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The map label for this gene is apt

Identifier: 34499227

GI number: 34499227

Start: 4070454

End: 4071035

Strand: Direct

Name: apt

Synonym: CV_3772

Alternate gene names: 34499227

Gene position: 4070454-4071035 (Clockwise)

Preceding gene: 34499226

Following gene: 34499233

Centisome position: 85.67

GC content: 61.51

Gene sequence:

>582_bases
TTGATTTCGAAGTACAATAGGCCCATGGAAAACCTCAGCAATCTCGACTACTCCAGCTACCTGAAGGGCTGGATCCGCAC
CGTGCCCAACTGGCCGCAGCAAGGCGTGATGTTCCGCGACATCACGCCGCTGCTGCAAAACCCGAAAACCTTCCGCATGC
TGATCGACATCTACGTCCATCGCTACATGATGGAAAAGGTGGACCTGGTGGCGGGCCTGGACGCGCGCGGCTTCATCATC
GGCTCGGTGCTGGCCTATGAGCTGAATGTCGGCTTCGTGCCCATCCGCAAGAAAGGCAAGCTGCCTTTCACCACGGTGGA
AGAGGAATACGAGCTGGAATACGGCAACGCCGCGGTGGAAATGCACACCGACGCCTGCAAGCCGGGCGACCGCGTGATCC
TGATCGACGACCTGGTGGCCACCGGCGGCACCATGATGGCCGGCTACAAGCTGCTCAAGCGCATGGGCGCCGACGTGCTG
GAAGCCGCGGCCATCATCGAACTGCCGGAACTGGGCGGCGGCCAGCTGGTTCGCGATGGCGGCCTGGACCTGTTCACGGT
CTGCAGCTACGAAGGCCACTGA

Upstream 100 bases:

>100_bases
GCTGGCGTTCTTCCACTAAAAGCACAATAATCCCTTCATCCGACGGCCTGCCCGCTACGCGCAGGCCGTCGTCGCGAACC
GTGTCAGTCGGCACAGTCTC

Downstream 100 bases:

>100_bases
GCGCGGCAGGCAAATCCGCGCGCGCATGCTGACAACGGAGCCGACGGCTCCGTTTTTTCATGCCGAAACGAAAAAGGCCC
GGCCTAGGGCCGGGCAAAGG

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 193; Mature: 193

Protein sequence:

>193_residues
MISKYNRPMENLSNLDYSSYLKGWIRTVPNWPQQGVMFRDITPLLQNPKTFRMLIDIYVHRYMMEKVDLVAGLDARGFII
GSVLAYELNVGFVPIRKKGKLPFTTVEEEYELEYGNAAVEMHTDACKPGDRVILIDDLVATGGTMMAGYKLLKRMGADVL
EAAAIIELPELGGGQLVRDGGLDLFTVCSYEGH

Sequences:

>Translated_193_residues
MISKYNRPMENLSNLDYSSYLKGWIRTVPNWPQQGVMFRDITPLLQNPKTFRMLIDIYVHRYMMEKVDLVAGLDARGFII
GSVLAYELNVGFVPIRKKGKLPFTTVEEEYELEYGNAAVEMHTDACKPGDRVILIDDLVATGGTMMAGYKLLKRMGADVL
EAAAIIELPELGGGQLVRDGGLDLFTVCSYEGH
>Mature_193_residues
MISKYNRPMENLSNLDYSSYLKGWIRTVPNWPQQGVMFRDITPLLQNPKTFRMLIDIYVHRYMMEKVDLVAGLDARGFII
GSVLAYELNVGFVPIRKKGKLPFTTVEEEYELEYGNAAVEMHTDACKPGDRVILIDDLVATGGTMMAGYKLLKRMGADVL
EAAAIIELPELGGGQLVRDGGLDLFTVCSYEGH

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=170, Percent_Identity=44.7058823529412, Blast_Score=150, Evalue=9e-37,
Organism=Homo sapiens, GI71773201, Length=121, Percent_Identity=47.9338842975207, Blast_Score=122, Evalue=2e-28,
Organism=Escherichia coli, GI1786675, Length=174, Percent_Identity=46.551724137931, Blast_Score=176, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI17509087, Length=173, Percent_Identity=45.6647398843931, Blast_Score=136, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6323619, Length=166, Percent_Identity=39.1566265060241, Blast_Score=115, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6320649, Length=169, Percent_Identity=34.9112426035503, Blast_Score=91, Evalue=9e-20,
Organism=Drosophila melanogaster, GI17136334, Length=165, Percent_Identity=40.6060606060606, Blast_Score=128, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_CHRVO (Q7NRK9)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_903442.1
- ProteinModelPortal:   Q7NRK9
- SMR:   Q7NRK9
- GeneID:   2548447
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_3772
- NMPDR:   fig|243365.1.peg.3772
- HOGENOM:   HBG703830
- OMA:   YVLVESH
- PhylomeDB:   Q7NRK9
- ProtClustDB:   PRK02304
- BioCyc:   CVIO243365:CV_3772-MONOMER
- BRENDA:   2.4.2.7
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 21627; Mature: 21627

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISKYNRPMENLSNLDYSSYLKGWIRTVPNWPQQGVMFRDITPLLQNPKTFRMLIDIYVH
CCCCCCCCHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHCCCHHHHCCHHHHHHHHHHHH
RYMMEKVDLVAGLDARGFIIGSVLAYELNVGFVPIRKKGKLPFTTVEEEYELEYGNAAVE
HHHHHHHHHHHCCCCCHHHHHHHHEEEECCCEEEECCCCCCCCEECCHHEEEECCCEEEE
MHTDACKPGDRVILIDDLVATGGTMMAGYKLLKRMGADVLEAAAIIELPELGGGQLVRDG
EECCCCCCCCEEEEEECHHHCCCHHHHHHHHHHHHCHHHHHHHHHEECCCCCCCEEEECC
GLDLFTVCSYEGH
CCCEEEEECCCCC
>Mature Secondary Structure
MISKYNRPMENLSNLDYSSYLKGWIRTVPNWPQQGVMFRDITPLLQNPKTFRMLIDIYVH
CCCCCCCCHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHCCCHHHHCCHHHHHHHHHHHH
RYMMEKVDLVAGLDARGFIIGSVLAYELNVGFVPIRKKGKLPFTTVEEEYELEYGNAAVE
HHHHHHHHHHHCCCCCHHHHHHHHEEEECCCEEEECCCCCCCCEECCHHEEEECCCEEEE
MHTDACKPGDRVILIDDLVATGGTMMAGYKLLKRMGADVLEAAAIIELPELGGGQLVRDG
EECCCCCCCCEEEEEECHHHCCCHHHHHHHHHHHHCHHHHHHHHHEECCCCCCCEEEECC
GLDLFTVCSYEGH
CCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782