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The map label for this gene is wecC [H]

Identifier: 34499474

GI number: 34499474

Start: 4344629

End: 4345870

Strand: Reverse

Name: wecC [H]

Synonym: CV_4019

Alternate gene names: 34499474

Gene position: 4345870-4344629 (Counterclockwise)

Preceding gene: 34499475

Following gene: 34499473

Centisome position: 91.47

GC content: 47.83

Gene sequence:

>1242_bases
GTGATGATGAATAAAACGGTTTGCGTAGTCGGCTTGGGATATATTGGCTTGCCTACTGCAGCATTATTGGCGAGCAATGG
TTATAAAGTTGTTGGTGTTGATTTGAATCAGCATGCAGTTGATACGATTAATCAAGGCAATGTTCATATTGTTGAGCCTG
ACCTGGATGGCTATGTGCGCTCTGCTGTTGCCACGGGAATGTTAAAGGCTTTTGTAACACCACAATCTGGCGATGTATAC
ATGATCTGTGTGCCTACTCCTTTCCATGAGGGGGGGGGCATTCCTCAGCCGAATATTGACCATGTGTTGGCGGCTACCAG
AAGCATTGCTCCATTTGTAAAAGAGGGTGATCTGGTCATCCTGGAGTCGACCTCTCCGGTTGGCACGACTGAGAAGATGG
CTGAGGTTTTGGCTGAGTCGGGCGTCGATGTAGGTAAAATCCACATCGCCTACTGCCCTGAGCGTGTGTTGCCAGGTAAA
ATTATGGTCGAACTGGTGGAGAATGACCGAATCGTTGGCGGTTTGACTCCCGAGGCGACGAGTGCGGTAGCTACTTTCTA
CCGTAGCTTTGTCTCCGGCGAGGTATTGGAGACAAATTCGAAAACGGCTGAGATGTGCAAGCTGACCGAGAATAGCTTTC
GTGATGTAAATATTGCTTTTGCCAATGAGCTCTCATTGATTTGTGCAAAAGAGAATATTGATGTGTGGAAATTGATTTCG
CTGGCAAATCGTCACCCGCGCGTAAATATTTTGCAGCCAGGCGTTGGCGTGGGGGGGCATTGTATTGCGGTTGATCCTTG
GTTTATCGTCGCTCGTGATCCTGAGAATGCGAGGCTCATTCGCTCGGCGCGTGAGGTTAACAACTCCAAGACGGATTGGG
TTGTAGATAGAATAAAGGCTGAAATCGCGGATGCTCATGTCAAGCTCGGCCGCGCTCCTCGTGTCGCCTGCCTTGGTTTG
GCATTCAAGCCTGATATTGATGATTTGCGCGAATCGCCGGCAGTGCAGGTGGTGGATGCTATCCTAAGAGCTGGCCATGA
TGTAATTGTGGTTGAGCCTAATATTAGAGAGCATAGTGAATATGTGCTTATTGATTTGGATAGCGCTTTGGATGTTGCGG
ACTTGATTGTGGTTTTGGTTCGACATAAGCAGTTTCTTGACCATGCGGTGAATCAGCGTTTACTAAGCTTGAATATCCAT
GATTATTGTGGACTTAGAGCCGCTAACAAAATTTCGCGATAA

Upstream 100 bases:

>100_bases
GGATGATTCCAATCATTATGAAATGATGTCCAAAGCGCATAATCCTTATGGTGATGGCAGCGCATGTGAACGGATTATTT
CTGCTTTAAAGAGGGTGTAA

Downstream 100 bases:

>100_bases
ACCGTAAGCAAATCAGGGAACAAGCTAGCTTCAACAATGCGTAATGCGTATCCAACCGACGTTCAAAGCGAATACGCAAC
TTGTCGAACCTCGCTAGCCA

Product: UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: UDP-ManNAc 6-dehydrogenase [H]

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MMMNKTVCVVGLGYIGLPTAALLASNGYKVVGVDLNQHAVDTINQGNVHIVEPDLDGYVRSAVATGMLKAFVTPQSGDVY
MICVPTPFHEGGGIPQPNIDHVLAATRSIAPFVKEGDLVILESTSPVGTTEKMAEVLAESGVDVGKIHIAYCPERVLPGK
IMVELVENDRIVGGLTPEATSAVATFYRSFVSGEVLETNSKTAEMCKLTENSFRDVNIAFANELSLICAKENIDVWKLIS
LANRHPRVNILQPGVGVGGHCIAVDPWFIVARDPENARLIRSAREVNNSKTDWVVDRIKAEIADAHVKLGRAPRVACLGL
AFKPDIDDLRESPAVQVVDAILRAGHDVIVVEPNIREHSEYVLIDLDSALDVADLIVVLVRHKQFLDHAVNQRLLSLNIH
DYCGLRAANKISR

Sequences:

>Translated_413_residues
MMMNKTVCVVGLGYIGLPTAALLASNGYKVVGVDLNQHAVDTINQGNVHIVEPDLDGYVRSAVATGMLKAFVTPQSGDVY
MICVPTPFHEGGGIPQPNIDHVLAATRSIAPFVKEGDLVILESTSPVGTTEKMAEVLAESGVDVGKIHIAYCPERVLPGK
IMVELVENDRIVGGLTPEATSAVATFYRSFVSGEVLETNSKTAEMCKLTENSFRDVNIAFANELSLICAKENIDVWKLIS
LANRHPRVNILQPGVGVGGHCIAVDPWFIVARDPENARLIRSAREVNNSKTDWVVDRIKAEIADAHVKLGRAPRVACLGL
AFKPDIDDLRESPAVQVVDAILRAGHDVIVVEPNIREHSEYVLIDLDSALDVADLIVVLVRHKQFLDHAVNQRLLSLNIH
DYCGLRAANKISR
>Mature_413_residues
MMMNKTVCVVGLGYIGLPTAALLASNGYKVVGVDLNQHAVDTINQGNVHIVEPDLDGYVRSAVATGMLKAFVTPQSGDVY
MICVPTPFHEGGGIPQPNIDHVLAATRSIAPFVKEGDLVILESTSPVGTTEKMAEVLAESGVDVGKIHIAYCPERVLPGK
IMVELVENDRIVGGLTPEATSAVATFYRSFVSGEVLETNSKTAEMCKLTENSFRDVNIAFANELSLICAKENIDVWKLIS
LANRHPRVNILQPGVGVGGHCIAVDPWFIVARDPENARLIRSAREVNNSKTDWVVDRIKAEIADAHVKLGRAPRVACLGL
AFKPDIDDLRESPAVQVVDAILRAGHDVIVVEPNIREHSEYVLIDLDSALDVADLIVVLVRHKQFLDHAVNQRLLSLNIH
DYCGLRAANKISR

Specific function: Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA) [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=388, Percent_Identity=26.0309278350515, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI296040443, Length=379, Percent_Identity=26.1213720316623, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI296040438, Length=282, Percent_Identity=25.531914893617, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI48994968, Length=402, Percent_Identity=58.2089552238806, Blast_Score=464, Evalue=1e-132,
Organism=Escherichia coli, GI1788340, Length=386, Percent_Identity=24.3523316062176, Blast_Score=86, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17560350, Length=402, Percent_Identity=27.8606965174129, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI17136908, Length=382, Percent_Identity=26.7015706806283, Blast_Score=108, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 44850; Mature: 44850

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMMNKTVCVVGLGYIGLPTAALLASNGYKVVGVDLNQHAVDTINQGNVHIVEPDLDGYVR
CCCCCEEEEEECCHHHHCHHHHHHCCCCEEEEEECCCHHHHCCCCCCEEEECCCHHHHHH
SAVATGMLKAFVTPQSGDVYMICVPTPFHEGGGIPQPNIDHVLAATRSIAPFVKEGDLVI
HHHHHHHHHHEECCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCHHCCCCEEE
LESTSPVGTTEKMAEVLAESGVDVGKIHIAYCPERVLPGKIMVELVENDRIVGGLTPEAT
EECCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHEEEECCCCEEEECCCCHHH
SAVATFYRSFVSGEVLETNSKTAEMCKLTENSFRDVNIAFANELSLICAKENIDVWKLIS
HHHHHHHHHHHCCCEEECCCCHHHHHHHHCCCCCEEEEEEECCEEEEEECCCCCHHHHHH
LANRHPRVNILQPGVGVGGHCIAVDPWFIVARDPENARLIRSAREVNNSKTDWVVDRIKA
HHCCCCEEEEECCCCCCCCEEEEECCEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHH
EIADAHVKLGRAPRVACLGLAFKPDIDDLRESPAVQVVDAILRAGHDVIVVEPNIREHSE
HHHHHHHHCCCCCCEEEEEEEECCCHHHHHCCCHHHHHHHHHHCCCCEEEECCCCCCCCC
YVLIDLDSALDVADLIVVLVRHKQFLDHAVNQRLLSLNIHDYCGLRAANKISR
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECHHHHCCCHHHHCCC
>Mature Secondary Structure
MMMNKTVCVVGLGYIGLPTAALLASNGYKVVGVDLNQHAVDTINQGNVHIVEPDLDGYVR
CCCCCEEEEEECCHHHHCHHHHHHCCCCEEEEEECCCHHHHCCCCCCEEEECCCHHHHHH
SAVATGMLKAFVTPQSGDVYMICVPTPFHEGGGIPQPNIDHVLAATRSIAPFVKEGDLVI
HHHHHHHHHHEECCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCHHCCCCEEE
LESTSPVGTTEKMAEVLAESGVDVGKIHIAYCPERVLPGKIMVELVENDRIVGGLTPEAT
EECCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHEEEECCCCEEEECCCCHHH
SAVATFYRSFVSGEVLETNSKTAEMCKLTENSFRDVNIAFANELSLICAKENIDVWKLIS
HHHHHHHHHHHCCCEEECCCCHHHHHHHHCCCCCEEEEEEECCEEEEEECCCCCHHHHHH
LANRHPRVNILQPGVGVGGHCIAVDPWFIVARDPENARLIRSAREVNNSKTDWVVDRIKA
HHCCCCEEEEECCCCCCCCEEEEECCEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHH
EIADAHVKLGRAPRVACLGLAFKPDIDDLRESPAVQVVDAILRAGHDVIVVEPNIREHSE
HHHHHHHHCCCCCCEEEEEEEECCCHHHHHCCCHHHHHHHHHHCCCCEEEECCCCCCCCC
YVLIDLDSALDVADLIVVLVRHKQFLDHAVNQRLLSLNIHDYCGLRAANKISR
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECHHHHCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]