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The map label for this gene is hmuU [H]

Identifier: 34499353

GI number: 34499353

Start: 4208401

End: 4209339

Strand: Direct

Name: hmuU [H]

Synonym: CV_3898

Alternate gene names: 34499353

Gene position: 4208401-4209339 (Clockwise)

Preceding gene: 34499352

Following gene: 34499354

Centisome position: 88.58

GC content: 74.33

Gene sequence:

>939_bases
CTGTGGCCTGTCCTGGTCATCGCCAGCGCGGCGCTGCCGCTGCTGGCGCTGGCCAGTTCCGCCGGCCACTTGGCATGGCC
CAATCTGGCGGATCCGCTGGTCGCCGAACTGCGCCTGCCGCGCGTGGTCGCCGCGCTCGGCGTCGGCGCGGCGCTGGCCG
CCAGCGGCGCCGCGCTGCAGGCGCTGTTCCGCAATCCGCTGGCCGATCCCGGCCTGATCGGCACCTCGAGCGGCGCCGCG
CTGGCGGTGATCGCGGTGCTGGCGCTGGGCATGGCTGGCCTGTCGCTGCCGCTGGCGGCCTTCGGCGGCGGCCTGGCCGC
CACCTGGCTGATCCTGGCGCTGGCGCGTCTGGCCAAAGGCGGCCTGGCCGGCCTGCTGCTGATGGGGCTGGTGGTCGGCG
CGTTCTGCGGCGCGGTGTCCAGCCTGATTCTGTTCCTGTCCGACGACCTGACGCTGCGCGCCGCCAGCAGCTGGCTGGCC
GGCAACCTGGGATCGGCGCTGCCCGGCCGGCTGTGGCCGTGCCTGCTGATCGCCGGGTTCGGCGTCGCGCTGCTGTGCGC
GATAGGGCGCGACCTGGACTGCCTGCTGCTGGGCGAGGAGACCGCCCGCTCGCTGGGCATAGACACCCGCCGCACCCGGC
GGCTGGCCGCCATCGGCGCGGCGCTGGCCACCGGCGGCGCGGTGGCGCTGTCCGGCGTGATCGGCTTCGTGGGCATGATG
ATTCCCAACGCGCTGGCGCTGCTGGTCGGCGGCTGCCGCCGCAAGCTGATCCTGACATCGGCGTGGGCCGGTGCGCTGTT
CCTGCTGGCGGTGGACACGCTGGCGCGCAACATCGCCTGGCCGCTTGACCTGCCGGTGGGGCTGATGGCCGCCTTCGCCG
GCCCGCCCTTCTTCATCTGGCTTTTCCGCCGCCAACAACGGAGCCCCCGCGATGCCTGA

Upstream 100 bases:

>100_bases
GGCGCATCTACCTGCTGCCGCCGCAGCAGGGCATGCTGATCGGCCTGGGCAGCCCGGAGGTGGTCGAACGGATGGTGAGG
ATGTGAGCGGCGCCCGACTG

Downstream 100 bases:

>100_bases
CACCCATACTCTGAAAGCGCGCGAACTCGGTTACAGCGTGAACGGCCGCGCGCTGCTGCGCGACATCCGCCTGGACCTGC
CTGCCGGCCAGGTCAGCGCG

Product: ABC transporter permease

Products: ADP; phosphate; iron dicitrate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MWPVLVIASAALPLLALASSAGHLAWPNLADPLVAELRLPRVVAALGVGAALAASGAALQALFRNPLADPGLIGTSSGAA
LAVIAVLALGMAGLSLPLAAFGGGLAATWLILALARLAKGGLAGLLLMGLVVGAFCGAVSSLILFLSDDLTLRAASSWLA
GNLGSALPGRLWPCLLIAGFGVALLCAIGRDLDCLLLGEETARSLGIDTRRTRRLAAIGAALATGGAVALSGVIGFVGMM
IPNALALLVGGCRRKLILTSAWAGALFLLAVDTLARNIAWPLDLPVGLMAAFAGPPFFIWLFRRQQRSPRDA

Sequences:

>Translated_312_residues
MWPVLVIASAALPLLALASSAGHLAWPNLADPLVAELRLPRVVAALGVGAALAASGAALQALFRNPLADPGLIGTSSGAA
LAVIAVLALGMAGLSLPLAAFGGGLAATWLILALARLAKGGLAGLLLMGLVVGAFCGAVSSLILFLSDDLTLRAASSWLA
GNLGSALPGRLWPCLLIAGFGVALLCAIGRDLDCLLLGEETARSLGIDTRRTRRLAAIGAALATGGAVALSGVIGFVGMM
IPNALALLVGGCRRKLILTSAWAGALFLLAVDTLARNIAWPLDLPVGLMAAFAGPPFFIWLFRRQQRSPRDA
>Mature_312_residues
MWPVLVIASAALPLLALASSAGHLAWPNLADPLVAELRLPRVVAALGVGAALAASGAALQALFRNPLADPGLIGTSSGAA
LAVIAVLALGMAGLSLPLAAFGGGLAATWLILALARLAKGGLAGLLLMGLVVGAFCGAVSSLILFLSDDLTLRAASSWLA
GNLGSALPGRLWPCLLIAGFGVALLCAIGRDLDCLLLGEETARSLGIDTRRTRRLAAIGAALATGGAVALSGVIGFVGMM
IPNALALLVGGCRRKLILTSAWAGALFLLAVDTLARNIAWPLDLPVGLMAAFAGPPFFIWLFRRQQRSPRDA

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790740, Length=277, Percent_Identity=38.9891696750903, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1790741, Length=289, Percent_Identity=35.9861591695502, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1788004, Length=281, Percent_Identity=38.7900355871886, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1786347, Length=283, Percent_Identity=33.9222614840989, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1786805, Length=283, Percent_Identity=36.3957597173145, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1786804, Length=291, Percent_Identity=32.6460481099656, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 31583; Mature: 31583

Theoretical pI: Translated: 11.08; Mature: 11.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWPVLVIASAALPLLALASSAGHLAWPNLADPLVAELRLPRVVAALGVGAALAASGAALQ
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALFRNPLADPGLIGTSSGAALAVIAVLALGMAGLSLPLAAFGGGLAATWLILALARLAKG
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
GLAGLLLMGLVVGAFCGAVSSLILFLSDDLTLRAASSWLAGNLGSALPGRLWPCLLIAGF
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
GVALLCAIGRDLDCLLLGEETARSLGIDTRRTRRLAAIGAALATGGAVALSGVIGFVGMM
HHHHHHHHCCCCEEEEECHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
IPNALALLVGGCRRKLILTSAWAGALFLLAVDTLARNIAWPLDLPVGLMAAFAGPPFFIW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHH
LFRRQQRSPRDA
HHHHHCCCCCCC
>Mature Secondary Structure
MWPVLVIASAALPLLALASSAGHLAWPNLADPLVAELRLPRVVAALGVGAALAASGAALQ
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALFRNPLADPGLIGTSSGAALAVIAVLALGMAGLSLPLAAFGGGLAATWLILALARLAKG
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
GLAGLLLMGLVVGAFCGAVSSLILFLSDDLTLRAASSWLAGNLGSALPGRLWPCLLIAGF
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
GVALLCAIGRDLDCLLLGEETARSLGIDTRRTRRLAAIGAALATGGAVALSGVIGFVGMM
HHHHHHHHCCCCEEEEECHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
IPNALALLVGGCRRKLILTSAWAGALFLLAVDTLARNIAWPLDLPVGLMAAFAGPPFFIW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHH
LFRRQQRSPRDA
HHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron dicitrate [Periplasm]; H2O [C]

Specific reaction: ATP + iron dicitrate [Periplasm] + H2O = ADP + phosphate + iron dicitrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]