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The map label for this gene is acbB [H]

Identifier: 34499490

GI number: 34499490

Start: 4362159

End: 4363082

Strand: Reverse

Name: acbB [H]

Synonym: CV_4035

Alternate gene names: 34499490

Gene position: 4363082-4362159 (Counterclockwise)

Preceding gene: 34499491

Following gene: 34499489

Centisome position: 91.83

GC content: 47.94

Gene sequence:

>924_bases
ATGCTCGTAAAGCAGGGTTATAAGGTCAAAGCGTTATCGCAGTACAACTCGTTCAATTACTGGGGCTGGTTGGAGGATGT
GGATTGCCTCCCGGAAATTGAAGTATTGAATGGCGATGTCCGCGATCCCCACTATTGCAAGCATATTACTAAGGGCATCG
ATACTGTATATCATCTAGCCGCGCTGATTGCCATTCCTTACTCTTATGTTGCTCCTGATAGCTATGTCGATACCAATGTA
AAGGGTACGCTGAACATATGCCAAGCCGCGCTTGATAATGGCGTCAGCAGGGTTATCCATACCTCTACTAGTGAGGTGTA
TGGAACTGCGCAATACGTGCCTATCGATGAGAAGCACCCGCTGCAACCCCAATCGCCTTACAGCGCGTCGAAAATCGGGG
CCGATGCGATGGCAATGAGCTTCTATAACGCATTCGATCTGCCCTTGACCATTGCGCGGCCGTTTAACACTTATGGCCCT
CGCCAATCGGCTCGCGCAGTGATCCCGACCATCATTAGTCAGATTGCGAACGGCAAAAAGCAGATAAAGCTGGGTGATGT
GACCCCAACTCGCGATTTTAATTACGTTGAAGATACCTGCAGGGGCTTCTTGGCGTTGGCGAATTGTGAACAGGCGATTG
GCGAAACCATCAATATTGGATCTAATTACGAAATCTCAGTTGGTGATACCTTAAATTTGATTCGTGAATTGATGAATAGC
GACGTTGAGTTCTTGACCGACGAGCAGCGTATCCGTCCTGAGAAATCTGAAGTGTTCCGGCTCTGGTGCGATAACAGAAA
GATCAATCAATTGACGGGTTTCATGCCTCAGCATGACATTCGCAGCGGTCTGGCTAAGACCATAGAATGGTTCACCAATC
CGGTGAATCTCGCCAAGTACAAGTCTGATATTTACAATGTGTGA

Upstream 100 bases:

>100_bases
ATTTTATTTATTTGTATAAAAATATCTACCTGCGTGGTGTTTGATGAAAACAGTTCTCGTTACCGGTGCCGACGGTTTTA
TTGGTTCCCATCTGACCGAA

Downstream 100 bases:

>100_bases
TCATTATGAATTTCGACGCTCTGATTGGATTTGTACGAGAACAGTACCGCACCGATGAATTTATTCCCCTGCATGCGCCG
ATTTTCTCGGGAAATGAGAA

Product: nucleotide sugar dehydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MLVKQGYKVKALSQYNSFNYWGWLEDVDCLPEIEVLNGDVRDPHYCKHITKGIDTVYHLAALIAIPYSYVAPDSYVDTNV
KGTLNICQAALDNGVSRVIHTSTSEVYGTAQYVPIDEKHPLQPQSPYSASKIGADAMAMSFYNAFDLPLTIARPFNTYGP
RQSARAVIPTIISQIANGKKQIKLGDVTPTRDFNYVEDTCRGFLALANCEQAIGETINIGSNYEISVGDTLNLIRELMNS
DVEFLTDEQRIRPEKSEVFRLWCDNRKINQLTGFMPQHDIRSGLAKTIEWFTNPVNLAKYKSDIYNV

Sequences:

>Translated_307_residues
MLVKQGYKVKALSQYNSFNYWGWLEDVDCLPEIEVLNGDVRDPHYCKHITKGIDTVYHLAALIAIPYSYVAPDSYVDTNV
KGTLNICQAALDNGVSRVIHTSTSEVYGTAQYVPIDEKHPLQPQSPYSASKIGADAMAMSFYNAFDLPLTIARPFNTYGP
RQSARAVIPTIISQIANGKKQIKLGDVTPTRDFNYVEDTCRGFLALANCEQAIGETINIGSNYEISVGDTLNLIRELMNS
DVEFLTDEQRIRPEKSEVFRLWCDNRKINQLTGFMPQHDIRSGLAKTIEWFTNPVNLAKYKSDIYNV
>Mature_307_residues
MLVKQGYKVKALSQYNSFNYWGWLEDVDCLPEIEVLNGDVRDPHYCKHITKGIDTVYHLAALIAIPYSYVAPDSYVDTNV
KGTLNICQAALDNGVSRVIHTSTSEVYGTAQYVPIDEKHPLQPQSPYSASKIGADAMAMSFYNAFDLPLTIARPFNTYGP
RQSARAVIPTIISQIANGKKQIKLGDVTPTRDFNYVEDTCRGFLALANCEQAIGETINIGSNYEISVGDTLNLIRELMNS
DVEFLTDEQRIRPEKSEVFRLWCDNRKINQLTGFMPQHDIRSGLAKTIEWFTNPVNLAKYKSDIYNV

Specific function: Probably involved in the biosynthesis of the acarviose moiety of the alpha-glucosidase inhibitor acarbose. Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4- hexulose via a three-step process involving oxidation, dehydration and re

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=275, Percent_Identity=33.4545454545455, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI42516563, Length=268, Percent_Identity=30.2238805970149, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI4504031, Length=226, Percent_Identity=26.5486725663717, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI48994969, Length=263, Percent_Identity=30.7984790874525, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1788353, Length=264, Percent_Identity=31.8181818181818, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1788366, Length=243, Percent_Identity=26.7489711934156, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786974, Length=274, Percent_Identity=28.1021897810219, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17539532, Length=315, Percent_Identity=27.9365079365079, Blast_Score=104, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17568069, Length=252, Percent_Identity=27.7777777777778, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI115532424, Length=191, Percent_Identity=31.413612565445, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI133901790, Length=214, Percent_Identity=25.7009345794392, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17539422, Length=215, Percent_Identity=26.5116279069767, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI133901786, Length=215, Percent_Identity=26.5116279069767, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17539424, Length=215, Percent_Identity=26.5116279069767, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI133901788, Length=215, Percent_Identity=26.5116279069767, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17507723, Length=250, Percent_Identity=24, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319493, Length=201, Percent_Identity=27.363184079602, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21356223, Length=308, Percent_Identity=25.974025974026, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI19923002, Length=262, Percent_Identity=24.0458015267176, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005888
- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.46 [H]

Molecular weight: Translated: 34550; Mature: 34550

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVKQGYKVKALSQYNSFNYWGWLEDVDCLPEIEVLNGDVRDPHYCKHITKGIDTVYHLA
CCCCCCCCEEEHHHCCCCCCCCCCCCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHH
ALIAIPYSYVAPDSYVDTNVKGTLNICQAALDNGVSRVIHTSTSEVYGTAQYVPIDEKHP
HHHHCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCEEECCCCCCCC
LQPQSPYSASKIGADAMAMSFYNAFDLPLTIARPFNTYGPRQSARAVIPTIISQIANGKK
CCCCCCCCHHHHCHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCC
QIKLGDVTPTRDFNYVEDTCRGFLALANCEQAIGETINIGSNYEISVGDTLNLIRELMNS
EEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEECCCCEEEECCHHHHHHHHHHCC
DVEFLTDEQRIRPEKSEVFRLWCDNRKINQLTGFMPQHDIRSGLAKTIEWFTNPVNLAKY
CHHHHCCHHHCCCCHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHH
KSDIYNV
HHHHCCC
>Mature Secondary Structure
MLVKQGYKVKALSQYNSFNYWGWLEDVDCLPEIEVLNGDVRDPHYCKHITKGIDTVYHLA
CCCCCCCCEEEHHHCCCCCCCCCCCCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHH
ALIAIPYSYVAPDSYVDTNVKGTLNICQAALDNGVSRVIHTSTSEVYGTAQYVPIDEKHP
HHHHCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCEEECCCCCCCC
LQPQSPYSASKIGADAMAMSFYNAFDLPLTIARPFNTYGPRQSARAVIPTIISQIANGKK
CCCCCCCCHHHHCHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCC
QIKLGDVTPTRDFNYVEDTCRGFLALANCEQAIGETINIGSNYEISVGDTLNLIRELMNS
EEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEECCCCEEEECCHHHHHHHHHHCC
DVEFLTDEQRIRPEKSEVFRLWCDNRKINQLTGFMPQHDIRSGLAKTIEWFTNPVNLAKY
CHHHHCCHHHCCCCHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHH
KSDIYNV
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10196166 [H]