Click here to switch to the map view.

The map label for this gene is bioC [H]

Identifier: 34499831

GI number: 34499831

Start: 4718704

End: 4719612

Strand: Reverse

Name: bioC [H]

Synonym: CV_4376

Alternate gene names: 34499831

Gene position: 4719612-4718704 (Counterclockwise)

Preceding gene: 34499832

Following gene: 34499830

Centisome position: 99.34

GC content: 67.0

Gene sequence:

>909_bases
ATGAGTGAAGCGTTTTACACCGACAAGGCGCGCGTGCGCGCCTCGTTCGAAAAGGCCGCGGCCAGCTACGATTCCGCCGC
GGTGCTGCAGCGCGAAGTCTCCGACCGCATGGCGGAACGGCTGGACTACATCAAGCACCAGCCGGCGGTGATCCTGGACG
CCGGCGCCGGCACCGGTTACGGCGCGGCCGAGCTCCGGCGGCGCTATCCGCAGGCGCGGGTGATCGAGCTGGACCTGGCG
CACGCGATGCTGCTGGCCTCGCGCGAGCGCGGCCGGGCCGGGGACGGCCTGTTGAAGAAGCTGTTCAAGCCCAGCCTGCC
GTGGCAGATCAACGCCGATATCGAAAAACTGCCTTTGGCCGACGCCAGCGTCGACATGATCTGGTCCAATCTGACCATCC
AGTGGATCAACGTGCCGGACAAGATGTTCGCCGAGCTGCGCCGGGTGCTGAAGCCGGACGGCATGCTGATGTTCTCCACG
CTGGGGCCGGACACGCTGTCCGAGCTGCGGGCGGCATTCGCCGGCGTGGACGGCGCCACCCACGTCAACCAGTTCATCGA
CATGCACGACATCGGCGACGCGCTGATGCGCGCCGGCTTCGCCGAGCCGGTGATGGACATGGAGAAGATCGCGTTGACCT
ACGACGACGCCCGCGCGGTGATGCGCGACCTGAAAGCCATCGGCGCGCACAACGCCACCGCCGGCCGCGGCCGCGGCCTG
ATGGGCAAGCAGGCCTGGCGCAAGGTGGAAGAAGCGTACGAGCGCTACCGCCGCGACGGCAAGCTGCCCGCCAGCTACGA
GGTGGTGTACGGCCACGCTTGGAAGGGCACCGAAAAAAAACTGGCCAAGATCAGCGACGACGGCCGCCAGGTGATCGAAT
TCGTCAAGAAAGCGCCGCGGGCCGATTGA

Upstream 100 bases:

>100_bases
ACGCCGTCCTTTATGAATTCCCGCAAGCGTCGCACGCCCCCTTCCTGTCGCATGAACAGGATTTCGTGCGCGCGCTTGCC
GAGCATCTGGAAACCCAGGC

Downstream 100 bases:

>100_bases
GCGGAAACCGGCGGAGCGGAAAGGAAGCCGCTGAATGAATGTGGAAATCCGCAGCGCCCGCCGCGAAGACGCGGCGTGTC
TCGCCGCCCTGTCGATACAG

Product: biotin synthesis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MSEAFYTDKARVRASFEKAAASYDSAAVLQREVSDRMAERLDYIKHQPAVILDAGAGTGYGAAELRRRYPQARVIELDLA
HAMLLASRERGRAGDGLLKKLFKPSLPWQINADIEKLPLADASVDMIWSNLTIQWINVPDKMFAELRRVLKPDGMLMFST
LGPDTLSELRAAFAGVDGATHVNQFIDMHDIGDALMRAGFAEPVMDMEKIALTYDDARAVMRDLKAIGAHNATAGRGRGL
MGKQAWRKVEEAYERYRRDGKLPASYEVVYGHAWKGTEKKLAKISDDGRQVIEFVKKAPRAD

Sequences:

>Translated_302_residues
MSEAFYTDKARVRASFEKAAASYDSAAVLQREVSDRMAERLDYIKHQPAVILDAGAGTGYGAAELRRRYPQARVIELDLA
HAMLLASRERGRAGDGLLKKLFKPSLPWQINADIEKLPLADASVDMIWSNLTIQWINVPDKMFAELRRVLKPDGMLMFST
LGPDTLSELRAAFAGVDGATHVNQFIDMHDIGDALMRAGFAEPVMDMEKIALTYDDARAVMRDLKAIGAHNATAGRGRGL
MGKQAWRKVEEAYERYRRDGKLPASYEVVYGHAWKGTEKKLAKISDDGRQVIEFVKKAPRAD
>Mature_301_residues
SEAFYTDKARVRASFEKAAASYDSAAVLQREVSDRMAERLDYIKHQPAVILDAGAGTGYGAAELRRRYPQARVIELDLAH
AMLLASRERGRAGDGLLKKLFKPSLPWQINADIEKLPLADASVDMIWSNLTIQWINVPDKMFAELRRVLKPDGMLMFSTL
GPDTLSELRAAFAGVDGATHVNQFIDMHDIGDALMRAGFAEPVMDMEKIALTYDDARAVMRDLKAIGAHNATAGRGRGLM
GKQAWRKVEEAYERYRRDGKLPASYEVVYGHAWKGTEKKLAKISDDGRQVIEFVKKAPRAD

Specific function: BioC is involved in an early, but chemically unexplored, step in the conversion of pimelic acid to biotin [H]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily [H]

Homologues:

Organism=Homo sapiens, GI40018642, Length=274, Percent_Identity=28.4671532846715, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI86792933, Length=274, Percent_Identity=26.6423357664234, Blast_Score=88, Evalue=8e-18,
Organism=Escherichia coli, GI1786994, Length=249, Percent_Identity=32.5301204819277, Blast_Score=123, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17535003, Length=265, Percent_Identity=26.7924528301887, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI19922210, Length=284, Percent_Identity=29.9295774647887, Blast_Score=101, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011814
- InterPro:   IPR013216 [H]

Pfam domain/function: PF08241 Methyltransf_11 [H]

EC number: NA

Molecular weight: Translated: 33673; Mature: 33542

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEAFYTDKARVRASFEKAAASYDSAAVLQREVSDRMAERLDYIKHQPAVILDAGAGTGY
CCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCC
GAAELRRRYPQARVIELDLAHAMLLASRERGRAGDGLLKKLFKPSLPWQINADIEKLPLA
CHHHHHHHCCCCEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEECCCHHHCCCC
DASVDMIWSNLTIQWINVPDKMFAELRRVLKPDGMLMFSTLGPDTLSELRAAFAGVDGAT
CCHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCHH
HVNQFIDMHDIGDALMRAGFAEPVMDMEKIALTYDDARAVMRDLKAIGAHNATAGRGRGL
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
MGKQAWRKVEEAYERYRRDGKLPASYEVVYGHAWKGTEKKLAKISDDGRQVIEFVKKAPR
CCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHCCC
AD
CC
>Mature Secondary Structure 
SEAFYTDKARVRASFEKAAASYDSAAVLQREVSDRMAERLDYIKHQPAVILDAGAGTGY
CCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCC
GAAELRRRYPQARVIELDLAHAMLLASRERGRAGDGLLKKLFKPSLPWQINADIEKLPLA
CHHHHHHHCCCCEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEECCCHHHCCCC
DASVDMIWSNLTIQWINVPDKMFAELRRVLKPDGMLMFSTLGPDTLSELRAAFAGVDGAT
CCHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCHH
HVNQFIDMHDIGDALMRAGFAEPVMDMEKIALTYDDARAVMRDLKAIGAHNATAGRGRGL
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
MGKQAWRKVEEAYERYRRDGKLPASYEVVYGHAWKGTEKKLAKISDDGRQVIEFVKKAPR
CCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHCCC
AD
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8250549 [H]