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The map label for this gene is hpuB [H]

Identifier: 34499351

GI number: 34499351

Start: 4204314

End: 4206521

Strand: Direct

Name: hpuB [H]

Synonym: CV_3896

Alternate gene names: 34499351

Gene position: 4204314-4206521 (Clockwise)

Preceding gene: 34499350

Following gene: 34499352

Centisome position: 88.49

GC content: 69.11

Gene sequence:

>2208_bases
ATGGCCCTGTTCCGTGCCACCCCTCTGGTGCTGAGCCTGGCGGCAGCCTGGCCCGCCTTCGCAGACACCGCCTCGCCGGC
GCTGGAGACCATCCAGGTCACCGCGCACCGCAGCGAGAAACCGCTGGCGGAAACCGCCCCCAACGCCGCCGTGGTGTCGC
GCCACAAGCTGGACGACCGGCTGATCCGCGATATTGCCGACGCGGCGAAATACGAGCCGGGCGTGGAGGTGGCCGCCGAC
CCCAGCCGCCGCGGCAACGCGGGGTGGACCATACGCGGCATCGACGGCAACCGCATCCTGATGCTGATCGACGGCGAGCG
GCTGCCTGAAGCCTATGCCGGCGGCGGCAACGGCAACGGCGCCATCGCCGGCCGCGACTTCGTCGAACTGGAAACGCTGC
GGGCGATCGACATCGTCAAGGGGCCGACCTCCAGCCTGTACGGCTCGGACGCCATCGGCGGCGTGATCGGCTACCGCACC
AAGGCGGTCGACGACTTCGTGCCGGAAGACCAGGGGATAGGCGGCAGCGTCAAGGCCTTCGGCGCCGGCGCGGACAATAG
CTGGGGGGGCAGCGCCGGCTTCGGCGCCAAGGGCGAGCGCGCCGACGCCATGCTGATCTACACTCATCGCAACGGCCATG
AAACCGGCAACCAAGGCGGCAACGGCAGCGACGGCGCCGCCCGCACCGCGCCCAATCCGCAAAGCTGGCACAGCGACAGC
CTGCTGGCCAAGCTGGGCTACAAGCTGGTCGAACGGCAGCGGCTGGAGCTGACGCTGGAGCATTTCCGGCGCGACACCGA
CACCAAGCTGCTGAACACGCTGTACCCGGCCTCCATCGACCGCCGCTCGGGCCGGCCCAAGCCGGCGCTGCAAGCGCAGA
CCGCCGCCGACCGCACCCAGCGCGACCGCGTTTCGCTTGGCTGGGAAGCGAAACGGACCGGGCCTTTCGAACGCCTGGCC
GTCAAGCTGTACCAGCAAAAGCTGGACAATGCCGACGACAGCCTCGAGCAGTACGGCAATGGCAGCCGCATCGCGTCGAA
TTACGGCTTCGACCAGAAAATCCTCGGCCTGAGCCTGGACGCCGAGCACCGTTTCGCCGCGCTGTCGGCCGAACAGCTGC
TGCTGTGGGGCGTGGACCTCTCGCGCACCGACACCAGCCGGCCACGGCTCAAGACGCAATACAACGCCGACGGCAGCGCC
AGCAACGTCGTGGGCGGCGAGACCTTCCCCAGCAAGACCTTCCCCGACAGCGCCTCGAACCGCGTCGGCCTGTTCGTTCA
GGACGAGATGAAGTTCGCGAACGGCGTCGTCCTGTCGCCATCGCTGCGCTGGGACCATTACAAGATGACCACCAGCCCGG
ACCAGGCCTATGCCAACAGCGGCGGCCAGGCCGTGCCGTCGTTCAGCGACAGCGCGTTCTCGCCCAAGCTGGGCCTGAGC
ATCCCGTTCGCCGGCCATTACACCGCCTTCGCCCAGCTGTCGTCCGGCTTCCGCGCGCCGCCGTTCGACGACGCCAACAT
GGCCTTCGTCAACCGCGCCCACGGCTACCAGGTGATCGTCAACCCCGCGCTGAAATCGGAAACCAGCCGCGGCGTCGAGC
TGGGATTGAAAGGCCAGTGGGACAGCGTCGACTTCGGCCTGACCGCCTATCAGAACCGCTACCGCGACTTCATCGAGCAG
CAGAGTCTGGGCATGGTGAACGGCCTGCTGACCTATCAGTACCAGAACATCGGCCGGGTCGACATCAAGGGGGCCGAAGC
GCGCGCCGCCTGGCGCTTCGCTCCGGGCTGGCAGACCCACGCCGCCGTCGCCTACACCCACGGCGAGGATCTCGACAGCC
ACACCGCGCTGGCGTCGGTCGCGCCGATGTCGGCGGTGCTGGGCCTGCGCTACGGCCAGGCGCGCTTCGGCGGGGAGGCG
CTGCTGCGCGCCGCCGTCCGCAACAACCGCGCGCCGGCGGTGGCGCTGCCCCCGCCTTCGGCCGGGCAGACCGCCGGTTT
CGAGACCCCGGGCTACGCGACGCTGGACCTGACCGCCTACTGGAAGCCGGCCAAGGGCACCACCGTGCGCGCCGGCGTGT
TCAACATCTTCGACCGCAAATACTGGAAGACCGCCGACGTGCGCGGCATGGCCGCCGGCGATCCGGCGCTGGACCGCTAC
ACCCAGCCCGGCCGCAACGTCAGCGCCAGCGTCGAATACCAATTCTGA

Upstream 100 bases:

>100_bases
CCTGCAGCTCACCCGCAACGGCAAACTGATACTGATCAAGTAACACCCGCAAGCCAGCCGACAGCCAGCCAGCGGAAACG
ACAACAACATTGGAGTTTCC

Downstream 100 bases:

>100_bases
TCCACCCGGCGGGCGGCCTCCCGCCCGCCGCCAACCACAGGAGAACACCATGAGCCAGCTATGGGACCGCTACCAGGCGC
TCAAAGCCAGCCAGCCCAAG

Product: TonB-dependent receptor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 735; Mature: 734

Protein sequence:

>735_residues
MALFRATPLVLSLAAAWPAFADTASPALETIQVTAHRSEKPLAETAPNAAVVSRHKLDDRLIRDIADAAKYEPGVEVAAD
PSRRGNAGWTIRGIDGNRILMLIDGERLPEAYAGGGNGNGAIAGRDFVELETLRAIDIVKGPTSSLYGSDAIGGVIGYRT
KAVDDFVPEDQGIGGSVKAFGAGADNSWGGSAGFGAKGERADAMLIYTHRNGHETGNQGGNGSDGAARTAPNPQSWHSDS
LLAKLGYKLVERQRLELTLEHFRRDTDTKLLNTLYPASIDRRSGRPKPALQAQTAADRTQRDRVSLGWEAKRTGPFERLA
VKLYQQKLDNADDSLEQYGNGSRIASNYGFDQKILGLSLDAEHRFAALSAEQLLLWGVDLSRTDTSRPRLKTQYNADGSA
SNVVGGETFPSKTFPDSASNRVGLFVQDEMKFANGVVLSPSLRWDHYKMTTSPDQAYANSGGQAVPSFSDSAFSPKLGLS
IPFAGHYTAFAQLSSGFRAPPFDDANMAFVNRAHGYQVIVNPALKSETSRGVELGLKGQWDSVDFGLTAYQNRYRDFIEQ
QSLGMVNGLLTYQYQNIGRVDIKGAEARAAWRFAPGWQTHAAVAYTHGEDLDSHTALASVAPMSAVLGLRYGQARFGGEA
LLRAAVRNNRAPAVALPPPSAGQTAGFETPGYATLDLTAYWKPAKGTTVRAGVFNIFDRKYWKTADVRGMAAGDPALDRY
TQPGRNVSASVEYQF

Sequences:

>Translated_735_residues
MALFRATPLVLSLAAAWPAFADTASPALETIQVTAHRSEKPLAETAPNAAVVSRHKLDDRLIRDIADAAKYEPGVEVAAD
PSRRGNAGWTIRGIDGNRILMLIDGERLPEAYAGGGNGNGAIAGRDFVELETLRAIDIVKGPTSSLYGSDAIGGVIGYRT
KAVDDFVPEDQGIGGSVKAFGAGADNSWGGSAGFGAKGERADAMLIYTHRNGHETGNQGGNGSDGAARTAPNPQSWHSDS
LLAKLGYKLVERQRLELTLEHFRRDTDTKLLNTLYPASIDRRSGRPKPALQAQTAADRTQRDRVSLGWEAKRTGPFERLA
VKLYQQKLDNADDSLEQYGNGSRIASNYGFDQKILGLSLDAEHRFAALSAEQLLLWGVDLSRTDTSRPRLKTQYNADGSA
SNVVGGETFPSKTFPDSASNRVGLFVQDEMKFANGVVLSPSLRWDHYKMTTSPDQAYANSGGQAVPSFSDSAFSPKLGLS
IPFAGHYTAFAQLSSGFRAPPFDDANMAFVNRAHGYQVIVNPALKSETSRGVELGLKGQWDSVDFGLTAYQNRYRDFIEQ
QSLGMVNGLLTYQYQNIGRVDIKGAEARAAWRFAPGWQTHAAVAYTHGEDLDSHTALASVAPMSAVLGLRYGQARFGGEA
LLRAAVRNNRAPAVALPPPSAGQTAGFETPGYATLDLTAYWKPAKGTTVRAGVFNIFDRKYWKTADVRGMAAGDPALDRY
TQPGRNVSASVEYQF
>Mature_734_residues
ALFRATPLVLSLAAAWPAFADTASPALETIQVTAHRSEKPLAETAPNAAVVSRHKLDDRLIRDIADAAKYEPGVEVAADP
SRRGNAGWTIRGIDGNRILMLIDGERLPEAYAGGGNGNGAIAGRDFVELETLRAIDIVKGPTSSLYGSDAIGGVIGYRTK
AVDDFVPEDQGIGGSVKAFGAGADNSWGGSAGFGAKGERADAMLIYTHRNGHETGNQGGNGSDGAARTAPNPQSWHSDSL
LAKLGYKLVERQRLELTLEHFRRDTDTKLLNTLYPASIDRRSGRPKPALQAQTAADRTQRDRVSLGWEAKRTGPFERLAV
KLYQQKLDNADDSLEQYGNGSRIASNYGFDQKILGLSLDAEHRFAALSAEQLLLWGVDLSRTDTSRPRLKTQYNADGSAS
NVVGGETFPSKTFPDSASNRVGLFVQDEMKFANGVVLSPSLRWDHYKMTTSPDQAYANSGGQAVPSFSDSAFSPKLGLSI
PFAGHYTAFAQLSSGFRAPPFDDANMAFVNRAHGYQVIVNPALKSETSRGVELGLKGQWDSVDFGLTAYQNRYRDFIEQQ
SLGMVNGLLTYQYQNIGRVDIKGAEARAAWRFAPGWQTHAAVAYTHGEDLDSHTALASVAPMSAVLGLRYGQARFGGEAL
LRAAVRNNRAPAVALPPPSAGQTAGFETPGYATLDLTAYWKPAKGTTVRAGVFNIFDRKYWKTADVRGMAAGDPALDRYT
QPGRNVSASVEYQF

Specific function: Acts as a receptor for hemoglobin or the hemoglobin/haptoglobin complex and is required for heme uptake [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tonB-dependent receptor family [H]

Homologues:

Organism=Escherichia coli, GI1788478, Length=800, Percent_Identity=23.75, Blast_Score=116, Evalue=7e-27,
Organism=Escherichia coli, GI1790405, Length=152, Percent_Identity=30.9210526315789, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012910
- InterPro:   IPR000531
- InterPro:   IPR010949
- InterPro:   IPR010917 [H]

Pfam domain/function: PF07715 Plug; PF00593 TonB_dep_Rec [H]

EC number: NA

Molecular weight: Translated: 79253; Mature: 79122

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALFRATPLVLSLAAAWPAFADTASPALETIQVTAHRSEKPLAETAPNAAVVSRHKLDDR
CCCEEHHHHHHHHHHHCCHHHCCCCCHHEEEEEEECCCCCCHHHCCCCHHHHHHHHHHHH
LIRDIADAAKYEPGVEVAADPSRRGNAGWTIRGIDGNRILMLIDGERLPEAYAGGGNGNG
HHHHHHHHHHCCCCCEEECCCCCCCCCCEEEEECCCCEEEEEECCCCCCHHHCCCCCCCC
AIAGRDFVELETLRAIDIVKGPTSSLYGSDAIGGVIGYRTKAVDDFVPEDQGIGGSVKAF
CCCCCCHHHHHHHHHEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEE
GAGADNSWGGSAGFGAKGERADAMLIYTHRNGHETGNQGGNGSDGAARTAPNPQSWHSDS
ECCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
LLAKLGYKLVERQRLELTLEHFRRDTDTKLLNTLYPASIDRRSGRPKPALQAQTAADRTQ
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHCCCCCCCCHHHHHHHHHHH
RDRVSLGWEAKRTGPFERLAVKLYQQKLDNADDSLEQYGNGSRIASNYGFDQKILGLSLD
HHHEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHCCCCCEEECCCCCCCEEEEEEEC
AEHRFAALSAEQLLLWGVDLSRTDTSRPRLKTQYNADGSASNVVGGETFPSKTFPDSASN
CCHHHHHHCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCC
RVGLFVQDEMKFANGVVLSPSLRWDHYKMTTSPDQAYANSGGQAVPSFSDSAFSPKLGLS
EEEEEEECCHHHHCCEEECCCCCCCEEEECCCCCHHHHCCCCCCCCCCCCCCCCCCCCEE
IPFAGHYTAFAQLSSGFRAPPFDDANMAFVNRAHGYQVIVNPALKSETSRGVELGLKGQW
CCCCCCHHHHHHHHCCCCCCCCCCCCEEEEECCCCCEEEECCHHHCCCCCCEEEECCCCC
DSVDFGLTAYQNRYRDFIEQQSLGMVNGLLTYQYQNIGRVDIKGAEARAAWRFAPGWQTH
CCCCCCHHHHHHHHHHHHHHHHCHHHHHEEEEEECCCCEEEECCCCCCEEEEECCCCCCC
AAVAYTHGEDLDSHTALASVAPMSAVLGLRYGQARFGGEALLRAAVRNNRAPAVALPPPS
EEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCC
AGQTAGFETPGYATLDLTAYWKPAKGTTVRAGVFNIFDRKYWKTADVRGMAAGDPALDRY
CCCCCCCCCCCEEEEEEEEEEECCCCCEEEHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
TQPGRNVSASVEYQF
CCCCCCCEEEEEECC
>Mature Secondary Structure 
ALFRATPLVLSLAAAWPAFADTASPALETIQVTAHRSEKPLAETAPNAAVVSRHKLDDR
CCEEHHHHHHHHHHHCCHHHCCCCCHHEEEEEEECCCCCCHHHCCCCHHHHHHHHHHHH
LIRDIADAAKYEPGVEVAADPSRRGNAGWTIRGIDGNRILMLIDGERLPEAYAGGGNGNG
HHHHHHHHHHCCCCCEEECCCCCCCCCCEEEEECCCCEEEEEECCCCCCHHHCCCCCCCC
AIAGRDFVELETLRAIDIVKGPTSSLYGSDAIGGVIGYRTKAVDDFVPEDQGIGGSVKAF
CCCCCCHHHHHHHHHEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEE
GAGADNSWGGSAGFGAKGERADAMLIYTHRNGHETGNQGGNGSDGAARTAPNPQSWHSDS
ECCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
LLAKLGYKLVERQRLELTLEHFRRDTDTKLLNTLYPASIDRRSGRPKPALQAQTAADRTQ
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHCCCCCCCCHHHHHHHHHHH
RDRVSLGWEAKRTGPFERLAVKLYQQKLDNADDSLEQYGNGSRIASNYGFDQKILGLSLD
HHHEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHCCCCCEEECCCCCCCEEEEEEEC
AEHRFAALSAEQLLLWGVDLSRTDTSRPRLKTQYNADGSASNVVGGETFPSKTFPDSASN
CCHHHHHHCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCC
RVGLFVQDEMKFANGVVLSPSLRWDHYKMTTSPDQAYANSGGQAVPSFSDSAFSPKLGLS
EEEEEEECCHHHHCCEEECCCCCCCEEEECCCCCHHHHCCCCCCCCCCCCCCCCCCCCEE
IPFAGHYTAFAQLSSGFRAPPFDDANMAFVNRAHGYQVIVNPALKSETSRGVELGLKGQW
CCCCCCHHHHHHHHCCCCCCCCCCCCEEEEECCCCCEEEECCHHHCCCCCCEEEECCCCC
DSVDFGLTAYQNRYRDFIEQQSLGMVNGLLTYQYQNIGRVDIKGAEARAAWRFAPGWQTH
CCCCCCHHHHHHHHHHHHHHHHCHHHHHEEEEEECCCCEEEECCCCCCEEEEECCCCCCC
AAVAYTHGEDLDSHTALASVAPMSAVLGLRYGQARFGGEALLRAAVRNNRAPAVALPPPS
EEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCC
AGQTAGFETPGYATLDLTAYWKPAKGTTVRAGVFNIFDRKYWKTADVRGMAAGDPALDRY
CCCCCCCCCCCEEEEEEEEEEECCCCCEEEHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
TQPGRNVSASVEYQF
CCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]