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The map label for this gene is mmgC [H]

Identifier: 34499373

GI number: 34499373

Start: 4231207

End: 4232394

Strand: Reverse

Name: mmgC [H]

Synonym: CV_3918

Alternate gene names: 34499373

Gene position: 4232394-4231207 (Counterclockwise)

Preceding gene: 34499375

Following gene: 34499372

Centisome position: 89.08

GC content: 65.82

Gene sequence:

>1188_bases
ATGGCAGCATCCACGCAGCGCGCCCCGTTCGCTTGGGAAGATCCCCTGCTGTTGCAGGACCGCTTGACCGATGACGAGCG
GCTGGTGCAGCAGAGCGCGCACGAGTATTGCCAGGAGCGGCTGCTGCCGCGGGTGCTGATGGCCAACCGCGAAGAGCGCT
TCGACCGCGAGATCATCAGCGAGATGGGTGAGCTGGGCTTCCTCGGCTGCACCATAGAAGGCTACGGCTGCGCCGGGCTG
TCCCACGTCGCCTACGGCCTGGTGGCGCGCGAAGTGGAGCGGGTGGATTCAGGCTACCGCTCGGCGATGAGCGTGCAGTC
GTCCTTGGTGATGCACCCGATCTGGGCCTACGGCTCCGACGCGCAGAAGGACAAGTATCTGCCCAGGCTCGCCAGCGGCG
AATGGCTGGGCTGCTTCGGCCTGACCGAGCCGGACTCCGGCTCCGACCCCGCCAGCATGAAGACCCGAGCCCGCAAGGTC
GACGGCGGTTACCTGCTGTCCGGCAGCAAGATGTGGATCACCAACAGCCCGGCCGCCGACGTGTTCGTGGTCTGGGCCAA
GGATGACGACGACGAGATCCGCGGCTTCATCCTGGAAAAAGGCATGAAGGGTCTGTCCGCGCCGGCGATACACGGCAAGT
TTTCCTTGCGCGCGTCCATCACCGGCGAAATCGTGATGGACGACGTGCTGGTGTCGGAAGACCAGCTGCTGCCAGGCGTC
AAGGGCCTGAAGGGACCGTTCGGCTGCCTGAACAAGGCGCGCTACGGCATCGCCTGGGGCGCGATGGGCGCCGCCGAGTT
CTGCTGGCACGCCGCCCGCCAGTACACGCTGGACCGCGAGCAGTTCGGCCGCCCGCTCGCCGCCAACCAGTTGATCCAGC
TGAAGCTGGCCAATATGCAGACTGAAATCGCGCTGGGCCTTTCCGCCGCGCTGCAGGTGGGCAGGCTGATGGACGAGGGC
CGCGCCGCGCCGGAGATGATTTCGCTGATCAAGCGCAACAACTGCGGCAAGGCGCTGGACATCGCCCGCGTCGCCCGCGA
CATGCACGGCGGCAACGGCATCTGCGACGAATTCCATGTGATCCGCCACGTGATGAATCTGGAGGCGGTCAACACTTACG
AGGGCACGCACGACGTGCACGCCCTGATTCTGGGCCGAGCCCAGACCGGTATTCAGGCATTTGCCTGA

Upstream 100 bases:

>100_bases
ATGACAGGTAAATCGCTTTACAAGCGCGCGGCAGAGTGTTTAGTCTATTCTGCATGGTGAAATCTAATTCCGCAATGCGG
AACTAAGAGGGAGAAGGCAG

Downstream 100 bases:

>100_bases
TAAGCCGGCGCGGCCGGAGGGCCGGCCGCGCCGTTGATTCCTGTCTGTCCTTTGTTGGCCCGGCTTGCCGGGCCACTTTT
TTTGCCGGAGCGCAGGGCGG

Product: glutaryl-CoA dehydrogenase

Products: crotonoyl-CoA; CO2; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MAASTQRAPFAWEDPLLLQDRLTDDERLVQQSAHEYCQERLLPRVLMANREERFDREIISEMGELGFLGCTIEGYGCAGL
SHVAYGLVAREVERVDSGYRSAMSVQSSLVMHPIWAYGSDAQKDKYLPRLASGEWLGCFGLTEPDSGSDPASMKTRARKV
DGGYLLSGSKMWITNSPAADVFVVWAKDDDDEIRGFILEKGMKGLSAPAIHGKFSLRASITGEIVMDDVLVSEDQLLPGV
KGLKGPFGCLNKARYGIAWGAMGAAEFCWHAARQYTLDREQFGRPLAANQLIQLKLANMQTEIALGLSAALQVGRLMDEG
RAAPEMISLIKRNNCGKALDIARVARDMHGGNGICDEFHVIRHVMNLEAVNTYEGTHDVHALILGRAQTGIQAFA

Sequences:

>Translated_395_residues
MAASTQRAPFAWEDPLLLQDRLTDDERLVQQSAHEYCQERLLPRVLMANREERFDREIISEMGELGFLGCTIEGYGCAGL
SHVAYGLVAREVERVDSGYRSAMSVQSSLVMHPIWAYGSDAQKDKYLPRLASGEWLGCFGLTEPDSGSDPASMKTRARKV
DGGYLLSGSKMWITNSPAADVFVVWAKDDDDEIRGFILEKGMKGLSAPAIHGKFSLRASITGEIVMDDVLVSEDQLLPGV
KGLKGPFGCLNKARYGIAWGAMGAAEFCWHAARQYTLDREQFGRPLAANQLIQLKLANMQTEIALGLSAALQVGRLMDEG
RAAPEMISLIKRNNCGKALDIARVARDMHGGNGICDEFHVIRHVMNLEAVNTYEGTHDVHALILGRAQTGIQAFA
>Mature_394_residues
AASTQRAPFAWEDPLLLQDRLTDDERLVQQSAHEYCQERLLPRVLMANREERFDREIISEMGELGFLGCTIEGYGCAGLS
HVAYGLVAREVERVDSGYRSAMSVQSSLVMHPIWAYGSDAQKDKYLPRLASGEWLGCFGLTEPDSGSDPASMKTRARKVD
GGYLLSGSKMWITNSPAADVFVVWAKDDDDEIRGFILEKGMKGLSAPAIHGKFSLRASITGEIVMDDVLVSEDQLLPGVK
GLKGPFGCLNKARYGIAWGAMGAAEFCWHAARQYTLDREQFGRPLAANQLIQLKLANMQTEIALGLSAALQVGRLMDEGR
AAPEMISLIKRNNCGKALDIARVARDMHGGNGICDEFHVIRHVMNLEAVNTYEGTHDVHALILGRAQTGIQAFA

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4503943, Length=395, Percent_Identity=71.8987341772152, Blast_Score=593, Evalue=1e-170,
Organism=Homo sapiens, GI7669494, Length=374, Percent_Identity=71.1229946524064, Blast_Score=555, Evalue=1e-158,
Organism=Homo sapiens, GI226958412, Length=376, Percent_Identity=31.9148936170213, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI4557233, Length=385, Percent_Identity=29.6103896103896, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI226958414, Length=369, Percent_Identity=32.2493224932249, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI4501859, Length=365, Percent_Identity=28.7671232876712, Blast_Score=158, Evalue=8e-39,
Organism=Homo sapiens, GI4557231, Length=396, Percent_Identity=29.7979797979798, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI187960098, Length=396, Percent_Identity=29.7979797979798, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI4557235, Length=337, Percent_Identity=32.3442136498516, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI76496475, Length=337, Percent_Identity=32.3442136498516, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI7656849, Length=384, Percent_Identity=28.3854166666667, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI21361497, Length=358, Percent_Identity=28.4916201117318, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI4501857, Length=373, Percent_Identity=26.2734584450402, Blast_Score=127, Evalue=2e-29,
Organism=Escherichia coli, GI1786223, Length=278, Percent_Identity=26.6187050359712, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87081958, Length=380, Percent_Identity=25.2631578947368, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17534353, Length=387, Percent_Identity=65.1162790697674, Blast_Score=531, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI17538396, Length=374, Percent_Identity=31.0160427807487, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17508101, Length=384, Percent_Identity=29.4270833333333, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17534899, Length=384, Percent_Identity=29.1666666666667, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17506239, Length=365, Percent_Identity=29.3150684931507, Blast_Score=147, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI71985184, Length=358, Percent_Identity=31.2849162011173, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17570075, Length=376, Percent_Identity=27.6595744680851, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17569725, Length=375, Percent_Identity=26.6666666666667, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI71990804, Length=278, Percent_Identity=32.3741007194245, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI71985192, Length=280, Percent_Identity=32.5, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI32563615, Length=225, Percent_Identity=36.4444444444444, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17533517, Length=381, Percent_Identity=26.509186351706, Blast_Score=118, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI71982178, Length=291, Percent_Identity=27.8350515463918, Blast_Score=117, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI17551932, Length=280, Percent_Identity=23.9285714285714, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17505929, Length=303, Percent_Identity=23.7623762376238, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI19920834, Length=398, Percent_Identity=64.070351758794, Blast_Score=520, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24666513, Length=368, Percent_Identity=31.7934782608696, Blast_Score=179, Evalue=4e-45,
Organism=Drosophila melanogaster, GI21356377, Length=370, Percent_Identity=29.4594594594595, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=31.4814814814815, Blast_Score=161, Evalue=6e-40,
Organism=Drosophila melanogaster, GI21355753, Length=375, Percent_Identity=30.1333333333333, Blast_Score=159, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24646207, Length=372, Percent_Identity=29.3010752688172, Blast_Score=159, Evalue=5e-39,
Organism=Drosophila melanogaster, GI281363737, Length=371, Percent_Identity=29.9191374663073, Blast_Score=139, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.7

Molecular weight: Translated: 43364; Mature: 43233

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAASTQRAPFAWEDPLLLQDRLTDDERLVQQSAHEYCQERLLPRVLMANREERFDREIIS
CCCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
EMGELGFLGCTIEGYGCAGLSHVAYGLVAREVERVDSGYRSAMSVQSSLVMHPIWAYGSD
HHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AQKDKYLPRLASGEWLGCFGLTEPDSGSDPASMKTRARKVDGGYLLSGSKMWITNSPAAD
CCHHHCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHCCCCCEEEECCEEEEECCCCCC
VFVVWAKDDDDEIRGFILEKGMKGLSAPAIHGKFSLRASITGEIVMDDVLVSEDQLLPGV
EEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCEEEHHHHHCCCHHCCCC
KGLKGPFGCLNKARYGIAWGAMGAAEFCWHAARQYTLDREQFGRPLAANQLIQLKLANMQ
CCCCCCHHHHHHHHCCEECCCCHHHHHHHHHHHHCCCCHHHHCCCHHHCCEEEEEHHCCH
TEIALGLSAALQVGRLMDEGRAAPEMISLIKRNNCGKALDIARVARDMHGGNGICDEFHV
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHH
IRHVMNLEAVNTYEGTHDVHALILGRAQTGIQAFA
HHHHHHHHHEECCCCCCCEEHHEEECHHCCHHHCC
>Mature Secondary Structure 
AASTQRAPFAWEDPLLLQDRLTDDERLVQQSAHEYCQERLLPRVLMANREERFDREIIS
CCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
EMGELGFLGCTIEGYGCAGLSHVAYGLVAREVERVDSGYRSAMSVQSSLVMHPIWAYGSD
HHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AQKDKYLPRLASGEWLGCFGLTEPDSGSDPASMKTRARKVDGGYLLSGSKMWITNSPAAD
CCHHHCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHCCCCCEEEECCEEEEECCCCCC
VFVVWAKDDDDEIRGFILEKGMKGLSAPAIHGKFSLRASITGEIVMDDVLVSEDQLLPGV
EEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCEEEHHHHHCCCHHCCCC
KGLKGPFGCLNKARYGIAWGAMGAAEFCWHAARQYTLDREQFGRPLAANQLIQLKLANMQ
CCCCCCHHHHHHHHCCEECCCCHHHHHHHHHHHHCCCCHHHHCCCHHHCCEEEEEHHCCH
TEIALGLSAALQVGRLMDEGRAAPEMISLIKRNNCGKALDIARVARDMHGGNGICDEFHV
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHH
IRHVMNLEAVNTYEGTHDVHALILGRAQTGIQAFA
HHHHHHHHHEECCCCCCCEEHHEEECHHCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glutaryl-CoA; acceptor

Specific reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]