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The map label for this gene is mutT [H]

Identifier: 34499066

GI number: 34499066

Start: 3916413

End: 3917285

Strand: Reverse

Name: mutT [H]

Synonym: CV_3611

Alternate gene names: 34499066

Gene position: 3917285-3916413 (Counterclockwise)

Preceding gene: 34499067

Following gene: 34499065

Centisome position: 82.45

GC content: 72.85

Gene sequence:

>873_bases
ATGCTGGGCAGCCGCCCCGAGGGCAAGCCTTACGCCGGCTACTGGGAGTTCCCTGGCGGCAAGGTGGAGGCCGGCGAGAC
GCCGCTGGCGGCGCTGAAGCGGGAATTCAACGAGGAAATGGGCATCACGGTCACCGCCGCCACGCCGTGGTTGACCAAGA
TCCACCATTACGAGCACGCATCGGTGCACCTGCGCTTTTTCCGCATCTGGGACTGGCTGGGCGATCCGCATCCGCGCGAA
GGCCAGTCCTTCGCCTGGCAGCGCCCGGGCCGGCTGACCGTGGCGCCGATGCTGCCGGCCAACGGGCCGATCCTGAAGTC
GCTGGCGCTGCCGTCCTGCTACGCGATCACCTGCGCCGCCGAAATCGGCGTCGAGGCGCAGCTGGCGCGGCTGGCCGAGC
GCGACTGGGGCATGGTCCAGGTGCGCGAGCGCGAGATGGGGCGCGAAGCGCTGGCCGATTTCGTCGCCCGCGCCGCCGCC
ATCGTCCGCCCGCGCGGCGGCAAGCTGGTGGTCAACGCCGATCCGGCGTGGCTGGAAGGCTGGCCGGTGGACGGCGTGCA
CCTGAACGGCGCGCGCCTGGCCGCGCTGGAATCGCGTCCGGCCTTCGACTGGGTGGGCGCGTCCATCCATGGCGCGGACG
AACTGGCGCGGGCCGGCGAGCTGGGACTGGACTACGCGCTGCTGAGCCCGGTCGCGCCCACGGCCACCCATCCCGGCGCG
TCGCTGCTGGGCTGGGACGGCTTCTCCGCTTGCCTGGCCGGCGGCGTGCCGCTGCCGGTGTACGCGCTGGGCGGCATGCG
CGCCGAGAACCTGGACCTGGCCCGCCTTCACGGCGCCCATGGCGTGGCGCTGATGCGCGGGGCGTGGCGATGA

Upstream 100 bases:

>100_bases
CCGGGCGCCAGGCGCCCATAGCCGACAGATTGAAGACATGACGAGCAACAAGATCATAGATGTAGTGGCGGGCGCGCTGA
TGCGGCCGGACGGCAGCTTC

Downstream 100 bases:

>100_bases
CGGCGAAGCAGCGCAAGCTGCTGATCCTGGGCGCGGCGCTGCTGGCCTTCGGCGCCGTCAAGTTCGGCCTGATCTACTAC
TGGTATTCGCATAACAGGCA

Product: hypothetical protein

Products: NA

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MLGSRPEGKPYAGYWEFPGGKVEAGETPLAALKREFNEEMGITVTAATPWLTKIHHYEHASVHLRFFRIWDWLGDPHPRE
GQSFAWQRPGRLTVAPMLPANGPILKSLALPSCYAITCAAEIGVEAQLARLAERDWGMVQVREREMGREALADFVARAAA
IVRPRGGKLVVNADPAWLEGWPVDGVHLNGARLAALESRPAFDWVGASIHGADELARAGELGLDYALLSPVAPTATHPGA
SLLGWDGFSACLAGGVPLPVYALGGMRAENLDLARLHGAHGVALMRGAWR

Sequences:

>Translated_290_residues
MLGSRPEGKPYAGYWEFPGGKVEAGETPLAALKREFNEEMGITVTAATPWLTKIHHYEHASVHLRFFRIWDWLGDPHPRE
GQSFAWQRPGRLTVAPMLPANGPILKSLALPSCYAITCAAEIGVEAQLARLAERDWGMVQVREREMGREALADFVARAAA
IVRPRGGKLVVNADPAWLEGWPVDGVHLNGARLAALESRPAFDWVGASIHGADELARAGELGLDYALLSPVAPTATHPGA
SLLGWDGFSACLAGGVPLPVYALGGMRAENLDLARLHGAHGVALMRGAWR
>Mature_290_residues
MLGSRPEGKPYAGYWEFPGGKVEAGETPLAALKREFNEEMGITVTAATPWLTKIHHYEHASVHLRFFRIWDWLGDPHPRE
GQSFAWQRPGRLTVAPMLPANGPILKSLALPSCYAITCAAEIGVEAQLARLAERDWGMVQVREREMGREALADFVARAAA
IVRPRGGKLVVNADPAWLEGWPVDGVHLNGARLAALESRPAFDWVGASIHGADELARAGELGLDYALLSPVAPTATHPGA
SLLGWDGFSACLAGGVPLPVYALGGMRAENLDLARLHGAHGVALMRGAWR

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus lea

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1788056, Length=108, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003561
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.-; 2.5.1.3

Molecular weight: Translated: 31284; Mature: 31284

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGSRPEGKPYAGYWEFPGGKVEAGETPLAALKREFNEEMGITVTAATPWLTKIHHYEHA
CCCCCCCCCCCCCEEECCCCEEECCCCHHHHHHHHHHHHCCEEEEECCCHHHHHHCCCCC
SVHLRFFRIWDWLGDPHPREGQSFAWQRPGRLTVAPMLPANGPILKSLALPSCYAITCAA
EEEEEEEEEHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHCCCCEEEEEEHH
EIGVEAQLARLAERDWGMVQVREREMGREALADFVARAAAIVRPRGGKLVVNADPAWLEG
HHCCHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCC
WPVDGVHLNGARLAALESRPAFDWVGASIHGADELARAGELGLDYALLSPVAPTATHPGA
CCCCCEEECCEEEEEECCCCCHHHCCCCCCCHHHHHHHCCCCCCHHHHCCCCCCCCCCCC
SLLGWDGFSACLAGGVPLPVYALGGMRAENLDLARLHGAHGVALMRGAWR
CEECCCCHHHHHHCCCCCCEEEECCCCCCCCCCEECCCCCCEEECCCCCC
>Mature Secondary Structure
MLGSRPEGKPYAGYWEFPGGKVEAGETPLAALKREFNEEMGITVTAATPWLTKIHHYEHA
CCCCCCCCCCCCCEEECCCCEEECCCCHHHHHHHHHHHHCCEEEEECCCHHHHHHCCCCC
SVHLRFFRIWDWLGDPHPREGQSFAWQRPGRLTVAPMLPANGPILKSLALPSCYAITCAA
EEEEEEEEEHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHCCCCEEEEEEHH
EIGVEAQLARLAERDWGMVQVREREMGREALADFVARAAAIVRPRGGKLVVNADPAWLEG
HHCCHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCC
WPVDGVHLNGARLAALESRPAFDWVGASIHGADELARAGELGLDYALLSPVAPTATHPGA
CCCCCEEECCEEEEEECCCCCHHHCCCCCCCHHHHHHHCCCCCCHHHHCCCCCCCCCCCC
SLLGWDGFSACLAGGVPLPVYALGGMRAENLDLARLHGAHGVALMRGAWR
CEECCCCHHHHHHCCCCCCEEEECCCCCCCCCCEECCCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe; Mn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]