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The map label for this gene is arcB

Identifier: 34499236

GI number: 34499236

Start: 4076434

End: 4077444

Strand: Reverse

Name: arcB

Synonym: CV_3781

Alternate gene names: 34499236

Gene position: 4077444-4076434 (Counterclockwise)

Preceding gene: 34499237

Following gene: 34499235

Centisome position: 85.82

GC content: 63.01

Gene sequence:

>1011_bases
ATGGCTTTCAATCTGCGCAACCGTAACTTCCTGAAAATGCTGGACTTCACCCCGCGTGAAATCCGTTACCTGCTGGACCT
GTCCCGCGATCTGAAGCGCGCCAAGTACAGCGGCACCGAACAGCAGCACCTGAAGGGCAAGAACGTCGCCCTGATCTTCG
AAAAGACCTCCACCCGCACCCGCTGCGCGTTCGAGGTGGCCTGCTTCGACCAGGGCGCCAACGTGTCCTACATCGGGCCG
TCCGGCTCGCAGATCGGCCACAAGGAATCGATGAAGGACACCGCCCGCGTGTTGGGCCGGATGTACGACGCCATCGAATA
CCGCGGCTACAGCCAGGACATGGTCGAGCATGAGTTGGCCGCCTACGCCGGCGTGCCGGTGTACAACGGGCTGACCGACG
AATACCACCCGACCCAGATGCTGGCCGACGTGCTGACCATGTGGGAGCACAGCGACAAGCCGATCTCCCAGATCAGCTAC
ACCTACCTCGGCGACGCCCGCAACAATATGGGCAACTCCCTGCTGGTGATCGGCTCCAAGCTGGGCATGGACGTGCGCAT
CGGCGCGCCGAAGCACCTGTGGCCGACCGACGAGCTGGTGGCCGAGTGCCGCGAGATCGCCAAGCGCACCGGCGCCCGCA
TCACGCTGACCGAAGATCCGAAGGAAGCCGTCAAGGGCACCGACTTCATCCACACCGACGTATGGGTGTCCATGGGCGAG
CCGGCCGAAGTGTGGGCCGAGCGCATCCGTCTGCTGAAGCCGTACCAGGTCAACAGCGCGCTGATGGCCGCCTCCGGCAA
TCCGCAGGTGAAGTTCATGCACTGCCTGCCGGCCTTCCACAACAGCGAAACCAAGGTGGGCAAGGAAATCTCCGCCCAGT
ATCCGGAACTGGCCAACGGCATCGAGGTGACCGAGGACGTGTTCGAGTCCGAGGCTTGCATCGCCTTCGAGCAGGCCGAG
AACCGCATGCACACCATCAAGGCCATCCTAGTATCCACCCTGGGCGATTGA

Upstream 100 bases:

>100_bases
TCCGTATCTAGTTCTAGTTTGTTTGCAAAAAGACAGGTTGACCGCCGCTTCCCCCGGGGACGACGGCCCGCTTGCCCAGA
CTCTAATCAGGAGCAATATC

Downstream 100 bases:

>100_bases
GCCCGCGGGCCAAGCGCCTGGTTTCAGACGCTTTGCGATTGGGGTTGCATGGGGCCGGCAAGCCGGCCTGATCGAATACC
GGCCGGCCAAGGACTCCTGA

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MAFNLRNRNFLKMLDFTPREIRYLLDLSRDLKRAKYSGTEQQHLKGKNVALIFEKTSTRTRCAFEVACFDQGANVSYIGP
SGSQIGHKESMKDTARVLGRMYDAIEYRGYSQDMVEHELAAYAGVPVYNGLTDEYHPTQMLADVLTMWEHSDKPISQISY
TYLGDARNNMGNSLLVIGSKLGMDVRIGAPKHLWPTDELVAECREIAKRTGARITLTEDPKEAVKGTDFIHTDVWVSMGE
PAEVWAERIRLLKPYQVNSALMAASGNPQVKFMHCLPAFHNSETKVGKEISAQYPELANGIEVTEDVFESEACIAFEQAE
NRMHTIKAILVSTLGD

Sequences:

>Translated_336_residues
MAFNLRNRNFLKMLDFTPREIRYLLDLSRDLKRAKYSGTEQQHLKGKNVALIFEKTSTRTRCAFEVACFDQGANVSYIGP
SGSQIGHKESMKDTARVLGRMYDAIEYRGYSQDMVEHELAAYAGVPVYNGLTDEYHPTQMLADVLTMWEHSDKPISQISY
TYLGDARNNMGNSLLVIGSKLGMDVRIGAPKHLWPTDELVAECREIAKRTGARITLTEDPKEAVKGTDFIHTDVWVSMGE
PAEVWAERIRLLKPYQVNSALMAASGNPQVKFMHCLPAFHNSETKVGKEISAQYPELANGIEVTEDVFESEACIAFEQAE
NRMHTIKAILVSTLGD
>Mature_335_residues
AFNLRNRNFLKMLDFTPREIRYLLDLSRDLKRAKYSGTEQQHLKGKNVALIFEKTSTRTRCAFEVACFDQGANVSYIGPS
GSQIGHKESMKDTARVLGRMYDAIEYRGYSQDMVEHELAAYAGVPVYNGLTDEYHPTQMLADVLTMWEHSDKPISQISYT
YLGDARNNMGNSLLVIGSKLGMDVRIGAPKHLWPTDELVAECREIAKRTGARITLTEDPKEAVKGTDFIHTDVWVSMGEP
AEVWAERIRLLKPYQVNSALMAASGNPQVKFMHCLPAFHNSETKVGKEISAQYPELANGIEVTEDVFESEACIAFEQAEN
RMHTIKAILVSTLGD

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family

Homologues:

Organism=Homo sapiens, GI38788445, Length=335, Percent_Identity=37.3134328358209, Blast_Score=196, Evalue=3e-50,
Organism=Escherichia coli, GI1786469, Length=334, Percent_Identity=61.0778443113772, Blast_Score=434, Evalue=1e-123,
Organism=Escherichia coli, GI1790703, Length=329, Percent_Identity=61.7021276595745, Blast_Score=432, Evalue=1e-122,
Organism=Escherichia coli, GI48994908, Length=382, Percent_Identity=23.2984293193717, Blast_Score=78, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6322373, Length=332, Percent_Identity=31.6265060240964, Blast_Score=158, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6322331, Length=293, Percent_Identity=26.2798634812287, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24642586, Length=234, Percent_Identity=25.6410256410256, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OTCC_CHRVO (Q7NRK0)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_903451.1
- ProteinModelPortal:   Q7NRK0
- SMR:   Q7NRK0
- GeneID:   2548111
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_3781
- NMPDR:   fig|243365.1.peg.3781
- HOGENOM:   HBG579429
- OMA:   MTPYQIN
- PhylomeDB:   Q7NRK0
- BioCyc:   CVIO243365:CV_3781-MONOMER
- BRENDA:   2.1.3.3
- HAMAP:   MF_01109
- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292
- PRINTS:   PR00100
- PRINTS:   PR00102
- TIGRFAMs:   TIGR00658

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N; SSF53671 Asp/Orn_carbamoyltranf

EC number: =2.1.3.3

Molecular weight: Translated: 37764; Mature: 37633

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: BINDING 108-108 BINDING 136-136

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFNLRNRNFLKMLDFTPREIRYLLDLSRDLKRAKYSGTEQQHLKGKNVALIFEKTSTRT
CCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCEEEEEECCCCCC
RCAFEVACFDQGANVSYIGPSGSQIGHKESMKDTARVLGRMYDAIEYRGYSQDMVEHELA
EEEEEEEEECCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
AYAGVPVYNGLTDEYHPTQMLADVLTMWEHSDKPISQISYTYLGDARNNMGNSLLVIGSK
HHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHEEEEEECCCCCCCCCEEEEEECC
LGMDVRIGAPKHLWPTDELVAECREIAKRTGARITLTEDPKEAVKGTDFIHTDVWVSMGE
CCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCHHHHHCCCCEEEEEEEEECCC
PAEVWAERIRLLKPYQVNSALMAASGNPQVKFMHCLPAFHNSETKVGKEISAQYPELANG
CHHHHHHHHHHCCCCCCCCEEEECCCCCCEEEEEECCCCCCCCHHHHHHHHHCCHHHHCC
IEVTEDVFESEACIAFEQAENRMHTIKAILVSTLGD
CHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AFNLRNRNFLKMLDFTPREIRYLLDLSRDLKRAKYSGTEQQHLKGKNVALIFEKTSTRT
CCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCEEEEEECCCCCC
RCAFEVACFDQGANVSYIGPSGSQIGHKESMKDTARVLGRMYDAIEYRGYSQDMVEHELA
EEEEEEEEECCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
AYAGVPVYNGLTDEYHPTQMLADVLTMWEHSDKPISQISYTYLGDARNNMGNSLLVIGSK
HHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHEEEEEECCCCCCCCCEEEEEECC
LGMDVRIGAPKHLWPTDELVAECREIAKRTGARITLTEDPKEAVKGTDFIHTDVWVSMGE
CCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCHHHHHCCCCEEEEEEEEECCC
PAEVWAERIRLLKPYQVNSALMAASGNPQVKFMHCLPAFHNSETKVGKEISAQYPELANG
CHHHHHHHHHHCCCCCCCCEEEECCCCCCEEEEEECCCCCCCCHHHHHHHHHCCHHHHCC
IEVTEDVFESEACIAFEQAENRMHTIKAILVSTLGD
CHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782