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The map label for this gene is dnaC [H]

Identifier: 37519603

GI number: 37519603

Start: 33259

End: 35388

Strand: Reverse

Name: dnaC [H]

Synonym: gll0034

Alternate gene names: 37519603

Gene position: 35388-33259 (Counterclockwise)

Preceding gene: 37519605

Following gene: 37519601

Centisome position: 0.76

GC content: 61.08

Gene sequence:

>2130_bases
ATGACCTCATCCGAACTCGACCTGCGCATCGAAGAGCGCCTGCCGCCCCAAAACATCGATGCGGAGGAGACGATTCTGGG
GGGACTGATGATGGATCCGGAGGCGCTCACCCGCGTCGTCGAACACCTGAGACCCGAGGCGTTCTACGTCGAGTCGCACC
AGATCATCTACCGCGCCGCCCTGGCGCTGCACGCTCAGGGAAGACCCACCGACCTGCTCACCCTGAGTGCCTGGCTCGAA
GATAACAAGCTCACCGAAAAGATCGGGGGCCGCACCTACCTGCGCCGCCTCACCGACGCCGCCATCAATACGATCAACAT
CGACGGCTACGGCCGCCTGGTATCGGACAAGTACGCCCTGCGCATGCTCATCCGCGCCGGCCAGGAAATCGCCGCCCTCG
GTTTCGATAGCGCCACCGAGATTCCAAAGCTGCTCGATCGAGCCGAACAAACGCTCTTTGCCGTTACCCAGGAGCGGGTG
CAACGCTCGCTGGTGCCCGCCTCCGAAGTGCTCATGAACATCTTCGAGCAACTGGAGACCCGCTACCAGGACGGCAGCAA
CGTCTTCGGCATCCCCACCCACTTCTACGATCTCGACAACTACACCCAGGGCCTGCAGCCGTCCGATCTGATTATCGTCG
CGGGCCGCCCCGGCATGGGCAAGTGCTGCGCAGCCGATACCCCCATCGCCGATCCGGTCACCGGCGCGCTGGTCACCATC
GAAGAAATCTACCGCCGCGGTGAGGCCGGAAAATTGGTGGAAGTGCTGACGCTGTTGGGCGACGGCAGACTGGCCCGCGT
CGAACCGAGTCACTTCGTAGACGACGGCATCAAGCCGGTCTACCGCGTGCGCACCGGCCTCGGGCGCGAGGTGAAGACGA
CCCTGACCCACCCCTACCTGACCCCGACCGGCTGGAAGCCCCTCGCCGAAATCGCCGCCGGGGCGCGCATTGCTGTGCCC
TGCCGCATCCCGGTTTTCGGCAGCGAGAGTCTGCCGCCCAAAGAAATCTCGCTGTTGTGCAGCCGGGCCACCCGGGATAA
CCGCATCCCCGACCCGGTTTTTCGGCTGCCGAGGGCGCAACTGGTCGCTTTTTTGAAGCAGCTCTGCATCACCGCCGACT
CCGCCCGGGTGAGCGACCGGACCGTCGAATTTACTTCACCCTCCAAGTCTTTTTGCCACCAACTGCAGCATCTGCTGTTG
CGCCTCGGGGTGCTCTCGGCTCTGCGCGAGGTGTCCGGGATATTTTATCTGGATATCAAACCCGCCGCTGAAACGCCAAT
CAAACCCGCCAGCCTTTGGAGCCAGGATCTCGCTCACCATTGCGACCTCCACTGGGATGAAATTGCGTCCATCGAGTATG
TGGGAAACGAGCAGGTCTACGACCTGACGGTGCCCGTCACCCACAACTTTGTCGCAGCCGATATCTGTCTGCACAACACC
GCCTTTTCCCTATCGATCGCCCAGCGTATCGCCCAAAAAGCCGGTTTGCCGGCGGTGGTCTTCAGTCTGGAAATGTCCAA
AGAACAACTCGTCCAGCGCCTGCTGTGCTCGGAAGCGGGTGTCGAAAGCCATCGGCTGCGGGCGGCGCGCATCAGCGAAA
ACGAATGGCAACGCATCGGCCAGGCCATCGGTGAACTGGCCAGTATTCCCCTCTACATCGACGATTCTCCGAACGCAACC
GTCACCGAAATCCGCTCCAAGGCCCGTCGCCTGCAGGCCGAGCAGGGCGGACGATTGGGACTGGTGATGATCGATTACTT
GCAATTGATGGAAGGGGCAGGATCCGACAACCGCGTCCAGGAGCTGTCGAAAATCACCCGCGGTCTCAAGGGCCTAGCCC
GCGAGTTGCGCGTGCCGGTAATGGCCCTCTCGCAGCTATCGCGCAGCGTCGAAGCGCGCACAAACAAGCGGCCCATGTTG
TCGGACTTGAGAGAATCGGGGTCCATAGAACAAGACGCCGATATCGTCTTAATGCTCTACCGCGACGACTACTACAACCC
CGACTCACCGGATCGCAACATTGCAGAAGTCAATATCGTCAAACATCGCAACGGTCCCACCGGTACCGTGAAATTGCTCT
TCGAAAATCAGTTCACCCGGTTTTTAAACCTGACTTCCGGCAACCACTGA

Upstream 100 bases:

>100_bases
CGGAGGTCCGGCGCAAGGATCGGGGCTTTCGGAGGCGAAGCTTTGCATCTGGGCGCTAGATATAGAGTAATATGGCGAAC
TGAAACGAAGGCCCGGCTCC

Downstream 100 bases:

>100_bases
CAGCAGGGATGTCAGCCGGTGGCCCACTCAGTCCCCACCACCGGAAGCGCCCAGCGCTCGATGGCGGCGGTCAACTGATC
GCGGCGTACCGGCTTGATCA

Product: replicative DNA helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 709; Mature: 708

Protein sequence:

>709_residues
MTSSELDLRIEERLPPQNIDAEETILGGLMMDPEALTRVVEHLRPEAFYVESHQIIYRAALALHAQGRPTDLLTLSAWLE
DNKLTEKIGGRTYLRRLTDAAINTINIDGYGRLVSDKYALRMLIRAGQEIAALGFDSATEIPKLLDRAEQTLFAVTQERV
QRSLVPASEVLMNIFEQLETRYQDGSNVFGIPTHFYDLDNYTQGLQPSDLIIVAGRPGMGKCCAADTPIADPVTGALVTI
EEIYRRGEAGKLVEVLTLLGDGRLARVEPSHFVDDGIKPVYRVRTGLGREVKTTLTHPYLTPTGWKPLAEIAAGARIAVP
CRIPVFGSESLPPKEISLLCSRATRDNRIPDPVFRLPRAQLVAFLKQLCITADSARVSDRTVEFTSPSKSFCHQLQHLLL
RLGVLSALREVSGIFYLDIKPAAETPIKPASLWSQDLAHHCDLHWDEIASIEYVGNEQVYDLTVPVTHNFVAADICLHNT
AFSLSIAQRIAQKAGLPAVVFSLEMSKEQLVQRLLCSEAGVESHRLRAARISENEWQRIGQAIGELASIPLYIDDSPNAT
VTEIRSKARRLQAEQGGRLGLVMIDYLQLMEGAGSDNRVQELSKITRGLKGLARELRVPVMALSQLSRSVEARTNKRPML
SDLRESGSIEQDADIVLMLYRDDYYNPDSPDRNIAEVNIVKHRNGPTGTVKLLFENQFTRFLNLTSGNH

Sequences:

>Translated_709_residues
MTSSELDLRIEERLPPQNIDAEETILGGLMMDPEALTRVVEHLRPEAFYVESHQIIYRAALALHAQGRPTDLLTLSAWLE
DNKLTEKIGGRTYLRRLTDAAINTINIDGYGRLVSDKYALRMLIRAGQEIAALGFDSATEIPKLLDRAEQTLFAVTQERV
QRSLVPASEVLMNIFEQLETRYQDGSNVFGIPTHFYDLDNYTQGLQPSDLIIVAGRPGMGKCCAADTPIADPVTGALVTI
EEIYRRGEAGKLVEVLTLLGDGRLARVEPSHFVDDGIKPVYRVRTGLGREVKTTLTHPYLTPTGWKPLAEIAAGARIAVP
CRIPVFGSESLPPKEISLLCSRATRDNRIPDPVFRLPRAQLVAFLKQLCITADSARVSDRTVEFTSPSKSFCHQLQHLLL
RLGVLSALREVSGIFYLDIKPAAETPIKPASLWSQDLAHHCDLHWDEIASIEYVGNEQVYDLTVPVTHNFVAADICLHNT
AFSLSIAQRIAQKAGLPAVVFSLEMSKEQLVQRLLCSEAGVESHRLRAARISENEWQRIGQAIGELASIPLYIDDSPNAT
VTEIRSKARRLQAEQGGRLGLVMIDYLQLMEGAGSDNRVQELSKITRGLKGLARELRVPVMALSQLSRSVEARTNKRPML
SDLRESGSIEQDADIVLMLYRDDYYNPDSPDRNIAEVNIVKHRNGPTGTVKLLFENQFTRFLNLTSGNH
>Mature_708_residues
TSSELDLRIEERLPPQNIDAEETILGGLMMDPEALTRVVEHLRPEAFYVESHQIIYRAALALHAQGRPTDLLTLSAWLED
NKLTEKIGGRTYLRRLTDAAINTINIDGYGRLVSDKYALRMLIRAGQEIAALGFDSATEIPKLLDRAEQTLFAVTQERVQ
RSLVPASEVLMNIFEQLETRYQDGSNVFGIPTHFYDLDNYTQGLQPSDLIIVAGRPGMGKCCAADTPIADPVTGALVTIE
EIYRRGEAGKLVEVLTLLGDGRLARVEPSHFVDDGIKPVYRVRTGLGREVKTTLTHPYLTPTGWKPLAEIAAGARIAVPC
RIPVFGSESLPPKEISLLCSRATRDNRIPDPVFRLPRAQLVAFLKQLCITADSARVSDRTVEFTSPSKSFCHQLQHLLLR
LGVLSALREVSGIFYLDIKPAAETPIKPASLWSQDLAHHCDLHWDEIASIEYVGNEQVYDLTVPVTHNFVAADICLHNTA
FSLSIAQRIAQKAGLPAVVFSLEMSKEQLVQRLLCSEAGVESHRLRAARISENEWQRIGQAIGELASIPLYIDDSPNATV
TEIRSKARRLQAEQGGRLGLVMIDYLQLMEGAGSDNRVQELSKITRGLKGLARELRVPVMALSQLSRSVEARTNKRPMLS
DLRESGSIEQDADIVLMLYRDDYYNPDSPDRNIAEVNIVKHRNGPTGTVKLLFENQFTRFLNLTSGNH

Specific function: Participates In Initiation And Elongation During Chromosome Replication; It Exhibits DNA-Dependent ATPase Activity And Contains Distinct Active Sites For ATP Binding, DNA Binding, And Interaction With DNAc Protein, Primase, And Other Prepriming Proteins.

COG id: COG0305

COG function: function code L; Replicative DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SF4 helicase domain [H]

Homologues:

Organism=Escherichia coli, GI1790486, Length=236, Percent_Identity=49.1525423728814, Blast_Score=219, Evalue=4e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR007692
- InterPro:   IPR007694
- InterPro:   IPR007693
- InterPro:   IPR016136 [H]

Pfam domain/function: PF00772 DnaB; PF03796 DnaB_C [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 78864; Mature: 78733

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: PS50817 INTEIN_N_TER ; PS50818 INTEIN_C_TER ; PS50819 INTEIN_ENDONUCLEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSSELDLRIEERLPPQNIDAEETILGGLMMDPEALTRVVEHLRPEAFYVESHQIIYRAA
CCCCCCCEEEHHCCCCCCCCHHHHHHCCCEECHHHHHHHHHHHCCCEEEECCHHHHHHHH
LALHAQGRPTDLLTLSAWLEDNKLTEKIGGRTYLRRLTDAAINTINIDGYGRLVSDKYAL
HHHCCCCCCCCEEEEEEHHCCCHHHHHHCHHHHHHHHHHHHHCEEEECCCCCHHHHHHHH
RMLIRAGQEIAALGFDSATEIPKLLDRAEQTLFAVTQERVQRSLVPASEVLMNIFEQLET
HHHHHCCCHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
RYQDGSNVFGIPTHFYDLDNYTQGLQPSDLIIVAGRPGMGKCCAADTPIADPVTGALVTI
HHCCCCCEEECCHHEEECCHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHH
EEIYRRGEAGKLVEVLTLLGDGRLARVEPSHFVDDGIKPVYRVRTGLGREVKTTLTHPYL
HHHHCCCCCCHHHHHHHHHCCCCEEEECCHHHHHCCCHHHHHHHHCCCCHHHHHHCCCCC
TPTGWKPLAEIAAGARIAVPCRIPVFGSESLPPKEISLLCSRATRDNRIPDPVFRLPRAQ
CCCCCCHHHHHHCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCHHHHCCHHH
LVAFLKQLCITADSARVSDRTVEFTSPSKSFCHQLQHLLLRLGVLSALREVSGIFYLDIK
HHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEC
PAAETPIKPASLWSQDLAHHCDLHWDEIASIEYVGNEQVYDLTVPVTHNFVAADICLHNT
CCCCCCCCCHHHHHHHHHHHCCCCHHHHCCEEEECCCEEEEEEECCCCCCEEHHHHHCCC
AFSLSIAQRIAQKAGLPAVVFSLEMSKEQLVQRLLCSEAGVESHRLRAARISENEWQRIG
HHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHH
QAIGELASIPLYIDDSPNATVTEIRSKARRLQAEQGGRLGLVMIDYLQLMEGAGSDNRVQ
HHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCCCHHHH
ELSKITRGLKGLARELRVPVMALSQLSRSVEARTNKRPMLSDLRESGSIEQDADIVLMLY
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCEEEEEE
RDDYYNPDSPDRNIAEVNIVKHRNGPTGTVKLLFENQFTRFLNLTSGNH
ECCCCCCCCCCCCCEEEEEEEECCCCCCEEEEEEEHHHHHHEECCCCCC
>Mature Secondary Structure 
TSSELDLRIEERLPPQNIDAEETILGGLMMDPEALTRVVEHLRPEAFYVESHQIIYRAA
CCCCCCEEEHHCCCCCCCCHHHHHHCCCEECHHHHHHHHHHHCCCEEEECCHHHHHHHH
LALHAQGRPTDLLTLSAWLEDNKLTEKIGGRTYLRRLTDAAINTINIDGYGRLVSDKYAL
HHHCCCCCCCCEEEEEEHHCCCHHHHHHCHHHHHHHHHHHHHCEEEECCCCCHHHHHHHH
RMLIRAGQEIAALGFDSATEIPKLLDRAEQTLFAVTQERVQRSLVPASEVLMNIFEQLET
HHHHHCCCHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
RYQDGSNVFGIPTHFYDLDNYTQGLQPSDLIIVAGRPGMGKCCAADTPIADPVTGALVTI
HHCCCCCEEECCHHEEECCHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHH
EEIYRRGEAGKLVEVLTLLGDGRLARVEPSHFVDDGIKPVYRVRTGLGREVKTTLTHPYL
HHHHCCCCCCHHHHHHHHHCCCCEEEECCHHHHHCCCHHHHHHHHCCCCHHHHHHCCCCC
TPTGWKPLAEIAAGARIAVPCRIPVFGSESLPPKEISLLCSRATRDNRIPDPVFRLPRAQ
CCCCCCHHHHHHCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCHHHHCCHHH
LVAFLKQLCITADSARVSDRTVEFTSPSKSFCHQLQHLLLRLGVLSALREVSGIFYLDIK
HHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEC
PAAETPIKPASLWSQDLAHHCDLHWDEIASIEYVGNEQVYDLTVPVTHNFVAADICLHNT
CCCCCCCCCHHHHHHHHHHHCCCCHHHHCCEEEECCCEEEEEEECCCCCCEEHHHHHCCC
AFSLSIAQRIAQKAGLPAVVFSLEMSKEQLVQRLLCSEAGVESHRLRAARISENEWQRIG
HHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHH
QAIGELASIPLYIDDSPNATVTEIRSKARRLQAEQGGRLGLVMIDYLQLMEGAGSDNRVQ
HHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCCCHHHH
ELSKITRGLKGLARELRVPVMALSQLSRSVEARTNKRPMLSDLRESGSIEQDADIVLMLY
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCEEEEEE
RDDYYNPDSPDRNIAEVNIVKHRNGPTGTVKLLFENQFTRFLNLTSGNH
ECCCCCCCCCCCCCEEEEEEEECCCCCCEEEEEEEHHHHHHEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377; 1312531 [H]