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The map label for this gene is aroP [H]

Identifier: 34499825

GI number: 34499825

Start: 4712919

End: 4714289

Strand: Reverse

Name: aroP [H]

Synonym: CV_4370

Alternate gene names: 34499825

Gene position: 4714289-4712919 (Counterclockwise)

Preceding gene: 34499827

Following gene: 34499824

Centisome position: 99.23

GC content: 65.72

Gene sequence:

>1371_bases
GTGAGCGAAGCCCACACCGGTTTGCAGCGCGAGCTGAAAAACCGCCACATCCAGCTGATCGCGCTGGGCGGCGCCGTCGG
CACCGGCCTGTTCCTCGGCTCGGCCAGCGTCCTGAAGTCGGCCGGCCCCTCGATGATCCTCGGCTACGCCATCGCCGGCT
TCATCGCCTTCATGATCATGCGCCAACTGGGCGAGATGGTGGCCGAGGAGCCGGTCGCCGGTTCGTTCAGCCACTTCGCC
TACCGCTACTGGGGCCGCTTCCCCGGCTTTCTGTCCGGCTGGAACTACTGGGTGCTGTACGTGCTGGTGAGCATGGCCGA
GCTGACCGCGGTCGGCGCCTACGTCCAGTACTGGTGGCCGCACGTGCCGGCCTGGCTGACCGCGCTGGTGTGCTTCGTCT
GCATCAACGGCATCAATCTCGCCAACGTCAAATCCTACGGCGAGACCGAATTCTGGTTCGCGCTGATCAAGGTGGCGGCG
GTGATCGGCATGATCCTGTTCGGCGGCTACCTGCTGCTGTCCGGCAGCGGCGGCCCGCAGGCCTCGGTCAGCAATCTGTG
GAACGACGGCGGCTTCTTCCCGCACGGTGTCAAAGGCCTGTTCATGATGATGGCGGTGATCATGTTCTCCTTCGGCGGCT
TGGAACTGATCGGCATGACCGCGGCCGAGGCGAACGACCCGCAGAAAACCATCCCCAAGGCCGTCAACCAGGTGATCTAC
CGCATCCTGATCTTCTACATCGGCTCGCTGGTGGTGCTGCTGTCGCTGTACCCGTGGAACAAGGTGGCCGCCGGCGGCAG
CCCCTTCGTGATGATCTTCGAGCAGATCGGCGCCGGCTTCACCGCGCACGCGCTGAACTTCGTGGTGCTGACCGCCGCGC
TGTCGGTGTACAACAGCTGCGTGTACGCCACCAGCCGCATGCTGTTCGGCCTGGCCCGACAAGGCAACGCGCCGCGGGCG
CTGGGCAAGCTGGACACGCGCGGCGTGCCGGTGTACGCCACGCTGTTCTCCGCGGCGGCCACTTTCGCCTGCGTGATCCT
GAACTACCTGCTGCCGGGCGAGGCGCTGGGCCTGCTGATGTCGCTGGTGGTGGCCGCGCTGGTCACCAACTGGGCGATGA
TCAGCCTGACCCATCTGAAGTTCCGCCGCGCCAAGGGCGGCCAGAAGCTGGTGTTCCCGTCGTTCTGGTTCCCGCTGTCC
AACTGGATCTGCCTGGCCTTCATGGTGATGATACTGGGCATCCTGCTGTTCACGCCGGGCATGGCGGTGTCGGTCTACGT
GCTGCCGGTGTGGCTGGGCCTGCTGTGGCTGGGCTTCCGCTTGAAGAAACCCTCGCCGGCCGAGGCCAGGCTGGCCGGAG
AGAACGCCTGA

Upstream 100 bases:

>100_bases
TGTATCCAATGGTTTGACGGCAACGCCGTGCCGATGTTTAGATGAACGCGCACCTGTCCGGGCGCGCGTTCGGCGCCCGC
ACCTCAACGGAGAATTCATA

Downstream 100 bases:

>100_bases
GCGCGCATGCCGGGCTTGACGCCTGCGGGCGTTAACCGGCATGCTTGAGCCATGATGAAGCAGATTATTTCACTCCAGAC
CCAGTATGGGTGGTGGCGCG

Product: aromatic amino acid transport protein

Products: L-tryptophan [Cytoplasm]; Proton [Cytoplasm]; Proton [Cytoplasm]; L-tyrosine [Cytoplasm]; Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: General aromatic amino acid permease [H]

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MSEAHTGLQRELKNRHIQLIALGGAVGTGLFLGSASVLKSAGPSMILGYAIAGFIAFMIMRQLGEMVAEEPVAGSFSHFA
YRYWGRFPGFLSGWNYWVLYVLVSMAELTAVGAYVQYWWPHVPAWLTALVCFVCINGINLANVKSYGETEFWFALIKVAA
VIGMILFGGYLLLSGSGGPQASVSNLWNDGGFFPHGVKGLFMMMAVIMFSFGGLELIGMTAAEANDPQKTIPKAVNQVIY
RILIFYIGSLVVLLSLYPWNKVAAGGSPFVMIFEQIGAGFTAHALNFVVLTAALSVYNSCVYATSRMLFGLARQGNAPRA
LGKLDTRGVPVYATLFSAAATFACVILNYLLPGEALGLLMSLVVAALVTNWAMISLTHLKFRRAKGGQKLVFPSFWFPLS
NWICLAFMVMILGILLFTPGMAVSVYVLPVWLGLLWLGFRLKKPSPAEARLAGENA

Sequences:

>Translated_456_residues
MSEAHTGLQRELKNRHIQLIALGGAVGTGLFLGSASVLKSAGPSMILGYAIAGFIAFMIMRQLGEMVAEEPVAGSFSHFA
YRYWGRFPGFLSGWNYWVLYVLVSMAELTAVGAYVQYWWPHVPAWLTALVCFVCINGINLANVKSYGETEFWFALIKVAA
VIGMILFGGYLLLSGSGGPQASVSNLWNDGGFFPHGVKGLFMMMAVIMFSFGGLELIGMTAAEANDPQKTIPKAVNQVIY
RILIFYIGSLVVLLSLYPWNKVAAGGSPFVMIFEQIGAGFTAHALNFVVLTAALSVYNSCVYATSRMLFGLARQGNAPRA
LGKLDTRGVPVYATLFSAAATFACVILNYLLPGEALGLLMSLVVAALVTNWAMISLTHLKFRRAKGGQKLVFPSFWFPLS
NWICLAFMVMILGILLFTPGMAVSVYVLPVWLGLLWLGFRLKKPSPAEARLAGENA
>Mature_455_residues
SEAHTGLQRELKNRHIQLIALGGAVGTGLFLGSASVLKSAGPSMILGYAIAGFIAFMIMRQLGEMVAEEPVAGSFSHFAY
RYWGRFPGFLSGWNYWVLYVLVSMAELTAVGAYVQYWWPHVPAWLTALVCFVCINGINLANVKSYGETEFWFALIKVAAV
IGMILFGGYLLLSGSGGPQASVSNLWNDGGFFPHGVKGLFMMMAVIMFSFGGLELIGMTAAEANDPQKTIPKAVNQVIYR
ILIFYIGSLVVLLSLYPWNKVAAGGSPFVMIFEQIGAGFTAHALNFVVLTAALSVYNSCVYATSRMLFGLARQGNAPRAL
GKLDTRGVPVYATLFSAAATFACVILNYLLPGEALGLLMSLVVAALVTNWAMISLTHLKFRRAKGGQKLVFPSFWFPLSN
WICLAFMVMILGILLFTPGMAVSVYVLPVWLGLLWLGFRLKKPSPAEARLAGENA

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan) [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI258645169, Length=397, Percent_Identity=24.4332493702771, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI110347453, Length=360, Percent_Identity=25.8333333333333, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI258614003, Length=400, Percent_Identity=22.5, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI258614005, Length=398, Percent_Identity=23.1155778894472, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI181337167, Length=360, Percent_Identity=23.6111111111111, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1786302, Length=445, Percent_Identity=69.8876404494382, Blast_Score=639, Evalue=0.0,
Organism=Escherichia coli, GI1786789, Length=441, Percent_Identity=60.7709750566893, Blast_Score=539, Evalue=1e-154,
Organism=Escherichia coli, GI1790653, Length=457, Percent_Identity=40.2625820568928, Blast_Score=342, Evalue=2e-95,
Organism=Escherichia coli, GI1786602, Length=458, Percent_Identity=42.3580786026201, Blast_Score=338, Evalue=3e-94,
Organism=Escherichia coli, GI48994972, Length=433, Percent_Identity=43.1870669745958, Blast_Score=337, Evalue=7e-94,
Organism=Escherichia coli, GI87081915, Length=454, Percent_Identity=35.6828193832599, Blast_Score=288, Evalue=6e-79,
Organism=Escherichia coli, GI1789017, Length=421, Percent_Identity=36.104513064133, Blast_Score=270, Evalue=2e-73,
Organism=Escherichia coli, GI87081708, Length=459, Percent_Identity=31.8082788671024, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI1788480, Length=472, Percent_Identity=33.4745762711864, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI87082023, Length=270, Percent_Identity=23.3333333333333, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17531343, Length=344, Percent_Identity=23.2558139534884, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6324924, Length=491, Percent_Identity=32.7902240325866, Blast_Score=218, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6320772, Length=437, Percent_Identity=34.5537757437071, Blast_Score=218, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6322892, Length=434, Percent_Identity=33.4101382488479, Blast_Score=208, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6324061, Length=407, Percent_Identity=33.9066339066339, Blast_Score=207, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6321053, Length=456, Percent_Identity=30.4824561403509, Blast_Score=199, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6319824, Length=396, Percent_Identity=31.0606060606061, Blast_Score=189, Evalue=9e-49,
Organism=Saccharomyces cerevisiae, GI6321629, Length=400, Percent_Identity=30.25, Blast_Score=187, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6324059, Length=478, Percent_Identity=32.2175732217573, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6320717, Length=399, Percent_Identity=29.8245614035088, Blast_Score=182, Evalue=7e-47,
Organism=Saccharomyces cerevisiae, GI6324553, Length=390, Percent_Identity=31.7948717948718, Blast_Score=182, Evalue=9e-47,
Organism=Saccharomyces cerevisiae, GI6324990, Length=363, Percent_Identity=33.3333333333333, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6319543, Length=400, Percent_Identity=30.25, Blast_Score=175, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6320251, Length=397, Percent_Identity=28.9672544080605, Blast_Score=172, Evalue=8e-44,
Organism=Saccharomyces cerevisiae, GI6319608, Length=454, Percent_Identity=28.6343612334802, Blast_Score=169, Evalue=7e-43,
Organism=Saccharomyces cerevisiae, GI6319542, Length=405, Percent_Identity=28.1481481481481, Blast_Score=166, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6322967, Length=402, Percent_Identity=29.6019900497512, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6324981, Length=397, Percent_Identity=29.2191435768262, Blast_Score=140, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6320364, Length=469, Percent_Identity=26.226012793177, Blast_Score=104, Evalue=3e-23,
Organism=Drosophila melanogaster, GI221512776, Length=358, Percent_Identity=23.1843575418994, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24666159, Length=358, Percent_Identity=23.1843575418994, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24667468, Length=372, Percent_Identity=24.1935483870968, Blast_Score=82, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49486; Mature: 49355

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEAHTGLQRELKNRHIQLIALGGAVGTGLFLGSASVLKSAGPSMILGYAIAGFIAFMIM
CCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHH
RQLGEMVAEEPVAGSFSHFAYRYWGRFPGFLSGWNYWVLYVLVSMAELTAVGAYVQYWWP
HHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
HVPAWLTALVCFVCINGINLANVKSYGETEFWFALIKVAAVIGMILFGGYLLLSGSGGPQ
CHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCC
ASVSNLWNDGGFFPHGVKGLFMMMAVIMFSFGGLELIGMTAAEANDPQKTIPKAVNQVIY
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHEEEEEHHCCCCCHHHHHHHHHHHHH
RILIFYIGSLVVLLSLYPWNKVAAGGSPFVMIFEQIGAGFTAHALNFVVLTAALSVYNSC
HHHHHHHHHHHHHHHHCCCCHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
VYATSRMLFGLARQGNAPRALGKLDTRGVPVYATLFSAAATFACVILNYLLPGEALGLLM
HHHHHHHHHHHHHCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
SLVVAALVTNWAMISLTHLKFRRAKGGQKLVFPSFWFPLSNWICLAFMVMILGILLFTPG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCC
MAVSVYVLPVWLGLLWLGFRLKKPSPAEARLAGENA
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCC
>Mature Secondary Structure 
SEAHTGLQRELKNRHIQLIALGGAVGTGLFLGSASVLKSAGPSMILGYAIAGFIAFMIM
CCCHHHHHHHHHCCCEEEEEECCHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHH
RQLGEMVAEEPVAGSFSHFAYRYWGRFPGFLSGWNYWVLYVLVSMAELTAVGAYVQYWWP
HHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
HVPAWLTALVCFVCINGINLANVKSYGETEFWFALIKVAAVIGMILFGGYLLLSGSGGPQ
CHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCC
ASVSNLWNDGGFFPHGVKGLFMMMAVIMFSFGGLELIGMTAAEANDPQKTIPKAVNQVIY
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHEEEEEHHCCCCCHHHHHHHHHHHHH
RILIFYIGSLVVLLSLYPWNKVAAGGSPFVMIFEQIGAGFTAHALNFVVLTAALSVYNSC
HHHHHHHHHHHHHHHHCCCCHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
VYATSRMLFGLARQGNAPRALGKLDTRGVPVYATLFSAAATFACVILNYLLPGEALGLLM
HHHHHHHHHHHHHCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
SLVVAALVTNWAMISLTHLKFRRAKGGQKLVFPSFWFPLSNWICLAFMVMILGILLFTPG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCC
MAVSVYVLPVWLGLLWLGFRLKKPSPAEARLAGENA
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-tryptophan [Periplasm]; Proton [Periplasm]; Proton [Periplasm]; L-tyrosine [Periplasm]; Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] +

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]