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The map label for this gene is moaC

Identifier: 34499790

GI number: 34499790

Start: 4675287

End: 4675760

Strand: Reverse

Name: moaC

Synonym: CV_4335

Alternate gene names: 34499790

Gene position: 4675760-4675287 (Counterclockwise)

Preceding gene: 34499791

Following gene: 34499786

Centisome position: 98.41

GC content: 68.57

Gene sequence:

>474_bases
ATGACACGACTCACCCATTTCGACGACAGCGGGCAAGCCCACATGGTGGATGTCGGCGGCAAGGCCGCCACTGCCCGCCG
CGCGGTGGCAGAGGGCGTGATCCGCATGCTGCCGGCCACGTTCGCGCTGGTGAAGGACGGCGGCCACAAGAAGGGCGACG
TGCTCGGCATCGCCCGCGTGGCCGCCATCATGGCGGCCAAGAAAACCTGGGACCTGATCCCGCTATGCCATCCGATCGCG
CTGACGCGGTTGGCGGTGGAGTTCGAGCTGCTGGACGCCGAGTCCGCGGTGCGGATAGCGGCGACCGCCGAGTGCATGGG
CCAGACCGGCGTGGAGATGGAGGCGCTGACCGCGGTCAACGTCGGCCTGCTGACCATCTACGACATGTGCAAGGCGGTGG
ACCGCGGCATGGAGATCACCGGGGTGCGTCTGCTGGAGAAGGATGGCGGCAAGAGCGGCCGCTGGCGGGCCTGA

Upstream 100 bases:

>100_bases
CCGCTGGAGCGCCGGCCTGTTGGTGGTCGTTTCCTGCTTCTGGCTGATTTTCCGCCTGCTGCGCTGAATGCGGCGGGCGT
TTTCATTTGAAGGGTACGCG

Downstream 100 bases:

>100_bases
GAGCTGTTCGGGAAAAAGCGCGAACGGGTTCTAACGTCCGGCCTGGCGCATCTCCGTTTCCAGCGCGCGGTCCAGGCCCG
GCGTATGGATTTCGCGCCAG

Product: molybdenum cofactor biosynthesis protein MoaC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 157; Mature: 156

Protein sequence:

>157_residues
MTRLTHFDDSGQAHMVDVGGKAATARRAVAEGVIRMLPATFALVKDGGHKKGDVLGIARVAAIMAAKKTWDLIPLCHPIA
LTRLAVEFELLDAESAVRIAATAECMGQTGVEMEALTAVNVGLLTIYDMCKAVDRGMEITGVRLLEKDGGKSGRWRA

Sequences:

>Translated_157_residues
MTRLTHFDDSGQAHMVDVGGKAATARRAVAEGVIRMLPATFALVKDGGHKKGDVLGIARVAAIMAAKKTWDLIPLCHPIA
LTRLAVEFELLDAESAVRIAATAECMGQTGVEMEALTAVNVGLLTIYDMCKAVDRGMEITGVRLLEKDGGKSGRWRA
>Mature_156_residues
TRLTHFDDSGQAHMVDVGGKAATARRAVAEGVIRMLPATFALVKDGGHKKGDVLGIARVAAIMAAKKTWDLIPLCHPIAL
TRLAVEFELLDAESAVRIAATAECMGQTGVEMEALTAVNVGLLTIYDMCKAVDRGMEITGVRLLEKDGGKSGRWRA

Specific function: Together with moaA, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z

COG id: COG0315

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaC family

Homologues:

Organism=Escherichia coli, GI1787001, Length=156, Percent_Identity=53.8461538461538, Blast_Score=169, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI32566331, Length=149, Percent_Identity=45.6375838926174, Blast_Score=135, Evalue=1e-32,
Organism=Drosophila melanogaster, GI28574490, Length=150, Percent_Identity=54, Blast_Score=157, Evalue=2e-39,
Organism=Drosophila melanogaster, GI28574492, Length=142, Percent_Identity=53.5211267605634, Blast_Score=146, Evalue=5e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MOAC_CHRVO (Q7NQ07)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_904005.1
- HSSP:   P0A738
- ProteinModelPortal:   Q7NQ07
- SMR:   Q7NQ07
- GeneID:   2549678
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_4335
- NMPDR:   fig|243365.1.peg.4335
- HOGENOM:   HBG605231
- OMA:   PMCHPLM
- PhylomeDB:   Q7NQ07
- ProtClustDB:   PRK09364
- BioCyc:   CVIO243365:CV_4335-MONOMER
- HAMAP:   MF_01224_B
- InterPro:   IPR023045
- InterPro:   IPR023046
- InterPro:   IPR002820
- Gene3D:   G3DSA:3.30.70.640
- TIGRFAMs:   TIGR00581

Pfam domain/function: PF01967 MoaC; SSF55040 MoaC

EC number: NA

Molecular weight: Translated: 16732; Mature: 16601

Theoretical pI: Translated: 8.09; Mature: 8.09

Prosite motif: NA

Important sites: ACT_SITE 128-128

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRLTHFDDSGQAHMVDVGGKAATARRAVAEGVIRMLPATFALVKDGGHKKGDVLGIARV
CCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHH
AAIMAAKKTWDLIPLCHPIALTRLAVEFELLDAESAVRIAATAECMGQTGVEMEALTAVN
HHHHHHHCCCCCCHHHHHHHHHHHHHHEEEECCCCCEEHHHHHHHHCCCCCCHHHHHHHH
VGLLTIYDMCKAVDRGMEITGVRLLEKDGGKSGRWRA
HHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
TRLTHFDDSGQAHMVDVGGKAATARRAVAEGVIRMLPATFALVKDGGHKKGDVLGIARV
CCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHH
AAIMAAKKTWDLIPLCHPIALTRLAVEFELLDAESAVRIAATAECMGQTGVEMEALTAVN
HHHHHHHCCCCCCHHHHHHHHHHHHHHEEEECCCCCEEHHHHHHHHCCCCCCHHHHHHHH
VGLLTIYDMCKAVDRGMEITGVRLLEKDGGKSGRWRA
HHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Involved in molybdopterin biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782