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The map label for this gene is arlS [H]

Identifier: 37519592

GI number: 37519592

Start: 21151

End: 22677

Strand: Reverse

Name: arlS [H]

Synonym: gll0023

Alternate gene names: 37519592

Gene position: 22677-21151 (Counterclockwise)

Preceding gene: 37519594

Following gene: 37519591

Centisome position: 0.49

GC content: 65.36

Gene sequence:

>1527_bases
GTGGGCGCAGGGCGTTTTTCAGATTGGGACAAGCAATTGAACCCATCCGTCGCACGGCTCTGGCGGCGAACCTTCGGGGG
AGTGCGCACGCGCATCCTCGCCTGGTACGTGCTGTTGATCGCCCTGTGCGGAGTGACCTCGGTCCTGGCGGTGCGCGAGA
TTCTGTTTATGCAATTGCAGGAGCGGCTGGAGACCTCGTTGGTGCGGGAGGTGCGGCTTTTTGAGCTTTTGAGCGCCGAG
GAGCCGGTTGTGCAGGAGCAGCCGATGCGCGAACGCGCCGCCCACATCTTCGATCGTTTTTTTTACCGCTACGTCCCGCA
CGACAACGAGTTCATGCTCGCCTACATCGACGGCGAACTCTACCGGACGATGCCCCAGAAGCTCGACGGCACCATGCGCG
CCAACGGCAAGCTCACCTCCCGCTGGTCGCATTTGCGCGCGCCGGAGCGCGACGAGCGCACGGGCTCGAGCGGCGAGAAG
TTTTTGTACATCGCCGAGCCGTTGCGCCTGGGCGGCGAGCCGCGCGGACTGTTGGTGGCGGCTTATTGTGTCTCCTGCGA
GCGCCGCGAGGTGGAGCGGTCGGTGATGGTGGTGGCCCAGGTCTTTATTGGGGCGACGCTGCTCGCTTCGCTATTGGCCT
GGATCGCCGCCGGCCGGGTGCTGGCGCCTTTGCGGCTGCTCGCCGAGACGGCCCGATCGATTGGCGAATCGGATCTGACC
CGGCGCATCCCGGCGGGCGACCGCGGCGAGTTGGGCGAACTGGCCGCCACCTTCAACCAGATGCTCGATCGTCTGGAGGC
GGCCTTCGCGAGCCAGCGCAACTTTATCAGCGACGCAGGCCACGAACTGCGCACGCCGATTACGATTGTCCGGGGTCACT
TGGAGTTGTTGGGAGACGATCCCGGCGAGCGGGCCGAGACGATGGCGATCGTGTACGACGAACTCGATCGCATGAACCGC
TTTGTCGACGACCTGCTGCTTTTGGCCAGGGCCGAGCGACCGGACTTTTTGTTCTTTGAGCTGTTCGATGTCGGCGAACT
GACCGACGAACTGTACGCAAAGGCCCGTGCCCTCGCCCCGCGCGAGTGGTCCATCGAGGCGCGCGGCAGCGGCCGGATGG
TCGCCGATCGCCAGCGGTTGACCCAGGCGGTGATCAATCTGGCCCAAAACGCCGTGCAGCACACTGCCCCGGGCGATCGC
ATCGCCATCGGCTCGGCCCTGCGGGGGGTGTGGGTGTATCTGTGGGTGAGCGACTGCGGGCCGGGCATTGCGCCGGAAGA
TCAGCGGCGCATCTTCGAGCGCTTCGAGCGCGGCAGCCATAGCCGCTACGAGGGCAGCGGCCTGGGACTCGCCATCGTAC
AGGCGATCGCCACCACCCACGGCGGCAGCATCCAACTGACAAGCGTACCGGGCGCAGGGGCGACCTTTACGCTGGTGCTG
CCCCTCGACCCGCCCCAGGAACTGCAATTGCACAATCAACTCGCAGGTCAGAGCTGCTCGACGGTGCTCTCGGTCTATTC
GCACTGA

Upstream 100 bases:

>100_bases
TTCGATACATGCCGCCTGGCGCGTGCAGGCCCGTCGGGTTTTGCGCTAGGCGCAGGCGGAGCTGCCTCCTCAGCAAATCG
GCGTTACCAGAGAGAGTACC

Downstream 100 bases:

>100_bases
ACTCCCTCAAATTTGGAGAACCGCCATGAACCGGATTTTGATTGCCGAGGATGAGACGCGCATTGCCGCATTTCTAGAAA
AAGGTCTGCGCGCCAACGGC

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 508; Mature: 507

Protein sequence:

>508_residues
MGAGRFSDWDKQLNPSVARLWRRTFGGVRTRILAWYVLLIALCGVTSVLAVREILFMQLQERLETSLVREVRLFELLSAE
EPVVQEQPMRERAAHIFDRFFYRYVPHDNEFMLAYIDGELYRTMPQKLDGTMRANGKLTSRWSHLRAPERDERTGSSGEK
FLYIAEPLRLGGEPRGLLVAAYCVSCERREVERSVMVVAQVFIGATLLASLLAWIAAGRVLAPLRLLAETARSIGESDLT
RRIPAGDRGELGELAATFNQMLDRLEAAFASQRNFISDAGHELRTPITIVRGHLELLGDDPGERAETMAIVYDELDRMNR
FVDDLLLLARAERPDFLFFELFDVGELTDELYAKARALAPREWSIEARGSGRMVADRQRLTQAVINLAQNAVQHTAPGDR
IAIGSALRGVWVYLWVSDCGPGIAPEDQRRIFERFERGSHSRYEGSGLGLAIVQAIATTHGGSIQLTSVPGAGATFTLVL
PLDPPQELQLHNQLAGQSCSTVLSVYSH

Sequences:

>Translated_508_residues
MGAGRFSDWDKQLNPSVARLWRRTFGGVRTRILAWYVLLIALCGVTSVLAVREILFMQLQERLETSLVREVRLFELLSAE
EPVVQEQPMRERAAHIFDRFFYRYVPHDNEFMLAYIDGELYRTMPQKLDGTMRANGKLTSRWSHLRAPERDERTGSSGEK
FLYIAEPLRLGGEPRGLLVAAYCVSCERREVERSVMVVAQVFIGATLLASLLAWIAAGRVLAPLRLLAETARSIGESDLT
RRIPAGDRGELGELAATFNQMLDRLEAAFASQRNFISDAGHELRTPITIVRGHLELLGDDPGERAETMAIVYDELDRMNR
FVDDLLLLARAERPDFLFFELFDVGELTDELYAKARALAPREWSIEARGSGRMVADRQRLTQAVINLAQNAVQHTAPGDR
IAIGSALRGVWVYLWVSDCGPGIAPEDQRRIFERFERGSHSRYEGSGLGLAIVQAIATTHGGSIQLTSVPGAGATFTLVL
PLDPPQELQLHNQLAGQSCSTVLSVYSH
>Mature_507_residues
GAGRFSDWDKQLNPSVARLWRRTFGGVRTRILAWYVLLIALCGVTSVLAVREILFMQLQERLETSLVREVRLFELLSAEE
PVVQEQPMRERAAHIFDRFFYRYVPHDNEFMLAYIDGELYRTMPQKLDGTMRANGKLTSRWSHLRAPERDERTGSSGEKF
LYIAEPLRLGGEPRGLLVAAYCVSCERREVERSVMVVAQVFIGATLLASLLAWIAAGRVLAPLRLLAETARSIGESDLTR
RIPAGDRGELGELAATFNQMLDRLEAAFASQRNFISDAGHELRTPITIVRGHLELLGDDPGERAETMAIVYDELDRMNRF
VDDLLLLARAERPDFLFFELFDVGELTDELYAKARALAPREWSIEARGSGRMVADRQRLTQAVINLAQNAVQHTAPGDRI
AIGSALRGVWVYLWVSDCGPGIAPEDQRRIFERFERGSHSRYEGSGLGLAIVQAIATTHGGSIQLTSVPGAGATFTLVLP
LDPPQELQLHNQLAGQSCSTVLSVYSH

Specific function: Member of the two-component regulatory system ArlS/ArlR. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to ArlR [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=303, Percent_Identity=32.3432343234323, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1788393, Length=274, Percent_Identity=32.1167883211679, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1786600, Length=268, Percent_Identity=32.4626865671642, Blast_Score=116, Evalue=4e-27,
Organism=Escherichia coli, GI1787894, Length=262, Percent_Identity=33.206106870229, Blast_Score=107, Evalue=3e-24,
Organism=Escherichia coli, GI1790346, Length=277, Percent_Identity=29.9638989169675, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1789403, Length=276, Percent_Identity=31.1594202898551, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1788549, Length=271, Percent_Identity=30.2583025830258, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1790436, Length=211, Percent_Identity=32.2274881516588, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1788279, Length=220, Percent_Identity=30.9090909090909, Blast_Score=96, Evalue=7e-21,
Organism=Escherichia coli, GI1786912, Length=236, Percent_Identity=30.5084745762712, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1788713, Length=237, Percent_Identity=27.4261603375527, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1789808, Length=281, Percent_Identity=27.7580071174377, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI145693157, Length=260, Percent_Identity=26.5384615384615, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1790861, Length=377, Percent_Identity=27.5862068965517, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1789149, Length=353, Percent_Identity=24.6458923512748, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87082128, Length=275, Percent_Identity=25.4545454545455, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87081816, Length=253, Percent_Identity=28.8537549407115, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1790551, Length=294, Percent_Identity=28.2312925170068, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1787374, Length=281, Percent_Identity=24.9110320284698, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI48994928, Length=235, Percent_Identity=28.5106382978723, Blast_Score=73, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 56807; Mature: 56676

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS50885 HAMP ; PS00027 HOMEOBOX_1 ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAGRFSDWDKQLNPSVARLWRRTFGGVRTRILAWYVLLIALCGVTSVLAVREILFMQLQ
CCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERLETSLVREVRLFELLSAEEPVVQEQPMRERAAHIFDRFFYRYVPHDNEFMLAYIDGEL
HHHHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHH
YRTMPQKLDGTMRANGKLTSRWSHLRAPERDERTGSSGEKFLYIAEPLRLGGEPRGLLVA
HHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEEECHHHCCCCCCHHHHH
AYCVSCERREVERSVMVVAQVFIGATLLASLLAWIAAGRVLAPLRLLAETARSIGESDLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
RRIPAGDRGELGELAATFNQMLDRLEAAFASQRNFISDAGHELRTPITIVRGHLELLGDD
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHCCC
PGERAETMAIVYDELDRMNRFVDDLLLLARAERPDFLFFELFDVGELTDELYAKARALAP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHCCC
REWSIEARGSGRMVADRQRLTQAVINLAQNAVQHTAPGDRIAIGSALRGVWVYLWVSDCG
CCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHEEEEEEECCC
PGIAPEDQRRIFERFERGSHSRYEGSGLGLAIVQAIATTHGGSIQLTSVPGAGATFTLVL
CCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEE
PLDPPQELQLHNQLAGQSCSTVLSVYSH
ECCCCHHHHHHHHHCCHHHHHHHHHHCC
>Mature Secondary Structure 
GAGRFSDWDKQLNPSVARLWRRTFGGVRTRILAWYVLLIALCGVTSVLAVREILFMQLQ
CCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERLETSLVREVRLFELLSAEEPVVQEQPMRERAAHIFDRFFYRYVPHDNEFMLAYIDGEL
HHHHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHH
YRTMPQKLDGTMRANGKLTSRWSHLRAPERDERTGSSGEKFLYIAEPLRLGGEPRGLLVA
HHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEEECHHHCCCCCCHHHHH
AYCVSCERREVERSVMVVAQVFIGATLLASLLAWIAAGRVLAPLRLLAETARSIGESDLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
RRIPAGDRGELGELAATFNQMLDRLEAAFASQRNFISDAGHELRTPITIVRGHLELLGDD
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHCCC
PGERAETMAIVYDELDRMNRFVDDLLLLARAERPDFLFFELFDVGELTDELYAKARALAP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHCCC
REWSIEARGSGRMVADRQRLTQAVINLAQNAVQHTAPGDRIAIGSALRGVWVYLWVSDCG
CCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHEEEEEEECCC
PGIAPEDQRRIFERFERGSHSRYEGSGLGLAIVQAIATTHGGSIQLTSVPGAGATFTLVL
CCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEE
PLDPPQELQLHNQLAGQSCSTVLSVYSH
ECCCCHHHHHHHHHCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA