length=233, Percent_Identity=27.0386266094421, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI48994928, Length=230, Percent_Identity=29.5652173913043, Blast_Score=95, Evalue=2e-20,
Organism=Escherichia coli, GI1786783, Length=288, Percent_Identity=26.7361111111111, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790346, Length=213, Percent_Identity=28.169014084507, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1790861, Length=235, Percent_Identity=26.8085106382979, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1787894, Length=228, Percent_Identity=26.3157894736842, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1789808, Length=248, Percent_Identity=24.5967741935484, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1790551, Length=224, Percent_Identity=27.2321428571429, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1789403, Length=211, Percent_Identity=32.7014218009479, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1790300, Length=337, Percent_Identity=26.1127596439169, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1786912, Length=229, Percent_Identity=27.0742358078603, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1788279, Length=202, Percent_Identity=24.7524752475248, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 72119; Mature: 71988

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIWQNDVIAVDITNASALNFSKNLQRWFSEFRIQTRLLAAAALIISLVLASFTFWALNY
CCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQEDARRSDQRFGEAVGNLLAATAAPLIALDQYPQLGEFTEEFLASNADNILYVLYADSK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEEEECCC
GDILYGSPFNTNDTRANAPVPALIRHIELPPVLPAKRQHRTPRGLVTDIFVPIEYGERQL
CCEEECCCCCCCCCCCCCCHHHHHHHCCCCCCCCCHHHCCCCCCCEEEEEEEECCCCCEE
GVVLVGINPEANLVSRSDLTRDVTVAVFVLVWIIAILGSVFNALTITQPLKELVQGVQRI
EEEEEEECCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQGNFKQRVTLAYPGEIGELITSFNLMAQRLQSYEEQNIEEITAEKAKLETFIATIADGG
HCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCC
ILLDSSLRILLVNPAMLRIFGWGSRVVGKNILDLLPVGMRAEVEEPLDSVSRNILEQAEC
EEECCCCEEEEECHHHEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
RVVLDKRTLRVLISPVLAPRGDNLLKGVVLTVQDLSKEAELNQAKSQFISNVSHELRTPL
EEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHH
SSIKSYIETVYEFGDSLDDSTKNEFLKTANQETDRLTRLVNDVLDLSRLESGREYHFEPV
HHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCH
DLVQPIEQTLRTHRLTARDREIELVSDIATDLPLVLGNYDLLQQVFSNLVGNALKFTEPG
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHCCCEEECCCC
GRVTLSARRTDDPAKVRVAVTDTGIGISEEDQRRIFERFFRVENRVHTLEGTGLGLSIVD
CEEEEEECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHEEEECCCCCCHHHHH
NIVKKHNAQVHIESEVGQGSTFWFDVEAYMETCEWPRREQEEVI
HHHHHCCCEEEEECCCCCCCEEEEEHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
GIWQNDVIAVDITNASALNFSKNLQRWFSEFRIQTRLLAAAALIISLVLASFTFWALNY
CCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQEDARRSDQRFGEAVGNLLAATAAPLIALDQYPQLGEFTEEFLASNADNILYVLYADSK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEEEECCC
GDILYGSPFNTNDTRANAPVPALIRHIELPPVLPAKRQHRTPRGLVTDIFVPIEYGERQL
CCEEECCCCCCCCCCCCCCHHHHHHHCCCCCCCCCHHHCCCCCCCEEEEEEEECCCCCEE
GVVLVGINPEANLVSRSDLTRDVTVAVFVLVWIIAILGSVFNALTITQPLKELVQGVQRI
EEEEEEECCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQGNFKQRVTLAYPGEIGELITSFNLMAQRLQSYEEQNIEEITAEKAKLETFIATIADGG
HCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCC
ILLDSSLRILLVNPAMLRIFGWGSRVVGKNILDLLPVGMRAEVEEPLDSVSRNILEQAEC
EEECCCCEEEEECHHHEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
RVVLDKRTLRVLISPVLAPRGDNLLKGVVLTVQDLSKEAELNQAKSQFISNVSHELRTPL
EEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHH
SSIKSYIETVYEFGDSLDDSTKNEFLKTANQETDRLTRLVNDVLDLSRLESGREYHFEPV
HHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCH
DLVQPIEQTLRTHRLTARDREIELVSDIATDLPLVLGNYDLLQQVFSNLVGNALKFTEPG
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHCCCEEECCCC
GRVTLSARRTDDPAKVRVAVTDTGIGISEEDQRRIFERFFRVENRVHTLEGTGLGLSIVD
CEEEEEECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHEEEECCCCCCHHHHH
NIVKKHNAQVHIESEVGQGSTFWFDVEAYMETCEWPRREQEEVI
HHHHHCCCEEEEECCCCCCCEEEEEHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8535519; 8905231; 3141423 [H]